Brain Tumor Stem Cell Dependence on Glutaminase Reveals a Metabolic Vulnerability through the Amino Acid Deprivation Response Pathway

This repository contains custom code used for single cell RNA-sequencing analysis and visualization in Restall IJ et al, Cancer Research (2020).

Data Availability

Single cell RNA-sequencing datasets used in this study were obtained from Richards LM et al., Nature Cancer, 2021. Raw sequencing data is available through the European Genome-Phenome Archive (EGAS00001004656; https://www.ebi.ac.uk/ega/studies/) repository. Processed single cell RNA-sequencing data are publically available through the Broad Institute Single-Cell Portal (https://singlecell.broadinstitute.org/single_cell/study/SCP1155).