diff --git a/conda-recipe/meta.yaml b/conda-recipe/meta.yaml
index 7a7ba552598..3688ad46e50 100644
--- a/conda-recipe/meta.yaml
+++ b/conda-recipe/meta.yaml
@@ -37,7 +37,7 @@ requirements:
     - recommonmark
   run:
     - python
-    - setuptools >=41.0.0
+    - setuptools >=51.0.0
     - numpy >=1.20.0
     - scipy >=1.9
     - scikit-learn >=1.1.0,<1.2.0
diff --git a/pyproject.toml b/pyproject.toml
index 822b2f1700e..cbe273137f6 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,6 +1,6 @@
 [build-system]
 requires = [
-    "setuptools>=41.0.0,<50.0",
+    "setuptools>=51.0",
     "wheel",
     "cython>=3.0",
     "oldest-supported-numpy",
diff --git a/requirements-core.txt b/requirements-core.txt
index 4f605eae0e6..1a4d7d4856a 100644
--- a/requirements-core.txt
+++ b/requirements-core.txt
@@ -15,7 +15,7 @@ chardet>=3.0.2
 joblib>=1.0.0
 keyring
 keyrings.alt    # for alternative keyring implementations
-setuptools>=41.0.0
+setuptools>=51.0.0
 serverfiles		# for Data Sets synchronization
 networkx
 python-louvain>=0.13
diff --git a/tox.ini b/tox.ini
index 21f5e88f041..a4a1d3f85be 100644
--- a/tox.ini
+++ b/tox.ini
@@ -56,7 +56,7 @@ deps =
     oldest: joblib==1.0.0
     # oldest: keyring
     # oldest: keyrings.alt
-    oldest: setuptools==41.0.0
+    oldest: setuptools==51.0.0
     # oldest: serverfiles
     # oldest: networkx
     oldest: python-louvain==0.13