diff --git a/requirements-core.txt b/requirements-core.txt
index 4f605eae0e6..1a4d7d4856a 100644
--- a/requirements-core.txt
+++ b/requirements-core.txt
@@ -15,7 +15,7 @@ chardet>=3.0.2
 joblib>=1.0.0
 keyring
 keyrings.alt    # for alternative keyring implementations
-setuptools>=41.0.0
+setuptools>=51.0.0
 serverfiles		# for Data Sets synchronization
 networkx
 python-louvain>=0.13
diff --git a/tox.ini b/tox.ini
index 21f5e88f041..a4a1d3f85be 100644
--- a/tox.ini
+++ b/tox.ini
@@ -56,7 +56,7 @@ deps =
     oldest: joblib==1.0.0
     # oldest: keyring
     # oldest: keyrings.alt
-    oldest: setuptools==41.0.0
+    oldest: setuptools==51.0.0
     # oldest: serverfiles
     # oldest: networkx
     oldest: python-louvain==0.13