GPR curation for Transport reactions (18)

[JHL-452b]

Current behavior:

30 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000167434	P22748	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000167434 encodes for an enzyme that catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons, playing a role in maintaining pH homeostasis. The provided reaction involves ATP, H2O, and lauric acid leading to the production of ADP, H+, lauric acid, and Pi, which is unrelated to the gene's function of CO2 and bicarbonate conversion. Thus, the gene does not participate in the described reaction.	No
ENSG00000165029	O95477	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes, coupled with the hydrolysis of ATP. This gene's activity involves transferring phospholipids like phosphatidylcholine, phosphatidylserine, and sphingomyelin and cholesterol between sides of a membrane, aiding in high-density lipoprotein (HDL) formation. However, the reaction provided involves the hydrolysis of ATP in the context of lauric acid, which is not a substrate or product mentioned in the gene's annotated activities. Thus, the gene does not correlate with the specific reaction involving lauric acid.	No
ENSG00000021488	P82251	MAR01909: dopamine + HCO3- + S-glutathionyl-ethacrynic acid <=> dopamine + HCO3- + S-glutathionyl-ethacrynic acid	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a transporter protein that mediates the electrogenic exchange of cationic and neutral amino acids, such as L-arginine with L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The described reaction, however, involves dopamine, HCO3-, and S-glutathionyl-ethacrynic acid. There is no mention of dopamine, HCO3-, or S-glutathionyl-ethacrynic acid being substrates or products associated with the gene's transporter activities. Therefore, the gene and the reaction are not related.	No
ENSG00000165349	Q8WY07	MAR05305: alanine + Na+ --> alanine + Na+	ENSG00000003989 or ENSG00000072041 or ENSG00000105281 or ENSG00000111371 or ENSG00000115902 or ENSG00000134294 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349 or ENSG00000174358	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: Based on the annotation of the gene ENSG00000165349, its function is to transport cationic L-amino acids such as L-arginine, L-lysine, and L-ornithine across membranes through passive diffusion, which is independent of sodium ions and pH. The specific reactions catalyzed by this gene involve the exchange of L-arginine, L-lysine, and L-ornithine between the inside and outside of the cell. However, the provided reaction involves the movement of alanine in the presence of sodium ions, which is not related to the transport activities mediated by this gene. Therefore, the gene ENSG00000165349 and the given reaction are not associated.	No
ENSG00000103064	Q92536	MAR05634: glutamine + Na+ + serine --> glutamine + Na+ + serine	ENSG00000103064 or ENSG00000105281	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions as an antiporter for cationic and neutral amino acids, specifically exporting L-arginine in exchange for other amino acids like L-leucine, L-glutamine, and sodium ions. The gene's catalytic activities involve various exchanges of L-arginine with other amino acids, such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine in the presence of sodium. However, the provided reaction "glutamine + Na+ + serine --> glutamine + Na+ + serine" does not involve L-arginine or any exchange mechanism that the gene is annotated for, making the gene irrelevant to the given reaction.	No
ENSG00000021488	P82251	MAR05957: glutamine + histidine --> glutamine + histidine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that functions as a transporter for cationic amino acids and neutral amino acids with specific catalytic activities, mainly involving the exchange of L-arginine with other amino acids such as leucine, histidine, phenylalanine, cysteine, cystine, and lysine. In contrast, the reaction provided involves the exchange between glutamine and histidine, which is not one of the catalytic activities associated with this gene. Therefore, the gene and the reaction are not related.	Yes
ENSG00000108932	O15403	MAR06008: 2-hydroxybutyrate + acetate <=> 2-hydroxybutyrate + acetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes for a monocarboxylate transporter involved in the transport of taurine across the plasma membrane. The reactions mentioned in the gene's function are related to the movement of taurine, which is pH- and sodium-independent. However, the reaction provided (2-hydroxybutyrate + acetate <=> 2-hydroxybutyrate + acetate) does not involve taurine and thus is not related to the annotated function or catalytic activity of the gene.	No
ENSG00000141526	O15427	MAR06041: (R)-3-hydroxybutanoate + formate <=> (R)-3-hydroxybutanoate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes for a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate, facilitating their transport across cell membranes. The annotated catalytic activities involve the transport of L-lactate and pyruvate coupled with protons. However, the reaction given involves (R)-3-hydroxybutanoate and formate, which are not substrates for the transporter encoded by the gene. Thus, there is no direct involvement or relevance of this gene to the specified reaction.	No
ENSG00000111684	Q6P1A2	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000111684 encodes an enzyme known as lysophospholipid O-acyltransferase (LPLAT) which catalyzes the reacylation of lysophospholipids, forming various classes of phospholipids through the transfer of fatty acyl chains from fatty acyl-CoA to lysophospholipids such as lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), and lysophosphatidylserine (LPS). The catalytic activities described involve specific enzymatic transformations in the phospholipid remodeling process. However, the reaction described involving butyryl-CoA and L-carnitine does not align with any of the aforementioned functions or catalytic activities of the enzyme encoded by this gene. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000102125	Q16635	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000102125 encodes an acyltransferase involved in the remodeling of phospholipids, specifically cardiolipin, within mitochondrial membranes. It catalyzes transacylations between various phospholipids and lysophospholipids, enhancing mitochondrial membrane flexibility and function. The reaction provided, "butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine," involves carnitine acyltransferase activity, which is unrelated to the cardiolipin remodeling activities of the encoded enzyme. Therefore, the annotated functions and catalytic activities of the gene do not correspond to the provided reaction.	No
ENSG00000125454	Q9HC21	MAR07806: dADP + dGDP <=> dADP + dGDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 is involved in mitochondrial transport, specifically mediating the uptake of thiamine diphosphate into mitochondria. It also acts as an antiporter for thiamine diphosphate and thiamine phosphate. The reaction described (dADP + dGDP <=> dADP + dGDP) does not involve thiamine diphosphate or thiamine phosphate and hence is unrelated to the function or catalytic activity of the gene.	No
ENSG00000117620	Q9Y2D2	MAR00918: UDP-galactose + UMP <=> UDP-galactose + UMP	ENSG00000117620 or ENSG00000130958 or ENSG00000205060	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000117620 encodes a transporter protein that exchanges UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) and UMP across the Golgi apparatus membrane, while the reaction provided relates to UDP-galactose and UMP, which does not match the substrate specificity or function described for the gene product. Therefore, the gene's annotated function does not align with the reaction involving UDP-galactose and UMP.	No
ENSG00000021488	P82251	MAR01899: HCO3- + noradrenaline + S-glutathionyl-2-4-dinitrobenzene <=> HCO3- + noradrenaline + S-glutathionyl-2-4-dinitrobenzene	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that forms a transporter complex with SLC3A1, mediating the exchange of cationic and neutral amino acids. The catalytic activities specified involve the transport of L-arginine and various amino acids across cell membranes. However, the reaction described involves HCO3-, noradrenaline, and S-glutathionyl-2-4-dinitrobenzene, which are not substrates or products involved in the transport functions mediated by the protein encoded by this gene. Therefore, the gene and the reaction are unrelated.	No
ENSG00000169710	P49327	MAR04844: adenosine + inosine <=> adenosine + inosine	ENSG00000169710	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000169710 encodes for a fatty acid synthetase, which is involved in the de novo biosynthesis of long-chain saturated fatty acids using acetyl-CoA and malonyl-CoA in the presence of NADPH. The reaction described in the text, "adenosine + inosine <=> adenosine + inosine," does not involve the metabolic pathways or functions associated with fatty acid synthetase. This reaction is unrelated to fatty acid biosynthesis and instead pertains to nucleoside metabolism, which falls outside the scope of the gene's annotated functions and catalytic activities.	No
ENSG00000103064	Q92536	MAR05944: ornithine + tryptophan --> ornithine + tryptophan	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily in the exchange of cationic amino acids such as L-arginine with neutral amino acids like L-leucine, L-glutamine, and others, often in the presence of sodium ions. The listed catalytic activities confirm exchanges involving L-arginine with various other amino acids, but there is no mention of the involvement of ornithine and tryptophan. The provided reaction, ornithine + tryptophan --> ornithine + tryptophan, does not align with the functions and catalytic activities associated with this gene, indicating that the gene and the reaction are not related.	Yes
ENSG00000141526	O15427	MAR06051: butyrate + retinoate <=> butyrate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter involved in the transport of monocarboxylates such as L-lactate and pyruvate. The annotated reactions for this gene involve the movement of L-lactate and pyruvate across cellular membranes in a proton-dependent manner. However, the provided reaction involves butyrate and retinoate, which are not substrates for this transporter. Therefore, the gene is not relevant to the specified reaction.	No
ENSG00000169239	Q9Y2D0	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000169239 encodes a mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate. However, the reaction provided involves the conversion of ATP, H2O, and lauric acid to ADP, H+, and lauric acid phosphate, which is not related to the catalytic activity of the carbonic anhydrase enzyme described.	No
ENSG00000149150	O75387	MAR05078: glutamine <=> glutamine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000149150 mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine, and operates through facilitated diffusion without involving sodium ions. It specifically catalyzes the exchange of these amino acids. In contrast, the reaction provided involves glutamine, which is not among the substrates listed for this gene. Therefore, the gene is not related to the reaction that involves glutamine.	Yes
ENSG00000021488	P82251	MAR05984: citrulline + threonine --> citrulline + threonine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes for a transporter that mediates the exchange between cationic and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine, in renal proximal tubules. However, the reaction provided involves citrulline and threonine, which are not mentioned as substrates for the transporter encoded by this gene. Therefore, the gene is not related to the reaction provided.	No
ENSG00000139514	P30825	MAR05084: cysteine --> cysteine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000139514 encodes a high-affinity, low capacity permease involved in the transport of cationic amino acids such as arginine, lysine, ornithine, and homoarginine across cell membranes. The annotated catalytic activities refer to the translocation of these specific amino acids. However, the reaction provided in the text involves cysteine, which is not one of the cationic amino acids mentioned in the gene's function or catalytic activities. Therefore, there is no functional or catalytic basis linking the gene ENSG00000139514 to the described cysteine reaction.	No
ENSG00000103064	Q92536	MAR05677: glycine + Na+ + phenylalanine --> glycine + Na+ + phenylalanine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions mainly as an antiporter for the transport of specific amino acids such as L-arginine, L-leucine, L-glutamine, and others, often in exchange with sodium ions. The reaction provided, however, involves glycine, sodium, and phenylalanine, which is not one of the combinations mentioned in the gene's annotated catalytic activities. Therefore, the gene's function does not align with the given reaction.	No
ENSG00000103064	Q92536	MAR05773: Na+ + phenylalanine + valine --> Na+ + phenylalanine + valine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a transporter that functions as an antiporter for cationic and neutral amino acids, specifically L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often involving sodium ions. The provided reaction involves Na+, phenylalanine, and valine, which are not substrates for the transporter encoded by ENSG00000103064 according to the given annotation. Therefore, the gene does not participate in the reaction mentioned.	No
ENSG00000103064	Q92536	MAR05807: homoserine + Na+ + proline --> homoserine + Na+ + proline	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter involved in the exchange of various cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often involving sodium ions. However, the given reaction involving homoserine, Na+, and proline does not align with the specific amino acids and exchange activities described for this gene's product, indicating that the gene is not associated with this particular reaction.	No
ENSG00000141526	O15427	MAR06024: AKG + propanoate <=> AKG + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes for a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate. It is primarily involved in the efflux of L-lactate from highly glycolytic cells and facilitates the transport of pyruvate and protons across the cell membrane. The gene's catalytic activities involve reactions like (S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out) and H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in). However, the reaction provided (AKG + propanoate <=> AKG + propanoate) does not involve L-lactate, pyruvate, or proton transport. Therefore, there is no relevance between the gene and the given reaction.	No
ENSG00000108932	O15403	MAR06025: acetoacetate + AKG <=> acetoacetate + AKG	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes for a monocarboxylate transporter selective for taurine, which mediates the influx or efflux of taurine across the plasma membrane. The reaction provided, however, involves acetoacetate and AKG (alpha-ketoglutarate), which are not related to taurine transport. Therefore, there is no connection between the gene and the provided reaction.	No
ENSG00000155380	P53985	MAR08364: acetone + H+ --> acetone + H+	ENSG00000118596 or ENSG00000141526 or ENSG00000155380	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000155380 encodes a protein that functions as a bidirectional proton-coupled monocarboxylate transporter, facilitating the transport of monocarboxylates like lactate, pyruvate, acetate, acetoacetate, beta-hydroxybutyrate, succinate, 3-methyl-2-oxobutanoate, and 4-methyl-2-oxopentanoate across the plasma membrane. The provided reaction involves acetone, which is not listed among the substrates that the transporter handles according to the provided annotation. Therefore, this gene's function does not relate to the specific reaction involving acetone and a proton.	No
ENSG00000103064	Q92536	MAR05622: glutamine + Na+ + phenylalanine --> glutamine + Na+ + phenylalanine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter for various amino acids, including L-arginine, L-leucine, L-glutamine, and others, often with a sodium ion. However, the provided reaction involves glutamine, sodium, and phenylalanine, which does not align with any of the known catalytic activities of this gene as it does not facilitate the transport or exchange involving phenylalanine. Therefore, the gene does not participate in the provided reaction.	No
ENSG00000103064	Q92536	MAR05776: leucine + Na+ + valine --> leucine + Na+ + valine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter, exchanging cationic amino acids such as L-arginine with neutral amino acids like L-leucine in a sodium-dependent manner. The provided reaction involves leucine, sodium ions, and valine without any exchange with arginine or other relevant amino acids described in the gene's function. Therefore, the gene does not participate in the reaction provided.	Yes
ENSG00000021488	P82251	MAR05949: ornithine + proline --> ornithine + proline	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is associated with the formation of a transporter complex that mediates the exchange between cationic amino acids and neutral amino acids, facilitating specific reactions involving L-arginine and various other amino acids as substrates. However, the reaction "ornithine + proline --> ornithine + proline" does not fall within the catalytic activities or functionalities mediated by this gene, and thus the gene does not participate in this specific reaction.	No
ENSG00000103064	Q92536	MAR05669: cysteine + Na+ + tryptophan --> cysteine + Na+ + tryptophan	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that primarily functions as an antiporter to transport L-arginine in exchange for other amino acids such as L-leucine, L-glutamine, L-lysine, and others, often involving sodium ions. The given reaction, however, involves cysteine, Na+, and tryptophan, which do not align with the substrates or products of the catalytic activities specified for this gene. Therefore, the gene does not participate in the provided reaction.	No

[hhl-24]

Keep ENSG00000021488 for MAR05949: ornithine + proline --> ornithine + proline, this gene associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids.
Remove ENSG00000103064 for MAR05944: ornithine + tryptophan --> ornithine + tryptophan，it seems to be in a sodium-dependent manner.