Trigeminal trophic syndrome

[galyea123]

Label

trigeminal trophic syndrome

Synonyms

No response

Synonym type

None

Definition

Trigeminal trophic syndrome (TTS) is an uncommon and relatively unknown cause of facial ulceration that occurs after damage to the trigeminal nerve. It characteristically involves non-healing facial ulceration(s) with accompanying anesthesia, paresthesia,
and dysesthesia along the distribution of a trigeminal dermatome. The ulcerations are believed to be self-induced in response to
paresthesia. The disease is most common in middle-aged women, manifesting as a unilateral crescent-shaped ulceration on the
ala nasi, with sparing of the nasal tip. The diagnosis is clinical and mostly based on exclusion of other possible causes of facial
ulcerations, with emphasis on neoplasms, infection-associated vasculitis, and factitial disorders. There are no specific histological or laboratory signs. There is no standard treatment protocol; however, a number of different successful strategies have been
reported, including pharmaceutical and surgical interventions, transcutaneous nerve stimulation, and simple occlusion dressings.
Due to the self-inflicted nature of this disorder, the cornerstone of management is patient education with behavioral modification.

Parent term

Skin ulcer HP:0200042

Children term(s)

No response

ORCID Identifier

No response

Website URL

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Additional comments

It is not listed in Orphanet or OMIM. Less than 200 reports. Please see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115313/