Localization of DECR1 and DECR2

[Devlin-Moyer]

Current behavior:

DECR1 and DECR2 both catalyze NADPH-dependent reduction of 2,4-dienoyl-CoAs during beta-oxidation, but DECR1 does so exclsively in mitochondria and DECR2 does so exclusively in peroxisomes. Several reactions in Human-GEM have GPRs of "DECR1 or DECR2"

ID	Reaction
MAR01176	8(R)-hydroxy-hexadeca-(2E,4E,6E,10Z)-tetraenoate [m] + H+ [m] + NADPH [m] --> 8(R)-hydroxy-hexadeca-(2E,6E,10Z)-trienoate [m] + NADP+ [m]
MAR01181	6(R)-hydroxy-tetradeca-(2E,4E,8Z)-trienoate [m] + H+ [m] + NADPH [m] <=> 6(R)-hydroxy-tetradeca-(2E,8Z)-dienoate [m] + NADP+ [m]
MAR01218	8(S)-hydroxy-hexadeca-(2E,4E,6E,10Z)-tetraenoate [m] + H+ [m] + NADPH [m] --> 8(S)-hydroxy-hexadeca-(2E,6E,10Z)-trienoate [m] + NADP+ [m]
MAR01222	6(S)-hydroxy-tetradeca-(2E,4E,8Z)-trienoate [m] + H+ [m] + NADPH [m] <=> 6(S)-hydroxy-tetradeca-(2E,8Z)-dienoate [m] + NADP+ [m]
MAR03296	2-trans-4-cis-decadienoyl-CoA [m] + H+ [m] + NADH [m] --> NAD+ [m] + trans-3-decenoyl-CoA [m]
MAR03446	2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA [m] + H+ [m] + NADPH [m] --> NADP+ [m] + trans-3-cis-8,11,14-eicosatetraenoyl-CoA [m]
MAR03457	(2E,4Z,7Z,10Z)-hexadecatetraenoyl-CoA [m] + H+ [m] + NADPH [m] <=> (3Z,7Z,10Z)-hexadecatrienoyl-CoA [m] + NADP+ [m]
MAR01297	18-COOH-(15E)-dinor-LTE4-CoA [x] + NADP+ [x] <=> 18-COOH-(16E)-dinor-LTE5-CoA [x] + H+ [x] + NADPH [x]
MAR03322	2-trans-4-cis-decadienoyl-CoA [x] + H+ [x] + NADH [x] --> NAD+ [x] + trans-3-decenoyl-CoA [x]
MAR03461	2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA [x] + H+ [x] + NADPH [x] --> NADP+ [x] + trans-3-cis-8,11,14-eicosatetraenoyl-CoA [x]
MAR03471	(2E,4Z,7Z,10Z)-hexadecatetraenoyl-CoA [x] + H+ [x] + NADPH [x] <=> (3Z,7Z,10Z)-hexadecatrienoyl-CoA [x] + NADP+ [x]

(Some of this was originally in #634; I split it out here because #634 was unmanageably large.)

Expected behavior:

The mitochondrial reactions should only be associated with DECR1 (ENSG00000104325), and the peroxisomal reactions should only be associated with DECR2 (ENSG00000242612). The first four should also involve acyl-CoAs and not free fatty acids, but I'm addressing that in #749. All of these should involve NADPH and not NADH, but I've addressed that in #736.

Proposed changes:

• Set the GPRs of MAR01176, MAR01181, MAR01218, MAR01222, MAR03296, MAR03446, and MAR03457 to ENSG00000104325
• Set the GPRs of MAR01297, MAR03322, MAR03461, and MAR03471 to ENSG00000242612

[haowang-bioinfo]

fixed by #788