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How to generate compact binders? #276

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bzhousd opened this issue Sep 5, 2024 · 0 comments
Open

How to generate compact binders? #276

bzhousd opened this issue Sep 5, 2024 · 0 comments

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@bzhousd
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bzhousd commented Sep 5, 2024

Thank you for your great work. I have been using rfdiffusion to design protein binders in my project, but I am having difficulty generating compact binders. I took an example in paper, IL7 Receptor α (PDB: 3DI3), I cannot reproduce the results(see my options below), Despite trying binder_ROG, the majority of designs still have long helices. Could you please provide the command line used in your paper's experiment to achieve better conformations? I appreciate your assistance with this matter.

Thanks

run_inference.py inference.output_prefix=test/rf inference.input_pdb=3di3.pdb contigmap.contigs=[B17-209/0 90-90] inference.num_designs=10 diffuser.T=50 ppi.hotspot_res=[B58, B80, B139] potentials.guiding_potentials=["type:binder_ROG,min_dist:5"]

@bzhousd bzhousd changed the title How to generate compact binder? How to generate compact binders? Sep 5, 2024
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