nlmixr short course @ PAGE 2018
The nlmixr team just completed its first full-day hands-on workshop at PAGE 2018 on simulation (RxODE) and parameter estimation using the free and open-source R-based nonlinear mixed effects modelling platform nlmixr. The course consisted of a mixture of lectures and hands-on exercises. Please find the agenda and a link to the course material below. Thank you to all participants from around the world who joined us for this exciting event!
| Time | Presenter | Topics |
|---|---|---|
| 9:00 | Matt Fidler | Vision of nlmixr |
| RxODE and nlmixr introduction | ||
| RxODE lecture | ||
| - RxODE syntax | ||
| - RxODE solving and simulations | ||
| - Exploring data with RxODE and Shiny | ||
| 9:30 | Coffee Break | |
| 10:00 | Matt Fidler | nlmixr algorithms & functionality |
| Comparison to NONMEM | ||
| Basic population PKPD modeling with nlmixr | ||
| - Model syntax | ||
| - Running nlmixr models | ||
| - Simulating from nlmixr models | ||
| 11:00 | Richard Hooijmaijers | Population model building made easy using an interactive shiny app |
| - nlmixr workflow | ||
| - shinyMixR | ||
| - xpose for nlmixr | ||
| 12:00 | Lunch Break | |
| 13:00 | Mirjam Trame, Yuan Xiong, Justin Wilkins | Introduction into Hands-On Case Studies |
| 13:30 | Hands-On: mAB model | |
| 14:00 | Hands-On: PBPK model | |
| 14:30 | Hands-On: Neutropenia model | |
| 15:00 | Hands-On: PopPK model including covariates | |
| 15:30 | Discussion of case studies and Q&A | |
| 16:30 | Wenping Wang | Outlook of additional nlmixr capabilities |
| 17:00 | END |
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Download and install nlmixr from here and use one of the different nlmixr installers depending on your operating system.
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Download the course material from the following links:
Best regards,
The nlmixr team
(Matthew Fidler, Teun M. Post, Richard Hooijmaijers, Rik Schoemaker, Mirjam N. Trame, Justin Wilkins, Yuan Xiong and Wenping Wang)