diff --git a/nanodi/nanodi.py b/nanodi/nanodi.py
index 56ea61a..7589903 100644
--- a/nanodi/nanodi.py
+++ b/nanodi/nanodi.py
@@ -23,6 +23,8 @@
 
 
 def Depends(dependency: Dependency, /, use_cache: bool = True) -> Any:  # noqa: N802
+    if dependency in _resources and not use_cache:
+        raise ValueError("use_cache=False is not supported for resources")
     return _Depends(dependency, use_cache)
 
 
diff --git a/tests/test_sync_resource.py b/tests/test_sync_resource.py
index 88e31ab..1101fd6 100644
--- a/tests/test_sync_resource.py
+++ b/tests/test_sync_resource.py
@@ -57,3 +57,13 @@ def my_service(redis: Redis = Depends(redis_dependency)):
 
     shutdown_resources()
     assert redis.closed is True
+
+
+def test_resources_cant_be_used_if_specified_without_cache(redis_dependency):
+    with pytest.raises(
+        ValueError, match="use_cache=False is not supported for resources"
+    ):
+
+        @inject
+        def my_service(redis1: Redis = Depends(redis_dependency, use_cache=False)):
+            return redis1