Workflow 3B Module 2: Tissue & System Anatomy

[karafecho]

MCATS Questions Focused on Tissue & System Anatomy

1. In which type of cell are ligand-gated ion channels most commonly found?
Correct: Cells that need to respond quickly to external stimuli
Incorrect: Cells that respond to mechanic forces; Cells that produce large proteins; Cells that are terminally differentiated

Mini-hackathon notes:
● GO terms for ligand-gated ion channels, for positively negatively regulates, positively/negatively regulates response to external stimuli
● GO term for ligand-gated ion channel activity
● SemMed terms for ligand-gated ion channels
● Alternative approach: list of cell types, list of properties? perhaps cluster? identify commonalities?

2. GABA is an inhibitory neurotransmitter. Which part of the cell does it interact with?
Correct: Dendrites
Incorrect: Myelin sheath; Soma; Axon

Mini-hackathon notes:
● CHEBI term for GABA
● GO terms for cellular components, dendrites
● UMLS term for GABA, location, dendrites
● RTX: GO (with MeSH disambiguation)->Uniprot KB->GO for GABA/gamma-aminobutyric acid, dendrites (shortest paths from node GABA/gamma-aminobutyric to nearest cellular components

3. We would expect to find smooth muscle in all of the following EXCEPT:
Correct: Myocardial tissue
Incorrect: Pulmonary circulatory tissue; Esophagus; Small intestine

4. Which of the following is NOT innervated by the autonomic nervous system?
Correct: Striated muscle cell
Incorrect: Branching muscle cell; Myocardial cell; Intestinal muscle cell

5. Myelogenous leukemias are caused by the cancerous production of innate (non-specific) immune system cells: in which tissue is such production most likely to occur?
Correct: Bone Marrow
Incorrect: Spleen, Thymus, Lymph nodes

Mini-hackathon notes:
● Innate (non-specific) immune system cells produce myelogenous leukemias in which tissue?
● Cell ontology term for immune cell
● HP term for chronic myelogeneous leukemia
● MONDO term for myeloid leukemia
● UBERONGRAPH relationship between MONDO term for myeloid leukemia, predicate disease has location, bone marrow

Comment
This ticket is for general considerations about Workflow 3B, Module 2 as a whole. Separate tickets may be created for issues specific to a particular submodule.