The impact of COVID-19 vaccination on patients with congenital heart disease in England: a case-control study
Catriona Harrison, Simon Frain, Farideh Jalalinajafabadi, Simon G Williams, Bernard Keavney, on behalf of the CVD-COVID-UK/COVID-IMPACT Consortium
Congenital heart disease (CHD) patients were identified during the COVID-19 pandemic as a vulnerable group at increased risk of severe outcomes from Sars-CoV-2 infection. Up-to-date health data following widespread vaccination enables a reassessment of these risks in the vaccinated CHD population.
In this sub-project, we aimed to:
- Characterise the risks from COVID-19 to vaccinated CHD patients compared to vaccinated controls.
- Compare the reduction in vaccine efficacy over time between CHD cases and controls.
- Examine the additional risk experienced by vaccinated CHD patients with increased anatomical complexity and physiological severity.
- Compare the incidence of vaccine-associated complications between CHD cases and controls.
Harrison C, Frain S, Jalalinajafabadi F, et alThe impact of COVID-19 vaccination on patients with congenital heart disease in England: a case-control studyHeart Published Online First: 11 October 2024. doi: https://doi.org/10.1136/heartjnl-2024-324470
- View the analysis code and phenotypes used in NHS England's SDE for England
- View the analysis code and phenotypes used in the SAIL Databank
This is a sub-project of project CCU068 approved by the CVD-COVID-UK / COVID-IMPACT Approvals & Oversight Board (sub-project: CCU068_01).
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