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change diseaseTreatment to diseaseMedicine and add new diseaseTreatme…
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…nt relation for processes
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apease committed Aug 8, 2023
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109 changes: 65 additions & 44 deletions Medicine.kif
Original file line number Diff line number Diff line change
Expand Up @@ -1378,7 +1378,7 @@ the female reproductive system, and the diabetic &%Foot.[from Wikipedia]")
(attribute ?H Diabetes)
(attribute ?H (ImpairedBodyPartFn Foot))))
(holdsDuring ?T
(diseaseTreatment InfectiousDisease Ertapenem Injecting)))
(diseaseMedicine InfectiousDisease Ertapenem Injecting)))

(instance Diabetes DiseaseOrSyndrome)
(documentation Diabetes EnglishLanguage "Diabetes, also known as diabetes mellitus, is a group of
Expand Down Expand Up @@ -1932,6 +1932,7 @@ measures.[from Wikipedia]")
(documentation diseaseCandidate EnglishLanguage "A summary predicate for a modal statement.
This means that some &%Agent &%believes that a given &%Human may have a &%DiseaseOrSyndrome.")
(format EnglishLanguage diseaseCandidate "%1 may have %2")
(relatedInternalConcept diseaseCandidate pathologyCandidate)

(=>
(diseaseCandidate ?H ?D)
Expand Down Expand Up @@ -2463,7 +2464,7 @@ injection.[from Wikipedia]")
(termFormat EnglishLanguage VitaminB1 "thiamine")

(instance Beriberi DiseaseOrSyndrome)
(diseaseTreatment Beriberi VitaminB1 Ingesting)
(diseaseMedicine Beriberi VitaminB1 Ingesting)

(subclass VitaminB2 VitaminBComplex)
(documentation VitaminB2 EnglishLanguage "Riboflavin, also known as
Expand Down Expand Up @@ -2516,7 +2517,7 @@ recommended. Decreasing sun exposure via sunscreen and proper
clothing is important while the skin heals. Without treatment death
may occur. The disease occurs most commonly in the developing
world, specifically sub-Saharan Africa.[from Wikipedia]")
(diseaseTreatment Pellagra VitaminB3 Ingesting)
(diseaseMedicine Pellagra VitaminB3 Ingesting)
(termFormat EnglishLanguage Pellagra "pellagra")

(subclass VitaminB5 VitaminBComplex)
Expand Down Expand Up @@ -2621,7 +2622,7 @@ Wikipedia]")
(termFormat EnglishLanguage VitaminC "ascorbic acid")

(subclass Scurvy DiseaseOrSyndrome)
(diseaseTreatment Scurvy VitaminC Ingesting)
(diseaseMedicine Scurvy VitaminC Ingesting)

(subclass VitaminD Vitamin)
(documentation VitaminD EnglishLanguage "Vitamin D is a group of
Expand All @@ -2647,7 +2648,7 @@ the skin cancer risk.[from Wikipedia]")
(termFormat EnglishLanguage VitaminD "calciferol")

(subclass Rickets DiseaseOrSyndrome)
(diseaseTreatment Rickets VitaminD Ingesting)
(diseaseMedicine Rickets VitaminD Ingesting)

(subclass VitaminE Vitamin)
(documentation VitaminE EnglishLanguage "Vitamin E is a group of eight
Expand Down Expand Up @@ -3591,9 +3592,9 @@ macrolide class and works by decreasing protein production of some
bacteria.[from Wikipedia]") (termFormat EnglishLanguage Clarithromycin
"clarithromycin")

(diseaseTreatment LymeDisease Clarithromycin Ingesting)
(diseaseTreatment StrepThroat Clarithromycin Ingesting)
(diseaseTreatment BacterialPneumonia Clarithromycin Ingesting)
(diseaseMedicine LymeDisease Clarithromycin Ingesting)
(diseaseMedicine StrepThroat Clarithromycin Ingesting)
(diseaseMedicine BacterialPneumonia Clarithromycin Ingesting)
(sideEffect Clarithromycin Nausea)
(sideEffect Clarithromycin Vomiting)
(sideEffect Clarithromycin Headache)
Expand All @@ -3618,7 +3619,7 @@ aplastic anemia. Use during pregnancy is not recommended, but some
sources show use during breastfeeding may be safe.[from Wikipedia]")
(termFormat EnglishLanguage Adalimumab "adalimumab")

(diseaseTreatment RheumatoidArthritis Clarithromycin Injecting)
(diseaseMedicine RheumatoidArthritis Clarithromycin Injecting)
(sideEffect Adalimumab SkinRash)
(sideEffect Adalimumab Headache)

Expand Down Expand Up @@ -3876,9 +3877,9 @@ benzodiazepines were the most prescribed medications globally; the
introduction of selective serotonin reuptake inhibitors (SSRIs), among
other factors, decreased rates of prescription, but they remain
frequently used worldwide.[from Wikipedia]")
(diseaseTreatment Anxiety Benzodiazepine Ingesting)
(diseaseTreatment Insomnia Benzodiazepine Ingesting)
(diseaseTreatment Seizure Benzodiazepine Ingesting)
(diseaseMedicine Anxiety Benzodiazepine Ingesting)
(diseaseMedicine Insomnia Benzodiazepine Ingesting)
(diseaseMedicine Seizure Benzodiazepine Ingesting)
(termFormat EnglishLanguage Benzodiazepine "benzodiazepine")

(subclass Chlordiazepoxide Benzodiazepine)
Expand Down Expand Up @@ -3908,9 +3909,9 @@ appears to be safe for the baby. Sulfasalazine is in the
disease-modifying antirheumatic drugs (DMARDs) family of
medications. It is unclear exactly how it works.[from Wikipedia]")
(termFormat EnglishLanguage Sulfasalazine "sulfasalazine")
(diseaseTreatment RheumatoidArthritis Sulfasalazine Ingesting)
(diseaseTreatment CrohnsDisease Sulfasalazine Ingesting)
(diseaseTreatment UlcerativeColitis Sulfasalazine Ingesting)
(diseaseMedicine RheumatoidArthritis Sulfasalazine Ingesting)
(diseaseMedicine CrohnsDisease Sulfasalazine Ingesting)
(diseaseMedicine UlcerativeColitis Sulfasalazine Ingesting)
(sideEffect Sulfasalazine Nausea)
(sideEffect Sulfasalazine Headache)
(sideEffect Sulfasalazine SkinRash)
Expand All @@ -3926,7 +3927,7 @@ has anti-inflammatory effects and is used as an orally administered
drug for the treatment of inflammatory conditions of the lungs such as
chronic obstructive pulmonary disease (COPD) [from Wikipedia]")
(termFormat EnglishLanguage Roflumilast "roflumilast")
(diseaseTreatment ChronicObstructivePulmonaryDisease Roflumilast Ingesting)
(diseaseMedicine ChronicObstructivePulmonaryDisease Roflumilast Ingesting)
(sideEffect Roflumilast Nausea)
(sideEffect Roflumilast Headache)
(sideEffect Roflumilast Diarrhea)
Expand Down Expand Up @@ -3973,7 +3974,7 @@ is usually less preferred than methylphenidate. Its effects generally
begin within 2 hours and last for up to 14 hours. [from Wikipedia]")

(termFormat EnglishLanguage Lisdexamfetamine "lisdexamfetamine")
(diseaseTreatment AttentionDeficitHyperactivityDisorder Lisdexamfetamine Ingesting)
(diseaseMedicine AttentionDeficitHyperactivityDisorder Lisdexamfetamine Ingesting)

(subclass Vyvanse Lisdexamfetamine)
(termFormat EnglishLanguage Vyvanse "Vyvanse")
Expand Down Expand Up @@ -4045,7 +4046,7 @@ and feeling tired. More serious side effects may include suicide in
people under the age of 25. [from Wikipedia]")

(termFormat EnglishLanguage Escitalopram "escitalopram")
(diseaseTreatment Depression Escitalopram Ingesting)
(diseaseMedicine Depression Escitalopram Ingesting)
(sideEffect Nausea Escitalopram)
(sideEffect SexualDysfunction Escitalopram)
(sideEffect Anxiety Escitalopram)
Expand Down Expand Up @@ -4371,7 +4372,7 @@ worsens the symptoms, and those affected have an increased risk of
skin infections. Many people with atopic dermatitis develop hay fever
or asthma.[from Wikipedia]")

(diseaseTreatment Eczema Crisaborole TopicalApplication)
(diseaseMedicine Eczema Crisaborole TopicalApplication)
(termFormat EnglishLanguage Eczema "eczema")
(termFormat EnglishLanguage Eczema "atopic eczema")
(termFormat EnglishLanguage Eczema "atopic dermatitis")
Expand Down Expand Up @@ -4613,12 +4614,12 @@ said to be immunocompromised.[from Wikipedia]")
(hasPurpose ?I
(and
(instance ?AID AutoImmuneDisorder)
(diseaseTreatment ?AID ?I ?P))))
(diseaseMedicine ?AID ?I ?P))))

(subclass Benelysta Immunosuppressive)
(documentation Benelysta EnglishLanguage "An &%Immunosuppressive
used to treat &%Lupus.")
(diseaseTreatment Lupus Benelysta Ingesting)
(diseaseMedicine Lupus Benelysta Ingesting)
(termFormat EnglishLanguage Benelysta "Benelysta")

(subclass OrganTransplant Surgery)
Expand Down Expand Up @@ -4673,9 +4674,9 @@ first heart attack (secondary prevention). They are also widely
used to treat high blood pressure (hypertension), although they are no
longer the first choice for initial treatment of most
patients.[from Wikipedia]")
(diseaseTreatment HeartAttack BetaBlocker Ingesting)
(diseaseTreatment HeartPalpitations BetaBlocker Ingesting)
(diseaseTreatment HighBloodPressure BetaBlocker Ingesting)
(diseaseMedicine HeartAttack BetaBlocker Ingesting)
(diseaseMedicine HeartPalpitations BetaBlocker Ingesting)
(diseaseMedicine HighBloodPressure BetaBlocker Ingesting)
(termFormat EnglishLanguage BetaBlocker "beta blocker")

(subclass Propranolol BetaBlocker)
Expand Down Expand Up @@ -4730,8 +4731,8 @@ or by injection into a vein. It comes as mycophenolate sodium and
mycophenolate mofetil. Common side effects include nausea,
infections, and diarrhea. [from Wikipedia]")
(termFormat EnglishLanguage MycophenolicAcid "mycophenolic acid")
(diseaseTreatment CrohnsDisease MycophenolicAcid Ingesting)
(diseaseTreatment Lupus MycophenolicAcid Ingesting)
(diseaseMedicine CrohnsDisease MycophenolicAcid Ingesting)
(diseaseMedicine Lupus MycophenolicAcid Ingesting)
(sideEffect MycophenolicAcid Nausea)
(sideEffect MycophenolicAcid Diarrhea)

Expand Down Expand Up @@ -4759,8 +4760,8 @@ stimulant of the phenethylamine class.[from Wikipedia]")
(ingredient Adderall Amphetamine)
(termFormat EnglishLanguage Adderall "Adderall")
(termFormat EnglishLanguage Adderall "Mydayis")
(diseaseTreatment ADHD Adderall Ingesting)
(diseaseTreatment Narcolepsy Adderall Ingesting)
(diseaseMedicine ADHD Adderall Ingesting)
(diseaseMedicine Narcolepsy Adderall Ingesting)

(instance Narcolepsy DiseaseOrSyndrome)

Expand Down Expand Up @@ -4945,7 +4946,7 @@ brand name Orencia, is a medication used to treat autoimmune diseases
like rheumatoid arthritis, by interfering with the immune activity of
T cells. It is a modified antibody.[from Wikipedia]")
(termFormat EnglishLanguage Abatacept "abatacept")
(diseaseTreatment Abatacept RheumatoidArthritis Ingesting)
(diseaseMedicine Abatacept RheumatoidArthritis Ingesting)

(subclass Orencia Abatacept)
(termFormat EnglishLanguage Orencia "Orencia")
Expand All @@ -4962,7 +4963,7 @@ Brand names include Tazac and Axid. [from Wikipedia]")
(instance PepticUlcers DiseaseOrSyndrome)
(documentation PepticUlcers EnglishLanguage "The presence of
&%Ulcers in the &%Stomach.")
(diseaseTreatment Nizatidine PepticUlcers Ingesting)
(diseaseMedicine Nizatidine PepticUlcers Ingesting)
(termFormat EnglishLanguage PepticUlcers "peptic ulcers")
(termFormat EnglishLanguage PepticUlcers "stomach ulcers")

Expand Down Expand Up @@ -5080,10 +5081,10 @@ It can be given by &%Mouth or by injection into a &%Muscle or into a &%Vein.
Common side effects include &%Diarrhea, constipation, &%Headache,
sleepiness, and itchiness. [from Wikipedia]")
(termFormat EnglishLanguage Ondansetron "ondansetron")
(diseaseTreatment Ondansetron Nausea Injecting)
(diseaseTreatment Ondansetron Nausea Ingesting)
(diseaseTreatment Ondansetron Vomiting Injecting)
(diseaseTreatment Ondansetron Vomiting Ingesting)
(diseaseMedicine Ondansetron Nausea Injecting)
(diseaseMedicine Ondansetron Nausea Ingesting)
(diseaseMedicine Ondansetron Vomiting Injecting)
(diseaseMedicine Ondansetron Vomiting Ingesting)
(sideEffect Ondansetron Diarrhea)
(sideEffect Ondansetron Headache)

Expand Down Expand Up @@ -5248,8 +5249,8 @@ include sleepiness, dry mouth, cough, vomiting, and diarrhea.[from
Wikipedia]")
(sideEffect Levocetirizine Vomiting)
(sideEffect Levocetirizine Diarrhea)
(diseaseTreatment Hives Levocetirizine Ingesting)
(diseaseTreatment AllergicRhinitis Levocetirizine Ingesting)
(diseaseMedicine Hives Levocetirizine Ingesting)
(diseaseMedicine AllergicRhinitis Levocetirizine Ingesting)

(subclass Xyzal Levocetirizine)
(termFormat EnglishLanguage Xyzal "Xyzal")
Expand All @@ -5263,7 +5264,7 @@ developed the drug for the treatment of rheumatoid arthritis (RA), for
which it received US FDA approval on 22 May 2017 and European
Medicines Agency approval on 23 June 2017.[from Wikipedia]")
(termFormat EnglishLanguage Sarilumab "sarilumab")
(diseaseTreatment RheumatoidArthritis Sarilumab Injecting)
(diseaseMedicine RheumatoidArthritis Sarilumab Injecting)

(subclass Kevzara Sarilumab)
(termFormat EnglishLanguage Kevzara "Kevzara")
Expand Down Expand Up @@ -5541,7 +5542,7 @@ treat active arthritis) did not work well or could not be tolerated.
It was developed by the biotech company &%AbbVie. Common side effects
include upper respiratory tract infections (common cold, sinus
infections), &%Nausea, &%Cough, and &%Fever.[from Wikipedia]")
(diseaseTreatment Upadacitinib RheumatoidArthritis Ingesting)
(diseaseMedicine Upadacitinib RheumatoidArthritis Ingesting)
(sideEffect Upadacitinib Nausea)
(sideEffect Upadacitinib Fever)
(termFormat EnglishLanguage Upadacitinib "upadacitinib")
Expand Down Expand Up @@ -5609,9 +5610,9 @@ taken by mouth, often in the form of hydroxychloroquine sulfate.
Common side effects may include vomiting, headache, changes in vision,
and muscle weakness. [from Wikipedia]")
(termFormat EnglishLanguage Hydroxychloroquine "hydroxychloroquine")
(diseaseTreatment Malaria Hydroxychloroquine Ingesting)
(diseaseTreatment RheumatoidArthritis Hydroxychloroquine Ingesting)
(diseaseTreatment Lupus Hydroxychloroquine Ingesting)
(diseaseMedicine Malaria Hydroxychloroquine Ingesting)
(diseaseMedicine RheumatoidArthritis Hydroxychloroquine Ingesting)
(diseaseMedicine Lupus Hydroxychloroquine Ingesting)
(sideEffect Hydroxychloroquine Vomiting)
(sideEffect Hydroxychloroquine Headache)

Expand All @@ -5628,7 +5629,7 @@ sleepiness, restlessness, and weakness.[from Wikipedia]")

(termFormat EnglishLanguage Chlorphenamine "chlorphenamine")
(termFormat EnglishLanguage Chlorphenamine "chlorpheniramine")
(diseaseTreatment AllergicRhinitis Chlorpheniramine Ingesting)
(diseaseMedicine AllergicRhinitis Chlorpheniramine Ingesting)

(subclass Phlegm Mucus)
(documentation Phlegm EnglishLanguage "&%Mucus produced by the &%Lungs,
Expand Down Expand Up @@ -5786,8 +5787,8 @@ followed by confusion, being &%Unconsciousness, or cardiac arrest, as complicati
Shock is divided into four main types based on the underlying cause: low volume, cardiogenic, obstructive,
and distributive shock. Low volume shock, also known as hypovolemic shock, may be from &%Bleeding, &%Diarrhea,
or &%Vomiting. Cardiogenic shock may be due to a heart attack or cardiac contusion. Obstructive shock may be
due to cardiac tamponade or a tension &%Pneumothorax. Distributive shock may be due to sepsis, anaphylaxis,
injury to the upper spinal cord, or certain overdoses.[from Wikipedia]")
due to cardiac tamponade or a tension &%Pneumothorax. Distributive shock may be due to &%Sepsis, &%Anaphylaxis,
injury to the upper &%SpinalCord, or certain overdoses.[from Wikipedia]")

(=>
(attribute ?H Shock)
Expand All @@ -5805,3 +5806,23 @@ injury to the upper spinal cord, or certain overdoses.[from Wikipedia]")
(subAttribute CardiogenicShock Shock)
(subAttribute ObstructiveShock Shock)
(subAttribute DistributiveShock Shock)

(instance diseaseTreatment BinaryPredicate)
(domain diseaseTreatment 1 DiseaseOrSyndrome)
(domainSubclass diseaseTreatment 2 TherapeuticProcess)
(documentation diseaseTreatment EnglishLanguage "A reasonable treatment for the given &%DiseaseOrSyndrome
is the given &%TherapeuticProcess.")

(=>
(and
(attribute ?H ?D)
(diseaseTreatment ?D ?P)
(instance ?TP TherpeuticProcess)
(agent ?TP ?DOC)
(patient ?TP ?H)
(attribute ?DOC MedicalDoctor))
(modalAttribute
(instance ?TP ?P)
Possibility))

; CardiacArrest
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