diff --git a/.changeset/two-tomatoes-deliver.md b/.changeset/two-tomatoes-deliver.md
new file mode 100644
index 0000000000..80ff3f3efc
--- /dev/null
+++ b/.changeset/two-tomatoes-deliver.md
@@ -0,0 +1,5 @@
+---
+'slate-react': minor
+---
+
+Fix invalid usage of the selection API in firefox
diff --git a/packages/slate-react/src/components/editable.tsx b/packages/slate-react/src/components/editable.tsx
index 7eb1b4f72c..093b703304 100644
--- a/packages/slate-react/src/components/editable.tsx
+++ b/packages/slate-react/src/components/editable.tsx
@@ -305,12 +305,33 @@ export const Editable = (props: EditableProps) => {
         return
       }
 
+      // Get anchorNode and focusNode
+      const focusNode = domSelection.focusNode
+      let anchorNode
+
+      // COMPAT: In firefox the normal seletion way does not work
+      // (https://github.com/ianstormtaylor/slate/pull/5486#issue-1820720223)
+      if (IS_FIREFOX && domSelection.rangeCount > 1) {
+        const firstRange = domSelection.getRangeAt(0)
+        const lastRange = domSelection.getRangeAt(domSelection.rangeCount - 1)
+
+        // Right to left
+        if (firstRange.startContainer === focusNode) {
+          anchorNode = lastRange.endContainer
+        } else {
+          // Left to right
+          anchorNode = firstRange.startContainer
+        }
+      } else {
+        anchorNode = domSelection.anchorNode
+      }
+
       // verify that the dom selection is in the editor
       const editorElement = EDITOR_TO_ELEMENT.get(editor)!
       let hasDomSelectionInEditor = false
       if (
-        editorElement.contains(domSelection.anchorNode) &&
-        editorElement.contains(domSelection.focusNode)
+        editorElement.contains(anchorNode) &&
+        editorElement.contains(focusNode)
       ) {
         hasDomSelectionInEditor = true
       }
@@ -336,7 +357,6 @@ export const Editable = (props: EditableProps) => {
           }
 
           // Ensure selection is inside the mark placeholder
-          const { anchorNode } = domSelection
           if (
             anchorNode?.parentElement?.hasAttribute(
               'data-slate-mark-placeholder'
@@ -391,19 +411,16 @@ export const Editable = (props: EditableProps) => {
       return newDomRange
     }
 
-    const newDomRange = setDomSelection()
+    // In firefox if there is more then 1 range and we call setDomSelection we remove the ability to select more cells in a table
+    if (domSelection.rangeCount <= 1) {
+      setDomSelection()
+    }
+
     const ensureSelection =
       androidInputManagerRef.current?.isFlushing() === 'action'
 
     if (!IS_ANDROID || !ensureSelection) {
       setTimeout(() => {
-        // COMPAT: In Firefox, it's not enough to create a range, you also need
-        // to focus the contenteditable element too. (2016/11/16)
-        if (newDomRange && IS_FIREFOX) {
-          const el = ReactEditor.toDOMNode(editor, editor)
-          el.focus()
-        }
-
         state.isUpdatingSelection = false
       })
       return
diff --git a/packages/slate-react/src/plugin/react-editor.ts b/packages/slate-react/src/plugin/react-editor.ts
index 15281ab649..f2e56ba300 100644
--- a/packages/slate-react/src/plugin/react-editor.ts
+++ b/packages/slate-react/src/plugin/react-editor.ts
@@ -829,15 +829,37 @@ export const ReactEditor: ReactEditorInterface = {
 
     if (el) {
       if (isDOMSelection(domRange)) {
-        anchorNode = domRange.anchorNode
-        anchorOffset = domRange.anchorOffset
-        focusNode = domRange.focusNode
-        focusOffset = domRange.focusOffset
+        // COMPAT: In firefox the normal seletion way does not work
+        // (https://github.com/ianstormtaylor/slate/pull/5486#issue-1820720223)
+        if (IS_FIREFOX && domRange.rangeCount > 1) {
+          focusNode = domRange.focusNode // Focus node works fine
+          const firstRange = domRange.getRangeAt(0)
+          const lastRange = domRange.getRangeAt(domRange.rangeCount - 1)
+
+          // Right to left
+          if (firstRange.startContainer === focusNode) {
+            anchorNode = lastRange.endContainer
+            anchorOffset = lastRange.endOffset
+            focusOffset = firstRange.startOffset
+          } else {
+            // Left to right
+            anchorNode = firstRange.startContainer
+            anchorOffset = firstRange.endOffset
+            focusOffset = lastRange.startOffset
+          }
+        } else {
+          anchorNode = domRange.anchorNode
+          anchorOffset = domRange.anchorOffset
+          focusNode = domRange.focusNode
+          focusOffset = domRange.focusOffset
+        }
+
         // COMPAT: There's a bug in chrome that always returns `true` for
         // `isCollapsed` for a Selection that comes from a ShadowRoot.
         // (2020/08/08)
         // https://bugs.chromium.org/p/chromium/issues/detail?id=447523
-        if (IS_CHROME && hasShadowRoot(anchorNode)) {
+        // IsCollapsed might not work in firefox, but this will
+        if ((IS_CHROME && hasShadowRoot(anchorNode)) || IS_FIREFOX) {
           isCollapsed =
             domRange.anchorNode === domRange.focusNode &&
             domRange.anchorOffset === domRange.focusOffset
@@ -876,15 +898,19 @@ export const ReactEditor: ReactEditorInterface = {
       focusOffset = anchorNode.textContent?.length || 0
     }
 
-    let anchor = ReactEditor.toSlatePoint(editor, [anchorNode, anchorOffset], {
-      exactMatch,
-      suppressThrow,
-    })
+    const anchor = ReactEditor.toSlatePoint(
+      editor,
+      [anchorNode, anchorOffset],
+      {
+        exactMatch,
+        suppressThrow,
+      }
+    )
     if (!anchor) {
       return null as T extends true ? Range | null : Range
     }
 
-    let focus = isCollapsed
+    const focus = isCollapsed
       ? anchor
       : ReactEditor.toSlatePoint(editor, [focusNode, focusOffset], {
           exactMatch,
@@ -894,46 +920,6 @@ export const ReactEditor: ReactEditorInterface = {
       return null as T extends true ? Range | null : Range
     }
 
-    /**
-     * suppose we have this document:
-     *
-     * { type: 'paragraph',
-     *   children: [
-     *     { text: 'foo ' },
-     *     { text: 'bar' },
-     *     { text: ' baz' }
-     *   ]
-     * }
-     *
-     * a double click on "bar" on chrome will create this range:
-     *
-     * anchor -> [0,1] offset 0
-     * focus  -> [0,1] offset 3
-     *
-     * while on firefox will create this range:
-     *
-     * anchor -> [0,0] offset 4
-     * focus  -> [0,2] offset 0
-     *
-     * let's try to fix it...
-     */
-
-    if (IS_FIREFOX && !isCollapsed && anchorNode !== focusNode) {
-      const isEnd = Editor.isEnd(editor, anchor!, anchor.path)
-      const isStart = Editor.isStart(editor, focus!, focus.path)
-
-      if (isEnd) {
-        const after = Editor.after(editor, anchor as Point)
-        // Editor.after() might return undefined
-        anchor = (after || anchor!) as T extends true ? Point | null : Point
-      }
-
-      if (isStart) {
-        const before = Editor.before(editor, focus as Point)
-        focus = (before || focus!) as T extends true ? Point | null : Point
-      }
-    }
-
     let range: Range = { anchor: anchor as Point, focus: focus as Point }
     // if the selection is a hanging range that ends in a void
     // and the DOM focus is an Element