diff --git a/src/common/tusb_mcu.h b/src/common/tusb_mcu.h
index 6b19ac9fe3..c77afecad0 100644
--- a/src/common/tusb_mcu.h
+++ b/src/common/tusb_mcu.h
@@ -293,6 +293,11 @@
   #define TUP_USBIP_FSDEV_STM32
   #define TUP_DCD_ENDPOINT_MAX    8
 
+#elif TU_CHECK_MCU(OPT_MCU_STM32U0)
+  #define TUP_USBIP_FSDEV
+  #define TUP_USBIP_FSDEV_STM32
+  #define TUP_DCD_ENDPOINT_MAX    8
+
 //--------------------------------------------------------------------+
 // Sony
 //--------------------------------------------------------------------+
diff --git a/src/portable/st/stm32_fsdev/fsdev_stm32.h b/src/portable/st/stm32_fsdev/fsdev_stm32.h
index 99fe8d55fd..03ea4c67e0 100644
--- a/src/portable/st/stm32_fsdev/fsdev_stm32.h
+++ b/src/portable/st/stm32_fsdev/fsdev_stm32.h
@@ -170,6 +170,30 @@
   #define USB_CNTR_LPMODE USB_CNTR_SUSPRDY
   #define USB_CNTR_FSUSP USB_CNTR_SUSPEN
 
+#elif CFG_TUSB_MCU == OPT_MCU_STM32U0
+  #include "stm32u0xx.h"
+  #define FSDEV_PMA_SIZE (2048u)
+  #define USB USB_DRD_FS
+
+  #define USB_EP_CTR_RX USB_EP_VTRX
+  #define USB_EP_CTR_TX USB_EP_VTTX
+  #define USB_EP_T_FIELD USB_CHEP_UTYPE
+  #define USB_EPREG_MASK USB_CHEP_REG_MASK
+  #define USB_EPTX_DTOGMASK USB_CHEP_TX_DTOGMASK
+  #define USB_EPRX_DTOGMASK USB_CHEP_RX_DTOGMASK
+  #define USB_EPTX_DTOG1 USB_CHEP_TX_DTOG1
+  #define USB_EPTX_DTOG2 USB_CHEP_TX_DTOG2
+  #define USB_EPRX_DTOG1 USB_CHEP_RX_DTOG1
+  #define USB_EPRX_DTOG2 USB_CHEP_RX_DTOG2
+  #define USB_EPRX_STAT USB_CH_RX_VALID
+  #define USB_EPKIND_MASK USB_EP_KIND_MASK
+  #define USB_CNTR_FRES USB_CNTR_USBRST
+  #define USB_CNTR_RESUME USB_CNTR_L2RES
+  #define USB_ISTR_EP_ID USB_ISTR_IDN
+  #define USB_EPADDR_FIELD USB_CHEP_ADDR
+  #define USB_CNTR_LPMODE USB_CNTR_SUSPRDY
+  #define USB_CNTR_FSUSP USB_CNTR_SUSPEN
+
 #else
   #error You are using an untested or unimplemented STM32 variant. Please update the driver.
   // This includes U0
@@ -249,6 +273,8 @@ static const IRQn_Type fsdev_irq[] = {
     USB_LP_IRQn,
   #elif CFG_TUSB_MCU == OPT_MCU_STM32U5
     USB_IRQn,
+  #elif CFG_TUSB_MCU == OPT_MCU_STM32U0
+    USB_DRD_FS_IRQn,
   #else
     #error Unknown arch in USB driver
   #endif
diff --git a/src/tusb_option.h b/src/tusb_option.h
index 79f49636f9..fdc9497476 100644
--- a/src/tusb_option.h
+++ b/src/tusb_option.h
@@ -91,6 +91,7 @@
 #define OPT_MCU_STM32U5           313 ///< ST U5
 #define OPT_MCU_STM32L5           314 ///< ST L5
 #define OPT_MCU_STM32H5           315 ///< ST H5
+#define OPT_MCU_STM32U0           316 ///< ST U0
 
 // Sony
 #define OPT_MCU_CXD56             400 ///< SONY CXD56