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BatoolMM authored Mar 7, 2024
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* You can read more about the MELD-B project on their page at [University of Southampton - MELD-B](https://www.southampton.ac.uk/publicpolicy/support-for-policymakers/policy-projects/Current%20projects/meld-b.page) or in their first blog post which you can find here: [University of Southampton - MELD-B Introductory Blog](https://www.southampton.ac.uk/publicpolicy/support-for-policymakers/blogs/evidence-to-policy-blog/meld-b-blog.page)

## CoMPuTE

> The Complex Multiple long-term conditions Phenotypes, Trends, and Endpoints (CoMPuTE) project uses Artificial Intelligence to help predict who is more likely to develop multiple long-term conditions. The project is funded by the National Institute for Health and Care Research (NIHR) under its Programme Grants for Applied Research Programme (NIHR204406). It is based on the University of Oxford, University of Leeds and University College London.
### Background to the CoMPuTE project

More than a quarter of adults in England have more than one health condition. By 2035 this is expected to increase by 10-17%. Having more than one condition is called ‘multiple long-term conditions’ (MLTC). The more conditions someone has, the more disabling the effects.

MLTC are difficult for both patients and carers: taking more medicines (with possible problems caused by conflicting or simply too many medications); the cost and wasted time of attending too many healthcare appointments; and the day-to-day challenges of living with multiple conditions.

This study hopes to predict who will suffer from MLTC and how MLTC will progress over a person’s lifetime. Previous research has focused on looking at causes of MLTC, however much is still unknown about why certain conditions appear together, how they relate to normal ageing, prevention, and appropriate care. Also, although the NHS currently invests significant amounts of money in trying to prevent specific health conditions (e.g. heart disease, cancer), many people do not engage. This is a missed opportunity to prevent future ill health.

### The CoMPuTE Research Aims

This project looks at whether using artificial intelligence (AI) can help us predict those more likely to develop MLTC – to get help sooner to those who need it and prevent people from developing MLTC in the first place.

Regular computer models are already used for research on electronic health records. We want to use AI techniques to process this information faster and more accurately. The data will be ‘anonymised’ so it cannot be traced to individuals. Because many people have concerns about how their data are used, members of the public have been involved in this work from the beginning and will be involved throughout. A public member leads one section of work. Other public members work on an equal level with the academic researchers.

- This study hopes to see whether it is possible to predict who will suffer from MLTC and how MLTC will progress over a person’s lifetime.
- It will investigate inequalities and the health and financial burden of MLTC.
- It brings in the public perspective on ethical and social questions about the use of AI in healthcare. Members of often-excluded communities will be actively involved in discussion groups, the development of study materials and the writing of papers. This is important to ensure that plans to help people with MLTC address everyone’s health and care needs.

### How CoMPuTE will involve patients and members of the public

One of the three CoMPuTE Themes (Ethics, Patients and the Public’) is entirely public-led and aims to adopt best practices and break new ground in public and patient involvement in directing the research. Our public stakeholder group brings a wide range of competencies and experience, including personal, geographical, ethnic, socio-economic and age diversity and lived experience of the immigrant experience and living with MLTC, and professional competencies in engineering, randomised control trials, medical communication, project management and health care delivery, to name a few.

Public members are linked with the data and epidemiology Themes (Themes 1 and 2) and are increasingly embedded in that work. Public members have already helped shift the direction of research. Public members already work with and will be presenting to researchers within and beyond the programme; we are planning a series of public-led mini-webinar; our public members will be co-authoring papers, and they will be forging the broader dissemination strategy.

## AI-MIXED Cluster

> Information coming soon.
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