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enhance germline analysis to run subsets of samples #860

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anoronh4 opened this issue Nov 30, 2020 · 0 comments · May be fixed by #870
Open

enhance germline analysis to run subsets of samples #860

anoronh4 opened this issue Nov 30, 2020 · 0 comments · May be fixed by #870
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enhancement New feature or request

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anoronh4 commented Nov 30, 2020

running germline separately and without running somatic analysis in the same project run may be necessary for the following reasons:

  • normal samples are often consented asynchronously from their tumor counterparts, and normal samples cannot be run until they are consented
  • currently germline mode automatically turns on somatic mode, so running germline analysis on an ad hoc basis will produce a second set of somatic results if somatic mode was already previously generated.

One option is to use a separate input stream (for example --germline <file with sample names> so we can use it in the wes_repo run. however, we would have to maintain this list up-to-date to keep up with PartC changes, which might be a challenge because PartC consent is not maintained in the lims. the other option is add an additional entry point for germline analysis that allows us to point to previously generated somatic results. It could look like --germline <file> where columns are:

TUMOR_ID	PATH
s_C_TUMORX_T001_d	/path/to/results

files required from somatic samples include facets output in the channel facetsForMafAnnoGermline, and the somatic bam. the latter can be provided with the --mapping/--bamMapping options.

@anoronh4 anoronh4 added this to the 1.4 milestone Dec 3, 2020
@anoronh4 anoronh4 self-assigned this Dec 3, 2020
@anoronh4 anoronh4 linked a pull request Jan 26, 2021 that will close this issue
@gongyixiao gongyixiao added the enhancement New feature or request label Jan 29, 2021
@gongyixiao gongyixiao linked a pull request Jan 29, 2021 that will close this issue
@gongyixiao gongyixiao removed this from the 1.4 milestone Feb 5, 2021
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