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Tumour evolution and microenvironment interactions in 2D and 3D space

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Overview

This is the repo for the manuscript "Spatial clonal evolution and clone-specific microenvironment interactions within three-dimensional tumor structures"

Repo structure

  • Figure 1. Spatial microregions across cancers
  • Figure 2. Focal clonal evolution in microregions
  • Figure 3. Genetic changes drive tumour disparities & Cellular pathways at tumour core and edge
  • Figure 4. Clonal-specific Tumor-TME interaction
  • Figure 5 & 6. 3D tumour structure and TME interactions

Data Access

Data file for each data type can be accessed using ID listed in the file "Data_access/Sample_ID_Lookup_table_v1.xlsx"

Manuscript:

DOI https://doi.org/10.1038/s41586-024-08087-4

Cite this article

Mo, CK., Liu, J., Chen, S. et al. Tumour evolution and microenvironment interactions in 2D and 3D space. Nature 634, 1178–1186 (2024). https://doi.org/10.1038/s41586-024-08087-4