diff --git a/.gitignore b/.gitignore index 34f016211..7427d5fd9 100644 --- a/.gitignore +++ b/.gitignore @@ -51,3 +51,4 @@ code/ARAX/ARAXQuery/Infer/data/xCRG_data/*.pt code/ARAX/ARAXQuery/Infer/data/xCRG_data/*.npz code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.json +code/UI/OpenAPI/specifications/export/KG2/*/openapi.json diff --git a/ISSUE_TEMPLATES/kg2rollout.md b/ISSUE_TEMPLATES/kg2rollout.md index bf284a44c..6a9b3d0f0 100644 --- a/ISSUE_TEMPLATES/kg2rollout.md +++ b/ISSUE_TEMPLATES/kg2rollout.md @@ -27,8 +27,8 @@ You will need: ##### Slack workspaces You will also need access to the following Slack workspaces: -- [ ] ARAXTeam (subscribe to #deployment) -- [ ] NCATSTranslator (subscribe to `#devops-teamexpanderagent) +- [ ] ARAXTeam (subscribe to `#deployment`) +- [ ] NCATSTranslator (subscribe to `#devops-teamexpanderagent`) #### Example ssh config for setting up login into `arax.ncats.io`: ``` @@ -45,18 +45,25 @@ Host arax.ncats.io - [ ] update the four hardcoded biolink version numbers in the branch (as needed): - [ ] in `code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml` ([github](https://github.com/RTXteam/RTX/tree/master/code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml#L18); [local](../code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml)) - [ ] in `code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml` ([github](https://github.com/RTXteam/RTX/tree/master/code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml#L18); [local](../code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml)) - - [ ] in `code/UI/OpenAPI/specifications/export/ARAX/1.5.0/openapi.yaml`([github](https://github.com/RTXteam/RTX/blob/master/code/UI/OpenAPI/specifications/export/ARAX/1.5.0/openapi.yaml)) - - [ ] in `code/UI/OpenAPI/specifications/export/KG2/1.5.0/openapi.yaml` ([github](https://github.com/RTXteam/RTX/blob/master/code/UI/OpenAPI/specifications/export/KG2/1.5.0/openapi.yaml)) + - [ ] in `code/UI/OpenAPI/specifications/export/ARAX/1.5.0/openapi.yaml`([github](https://github.com/RTXteam/RTX/blob/master/code/UI/OpenAPI/specifications/export/ARAX/1.5.0/openapi.yaml#L18)) + - [ ] in `code/UI/OpenAPI/specifications/export/KG2/1.5.0/openapi.yaml` ([github](https://github.com/RTXteam/RTX/blob/master/code/UI/OpenAPI/specifications/export/KG2/1.5.0/openapi.yaml#L18)) - [ ] build a new KG2c on `buildkg2c.rtx.ai` from the branch (how-to is [here](https://github.com/RTXteam/RTX/tree/master/code/kg2c#build-kg2canonicalized)) - [ ] before starting the build: - [ ] make sure there is enough disk space available on `arax-databases.rtx.ai` (need at least 100G, ideally >120G). delete old KG2 database directories as needed (warn the team on Slack in advance). - - [ ] make sure to choose to build a new synonymizer in `kg2c_config.json`, as described in the how-to - - [ ] after the build is done, verify it looks ok: - - [ ] `node_synonymizer.sqlite` should be around 8-15 GB - - [ ] make sure `node_synonymizer.sqlite`'s last modified date is today (or whatever day the build was run) - - [ ] make sure `kg2c_lite.json.gz`'s last modified date is today (or whatever day the build was run) - - [ ] the entire build runtime (synonymizer + KG2c) shouldn't have been more than 24 hours - - [ ] the synonymizer and KG2c artifacts should have been auto-uploaded into the proper directory on `arax-databases.rtx.ai` (`/home/rtxconfig/KG2.X.Y`) + + **NOTE:** For detailed deployment instructions, follow the instructions [here](https://github.com/RTXteam/RTX/tree/master/code/kg2c#building-kg2c) + - [ ] to do a standard build of a new synonymizer (expected runtime: 2-4 hours), run: + - [ ] `cd RTX/code/kg2c/synonymizer_build` + - [ ] `python build_synonymizer.py 2.X.Y v1.0 --downloadkg2pre --uploadartifacts` + - [ ] after the build, run the Synonymizer pytest regression test suite: + - [ ] `pytest -vs test_synonymizer.py --synonymizername node_synonymizer_v1.0_KG2.X.Y.sqlite` + - [ ] make sure that `node_synonymizer_v1.0_KG2.X.Y.sqlite` is about 8-15 GB and its last modified date is today + - [ ] to do a standard full build of a new KG2c (expected runtime: 8-10 hours), run: + - [ ] `cd RTX/code/kg2c` + - [ ] `python build_kg2c.py 2.X.Y v1.0 4.2.1 --uploadartifacts` + - **NOTE:** 4.2.1 is the Biolink version, please use the latest biolink version based on the KG2pre build's biolink version. Add a `--test` flag to the KG2c build execution to do a test build. + - [ ] after the build is done, make sure `kg2c_lite.json.gz`'s last modified date is today (or whatever day the build was run) + - [ ] the synonymizer and KG2c artifacts should have been auto-uploaded into the proper directory on `arax-databases.rtx.ai` (`/home/rtxconfig/KG2.X.Y`) and to `kg2webhost.rtx.ai` (if `--uploadartifacts` flag during the KG2c build is set). If not, manually upload the files using `scp`. - [ ] load the new KG2c into neo4j at http://kg2-X-Yc.rtx.ai:7474/browser/ (how to is [here](https://github.com/RTXteam/RTX/tree/master/code/kg2c#host-kg2canonicalized-in-neo4j)) - [ ] verify the correct KG2 version was uploaded by running this query: `match (n {id:"RTX:KG2c"}) return n` - [ ] update `RTX/code/config_dbs.json` in the branch: @@ -66,19 +73,18 @@ Host arax.ncats.io - [ ] update the meta_kg version number/path - [ ] update the kg2c sqlite version number/path - [ ] update the KG2pre and KG2c Neo4j endpoints -- [ ] copy the `kg2c_lite_2.X.Y.json.gz` file (which you can get from the S3 bucket `s3://rtx-kg2/kg2c_lite.json.gz` (but CHECK THE DATE AND MD5 HASH TO BE SURE YOU ARE NOT GETTING AN OLD FILE) to the directory `/home/ubuntu/nginx-document-root/` on `kg2webhost.rtx.ai` -- [ ] load the new KG2c into Plover (how-to is [here](https://github.com/RTXteam/PloverDB/wiki/Deployment-how-tos#to-build-plover-from-a-new-kg2-version)) -- [ ] start the new self-hosted PloverDB on `kg2cploverN.rtx.ai`: +- [ ] load the new KG2c into Plover (how-to is [here](https://github.com/RTXteam/PloverDB/wiki/Deployment-how-tos#to-build-plover-from-a-new-kg2-version)) + - [ ] update `config_kg2c.json` in the `kg2.X.Yc` branch of the Plover repo to point to the new KG2.X.Yc json lines nodes and edges files on `kg2webhost.rtx.ai` (push this change) - [ ] `ssh ubuntu@kg2cploverN.rtx.ai` - [ ] `cd PloverDB && git pull origin kg2.X.Yc` - [ ] if you have **not** yet built the 2.X.Y docker image/container on this instance, run: - - [ ] `./run.sh ploverimage2.X.Y plovercontainer2.X.Y "sudo docker"` (takes about an hour) + - [ ] `bash -x run.sh` (takes about an hour) - [ ] otherwise, simply run: - - [ ] `sudo docker start plovercontainer2.X.Y` (takes about five minutes) -- [ ] verify that Plover's regression tests pass, and fix any broken tests (note: tests must use **canonical** curies!); from any instance/computer, run: - - [ ] `cd PloverDB` - - [ ] `pytest -v test/test.py --endpoint http://kg2cploverN.rtx.ai:9990` -- [ ] update `config_dbs.json` in the branch for this KG2 version in the RTX repo to point to the new Plover **for the 'dev' maturity level** + - [ ] `sudo docker start plovercontainer` (takes about ten minutes) +- [ ] verify that Plover's regression tests pass, and fix any broken tests; from any instance/computer, run: + - [ ] `cd PloverDB/test` + - [ ] `pytest -v --endpoint https://kg2cploverN.rtx.ai:9990` +- [ ] update `config_dbs.json` in the branch for this KG2 version in the RTX repo to point to the new Plover in the `plover_url_override` slot #### 2. Rebuild downstream databases: @@ -88,6 +94,8 @@ The following databases should be rebuilt and copies of them should be put in `/ - [ ] Build CURIE NGD database @mohsenht - [ ] refreshed XDTD database @chunyuma - [ ] XDTD database @chunyuma _(may be skipped - depends on the changes in this KG2 version)_ +- [ ] refreshed XCRG database @chunyuma +- [ ] XCRG database @chunyuma _(may be skipped - depends on the changes in this KG2 version)_ **NOTE**: As databases are rebuilt, `RTX/code/config_dbs.json` will need to be updated to point to their new paths! Push these changes to the branch for this KG2 version, unless the rollout of this KG2 version has already occurred, in which case you should push to `master` (but first follow the steps described [here](https://github.com/RTXteam/RTX/wiki/Config,-databases,-and-SFTP#config_dbsjson)). @@ -95,16 +103,10 @@ The following databases should be rebuilt and copies of them should be put in `/ All code changes should **go in the branch for this KG2 version**! -- [ ] regenerate the KG2c test triples file in the branch for this KG2 version - - [ ] ensure the new KG2c Neo4j is currently running - - [ ] check out the branch and pull to get the latest changes (this is important for ensuring the correct KG2c Neo4j is used) - - [ ] run [create_json_of_kp_predicate_triples.py](https://github.com/RTXteam/RTX/blob/master/code/ARAX/KnowledgeSources/create_json_of_kp_predicate_triples.py) - - [ ] push the regenerated file to `RTX/code/ARAX/KnowledgeSources/RTX_KG2c_test_triples.json` - [ ] update Expand code as needed - [ ] update any other modules as needed - [ ] test everything together: - [ ] check out the branch and pull to get the latest changes - - [ ] locally set `force_local = True` in `ARAX_expander.py` (to avoid using the old KG2 API) - [ ] then run the entire ARAX pytest suite (i.e., `pytest -v`) - [ ] address any failing tests - [ ] update the KG2 and ARAX version numbers in the appropriate places (in the branch for this KG2 version) @@ -121,8 +123,8 @@ Before rolling out, we need to pre-upload the new databases (referenced in `conf - [ ] copy the new databases from `arax-databases.rtx.ai` to `arax.ncats.io:/translator/data/orangeboard/databases/KG2.X.Y`; example for KG2.8.0: - [ ] `ssh myuser@arax.ncats.io` - [ ] `cd /translator/data/orangeboard/databases/` - - [ ] `mkdir -m 777 KG2.8.0` - - [ ] `scp rtxconfig@arax-databases.rtx.ai:/home/rtxconfig/KG2.8.0/*2.8.0* KG2.8.0/` + - [ ] `mkdir -m 777 KG2.X.Y` + - [ ] `scp rtxconfig@arax-databases.rtx.ai:/home/rtxconfig/KG2.X.Y/*2.X.Y* KG2.X.Y/` - [ ] upload the new databases and their md5 checksums to ITRB's SFTP server using the steps detailed [here](https://github.com/RTXteam/RTX/wiki/Config,-databases,-and-SFTP#steps-for-all-databases-at-once) #### 5. Rollout new KG2c version to `arax.ncats.io` development endpoints @@ -148,9 +150,7 @@ Before rolling out, we need to pre-upload the new databases (referenced in `conf - [ ] look up `RTX:KG2` in the Synonyms tab in the UI - [ ] roll `master` out to the various `arax.ncats.io` development endpoints. Usually in this order: - [ ] `devED` - - [ ] `kg2beta` - [ ] `beta` - - [ ] `kg2test` - [ ] `test` - [ ] `devLM` - [ ] inside the Docker `rtx1` container, run the pytest suite on the various ARAX development endpoints (that means `devED`, `devLM`, `test`, and `beta`): @@ -176,8 +176,8 @@ Before rolling out, we need to pre-upload the new databases (referenced in `conf - [ ] `ssh ubuntu@kg2-X-Zc.rtx.ai` - [ ] `sudo service neo4j stop` - [ ] In the AWS console, stop the instance `kg2canonicalizedN.rtx.ai` -- [ ] turn off the old KG2c version's plover instance (if it has not already been turned off during the previous KG2c roll-out; under normal circumstances, we turn off the self-hosted PloverDB for the new KG2c, during clean-up) - - [ ] Determine what is the DNS A record hostname for `kg2-X-Zcplover.rtx.ai` (where `Z` is one less than the new minor release version): run `nslookup kg2-X-Zploverc.rtx.ai` (it will return either `kg2cplover.rtx.ai`, `kg2cplover2.rtx.ai`, or `kg2cplover3.rtx.ai`; we'll call it `kg2cploverN.rtx.ai`). +- [ ] turn off the **old** KG2c version's plover instance (if it has not already been turned off during the previous KG2c roll-out; under normal circumstances, we turn off the self-hosted PloverDB for the new KG2c, during clean-up) + - [ ] Determine what is the DNS A record hostname for `kg2-X-Zcplover.rtx.ai` (where `Z` is one less than the new minor release version): run `nslookup kg2-X-Zploverc.rtx.ai` (it will return either `kg2cplover.rtx.ai` or `kg2cplover3.rtx.ai`; we'll call it `kg2cploverN.rtx.ai`). - [ ] message the `#deployment` channel in the `ARAXTeam` Slack workspace that you will be stopping the `kg2-X-Zcplover.rtx.ai` PloverDB service - [ ] Log into `kg2cploverN.rtx.ai`: `ssh ubuntu@kg2cploverN.rtx.ai` - [ ] Stop the PloverDB container: `sudo docker stop plovercontainer2.X.Z` (if you are not sure of the container name, use `sudo docker container ls -a` to get the container name). @@ -185,42 +185,20 @@ Before rolling out, we need to pre-upload the new databases (referenced in `conf - [ ] deploy new PloverDB service into ITRB CI that is backed by the new KG2c database: - [ ] merge PloverDB `main` branch into `kg2.X.Yc` branch (if `main` has any commits ahead of `kg2.X.Yc`). Reference this issue (via its full GitHub URL) in the merge message. - [ ] merge PloverDB `kg2.X.Yc` branch into `main` branch. Reference this issue (via its full GitHub URL) in the merge message. - - [ ] update `kg_config.json` in the `main` branch of the Plover repo to point to the new `kg2c_lite_2.X.Y.json.gz` file (push this change) - - [ ] wait about 60 minutes for Jenkins to build the PloverDB project and deploy it to `kg2cploverdb.ci.transltr.io` - - [ ] verify the CI Plover is running the new KG2 version by running the following test and inspecting the command line output: `cd PloverDB && pytest -vs test/test.py -k test_version --endpoint https://kg2cploverdb.ci.transltr.io` - - [ ] run Plover tests to verify it's working: `cd PloverDB && pytest -v test/test.py --endpoint https://kg2cploverdb.ci.transltr.io` - - [ ] run the ARAX pytest suite with the NCATS endpoint plugged in (locally change the URL in `RTX/code/config_dbs.json` and set `force_local = True` in Expand) - - [ ] if all tests pass, update `RTX/code/config_dbs.json` in the `master` branch to point to the ITRB Plover endpoints (all maturity levels): (`dev`: `kg2cploverdb.ci.transltr.io`; `test`: `kg2cploverdb.test.transltr.io`; `prod`: `kg2cploverdb.transltr.io`) - - [ ] push the latest `master` branch code commit to the various endpoints on `arax.ncats.io` that you previously updated (this is in order to get the changed `config_dbs.json` file) and restart ARAX and KG2 services + - [ ] wait about 70 minutes for Jenkins to build the PloverDB project and deploy it to `kg2cploverdb.ci.transltr.io` + - [ ] verify that the CI Plover is running the new KG2 version by: + - [ ] going to https://kg2cploverdb.ci.transltr.io/code_version and verifying that the correct nodes and edges jsonlines files were used + - [ ] running the following test and inspecting the command line output: `cd PloverDB/test && pytest -vsk test_version --endpoint https://kg2cploverdb.ci.transltr.io` + - [ ] run the full Plover test suite to verify everything is working: `cd PloverDB/test && pytest -v --endpoint https://kg2cploverdb.ci.transltr.io` + - [ ] run the ARAX pytest suite using the CI KG2 Plover (locally remove the `plover_url_override` in `RTX/code/config_dbs.json` by setting it to `null`) + - [ ] if all tests pass, update `RTX/code/config_dbs.json` in the `master` branch with your local change: (`plover_url_override: null`) + - [ ] push the latest `master` branch code commit to the various endpoints on `arax.ncats.io` that you previously updated (this is in order to get the changed `config_dbs.json` file) and restart ARAX services - [ ] check the [Test Build](https://github.com/RTXteam/RTX/actions/workflows/pytest.yml) (CI/CD tests) to make sure all non-skipped pytest tests have passed - [ ] turn off the self-hosted plover endpoint for the new version of KG2c - [ ] message the `#deployment` channel to notify people what you are about to do - [ ] `ssh ubuntu@kg2cploverM.rtx.ai` - - [ ] `sudo docker container ls -a` (gives you the name of the container; assume it is `plovercontainer2.X.Y`) - - [ ] `sudo docker stop plovercontainer2.X.Y` + - [ ] `sudo docker container ls -a` (gives you the name of the container; assume it is `plovercontainer`) + - [ ] `sudo docker stop plovercontainer` - [ ] verify once more that ARAX is still working properly, even with the self-hosted new-KG2c-version PloverDB service turned off - [ ] delete the `kg2.X.Yc` branch in the PloverDB repo (since it has been merged into `main` at this point) - [ ] upload the new `kg2c_lite_2.X.Y.json.gz` file to the [translator-lfs-artifacts](https://github.com/ncats/translator-lfs-artifacts/tree/main/files) repo (ask Amy Glen or Sundar Pullela, who have permission to do this) -- [ ] upload the new `kg2_nodes_not_in_sri_nn.tsv` file to the [translator-lfs-artifacts](https://github.com/ncats/translator-lfs-artifacts/tree/main/files) repo - -#### 7. Roll-out to ITRB TEST -- [ ] In GitHub, for the RTXteam/RTX project, merge `master` to `itrb-test`. Record this issue number in the merge message. -- [ ] In GitHub, for the RTXteam/PloverDB project, merge `main` to `itrb-test`. -- [ ] Tag the release using the `master` branch of RTXteam/RTX project. -- [ ] Tag the release using the `main` branch of RTXteam/PloverDB project. -- [ ] Via a message in the `#devops-teamexpanderagent` channel in the `NCATSTranslator` Slack workspace, put in a request to `@Sarah Stemann` to open a ticket to re-deploy ARAX, RTX-KG2, and PloverDB to ITRB test -- [ ] Monitor the `#devops-teamexpanderagent` channel to follow the roll-out of the updated services in ITRB test (i.e., to see if there are any errors reported by ITRB) -- [ ] Check proper functioning of `kg2cploverdb.test.transltr.io` - - [ ] from any git checkout of `RTXteam/PloverDB` project's `master` branch, do : `cd PloverDB && pytest -v test/test.py --endpoint https://kg2cploverdb.test.transltr.io` -- [ ] Check proper functioning of `kg2.test.transltr.io` (look at messages log `debug` mesages to verify that it is indeed querying `kg2cploverdb.test.transltr.io`) -- [ ] Check proper functioning of `arax.test.transltr.io` (look at messages log `debug` mesages to verify that ARAX-Expand is indeed querying `kg2.test.transltr.io`) - -#### 8. Roll-out to ITRB PRODUCTION -- [ ] In GitHub, for the RTXteam/RTX project, merge `master` to `production`. Record this issue number in the merge message. -- [ ] In GitHub, for the RTXteam/PloverDB project, merge `main` to `production`. -- [ ] Via a message in the `#devops-teamexpanderagent` channel in the `NCATSTranslator` Slack workspace, put in a request to `@Sarah Stemann` to open a ticket to re-deploy ARAX, RTX-KG2, and PloverDB to ITRB production -- [ ] Monitor the `#devops-teamexpanderagent` channel to follow (i.e., to see if there are any errors reported by ITRB) the roll-out of the updated services in ITRB production (this could take several days, as there is a formal approval process for deployments to ITRB production) -- [ ] Check proper functioning of `kg2cploverdb.transltr.io` -- [ ] Check proper functioning of `kg2.transltr.io` (look at messages log `debug` mesages to verify that it is indeed querying `kg2cploverdb.transltr.io`) -- [ ] Check proper functioning of `arax.transltr.io` (look at messages log `debug` mesages to verify that ARAX-Expand is indeed querying `kg2.transltr.io`) - diff --git a/README.md b/README.md index 3a1f7f5cd..c2fe25ed4 100644 --- a/README.md +++ b/README.md @@ -82,7 +82,7 @@ it. ARAX is a tool for querying, manipulating, filtering, and exploring biomedical knowledge graphs. It is designed to be a type of middleware—an *autonomous -relay agent*—within the Translator system. The top-level layer of +relay agent*—within the [Translator system](https://github.com/NCATSTranslator/Translator-All/wiki). The top-level layer of Translator (which is called the *autonomous relay system*) will issue structured queries to ARAX via ARAX's web application programming interface. Then, based on the query type, ARAX will determine which *knowledge providers* it needs to consult in diff --git a/code/ARAX/ARAXQuery/ARAX_connect.py b/code/ARAX/ARAXQuery/ARAX_connect.py index 9ca9e65a5..11e985d00 100644 --- a/code/ARAX/ARAXQuery/ARAX_connect.py +++ b/code/ARAX/ARAXQuery/ARAX_connect.py @@ -1,6 +1,5 @@ import sys -import requests from RTXConfiguration import RTXConfiguration @@ -35,50 +34,29 @@ def __init__(self): self.allowable_actions = { 'connect_nodes', } - self.report_stats = False # Set this to False when ready to go to production, this is only for debugging purposes - # parameter descriptions + # Set this to False when ready to go to production, this is only for debugging purposes + self.report_stats = False + self.max_path_length_info = { "is_required": False, "examples": [2, 3, 5], "min": 1, "max": 5, "type": "integer", - "description": "The maximum edges to connect two nodes with. If not provided defaults to 2." - } - self.qnode_keys_info = { - "is_required": True, - "examples": [['n01', 'n02'], []], - "type": "list", - "description": "List with just two qnode keys to connect. example: [n1, n2]" - } - self.node_category_constraint_info = { - "is_required": False, - "examples": ['biolink:Disease', 'biolink:Gene', 'biolink:ChemicalEntity'], - "type": "string", - "description": "This constraint will display paths that only pass through the user-specified category." + "description": "The maximum edges to connect two nodes with. If not provided defaults to 4." } - # command descriptions self.command_definitions = { "connect_nodes": { "dsl_command": "connect(action=connect_nodes)", "description": """ -`connect_nodes` Try to find reasonable paths between two bio entities. - -Use cases include: - -* finding out how 2 concepts are connected. - -You have the option to limit the maximum number of edges in a path (via `max_path_length=`) - """, - 'brief_description': """ -connect_nodes adds paths between two nodes specified in the query. + `connect_nodes` Try to find reasonable paths between two bio entities. + You have the option to limit the maximum number of edges in a path (via `max_path_length=`) """, + 'brief_description': "connect_nodes adds paths between two nodes specified in the query.", "parameters": { - "max_path_length": self.max_path_length_info, - "qnode_keys": self.qnode_keys_info, - "node_category_constraint": self.node_category_constraint_info + "max_path_length": self.max_path_length_info } } } @@ -89,22 +67,29 @@ def report_response_stats(self, response): """ message = self.message if self.report_stats: - # report number of nodes and edges, and their type in the QG + if hasattr(message, 'query_graph') and message.query_graph: response.debug(f"Query graph is {message.query_graph}") - if hasattr(message, 'knowledge_graph') and message.knowledge_graph and hasattr(message.knowledge_graph, - 'nodes') and message.knowledge_graph.nodes and hasattr( - message.knowledge_graph, 'edges') and message.knowledge_graph.edges: + + if (hasattr(message, 'knowledge_graph') and + message.knowledge_graph and + hasattr(message.knowledge_graph, 'nodes') and + message.knowledge_graph.nodes and + hasattr(message.knowledge_graph, 'edges') and + message.knowledge_graph.edges): + response.debug(f"Number of nodes in KG is {len(message.knowledge_graph.nodes)}") response.debug( - f"Number of nodes in KG by type is {Counter([x.categories[0] for x in message.knowledge_graph.nodes.values()])}") # type is a list, just get the first one - # response.debug(f"Number of nodes in KG by with attributes are {Counter([x.category for x in message.knowledge_graph.nodes.values()])}") # don't really need to worry about this now + f"Number of nodes in KG by type is " + f"{Counter([x.categories[0] for x in message.knowledge_graph.nodes.values()])}") response.debug(f"Number of edges in KG is {len(message.knowledge_graph.edges)}") response.debug( - f"Number of edges in KG by type is {Counter([x.predicate for x in message.knowledge_graph.edges.values()])}") + f"Number of edges in KG by type is " + f"{Counter([x.predicate for x in message.knowledge_graph.edges.values()])}") response.debug( - f"Number of edges in KG with attributes is {len([x for x in message.knowledge_graph.edges.values() if x.attributes])}") - # Collect attribute names, could do this with list comprehension, but this is so much more readable + f"Number of edges in KG with attributes is " + f"{len([x for x in message.knowledge_graph.edges.values() if x.attributes])}") + attribute_names = [] for x in message.knowledge_graph.edges.values(): if x.attributes: @@ -136,26 +121,16 @@ def check_params(self, allowable_parameters): f"Supplied parameter {key} is not permitted. Allowable parameters are: {list(allowable_parameters.keys())}", error_code="UnknownParameter") return -1 - elif type(item) == list or type(item) == set: - for item_val in item: - if item_val not in allowable_parameters[key]: - self.response.warning( - f"Supplied value {item_val} is not permitted. In action {allowable_parameters['action']}, allowable values to {key} are: {list(allowable_parameters[key])}") - return -1 - elif item not in allowable_parameters[key]: - if any([type(x) == float for x in - allowable_parameters[key]]): # if it's a float, just accept it as it is - continue - elif any([type(x) == int for x in allowable_parameters[key]]): + if item not in allowable_parameters[key]: + if any([type(x) == int for x in allowable_parameters[key]]): continue - elif any([type(x) == str for x in allowable_parameters[key]]): - continue - else: # otherwise, it's really not an allowable parameter - self.response.warning( - f"Supplied value {item} is not permitted. In action {allowable_parameters['action']}, allowable values to {key} are: {list(allowable_parameters[key])}") + else: + self.response.error( + f"Supplied value {item} is not permitted. In action " + f"{allowable_parameters['action']}, " + f"allowable values to {key} are: {list(allowable_parameters[key])}") return -1 - #### Top level decision maker for applying filters def apply(self, input_response, input_parameters): self.response = input_response @@ -163,15 +138,12 @@ def apply(self, input_response, input_parameters): if self.message.knowledge_graph is None: self.message.knowledge_graph = KnowledgeGraph(nodes=dict(), edges=dict()) - #### Basic checks on arguments if not isinstance(input_parameters, dict): self.response.error("Provided parameters is not a dict", error_code="ParametersNotDict") return self.response - # list of actions that have so far been created for ARAX_overlay allowable_actions = self.allowable_actions - # check to see if an action is actually provided if 'action' not in input_parameters: self.response.error(f"Must supply an action. Allowable actions are: action={allowable_actions}", error_code="MissingAction") @@ -180,173 +152,150 @@ def apply(self, input_response, input_parameters): f"Supplied action {input_parameters['action']} is not permitted. Allowable actions are: {allowable_actions}", error_code="UnknownAction") - #### Return if any of the parameters generated an error (showing not just the first one) if self.response.status != 'OK': return self.response - # populate the parameters dict parameters = dict() for key, value in input_parameters.items(): parameters[key] = value - #### Store these final parameters for convenience self.response.data['parameters'] = parameters self.parameters = parameters - # convert the action string to a function call (so I don't need a ton of if statements getattr(self, '_' + self.__class__.__name__ + '__' + parameters[ 'action'])() # thank you https://stackoverflow.com/questions/11649848/call-methods-by-string - self.response.debug( - f"Applying Connect to Message with parameters {parameters}") # TODO: re-write this to be more specific about the actual action + self.response.debug(f"Applying Connect to Message with parameters {parameters}") - #### Return the response and done if self.report_stats: # helper to report information in debug if class self.report_stats = True self.response = self.report_response_stats(self.response) return self.response + def get_pinned_nodes(self): + pinned_nodes = [] + for key, node in self.message.query_graph.nodes.items(): + if node.ids and len(node.ids) > 0: + pinned_nodes.append(key) + if len(pinned_nodes) != 2: + self.response.error(f"Query graph must have exactly 2 pinned nodes to connect. " + f"Number of pinned nodes: {len(pinned_nodes)}") + return pinned_nodes + + def get_constraint_node(self): + constraint_node = [] + for key, node in self.message.query_graph.nodes.items(): + if node.categories and len(node.categories) > 0: + constraint_node.append(key) + if len(constraint_node) > 1: + self.response.error(f"For now PathFinder can only handle one constraint node. " + f"Number of pinned nodes: {len(constraint_node)}") + return constraint_node + + def get_normalize_nodes(self, nodes, pinned_qnode_id): + synonymizer = NodeSynonymizer() + try: + return synonymizer.get_canonical_curies( + curies=nodes[pinned_qnode_id].ids[0])[nodes[pinned_qnode_id].ids[0]]['preferred_curie'] + except Exception as e: + self.response.error(f"PathFinder could not get canonical CURIE for the node: {pinned_qnode_id}" + f" with id: {nodes[pinned_qnode_id].ids[0]}." + f" You need to provide id (CURIE) or name for this node." + f" Error message is: {e}") + return self.response + + def get_src_node(self, pinned_nodes): + for key_node in pinned_nodes: + for key_edge, edge in self.message.query_graph.edges.items(): + if edge.subject == key_node: + return key_node + self.response.error(f"Could not find source node") + + def get_dst_node(self, pinned_nodes): + for key_node in pinned_nodes: + for key_edge, edge in self.message.query_graph.edges.items(): + if edge.object == key_node: + return key_node + self.response.error(f"Could not find destination node") + + def get_q_src_dest_edge_name(self, src_key, dst_key): + for key_edge, edge in self.message.query_graph.edges.items(): + if edge.subject == src_key and edge.object == dst_key: + return key_edge + self.response.error(f"Could not find source to destination edge") + + def get_q_src_mid_edge_name(self, src_key, mid_key): + for key_edge, edge in self.message.query_graph.edges.items(): + if edge.subject == src_key and edge.object == mid_key: + return key_edge + self.response.error(f"Could not find source to constraint edge") + + def get_q_mid_dest_edge_name(self, mid_key, dst_key): + for key_edge, edge in self.message.query_graph.edges.items(): + if edge.subject == mid_key and edge.object == dst_key: + return key_edge + self.response.error(f"Could not find constraint to destination edge") + def __connect_nodes(self, describe=False): """ - Connects qnodes and runs expand. - Allowable parameters: {'edge_predicate': str, - 'edge_property': str, - 'direction': {'above', 'below'}} + PathFinder try to find paths between two pinned nodes. :return: """ - message = self.message - parameters = self.parameters - # make a list of the allowable parameters (keys), and their possible values (values). Note that the action and corresponding name will always be in the allowable parameters - if message and parameters and hasattr(message, 'query_graph') and hasattr(message.query_graph, 'nodes'): - allowable_parameters = {'action': {'connect_nodes'}, - 'max_path_length': {int()}, - 'node_category_constraint': {str()}, - 'qnode_keys': set(self.message.query_graph.nodes.keys()) - } - else: - allowable_parameters = {'action': {'connect_nodes'}, - 'max_path_length': { - 'A maximum path length to use to connect qnodes. Defaults to 2.'}, - 'node_category_constraint': { - 'All paths must include at least one node from this category constraint.'}, - 'qnode_keys': {'A list with just two query keys to connect'} - } - - # A little function to describe what this thing does + + allowable_parameters = { + 'action': {'connect_nodes'}, + 'max_path_length': {1, 2, 3, 4, 5} + } if describe: allowable_parameters['brief_description'] = self.command_definitions['connect_nodes'] return allowable_parameters - # Make sure only allowable parameters and values have been passed - resp = self.check_params(allowable_parameters) - # return if bad parameters have been passed - if self.response.status != 'OK' or resp == -1: - return self.response - - if 'qnode_keys' not in self.parameters or len(self.parameters['qnode_keys']) == 0: - self.parameters['qnode_keys'] = list(set(self.message.query_graph.nodes.keys())) - if len(self.parameters['qnode_keys']) < 2: - self.response.error( - f"Query graph must have at least 2 nodes to connect.", - error_code="QueryGraphError") - elif len(self.parameters['qnode_keys']) == 1: - self.response.error( - f"If qnode keys are provided you must provide at least 2 qnode keys.", - error_code="ValueError") - if 'max_path_length' not in self.parameters: - self.parameters['max_path_length'] = 2 - if 'node_category_constraint' not in self.parameters: - self.parameters['node_category_constraint'] = '' - # convert path length to int if it isn't already + self.parameters['max_path_length'] = 4 if type(self.parameters['max_path_length']) != int: self.parameters['max_path_length'] = int(self.parameters['max_path_length']) - if self.parameters['max_path_length'] < 1 or self.parameters['max_path_length'] > 5: - self.response.error( - f"Maximum path length must be betwen 1 and 5 inclusive.", - error_code="ValueError") - + self.response.error(f"Maximum path length must be between 1 and 5 inclusive.", error_code="ValueError") if self.response.status != 'OK': return self.response - mode = 'ARAX' + resp = self.check_params(allowable_parameters) + if self.response.status != 'OK' or resp == -1: + return self.response - if len(self.parameters['qnode_keys']) != 2: - self.response.error( - f"Connect works with just two qnodes. qnode list size: {len(self.parameters['qnode_keys'])}" - ) + pinned_nodes = self.get_pinned_nodes() + src_pinned_node = self.get_src_node(pinned_nodes) + dst_pinned_node = self.get_dst_node(pinned_nodes) + constraint_node = self.get_constraint_node()[0] + q_src_dest_edge_name = self.get_q_src_dest_edge_name(src_pinned_node, dst_pinned_node) + q_src_mid_edge_name = self.get_q_src_mid_edge_name(src_pinned_node, constraint_node) + q_mid_dest_edge_name = self.get_q_mid_dest_edge_name(constraint_node, dst_pinned_node) + if self.response.status != 'OK' or resp == -1: return self.response - nodes = {k: v for k, v in self.response.envelope.message.query_graph.nodes.items() if - k in self.parameters['qnode_keys']} - if len(nodes) != 2: - self.response.error(f"Need to have two nodes to find paths between them. Number of nodes: {len(nodes)}") + normalize_src_node_id = self.get_normalize_nodes(self.message.query_graph.nodes, src_pinned_node) + normalize_dst_node_id = self.get_normalize_nodes(self.message.query_graph.nodes, dst_pinned_node) path_finder = BidirectionalPathFinder( "NGDSortedNeighborsRepo", self.response ) - qnode_1_id = self.parameters['qnode_keys'][0] - qnode_2_id = self.parameters['qnode_keys'][1] - synonymizer = NodeSynonymizer() - try: - node_1_id = synonymizer.get_canonical_curies(curies=nodes[qnode_1_id].ids[0])[nodes[qnode_1_id].ids[0]][ - 'preferred_curie'] - except Exception as e: - self.response.error(f"PathFinder could not get canonical CURIE for the node: {qnode_1_id}." - f" You need to provide id (CURIE) or name for this node" - f" Error message is: {e}") - return self.response - - try: - node_2_id = synonymizer.get_canonical_curies(curies=nodes[qnode_2_id].ids[0])[nodes[qnode_2_id].ids[0]][ - 'preferred_curie'] - except Exception as e: - self.response.error(f"PathFinder could not get canonical CURIE for the node: {qnode_2_id}" - f" You need to provide id (CURIE) or name for this node." - f" Error message is: {e}") - return self.response - - paths = path_finder.find_all_paths(node_1_id, node_2_id, hops_numbers=self.parameters['max_path_length']) + paths = path_finder.find_all_paths( + normalize_src_node_id, + normalize_dst_node_id, + hops_numbers=self.parameters['max_path_length'] + ) self.response.debug(f"PathFinder found {len(paths)} paths") if len(paths) == 0: - self.response.warning(f"Could not connect the nodes {qnode_1_id} and {qnode_2_id} " + self.response.warning(f"Could not connect the nodes {src_pinned_node} and {dst_pinned_node} " f"with a max path length of {self.parameters['max_path_length']}.") return self.response - qnode_mid_id = "qnode_mid_id" - self.response.envelope.message.query_graph.nodes[qnode_mid_id] = QNode( - ids=[], - categories=None, - is_set=False, - set_interpretation='BATCH', - set_id=None, - constraints=[], - option_group_id=None - ) - - q_edge_src_dest = 'q_edge_src_dest' - self.response.envelope.message.query_graph.edges[q_edge_src_dest] = QEdge( - object=qnode_1_id, - subject=qnode_2_id - ) - q_edge_src_mid = 'q_edge_src_mid' - self.response.envelope.message.query_graph.edges[q_edge_src_mid] = QEdge( - object=qnode_1_id, - subject=qnode_mid_id - ) - q_edge_mid_dest = 'q_edge_mid_dest' - self.response.envelope.message.query_graph.edges[q_edge_mid_dest] = QEdge( - object=qnode_mid_id, - subject=qnode_2_id - ) - names = Names( - q_src_dest_edge_name=q_edge_src_dest, - q_src_mid_edge_name=q_edge_src_mid, - q_mid_dest_edge_name=q_edge_mid_dest, + q_src_dest_edge_name=q_src_dest_edge_name, + q_src_mid_edge_name=q_src_mid_edge_name, + q_mid_dest_edge_name=q_mid_dest_edge_name, result_name="result", auxiliary_graph_name="aux", kg_src_dest_edge_name="kg_src_dest_edge", @@ -358,16 +307,17 @@ def __connect_nodes(self, describe=False): ) SuperNodeConverter( paths, - node_1_id, - node_2_id, - qnode_1_id, - qnode_2_id, - qnode_mid_id, + normalize_src_node_id, + normalize_dst_node_id, + src_pinned_node, + dst_pinned_node, + constraint_node, names, edge_extractor, - self.parameters['node_category_constraint'] + self.message.query_graph.nodes[constraint_node].categories[0] ).convert(self.response) + mode = 'ARAX' if mode != "RTXKG2" and not hasattr(self.response, "original_query_graph"): self.response.original_query_graph = copy.deepcopy(self.response.envelope.message.query_graph) return self.response diff --git a/code/ARAX/ARAXQuery/ARAX_expander.py b/code/ARAX/ARAXQuery/ARAX_expander.py index 2dc53d814..bb4d40f52 100644 --- a/code/ARAX/ARAXQuery/ARAX_expander.py +++ b/code/ARAX/ARAXQuery/ARAX_expander.py @@ -28,6 +28,7 @@ from openapi_server.models.edge import Edge from openapi_server.models.attribute_constraint import AttributeConstraint from openapi_server.models.attribute import Attribute +from openapi_server.models.retrieval_source import RetrievalSource from Expand.kg2_querier import KG2Querier from Expand.trapi_querier import TRAPIQuerier @@ -318,7 +319,6 @@ def apply(self, response, input_parameters, mode: str = "ARAX"): # Expand any specified edges inferred_qedge_keys = [qedge_key for qedge_key, qedge in query_graph.edges.items() if qedge.knowledge_type == "inferred"] - do_issue_2328_patch = True # Turns on/off the patch for #2328 (treats refactor issue) if qedge_keys_to_expand: query_sub_graph = self._extract_query_subgraph(qedge_keys_to_expand, query_graph, log) log.debug(f"Query graph for this Expand() call is: {query_sub_graph.to_dict()}") @@ -359,8 +359,8 @@ def apply(self, response, input_parameters, mode: str = "ARAX"): for kp in kp_selector.valid_kps: response.update_query_plan(qedge_key, kp, 'Waiting', 'Prepping query to send to KP') qedge = query_graph.edges[qedge_key] - alter_kg2_treats_edges = True if (do_issue_2328_patch and qedge_key in inferred_qedge_keys - and "biolink:treats" in qedge.predicates) else False + be_creative_treats = True if (qedge_key in inferred_qedge_keys + and "biolink:treats" in qedge.predicates) else False # Create a query graph for this edge (that uses curies found in prior steps) one_hop_qg = self._get_query_graph_for_edge(qedge_key, query_graph, overarching_kg, log) @@ -435,7 +435,7 @@ def apply(self, response, input_parameters, mode: str = "ARAX"): kp_selector, log, multiple_kps=True, - alter_kg2_treats_edges=alter_kg2_treats_edges) + be_creative_treats=be_creative_treats) for kp_to_use in kps_to_query] task_group = asyncio.gather(*tasks) kp_answers = loop.run_until_complete(task_group) @@ -507,17 +507,58 @@ def apply(self, response, input_parameters, mode: str = "ARAX"): for kedge_key in kedges_to_remove: if kedge_key in overarching_kg.edges_by_qg_id[qedge_key]: del overarching_kg.edges_by_qg_id[qedge_key][kedge_key] - # Remove KG2 SemMedDB treats_or_applied-type edges if this is an inferred treats query - if alter_kg2_treats_edges: + # Handle Expand's creative treats predicate answers + if be_creative_treats and qedge_key in overarching_kg.edges_by_qg_id: # Skip if no answers + # First remove any SemMedDB treats_or_applied-type edges (not trustworthy) edge_keys_to_remove = {edge_key for edge_key, edge in overarching_kg.edges_by_qg_id[qedge_key].items() if edge.predicate in self.treats_like_predicates and - any(source.resource_id == "infores:rtx-kg2" for source in edge.sources) and any(source.resource_id == "infores:semmeddb" for source in edge.sources)} - log.debug(f"Removing {len(edge_keys_to_remove)} KG2 semmeddb treats_or_applied-type edges " + log.debug(f"Removing {len(edge_keys_to_remove)} semmeddb treats_or_applied-type edges " f"fulfilling {qedge_key}") for edge_key in edge_keys_to_remove: del overarching_kg.edges_by_qg_id[qedge_key][edge_key] + # Use remaining treats-like edges as support for one merged 'treats' edge (per subj/obj pair) + higher_level_treats_edges = {edge_key: edge + for edge_key, edge in overarching_kg.edges_by_qg_id[qedge_key].items() + if edge.predicate in self.treats_like_predicates} + if higher_level_treats_edges: + # Add a virtual edge to the QG to capture all higher-level treats edges ('support' edges) + virtual_qedge_key = f"creative_expand_treats_{qedge_key}" + virtual_qedge = QEdge(subject=qedge.subject, + object=qedge.object, + option_group_id=f"creative_expand_treats_group_{qedge_key}") + virtual_qedge.filled = True # Resultify needs this flag + message.query_graph.edges[virtual_qedge_key] = virtual_qedge + overarching_kg.edges_by_qg_id[virtual_qedge_key] = dict() + + # Lump the higher-level treats edges together by subject/object + subj_obj_map = defaultdict(set) + for higher_treats_edge_key, higher_treats_edge in higher_level_treats_edges.items(): + hash_key = (higher_treats_edge.subject, higher_treats_edge.object) + subj_obj_map[hash_key].add(higher_treats_edge_key) + + for (subj_key, obj_key), higher_treats_edge_keys in subj_obj_map.items(): + # Create a lumped edge to represent all of these edges + lumped_edge = Edge(subject=subj_key, object=obj_key, predicate="biolink:treats", + sources=[RetrievalSource(resource_id="infores:arax", + resource_role="primary_knowledge_source")], + attributes=[Attribute(attribute_type_id="biolink:agent_type", + value="computational_model", + attribute_source="infores:arax"), + Attribute(attribute_type_id="biolink:knowledge_level", + value="not_provided", + attribute_source="infores:arax")]) + lumped_edge_key = f"creative_expand_treats_edge:{subj_key}--treats--{obj_key}--infores:arax" + overarching_kg.edges_by_qg_id[qedge_key][lumped_edge_key] = lumped_edge + + # Move the higher-level treats edges so that they fulfill the virtual qedge instead + for higher_treats_edge_key in higher_treats_edge_keys: + higher_treats_edge = overarching_kg.edges_by_qg_id[qedge_key][higher_treats_edge_key] + overarching_kg.edges_by_qg_id[virtual_qedge_key][higher_treats_edge_key] = higher_treats_edge + del overarching_kg.edges_by_qg_id[qedge_key][higher_treats_edge_key] + + if mode != "RTXKG2": # Apply any kryptonite ("not") qedges self._apply_any_kryptonite_edges(overarching_kg, message.query_graph, @@ -586,30 +627,6 @@ def apply(self, response, input_parameters, mode: str = "ARAX"): decorator = ARAXDecorator() decorator.decorate_edges(response, kind="SEMMEDDB") - # Second half of patch for #2328; edit KG2 'treats_or_applied_or_studied_to_treat' edges to just 'treats' - response.info(f"Treats-like predicates are: {self.treats_like_predicates}") - response.info(f"BiolinkHelper Biolink version is: {self.bh.biolink_version}") - response.info(f"Mode is {mode}, do_issue_2328_patch is {do_issue_2328_patch}, " - f"inferred_qedge_keys is {inferred_qedge_keys}") - if mode != "RTXKG2" and do_issue_2328_patch and inferred_qedge_keys: - response.info(f"Made it into block where KG2 treats-like edge alteration happens") - num_edges_altered = 0 - for edge in message.knowledge_graph.edges.values(): - is_kg2_edge = any(source.resource_id == "infores:rtx-kg2" for source in edge.sources) - if is_kg2_edge and edge.predicate in self.treats_like_predicates: - # Record the original KG2 predicate in an attribute - edge.attributes.append(Attribute(attribute_type_id="biolink:original_predicate", - value=edge.predicate, - value_type_id="biolink:predicate", - description="Predicate as it appears in RTX-KG2, prior to " - "alteration by ARAX.", - attribute_source="infores:arax")) - # Then change the predicate to treats - edge.predicate = "biolink:treats" - num_edges_altered += 1 - if num_edges_altered: - log.info(f"Modified the predicate of {num_edges_altered} KG2 edges to biolink:treats") - # Map canonical curies back to the input curies in the QG (where applicable) #1622 self._map_back_to_input_curies(message.knowledge_graph, query_graph, log) if mode == "RTXKG2": @@ -772,7 +789,7 @@ async def _expand_edge_async(self, edge_qg: QueryGraph, kp_selector: KPSelector, log: ARAXResponse, multiple_kps: bool = False, - alter_kg2_treats_edges: bool = False) -> Tuple[QGOrganizedKnowledgeGraph, ARAXResponse]: + be_creative_treats: bool = False) -> Tuple[QGOrganizedKnowledgeGraph, ARAXResponse]: # This function answers a single-edge (one-hop) query using the specified knowledge provider qedge_key = next(qedge_key for qedge_key in edge_qg.edges) log.info(f"Expanding qedge {qedge_key} using {kp_to_use}") @@ -799,7 +816,7 @@ async def _expand_edge_async(self, edge_qg: QueryGraph, kp_selector=kp_selector, force_local=force_local) answer_kg = await kp_querier.answer_one_hop_query_async(edge_qg, - alter_kg2_treats_edges=alter_kg2_treats_edges) + be_creative_treats=be_creative_treats) except Exception: tb = traceback.format_exc() error_type, error, _ = sys.exc_info() diff --git a/code/ARAX/ARAXQuery/ARAX_filter.py b/code/ARAX/ARAXQuery/ARAX_filter.py index e718a9779..98ace21a1 100644 --- a/code/ARAX/ARAXQuery/ARAX_filter.py +++ b/code/ARAX/ARAXQuery/ARAX_filter.py @@ -167,10 +167,10 @@ def main(): actions = result.data['actions'] #### Read message #2 from the database. This should be the acetaminophen proteins query result message - sys.path.append(os.path.dirname(os.path.abspath(__file__))+"/../../UI/Feedback") - from RTXFeedback import RTXFeedback - araxdb = RTXFeedback() - message_dict = araxdb.getMessage(2) + sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../ResponseCache") + from response_cache import ResponseCache + response_cache = ResponseCache() + message_dict = response_cache.get_response(314204) #### The stored message comes back as a dict. Transform it to objects sys.path.append(os.path.dirname(os.path.abspath(__file__))+"/../OpenAPI/python-flask-server/") diff --git a/code/ARAX/ARAXQuery/ARAX_filter_kg.py b/code/ARAX/ARAXQuery/ARAX_filter_kg.py index 6abfc45e7..0aef1585e 100644 --- a/code/ARAX/ARAXQuery/ARAX_filter_kg.py +++ b/code/ARAX/ARAXQuery/ARAX_filter_kg.py @@ -1525,9 +1525,9 @@ def main(): actions = result.data['actions'] #### Read message #2 from the database. This should be the acetaminophen proteins query result message - sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../../UI/Feedback") - from RTXFeedback import RTXFeedback - araxdb = RTXFeedback() + sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../ResponseCache") + from response_cache import ResponseCache + response_cache = ResponseCache() #message_dict = araxdb.getMessage(2) # acetaminophen2proteins graph # message_dict = araxdb.getMessage(13) # ibuprofen -> proteins -> disease # work computer @@ -1535,7 +1535,7 @@ def main(): # message_dict = araxdb.getMessage(16) # atherosclerosis -> phenotypic_feature # work computer # message_dict = araxdb.getMessage(5) # atherosclerosis -> phenotypic_feature # home computer # message_dict = araxdb.getMessage(10) - message_dict = araxdb.getMessage(40) + message_dict = response_cache.get_response(314204) #### The stored message comes back as a dict. Transform it to objects from ARAX_messenger import ARAXMessenger diff --git a/code/ARAX/ARAXQuery/ARAX_filter_results.py b/code/ARAX/ARAXQuery/ARAX_filter_results.py index 97469f40a..0c3778982 100644 --- a/code/ARAX/ARAXQuery/ARAX_filter_results.py +++ b/code/ARAX/ARAXQuery/ARAX_filter_results.py @@ -942,9 +942,9 @@ def main(): actions = result.data['actions'] #### Read message #2 from the database. This should be the acetaminophen proteins query result message - sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../../UI/Feedback") - from RTXFeedback import RTXFeedback - araxdb = RTXFeedback() + sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../ResponseCache") + from response_cache import ResponseCache + response_cache = ResponseCache() #message_dict = araxdb.getMessage(2) # acetaminophen2proteins graph # message_dict = araxdb.getMessage(13) # ibuprofen -> proteins -> disease # work computer @@ -952,7 +952,7 @@ def main(): # message_dict = araxdb.getMessage(16) # atherosclerosis -> phenotypic_feature # work computer # message_dict = araxdb.getMessage(5) # atherosclerosis -> phenotypic_feature # home computer # message_dict = araxdb.getMessage(10) - message_dict = araxdb.getMessage(40) + message_dict = response_cache.get_response(314204) #### The stored message comes back as a dict. Transform it to objects from ARAX_messenger import ARAXMessenger diff --git a/code/ARAX/ARAXQuery/ARAX_infer.py b/code/ARAX/ARAXQuery/ARAX_infer.py index 22b06d1d7..e23324500 100644 --- a/code/ARAX/ARAXQuery/ARAX_infer.py +++ b/code/ARAX/ARAXQuery/ARAX_infer.py @@ -857,8 +857,8 @@ def __chemical_gene_regulation_graph_expansion(self, describe=False): self.response.warning(f"Could not get predicted genes for chemical {preferred_subject_curie}. Likely the model was not trained with this chemical.") return self.response if top_paths is None or len(top_paths) == 0: - self.response.warning(f"Could not get any predicted paths for chemical {preferred_subject_curie}. Likely the model considers there is no reasonable path for this chemical.") - + self.response.warning(f"Could not get any predicted paths for chemical {preferred_subject_curie}. Either Plover is not reachable or no paths found") + return self.response iu = InferUtilities() qedge_id = self.parameters.get('qedge_id') self.response, self.kedge_global_iter, self.qedge_global_iter, self.qnode_global_iter, self.option_global_iter = iu.genrete_regulate_subgraphs(self.response, normalized_subject_curie, None, top_predictions, top_paths, qedge_id, self.parameters['regulation_type'], self.kedge_global_iter, self.qedge_global_iter, self.qnode_global_iter, self.option_global_iter) @@ -875,8 +875,8 @@ def __chemical_gene_regulation_graph_expansion(self, describe=False): self.response.warning(f"Could not get predicted chemicals for gene {preferred_object_curie}. Likely the model was not trained with this gene.") return self.response if top_paths is None or len(top_paths) == 0: - self.response.warning(f"Could not get any predicted paths for gene {preferred_object_curie}. Likely the model considers there is no reasonable path for this gene.") - + self.response.warning(f"Could not get any predicted paths for gene {preferred_object_curie}. Either Plover is not reachable or no paths found") + return self.response iu = InferUtilities() qedge_id = self.parameters.get('qedge_id') diff --git a/code/ARAX/ARAXQuery/ARAX_overlay.py b/code/ARAX/ARAXQuery/ARAX_overlay.py index f7954a8b0..702de3d36 100644 --- a/code/ARAX/ARAXQuery/ARAX_overlay.py +++ b/code/ARAX/ARAXQuery/ARAX_overlay.py @@ -1038,9 +1038,9 @@ def main(): actions = result.data['actions'] #### Read message #2 from the database. This should be the acetaminophen proteins query result message - sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../../UI/Feedback") - from RTXFeedback import RTXFeedback - araxdb = RTXFeedback() + sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../ResponseCache") + from response_cache import ResponseCache + response_cache = ResponseCache() # message_dict = araxdb.getMessage(2) # acetaminophen2proteins graph # message_dict = araxdb.getMessage(13) # ibuprofen -> proteins -> disease # work computer @@ -1050,7 +1050,7 @@ def main(): # message_dict = araxdb.getMessage(10) # message_dict = araxdb.getMessage(36) # test COHD obs/exp, via ARAX_query.py 16 # message_dict = araxdb.getMessage(39) # ngd virtual edge test - message_dict = araxdb.getMessage(1) + message_dict = response_cache.get_response(314204) #### The stored message comes back as a dict. Transform it to objects from ARAX_messenger import ARAXMessenger diff --git a/code/ARAX/ARAXQuery/ARAX_query_graph_interpreter.py b/code/ARAX/ARAXQuery/ARAX_query_graph_interpreter.py index 959a8e204..404720cc5 100644 --- a/code/ARAX/ARAXQuery/ARAX_query_graph_interpreter.py +++ b/code/ARAX/ARAXQuery/ARAX_query_graph_interpreter.py @@ -61,11 +61,34 @@ def translate_to_araxi(self, response, describe=False): result = query_graph_info.assess(message) response.merge(result) if result.status != 'OK': - #print(response.show(level=ARAXResponse.DEBUG)) + #eprint(response.show(level=ARAXResponse.DEBUG)) + return response + + # Add some bespoke code to detect "pathfinder" queries and branch off to different behavior + # Perhaps this could be done through the templating, but seems difficult and may change soon, + # so put in this patch for now and see if we need to change it later. + # Current trigger: + # - Any edge has knowledge_type = pathfinder OR + # - Two or more edges have knowledge_type = inferred + #eprint(json.dumps(query_graph_info.edge_info,sort_keys=True,indent=2)) + pathfinder = False + n_inferred_edges = 0 + for edge_id, edge in query_graph_info.edge_info.items(): + if edge['knowledge_type'] == 'pathfinder': + pathfinder = True + if edge['knowledge_type'] == 'inferred': + n_inferred_edges += 1 + if n_inferred_edges > 1: + pathfinder = True + if pathfinder is True: + response.info("QueryGraphInterpreter recognized query_graph as a 'pathfinder' query: triggering pathfinder subsystem.") + response.data['araxi_commands'] = [ + 'connect(action=connect_nodes, max_path_length=4)', + ] return response query_graph_template = query_graph_info.query_graph_templates['detailed'] - #print(json.dumps(query_graph_template,sort_keys=True,indent=2)) + #eprint(json.dumps(query_graph_template,sort_keys=True,indent=2)) # Check the number of nodes since the tree is based on the number of nodes n_nodes = query_graph_template['n_nodes'] @@ -80,7 +103,7 @@ def translate_to_araxi(self, response, describe=False): # Now look over each component looking for matches possible_next_steps = [] for component in query_graph_template['components']: - if debug: print(f"- Component is {component}") + if debug: eprint(f"- Component is {component}") possible_next_steps = [] #### If the component is a node, then score it @@ -127,20 +150,20 @@ def translate_to_araxi(self, response, describe=False): new_tree_pointers = [] for tree_pointer in tree_pointers: if debug: - #print(f" - pointer={tree_pointer}") - #print(f" - pointer...") + #eprint(f" - pointer={tree_pointer}") + #eprint(f" - pointer...") #for tp_key,tp_pointer in tree_pointer['pointer'].items(): - # print(f" - {tp_key} = {tp_pointer}") + # eprint(f" - {tp_key} = {tp_pointer}") pass # Consider each of the new possibilities for possible_next_step in possible_next_steps: component_string = f"{component['component_id']}({possible_next_step['content']})" - if debug: print(f" - component_string={component_string}") + if debug: eprint(f" - component_string={component_string}") # If this component is a possible next step in the tree, then add the next step to new_tree_pointers if component_string in tree_pointer['pointer']: - if debug: print(f" - Found this component with score {possible_next_step['score']}") + if debug: eprint(f" - Found this component with score {possible_next_step['score']}") new_tree_pointers.append( { 'pointer': tree_pointer['pointer'][component_string], 'score': tree_pointer['score'] + possible_next_step['score'] }) #tree_pointer = tree_pointer[component_string] @@ -152,7 +175,7 @@ def translate_to_araxi(self, response, describe=False): best_score = -1 for tree_pointer in tree_pointers: if 'name' in tree_pointer['pointer']: - if debug: print(f"==> Found template is {tree_pointer['pointer']['name']} with score {tree_pointer['score']}") + if debug: eprint(f"==> Found template is {tree_pointer['pointer']['name']} with score {tree_pointer['score']}") if tree_pointer['score'] > best_score: query_graph_template_name = tree_pointer['pointer']['name'] best_score = tree_pointer['score'] @@ -685,6 +708,7 @@ def QGI_test6(): with open('QGI_test6.json', 'w', encoding='utf-8') as f: json.dump(ast.literal_eval(repr(envelope)), f, ensure_ascii=False, indent=4) + def QGI_test7(): # This is to test a three hop query with one end pinned (should result in FET ARAXi commands), and actually run the query input_query_graph = { @@ -776,6 +800,81 @@ def QGI_test7(): # save message to file (since I can't get the UI working locally for some reason) with open('QGI_test7.json', 'w', encoding='utf-8') as f: json.dump(ast.literal_eval(repr(envelope)), f, ensure_ascii=False, indent=4) + + +def QGI_test8(): + # Test of the Pathfinder query recognition + input_query_graph = { + "message": { + "query_graph": { + "nodes": { + "n0": { + "ids": [ + "CHEBI:49662" + ] + }, + "un": { + "categories": [ + "biolink:NamedThing" + ] + }, + "n2": { + "ids": [ + "NCBIGene:1719" + ] + } + }, + "edges": { + "e0": { + "subject": "n0", + "object": "un", + "predicates": [ + "biolink:related_to" + ], + "knowledge_type": "inferred" + }, + "e1": { + "subject": "un", + "object": "n2", + "predicates": [ + "biolink:related_to" + ], + "knowledge_type": "inferred" + }, + "e2": { + "subject": "n0", + "object": "n2", + "predicates": [ + "biolink:related_to" + ], + "knowledge_type": "inferred" + } + } + } + } + } + + #### Create a template Message + response = ARAXResponse() + messenger = ARAXMessenger() + messenger.create_envelope(response) + message = ARAXMessenger().from_dict(input_query_graph['message']) + response.envelope.message.query_graph = message.query_graph + + interpreter = ARAXQueryGraphInterpreter() + interpreter.translate_to_araxi(response) + if response.status != 'OK': + print(response.show(level=ARAXResponse.DEBUG)) + return response + + araxi_commands = response.data['araxi_commands'] + eprint("Series of ARAXi commands:") + for cmd in araxi_commands: + print(f" - {cmd}") + + return + + ########################################################################################## def main(): @@ -798,6 +897,8 @@ def main(): QGI_test6() elif params.test_number[0] == '7': QGI_test7() + elif params.test_number[0] == '8': + QGI_test8() else: QGI_test1() diff --git a/code/ARAX/ARAXQuery/ARAX_ranker.py b/code/ARAX/ARAXQuery/ARAX_ranker.py index 1a8c7d6a3..02f6343ae 100644 --- a/code/ARAX/ARAXQuery/ARAX_ranker.py +++ b/code/ARAX/ARAXQuery/ARAX_ranker.py @@ -33,8 +33,8 @@ def _get_nx_edges_by_attr(G: Union[nx.MultiDiGraph, nx.MultiGraph], key: str, va def _get_query_graph_networkx_from_query_graph(query_graph: QueryGraph) -> nx.MultiDiGraph: query_graph_nx = nx.MultiDiGraph() - query_graph_nx.add_nodes_from([key for key, node in query_graph.nodes.items() if 'creative_DTD_qnode' not in key and 'creative_CRG_qnode' not in key]) - edge_list = [[edge.subject, edge.object, key, {'weight': 0.0}] for key,edge in query_graph.edges.items() if 'creative_DTD_qedge' not in key and 'creative_CRG_qedge' not in key] + query_graph_nx.add_nodes_from([key for key, node in query_graph.nodes.items() if 'creative_' not in key]) + edge_list = [[edge.subject, edge.object, key, {'weight': 0.0}] for key,edge in query_graph.edges.items() if 'creative_' not in key] query_graph_nx.add_edges_from(edge_list) return query_graph_nx @@ -124,7 +124,7 @@ def _get_weighted_graph_networkx_from_result_graph(kg_edge_id_to_edge: Dict[str, qg_edge_key_to_edge_tuple = {edge_tuple[2]: edge_tuple for edge_tuple in qg_edge_tuples} for analysis in result.analyses: # For now we only ever have one Analysis per Result for qedge_key, edge_binding_list in analysis.edge_bindings.items(): - if 'creative_DTD_qedge' not in qedge_key and 'creative_CRG_qedge' not in qedge_key: + if 'creative_' not in qedge_key: qedge_tuple = qg_edge_key_to_edge_tuple[qedge_key] res_graph[qedge_tuple[0]][qedge_tuple[1]][qedge_tuple[2]]['weight'] = _calculate_final_result_score(kg_edge_id_to_edge, edge_binding_list) @@ -828,7 +828,7 @@ def main(): import argparse argparser = argparse.ArgumentParser(description='Ranker system') - argparser.add_argument('--local', action='store_true', help='If set, use local RTXFeedback database to fetch messages') + argparser.add_argument('--local', action='store_true', help='If set, use local ResponseCache database to fetch messages') params = argparser.parse_args() # --- Create a response object @@ -849,10 +849,10 @@ def main(): # For local messages due to local changes in code not rolled out to production: if params.local: - sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../../UI/Feedback") - from RTXFeedback import RTXFeedback - araxdb = RTXFeedback() - message_dict = araxdb.getMessage(294) # local version of 2709 but with updates to COHD + sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../ResponseCache") + from response_cache import ResponseCache + response_cache = ResponseCache() + message_dict = response_cache.get_response(314204) # message_dict = araxdb.getMessage(297) # message_dict = araxdb.getMessage(298) # message_dict = araxdb.getMessage(299) # observed_expected_ratio different disease diff --git a/code/ARAX/ARAXQuery/Expand/kp_info_cacher.py b/code/ARAX/ARAXQuery/Expand/kp_info_cacher.py index 946adfa6c..b0c2f1359 100644 --- a/code/ARAX/ARAXQuery/Expand/kp_info_cacher.py +++ b/code/ARAX/ARAXQuery/Expand/kp_info_cacher.py @@ -102,19 +102,8 @@ def _get_kp_url_from_smartapi_registration(self, kp_smart_api_registration: dict # Handle the special case of RTX-KG2 if kp_smart_api_registration["infores_name"] == "infores:rtx-kg2": - # Choose which KG2 URL to use based on whether this is an ITRB instance and any potential overrides - all_kg2_urls = {server["url"] for server in kp_smart_api_registration["servers"]} - if self.rtx_config.rtx_kg2_url: - # This means there's an override in place; we'll use whatever URL was specified - raw_url = self.rtx_config.rtx_kg2_url - elif self.rtx_config.is_itrb_instance: - itrb_kg2_urls = [url for url in all_kg2_urls if "transltr.io" in url] - if itrb_kg2_urls: - raw_url = itrb_kg2_urls[0] # Should really only be one KG2 per TRAPI version / maturity level - else: - non_itrb_kg2_urls = [url for url in all_kg2_urls if "transltr.io" not in url] - if non_itrb_kg2_urls: - raw_url = non_itrb_kg2_urls[0] + # Captures an override if one is in place; otherwise server is read from our SmartAPI yaml/JSON + raw_url = self.rtx_config.plover_url # Remove any trailing slashes return raw_url.strip("/") if isinstance(raw_url, str) else raw_url diff --git a/code/ARAX/ARAXQuery/Expand/trapi_querier.py b/code/ARAX/ARAXQuery/Expand/trapi_querier.py index a0ee1c477..bca5ac1cf 100644 --- a/code/ARAX/ARAXQuery/Expand/trapi_querier.py +++ b/code/ARAX/ARAXQuery/Expand/trapi_querier.py @@ -52,13 +52,13 @@ def __init__(self, response_object: ARAXResponse, kp_name: str, user_specified_k upstream_resource_ids=[self.kp_infores_curie]) async def answer_one_hop_query_async(self, query_graph: QueryGraph, - alter_kg2_treats_edges: bool = False) -> QGOrganizedKnowledgeGraph: + be_creative_treats: bool = False) -> QGOrganizedKnowledgeGraph: """ This function answers a one-hop (single-edge) query using the specified KP. :param query_graph: A TRAPI query graph. - :param alter_kg2_treats_edges: If true, will query KG2 for higher-level treats-type predicates instead of just - 'treats'. Any higher-level returned edges will later be altered to have 'treats' - predicates in ARAX_expander.py. + :param be_creative_treats: If true, will query KP for higher-level treats-type predicates instead of just + 'treats'. Any higher-level returned edges will later be altered appropriately + in ARAX_expander.py. :return: An (almost) TRAPI knowledge graph containing all of the nodes and edges returned as results for the query. (Organized by QG IDs.) """ @@ -90,12 +90,13 @@ async def answer_one_hop_query_async(self, query_graph: QueryGraph, log.update_query_plan(qedge_key, self.kp_infores_curie, "Skipped", skipped_message) return final_kg - # Patch to address lack of answers from KG2 for treats queries after treats refactor #2328 - if alter_kg2_treats_edges and self.kp_infores_curie == "infores:rtx-kg2": + # Treat this as a creative 'treats' query + if be_creative_treats: for qedge in qg_copy.edges.values(): # Note there's only ever one qedge per QG here - qedge.predicates = list(set(qedge.predicates).union({"biolink:treats_or_applied_or_studied_to_treat"})) - log.info(f"For querying infores:rtx-kg2, edited {qedge_key} to use higher treats-type predicate: " - f"{qedge.predicates}") + qedge.predicates = list(set(qedge.predicates).union({"biolink:treats_or_applied_or_studied_to_treat", + "biolink:applied_to_treat"})) # Just to be safe + log.info(f"For querying {self.kp_infores_curie}, edited {qedge_key} to use higher treats-type " + f"predicates: {qedge.predicates}") # Answer the query using the KP and load its answers into our object model final_kg = await self._answer_query_using_kp_async(qg_copy) diff --git a/code/ARAX/ARAXQuery/Filter_KG/remove_nodes.py b/code/ARAX/ARAXQuery/Filter_KG/remove_nodes.py index d2fb0345f..2a0f7a467 100644 --- a/code/ARAX/ARAXQuery/Filter_KG/remove_nodes.py +++ b/code/ARAX/ARAXQuery/Filter_KG/remove_nodes.py @@ -156,6 +156,28 @@ def remove_orphaned_nodes(self): return self.response + def _is_general_concept(self, node): + curies = set() + synonyms = set() + if not node['attributes']: + return False + for attribute in node['attributes']: + if attribute['attribute_type_id'] == 'biolink:xref' and isinstance(attribute.get('value', []),list): + curies.update(map(str.lower, attribute.get('value', []))) + if attribute['attribute_type_id'] == 'biolink:synonym' and isinstance(attribute.get('value', []),list): + synonyms.update(map(str.lower, attribute.get('value', []))) + if node['name']: + synonyms.add(node['name'].lower()) + if self.block_list_curies.intersection(curies) or self.block_list_synonyms.intersection(synonyms): + return True + + for synonym in synonyms: + if not isinstance(synonym,str): + continue + if any(p.match(synonym) for p in self.block_list_patterns): + return True + return False + def remove_general_concept_nodes(self): node_params = self.node_parameters if 'perform_action' not in node_params: @@ -177,44 +199,31 @@ def remove_general_concept_nodes(self): file_name = 'general_concepts.json' with open(blocklist_file_path) as fp: block_list_dict = json.loads(fp.read()) - block_list_synonyms = set(block_list_dict["synonyms"]) - block_list_curies = set(block_list_dict["curies"]) - nodes_to_remove = set() - names = [] - for key, node in self.message.knowledge_graph.nodes.items(): - node_dict = node.to_dict() - synonyms = [] - curies = [] - if not node_dict['attributes']: + self.block_list_synonyms = set(block_list_dict["synonyms"]) + self.block_list_curies = set(block_list_dict["curies"]) + node_to_remove = set() + self.block_list_patterns = [re.compile(pattern,re.IGNORECASE) for pattern in block_list_dict["patterns"]] + # iterate over edges find edges connected to the nodes + edges_to_remove = [] + for key, edge in self.message.knowledge_graph.edges.items(): + if set({edge.subject, edge.object}).intersection(node_to_remove): + edges_to_remove.append(key) + continue - for attribute in node_dict['attributes']: - if attribute['attribute_type_id'] == 'biolink:xref': - curies += attribute.get('value',[]) - if attribute['attribute_type_id'] == 'biolink:synonym': - synonyms += attribute.get('value',[]) - if node_dict['name']: - synonyms.append(node_dict['name'].lower()) - if block_list_curies.intersection([curie.lower() for curie in curies if curie]): - nodes_to_remove.add(key) + subject_node = self.message.knowledge_graph.nodes[edge.subject].to_dict() + object_node = self.message.knowledge_graph.nodes[edge.object].to_dict() + + if self._is_general_concept(subject_node): + node_to_remove.add(edge.subject) + edges_to_remove.append(key) continue - for synonym in synonyms: - for block_list_synonym in block_list_synonyms: - if isinstance(synonym,str) and isinstance(block_list_synonym,str) and re.match(block_list_synonym, synonym,re.IGNORECASE): - nodes_to_remove.add(key) - - for key in nodes_to_remove: - del self.message.knowledge_graph.nodes[key] - self.response.info(f"Removed {len(nodes_to_remove)} nodes from the knowledge graph which are general concepts") - edges_to_remove = set() - # iterate over edges find edges connected to the nodes - for key, edge in self.message.knowledge_graph.edges.items(): - if edge.subject in nodes_to_remove or edge.object in nodes_to_remove: - edges_to_remove.add(key) - # remove edges - #self.message.knowledge_graph.edges = [val for idx, val in enumerate(self.message.knowledge_graph.edges) if idx not in edges_to_remove] - for key in edges_to_remove: - del self.message.knowledge_graph.edges[key] + if self._is_general_concept(object_node): + node_to_remove.add(edge.object) + edges_to_remove.append(key) + continue + for edge_id in edges_to_remove: + del self.message.knowledge_graph.edges[edge_id] self.remove_orphaned_nodes() except: tb = traceback.format_exc() diff --git a/code/ARAX/ARAXQuery/Infer/scripts/creativeCRG.py b/code/ARAX/ARAXQuery/Infer/scripts/creativeCRG.py index 75c40d043..f73e530dd 100644 --- a/code/ARAX/ARAXQuery/Infer/scripts/creativeCRG.py +++ b/code/ARAX/ARAXQuery/Infer/scripts/creativeCRG.py @@ -28,6 +28,7 @@ def eprint(*args, **kwargs): print(*args, file=sys.stderr, **kwargs) def call_plover(curies: List, respect_predicate_symmetry: bool=False): json = {} plover_url = RTXConfig.plover_url + status_code = 500 endpoint = "/query" body = { "edges": { @@ -49,33 +50,12 @@ def call_plover(curies: List, respect_predicate_symmetry: bool=False): } try: response = requests.post(plover_url + endpoint, headers={'accept': 'application/json'}, json=body) + status_code = response.status_code json = response.json() except Exception as e: pass - return json - -# class TFDatabase: -# def __init__(self): -# database = '/Users/kevin/Documents/GitHub/RTX/code/ARAX/ARAXQuery/Infer/data/xCRG_data/tf_db_kg2.10.0.db' -# self.connection = sqlite3.connect(database) -# self.connection.row_factory = sqlite3.Row - -# def _query_database(self, query): -# cursor = self.connection.cursor() -# cursor.execute(query) -# res = cursor.fetchall() -# return res - -# # def get_tf_neighbors(self): -# # query = "select * from edges ;" -# # return self._query_database(query) - -# def __del__(self): -# try: -# self.connection.commit() -# self.connection.close() -# except: -# pass + return status_code, json + def load_ML_CRGmodel(response: ARAXResponse, model_path: str, model_type: str): @@ -216,7 +196,7 @@ def __init__(self, response: ARAXResponse, data_path: str): self.tf_list = json.loads(fp.read())['tf'] def get_tf_neighbors(self): - response = call_plover(self.tf_list,respect_predicate_symmetry=False) + status_code, response = call_plover(self.tf_list,respect_predicate_symmetry=False) edges = response.get("edges",{}).get("e00",{}) query_tf_neighbor_data = [] answer_tf_neigbor_data = [] @@ -236,7 +216,7 @@ def get_tf_neighbors(self): curie = c1 tf = c2 query_tf_neighbor_data.append({"edge_id": edge, "transcription_factor":tf, "neighbour": curie, "depth": depth}) - return query_tf_neighbor_data,answer_tf_neigbor_data, edges + return status_code, query_tf_neighbor_data,answer_tf_neigbor_data, edges def add_node_ids_to_path(self, paths, tf_edges,chemical_edges, gene_edges): kg2_querier = KG2Querier(self.response, RTXConfig.plover_url) @@ -255,6 +235,8 @@ def add_node_ids_to_path(self, paths, tf_edges,chemical_edges, gene_edges): _path_to_add.append({edge:trapi_edge}) _path_to_add.append(plover_edge[1]) final_paths[(query,answer)].append(_path_to_add) + if len(final_paths[(query,answer)]) == 0: + del final_paths[(query,answer)] return final_paths @@ -266,7 +248,9 @@ def get_preferred_curies(self, curies: list): return preferred_curies normalizer_res = self.synonymizer.get_canonical_curies(curies) for curie in curies: - preferred_curies[curie] = normalizer_res.get(curie,{}).get('preferred_curie',None) + synonymizer_result = normalizer_res.get(curie) + if synonymizer_result is not None: + preferred_curies[curie] = synonymizer_result.get('preferred_curie',None) return preferred_curies def predict_top_N_chemicals(self, query_gene: str, N: int = 10, threshold: float = 0.5, model_type: str = 'increase'): @@ -493,12 +477,22 @@ def _check_params(query_chemical: Optional[str], query_gene: Optional[str], mode self.response.warning(f"There is no chemical-gene pair satisfying the requirement of top {N} with threshold >={threshold}. Perhaps try using more loose threshold.") return None top_paths = dict() - chemical_neighbors = call_plover([query_chemical]) + status_code, chemical_neighbors = call_plover([query_chemical]) + if status_code != 200: + self.response.warning(f"Could not get answers from Plover. Plover responded with status code: {status_code}") + return None answers = res['gene_id'].tolist() self.preferred_curies = self.get_preferred_curies(answers) + self.preferred_to_original_curie = {value: key for key, value in self.preferred_curies.items() if value} valid_genes = [item for item in self.preferred_curies.values() if item] - gene_neighbors = call_plover(valid_genes) - query_tf_neighbors, answer_tf_neigbors, tf_edges = self.get_tf_neighbors() + status_code, gene_neighbors = call_plover(valid_genes) + if status_code != 200: + self.response.warning(f"Could not get answers from Plover. Plover responded with status code: {status_code}") + return None + status_code, query_tf_neighbors, answer_tf_neigbors, tf_edges = self.get_tf_neighbors() + if status_code != 200: + self.response.warning(f"Could not get answers from Plover. Plover responded with status code: {status_code}") + return None paths = self.get_paths(preferred_query_chemical, res['gene_id'].tolist(), chemical_neighbors, gene_neighbors, query_tf_neighbors, answer_tf_neigbors, self.tf_list, M) @@ -520,12 +514,23 @@ def _check_params(query_chemical: Optional[str], query_gene: Optional[str], mode top_paths = dict() - gene_neighbors = call_plover([preferred_query_gene]) + status_code, gene_neighbors = call_plover([preferred_query_gene]) + if status_code != 200: + self.response.warning(f"Could not get answers from Plover. Plover responded with status code: {status_code}") + return None answers = res['chemical_id'].tolist() self.preferred_curies = self.get_preferred_curies(answers) + self.preferred_to_original_curie = {value: key for key, value in self.preferred_curies.items() if value} valid_chemicals = [item for item in self.preferred_curies.values() if item] - chemical_neighbors = call_plover(valid_chemicals) - query_tf_neighbors, answer_tf_neigbors, tf_edges = self.get_tf_neighbors() + status_code, chemical_neighbors = call_plover(valid_chemicals) + if status_code != 200: + self.response.warning(f"Could not get answers from Plover. Plover responded with status code: {status_code}") + return None + status_code, query_tf_neighbors, answer_tf_neigbors, tf_edges = self.get_tf_neighbors() + if status_code != 200: + self.response.warning(f"Could not get answers from Plover. Plover responded with status code: {status_code}") + return None + paths = self.get_paths(preferred_query_gene, res['chemical_id'].tolist(), gene_neighbors, chemical_neighbors, query_tf_neighbors, answer_tf_neigbors,self.tf_list, M) final_paths = self.add_node_ids_to_path(paths, tf_edges, chemical_neighbors, gene_neighbors) return final_paths @@ -541,13 +546,59 @@ def get_paths(self, query_curie, answer_curies, query_neighbors, answer_neighbor valid_answer_tf_list = {} for answer in answer_curies: valid_answer_tf_list[answer] = [] + edges_to_ignore = set() + for edge_id, edge in answer_neighbors['edges']['e00'].items(): + if edge[1] not in self.preferred_to_original_curie: + continue + if edge[0] == query_curie or edge[1] == query_curie: + edges_to_ignore.add(edge_id) + continue + relevant_node = False + answer = self.preferred_to_original_curie[edge[1]] + neighbor = edge[0] + # ignoring lookup edges + if neighbor == query_curie: + edges_to_ignore.add(edge_id) + continue + neighbor_category = answer_neighbors['nodes']['n01'][neighbor][1] + if neighbor_category in self.relevant_node_categories: + relevant_node = True + # one hop from answer + if answer not in answer_path: + answer_path[answer] = dict() + if neighbor in tf_list and neighbor not in answer_path[answer]: + valid_answer_tf_list[answer].append(neighbor) + answer_path[answer][neighbor] = [edge_id, self.predicate_depth_map[edge[2]]] + elif neighbor in tf_list and neighbor in answer_path[answer]: + if answer_path[answer][neighbor][-1] < self.predicate_depth_map[edge[2]]: + answer_path[answer][neighbor] = [edge_id, self.predicate_depth_map[edge[2]]] + + # two hop from answer + for item in answer_tf_neighbors_dict.get(neighbor,[]): + neighbor_category = answer_neighbors['nodes']['n01'][neighbor][1] + if relevant_node and item[1] not in valid_answer_tf_list[answer]: + valid_answer_tf_list[answer].append(item[1]) + if item[1] not in answer_path[answer]: + answer_path[answer][item[1]] = [item[0],edge_id, item[2]] + elif answer_path[answer][item[1]][-1] < item[2] and ((item[1] not in valid_answer_tf_list[answer]) or relevant_node): + answer_path[answer][item[1]] = [item[0], edge_id, min(item[2],self.predicate_depth_map[edge[2]])] for record in query_tf_neighbors: + if record['edge_id'] in edges_to_ignore: + continue query_tf_neighbors_dict[record['neighbour']] = query_tf_neighbors_dict.get(record['neighbour'],[]) + [(record['edge_id'],record['transcription_factor'], record['depth'])] for record in answer_tf_neighbors: + if record['edge_id'] in edges_to_ignore: + continue answer_tf_neighbors_dict[record['neighbour']] = answer_tf_neighbors_dict.get(record['neighbour'],[]) + [(record['edge_id'],record['transcription_factor'], record['depth'])] # one hop from query for edge_id, edge in query_neighbors['edges']['e00'].items(): + if edge_id in edges_to_ignore: + continue + if edge[0] in self.preferred_to_original_curie or edge[1] in self.preferred_to_original_curie: + continue + if (edge[1] == query_curie and edge[0] in self.preferred_to_original_curie) or (edge[0] == query_curie and edge[1] in self.preferred_to_original_curie): + continue if edge[1] in tf_list and edge[1] not in query_path: valid_query_tf_list.append(edge[1]) query_path[edge[1]] = [edge_id,self.predicate_depth_map[edge[2]]] @@ -557,6 +608,8 @@ def get_paths(self, query_curie, answer_curies, query_neighbors, answer_neighbor # two hop from query for edge_id, edge in query_neighbors['edges']['e00'].items(): + if edge[0] in self.preferred_to_original_curie or edge[1] in self.preferred_to_original_curie: + continue if edge[0] != query_curie: continue relevant_node = False @@ -575,40 +628,12 @@ def get_paths(self, query_curie, answer_curies, query_neighbors, answer_neighbor - for edge_id, edge in answer_neighbors['edges']['e00'].items(): - if edge[1] not in self.preferred_curies.values(): - continue - relevant_node = False - answer = edge[1] - neighbor = edge[0] - neighbor_category = answer_neighbors['nodes']['n01'][neighbor][1] - if neighbor_category in self.relevant_node_categories: - relevant_node = True - # one hop from answer - if answer not in answer_path: - answer_path[answer] = dict() - if neighbor in tf_list and neighbor not in answer_path[answer]: - valid_answer_tf_list[answer].append(neighbor) - answer_path[answer][neighbor] = [edge_id, self.predicate_depth_map[edge[2]]] - elif neighbor in tf_list and neighbor in answer_path[answer]: - if answer_path[answer][neighbor][-1] < self.predicate_depth_map[edge[2]]: - answer_path[answer][neighbor] = [edge_id, self.predicate_depth_map[edge[2]]] - - # two hop from answer - for item in answer_tf_neighbors_dict.get(neighbor,[]): - neighbor_category = answer_neighbors['nodes']['n01'][neighbor][1] - if relevant_node and item[1] not in valid_answer_tf_list[answer]: - valid_answer_tf_list[answer].append(item[1]) - if item[1] not in answer_path[answer]: - answer_path[answer][item[1]] = [item[0],edge_id, item[2]] - elif answer_path[answer][item[1]][-1] < item[2] and ((item[1] not in valid_answer_tf_list[answer]) or relevant_node): - answer_path[answer][item[1]] = [item[0], edge_id, min(item[2],self.predicate_depth_map[edge[2]])] # joining paths for answer in answer_curies: combined_path[(query_curie,answer)] = list() - if not self.preferred_curies[answer]: + if answer not in self.preferred_curies or not self.preferred_curies[answer]: continue - key = self.preferred_curies[answer] + key = answer if key not in answer_path: continue diff --git a/code/ARAX/ARAXQuery/Infer/scripts/infer_utilities.py b/code/ARAX/ARAXQuery/Infer/scripts/infer_utilities.py index dcf3bc5fe..30e170aae 100644 --- a/code/ARAX/ARAXQuery/Infer/scripts/infer_utilities.py +++ b/code/ARAX/ARAXQuery/Infer/scripts/infer_utilities.py @@ -758,7 +758,7 @@ def genrete_regulate_subgraphs(self, response: ARAXResponse, query_chemical: Opt message.knowledge_graph.nodes[object_curie].qnode_keys.append(object_qnode_key) new_edge = edge_tuples[i][1] for key in new_edge: - edge_name = decorator._get_kg2c_edge_key(new_edge[key]) + edge_name = 'infores:rtx-kg2:' + decorator._get_kg2c_edge_key(new_edge[key]) message.knowledge_graph.edges[edge_name] = new_edge[key] message.knowledge_graph.edges[edge_name].qedge_keys = [path_keys[path_idx]["qedge_keys"][i]] diff --git a/code/ARAX/ARAXQuery/Path_Finder/converter/EdgeExtractorFromPloverDB.py b/code/ARAX/ARAXQuery/Path_Finder/converter/EdgeExtractorFromPloverDB.py index 13e1504ce..576cd4145 100644 --- a/code/ARAX/ARAXQuery/Path_Finder/converter/EdgeExtractorFromPloverDB.py +++ b/code/ARAX/ARAXQuery/Path_Finder/converter/EdgeExtractorFromPloverDB.py @@ -45,7 +45,8 @@ def get_edges(self, pairs, arax_response): if cached_nodes[1] in self.knowledge_graph['nodes']: knowledge_graph['nodes'][cached_nodes[1]] = self.knowledge_graph['nodes'][cached_nodes[1]] for edge in list_of_edges: - knowledge_graph['edges'][edge] = self.knowledge_graph['edges'][edge] + if str(edge) in self.knowledge_graph['edges']: + knowledge_graph['edges'][str(edge)] = self.knowledge_graph['edges'][str(edge)] return knowledge_graph except Exception as e: arax_response.warning(f"Cannot retrieve {query} from plover DB with url: {url}, Error: {e}") diff --git a/code/ARAX/ARAXQuery/Path_Finder/converter/HugeGraphConverter.py b/code/ARAX/ARAXQuery/Path_Finder/converter/HugeGraphConverter.py index 23fecb398..016c17aa9 100644 --- a/code/ARAX/ARAXQuery/Path_Finder/converter/HugeGraphConverter.py +++ b/code/ARAX/ARAXQuery/Path_Finder/converter/HugeGraphConverter.py @@ -57,7 +57,7 @@ def convert(self, response): response.warning(f"Could not find main node id name: {self.node_in_between_id} to fill essence variable!") return - if (self.node_category_constraint != '' + if (self.node_category_constraint != 'biolink:NamedThing' and self.node_category_constraint not in knowledge_graph_src_dest.nodes[self.node_in_between_id].categories): return diff --git a/code/ARAX/ARAXQuery/Path_Finder/converter/SuperNodeConverter.py b/code/ARAX/ARAXQuery/Path_Finder/converter/SuperNodeConverter.py index 33322478e..b2953e959 100644 --- a/code/ARAX/ARAXQuery/Path_Finder/converter/SuperNodeConverter.py +++ b/code/ARAX/ARAXQuery/Path_Finder/converter/SuperNodeConverter.py @@ -56,7 +56,6 @@ def convert(self, response): ) for key, values in sorted_occurrence_list_by_node_id.items(): - response.envelope.message.query_graph.nodes[self.qnode_mid_id].ids.append(key) new_path = [] for value in values: new_path.append(self.paths[value]) diff --git a/code/ARAX/ARAXQuery/knowledge_graph_info.py b/code/ARAX/ARAXQuery/knowledge_graph_info.py index d2871fb6b..8ef18352b 100644 --- a/code/ARAX/ARAXQuery/knowledge_graph_info.py +++ b/code/ARAX/ARAXQuery/knowledge_graph_info.py @@ -186,10 +186,10 @@ def main(): actions = result.data['actions'] #### Read message #2 from the database. This should be the acetaminophen proteins query result message - sys.path.append(os.path.dirname(os.path.abspath(__file__))+"/../../UI/Feedback") - from RTXFeedback import RTXFeedback - araxdb = RTXFeedback() - message_dict = araxdb.getMessage(2) + sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../ResponseCache") + from response_cache import ResponseCache + response_cache = ResponseCache() + message_dict = response_cache.get_response(314204) #### The stored message comes back as a dict. Transform it to objects from ARAX_messenger import ARAXMessenger diff --git a/code/ARAX/ARAXQuery/query_graph_info.py b/code/ARAX/ARAXQuery/query_graph_info.py index 85ea7dbeb..9a04449cc 100644 --- a/code/ARAX/ARAXQuery/query_graph_info.py +++ b/code/ARAX/ARAXQuery/query_graph_info.py @@ -156,6 +156,7 @@ def assess(self, message): continue edge_info[key] = { 'key': key, 'has_predicates': False, 'subject': qedge.subject, 'object': qedge.object, 'predicates': None, 'exclude': False } + edge_info[key]['knowledge_type'] = qedge.knowledge_type if qedge.exclude is not None: edge_info[key]['exclude'] = qedge.exclude @@ -533,10 +534,10 @@ def main(): actions = result.data['actions'] #### Read message #2 from the database. This should be the acetaminophen proteins query result message - sys.path.append(os.path.dirname(os.path.abspath(__file__))+"/../../UI/Feedback") - from RTXFeedback import RTXFeedback - araxdb = RTXFeedback() - message_dict = araxdb.getMessage(2) + sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../ResponseCache") + from response_cache import ResponseCache + response_cache = ResponseCache() + message_dict = response_cache.get_response(314204) #### The stored message comes back as a dict. Transform it to objects from ARAX_messenger import ARAXMessenger diff --git a/code/ARAX/ARAXQuery/result_transformer.py b/code/ARAX/ARAXQuery/result_transformer.py index 2f88691b6..d11ea4417 100644 --- a/code/ARAX/ARAXQuery/result_transformer.py +++ b/code/ARAX/ARAXQuery/result_transformer.py @@ -64,7 +64,10 @@ def transform(response: ARAXResponse): message.auxiliary_graphs[aux_graph_key] = AuxiliaryGraph(edges=list(group_edge_keys),attributes=[]) # Refer to this aux graph from the current Result or Edge (if this is an Infer support graph) - if group_id and (group_id.startswith("creative_DTD_") or group_id.startswith("creative_CRG_")): + if group_id and group_id.startswith("creative_"): + # Figure out which creative tool/method we're dealing with (e.g. creative_DTD, creative_expand) + group_id_prefix = "_".join(group_id.split("_")[:2]) + # Create an attribute for the support graph that we'll tack onto the treats edge for this result support_graph_attribute = Attribute(attribute_type_id="biolink:support_graphs", value=[aux_graph_key], @@ -83,18 +86,19 @@ def transform(response: ARAXResponse): else: inferred_qedge_key = inferred_qedge_keys[0] inferred_edge_keys = {edge_binding.id for edge_binding in - result.analyses[0].edge_bindings[inferred_qedge_key] if "creative_" in edge_binding.id} + result.analyses[0].edge_bindings[inferred_qedge_key] + if group_id_prefix in edge_binding.id} # Refer to the support graph from the proper edge(s) for inferred_edge_key in inferred_edge_keys: inferred_edge = message.knowledge_graph.edges[inferred_edge_key] if inferred_edge.attributes: - support_graph_attributes = [attribute for attribute in inferred_edge.attributes + existing_sg_attributes = [attribute for attribute in inferred_edge.attributes if attribute.attribute_type_id == "biolink:support_graphs"] - if support_graph_attributes: + if existing_sg_attributes: # Refer to this support graph from the first existing support graph attribute - existing_support_graph_attribute = support_graph_attributes[0] - if aux_graph_key not in existing_support_graph_attribute.value: - existing_support_graph_attribute.value.append(aux_graph_key) + existing_sg_attribute = existing_sg_attributes[0] + if aux_graph_key not in existing_sg_attribute.value: + existing_sg_attribute.value.append(aux_graph_key) else: inferred_edge.attributes.append(support_graph_attribute) else: diff --git a/code/ARAX/BiolinkHelper/biolink_helper.py b/code/ARAX/BiolinkHelper/biolink_helper.py index b48c52f7a..21e2884e6 100644 --- a/code/ARAX/BiolinkHelper/biolink_helper.py +++ b/code/ARAX/BiolinkHelper/biolink_helper.py @@ -111,7 +111,7 @@ def get_descendants(self, biolink_items: Union[str, List[str], Set[str]], includ descendants.update(self.biolink_lookup_map["directions"][direction]["descendants"]) return list(descendants) - def get_canonical_predicates(self, predicates: Union[str, List[str], Set[str]]) -> List[str]: + def get_canonical_predicates(self, predicates: Union[str, List[str], Set[str]], print_warnings: bool = True) -> List[str]: """ Returns the canonical version of the input predicate(s). Accepts a single predicate or multiple predicates as input and always returns the canonical predicate(s) in a list. Works with both proper and mixin predicates. @@ -119,7 +119,7 @@ def get_canonical_predicates(self, predicates: Union[str, List[str], Set[str]]) input_predicate_set = self._convert_to_set(predicates) valid_predicates = input_predicate_set.intersection(self.biolink_lookup_map["predicates"]) invalid_predicates = input_predicate_set.difference(valid_predicates) - if invalid_predicates: + if invalid_predicates and print_warnings: eprint(f"WARNING: Provided predicate(s) {invalid_predicates} do not exist in Biolink {self.biolink_version}") canonical_predicates = {self.biolink_lookup_map["predicates"][predicate]["canonical_predicate"] for predicate in valid_predicates} diff --git a/code/ARAX/KnowledgeSources/RTX_KG2c_test_triples.json b/code/ARAX/KnowledgeSources/RTX_KG2c_test_triples.json index fd9a873ce..999df903a 100644 --- a/code/ARAX/KnowledgeSources/RTX_KG2c_test_triples.json +++ b/code/ARAX/KnowledgeSources/RTX_KG2c_test_triples.json @@ -4,10 +4,10 @@ "edges": [ { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "HP:0000016", - "object_id": "UMLS:C0003385", + "object_id": "CHEBI:7003", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21,10 +21,10 @@ }, { "subject_category": "biolink:Protein", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1854", - "object_id": "UNII:20ED16GHEB", + "subject_id": "CHEMBL.TARGET:CHEMBL1075126", + "object_id": "UNII:N4JTA67V3O", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -38,10 +38,10 @@ }, { "subject_category": "biolink:Drug", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "CHEBI:28017", + "subject_id": "CHV:0000010203", + "object_id": "CHEBI:27899", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -55,10 +55,10 @@ }, { "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "UMLS:C0002085", - "object_id": "CHEBI:28017", + "object_id": "CHEBI:28966", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -72,10 +72,10 @@ }, { "subject_category": "biolink:Gene", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "HGNC:12529", - "object_id": "UMLS:C0013227", + "object_id": "CHEBI:4462", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -89,10 +89,10 @@ }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "CHEBI:10545", - "object_id": "PUBCHEM.COMPOUND:23686432", + "object_id": "CHEBI:24828", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -106,10 +106,10 @@ }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "CHEBI:100", - "object_id": "UMLS:C0003402", + "object_id": "CHEBI:9180", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -122,11 +122,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Drug", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "UMLS:C0003304", + "subject_id": "CHEBI:131391", + "object_id": "CHEBI:6636", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -140,10 +140,10 @@ }, { "subject_category": "biolink:Protein", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1786", - "object_id": "PUBCHEM.COMPOUND:11125", + "subject_id": "CHEMBL.TARGET:CHEMBL1275216", + "object_id": "UNII:9X9581N56R", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -157,10 +157,10 @@ }, { "subject_category": "biolink:Gene", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "HGNC:12529", - "object_id": "UMLS:C0002842", + "subject_id": "HGNC:12280", + "object_id": "CHEBI:8361", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -174,10 +174,10 @@ }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "EFO:0004351", - "object_id": "UMLS:C0013227", + "subject_id": "HP:0000016", + "object_id": "CHEBI:4462", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -191,10 +191,10 @@ }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "CHEBI:10545", - "object_id": "UMLS:C0003451", + "object_id": "CHEBI:18070", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -208,10 +208,10 @@ }, { "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D000089703", - "object_id": "UNII:G9WJT6RD29", + "subject_id": "CHV:0000021208", + "object_id": "CHEBI:134126", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -225,10 +225,10 @@ }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:100147", - "object_id": "UMLS:C0013227", + "subject_id": "CHEBI:10002", + "object_id": "PUBCHEM.COMPOUND:161498078", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -242,10 +242,10 @@ }, { "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10008573", - "object_id": "UMLS:C0003289", + "subject_id": "CHEBI:114786", + "object_id": "CHEBI:4698", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -259,10 +259,10 @@ }, { "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCIT:C19989", - "object_id": "UMLS:C0002932", + "subject_id": "UMLS:C0004048", + "object_id": "CHEBI:26710", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -276,10 +276,10 @@ }, { "subject_category": "biolink:Drug", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "CHEBI:28017", + "subject_id": "CHV:0000010203", + "object_id": "CHEBI:52104", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -293,10 +293,10 @@ }, { "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "GO:0005604", - "object_id": "UMLS:C0077803", + "object_id": "CHEBI:34956", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -310,10 +310,10 @@ }, { "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHV:0000004522", - "object_id": "UMLS:C0001645", + "subject_id": "CHV:0000000950", + "object_id": "CHEBI:27899", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -327,10 +327,10 @@ }, { "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "GO:0000049", - "object_id": "UMLS:C0013227", + "object_id": "CHEBI:17843", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -344,10 +344,10 @@ }, { "subject_category": "biolink:Cell", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "CHEBI:16261", + "subject_id": "CL:0000010", + "object_id": "CHEBI:2417", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -361,10 +361,10 @@ }, { "subject_category": "biolink:Disease", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "DOID:0081144", - "object_id": "UNII:JGA39ICE2V", + "subject_id": "DOID:9007", + "object_id": "CHEBI:6484", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -378,10 +378,10 @@ }, { "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "GO:0000724", - "object_id": "UMLS:C0013227", + "subject_id": "GO:0006260", + "object_id": "CHEBI:17843", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -395,10 +395,10 @@ }, { "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "UBERON:0000044", - "object_id": "CHEBI:16261", + "object_id": "CHEBI:26710", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -412,10 +412,10 @@ }, { "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCIT:C77665", - "object_id": "CHEBI:28017", + "subject_id": "UBERON:0000002", + "object_id": "PUBCHEM.COMPOUND:168266256", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -429,10 +429,10 @@ }, { "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000854", - "object_id": "CHEBI:61995", + "subject_id": "UMLS:C0001166", + "object_id": "CHEBI:134126", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -446,10 +446,10 @@ }, { "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "UMLS:C0005938", - "object_id": "MESH:D044243", + "object_id": "CHEBI:190513", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -466,7 +466,7 @@ "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", "subject_id": "CHEBI:10545", - "object_id": "CHEBI:100241", + "object_id": "CHEBI:134856", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -483,7 +483,7 @@ "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", "subject_id": "CHEBI:100", - "object_id": "CHEBI:16914", + "object_id": "CHEBI:28420", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -500,7 +500,7 @@ "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", "subject_id": "HGNC:10082", - "object_id": "CHEBI:15903", + "object_id": "CHEBI:4167", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -517,7 +517,7 @@ "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", "subject_id": "CHEMBL.TARGET:CHEMBL1075091", - "object_id": "PUBCHEM.COMPOUND:139394142", + "object_id": "UNII:16F6055SMG", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -584,8 +584,8 @@ "subject_category": "biolink:Disease", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "DOID:0081144", - "object_id": "CHEBI:957", + "subject_id": "DOID:0111253", + "object_id": "CHEBI:63620", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -601,8 +601,8 @@ "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHV:0000004522", - "object_id": "CHEBI:10138", + "subject_id": "CHV:0000000950", + "object_id": "CHEBI:15367", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -618,8 +618,8 @@ "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCIT:C77665", - "object_id": "CHEBI:15603", + "subject_id": "UBERON:0000002", + "object_id": "CHEBI:15377", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -636,7 +636,7 @@ "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", "subject_id": "CHEMBL.TARGET:CHEMBL1075126", - "object_id": "PUBCHEM.COMPOUND:135338378", + "object_id": "UNII:2WTV10SIKH", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -649,11 +649,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10008573", - "object_id": "CHEBI:28177", + "subject_id": "HGNC:10082", + "object_id": "CHEBI:4167", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -669,8 +669,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "CHEBI:10033", + "subject_id": "CHV:0000010203", + "object_id": "CHEBI:15366", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -683,11 +683,11 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Device", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "HGNC:10082", - "object_id": "CHEBI:15903", + "subject_id": "UMLS:C0002671", + "object_id": "CHEBI:7582", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -700,11 +700,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "CHEBI:10362", + "subject_id": "CHEBI:114786", + "object_id": "CHEBI:15551", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -717,11 +717,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Food", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL3826826", - "object_id": "PUBCHEM.COMPOUND:131842141", + "subject_id": "UMLS:C0006494", + "object_id": "CHEBI:15366", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -734,11 +734,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "MESH:D059365", - "object_id": "CHEBI:16523", + "subject_id": "UMLS:C0002085", + "object_id": "CHEBI:10362", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -751,11 +751,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0009008", - "object_id": "CHEBI:15414", + "subject_id": "CHEMBL.TARGET:CHEMBL3826826", + "object_id": "UNII:8CQO07490I", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -768,11 +768,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHV:0000045014", - "object_id": "CHEBI:27584", + "subject_id": "MESH:D059365", + "object_id": "CHEBI:16523", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -785,11 +785,11 @@ ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002671", - "object_id": "CHEBI:7582", + "subject_id": "GO:0009008", + "object_id": "CHEBI:15414", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -802,11 +802,11 @@ ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "CHEBI:15366", + "subject_id": "CHV:0000021208", + "object_id": "CHEBI:10043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -819,11 +819,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Activity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB12768", - "object_id": "CHEBI:15864", + "subject_id": "UMLS:C0001288", + "object_id": "CHEBI:25805", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -836,11 +836,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "HP:0003651", - "object_id": "CHEBI:16467", + "subject_id": "DRUGBANK:DB12768", + "object_id": "CHEBI:15864", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -853,11 +853,11 @@ ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "CHEBI:15428", + "subject_id": "HP:0003651", + "object_id": "CHEBI:16467", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -870,11 +870,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", + "subject_category": "biolink:Cell", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0019868", - "object_id": "CHEBI:16240", + "subject_id": "CL:0000010", + "object_id": "CHEBI:135946", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -890,8 +890,8 @@ "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "EFO:0004351", - "object_id": "CHEBI:85966", + "subject_id": "HP:0000016", + "object_id": "CHEBI:3084", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -907,8 +907,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "CHEBI:10022", + "subject_id": "CHV:0000010203", + "object_id": "CHEBI:15422", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -941,8 +941,8 @@ "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCIT:C19989", - "object_id": "CHEBI:119915", + "subject_id": "UMLS:C0000936", + "object_id": "CHEBI:6790", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -958,8 +958,8 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2366047", - "object_id": "CHEBI:45081", + "subject_id": "UMLS:C0004793", + "object_id": "CHEBI:15396", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -992,8 +992,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200448", - "object_id": "CHEBI:15422", + "subject_id": "CHEBI:114786", + "object_id": "CHEBI:16240", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1009,8 +1009,8 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:15033", - "object_id": "CHEBI:94291", + "subject_id": "CHV:0000021208", + "object_id": "CHEBI:10127", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1111,8 +1111,8 @@ "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB11003", - "object_id": "UMLS:C0040549", + "subject_id": "DRUGBANK:DB15794", + "object_id": "CHEBI:16978", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1125,11 +1125,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Procedure", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "HP:0000010", - "object_id": "CHEBI:16737", + "subject_id": "UMLS:C0001884", + "object_id": "CHEBI:135209", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1142,11 +1142,11 @@ ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "CHEBI:113532", + "subject_id": "GO:0000049", + "object_id": "CHEBI:15353", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1159,11 +1159,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0005604", - "object_id": "CHEBI:15647", + "subject_id": "GO:0000373", + "object_id": "PUBCHEM.COMPOUND:161830", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1176,11 +1176,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", + "subject_category": "biolink:Cell", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000854", - "object_id": "CHEBI:17760", + "subject_id": "CL:0000010", + "object_id": "CHEBI:107643", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1193,11 +1193,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0000049", - "object_id": "CHEBI:15353", + "subject_id": "UMLS:C0005373", + "object_id": "CHEBI:17051", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1210,11 +1210,11 @@ ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "CHEBI:135209", + "subject_id": "HP:0000010", + "object_id": "CHEBI:16737", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1227,11 +1227,11 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0000373", - "object_id": "PUBCHEM.COMPOUND:161830", + "subject_id": "UMLS:C0000854", + "object_id": "CHEBI:17760", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1244,11 +1244,11 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005373", - "object_id": "CHEBI:17051", + "subject_id": "GO:0005604", + "object_id": "CHEBI:15647", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1264,8 +1264,8 @@ "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "MESH:D011387", - "object_id": "CHEBI:10022", + "subject_id": "UMLS:C1167395", + "object_id": "CHEBI:133011", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1295,11 +1295,11 @@ ] }, { - "subject_category": "biolink:Behavior", + "subject_category": "biolink:Activity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002957", - "object_id": "CHEBI:17895", + "subject_id": "UMLS:C0038813", + "object_id": "CHEBI:27616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1312,15 +1312,15 @@ ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001288", - "object_id": "CHEBI:25805", + "subject_id": "UMLS:C1511997", + "object_id": "CHEBI:135554", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -1329,11 +1329,11 @@ ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:Behavior", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0038813", - "object_id": "CHEBI:27616", + "subject_id": "UMLS:C0002957", + "object_id": "CHEBI:17895", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1346,15 +1346,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C1511997", - "object_id": "CHEBI:135554", + "subject_id": "UMLS:C0019868", + "object_id": "CHEBI:16240", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -1383,8 +1383,8 @@ "subject_category": "biolink:CellularComponent", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0009279", - "object_id": "CHEBI:71229", + "subject_id": "MESH:D000086942", + "object_id": "CHEBI:5931", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1451,8 +1451,8 @@ "subject_category": "biolink:Phenomenon", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0178576", - "object_id": "CHEBI:8027", + "subject_id": "UMLS:C0242290", + "object_id": "CHEBI:15930", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1499,11 +1499,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10022", - "object_id": "PUBCHEM.COMPOUND:145945263", + "subject_id": "HGNC:12278", + "object_id": "MESH:C022466", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1516,11 +1516,28 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "CHEBI:100", + "object_id": "MESH:D004798", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10313163", - "object_id": "PUBCHEM.COMPOUND:135442941", + "subject_id": "CHEBI:100", + "object_id": "CHEBI:25029", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1533,11 +1550,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005778", - "object_id": "PUBCHEM.COMPOUND:11313", + "subject_id": "CHEBI:10545", + "object_id": "CHEBI:18276", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1550,11 +1567,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHV:0000004522", - "object_id": "PUBCHEM.COMPOUND:168266256", + "subject_id": "HP:0000010", + "object_id": "CHEBI:50114", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1567,11 +1584,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000044", - "object_id": "PUBCHEM.COMPOUND:2723710", + "subject_id": "CHV:0000000950", + "object_id": "CHEBI:17761", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1584,11 +1601,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCIT:C77665", - "object_id": "PUBCHEM.COMPOUND:168009821", + "subject_id": "UBERON:0000044", + "object_id": "CHEBI:16261", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1601,11 +1618,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100", - "object_id": "CHEBI:27834", + "subject_id": "GO:0000049", + "object_id": "CHEBI:15986", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1613,20 +1630,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "CHEBI:100241", + "subject_id": "UMLS:C0000854", + "object_id": "CHEBI:32952", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -1635,15 +1652,15 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C000632500", - "object_id": "CHEBI:61076", + "subject_id": "UBERON:0000002", + "object_id": "CHEBI:35341", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -1652,11 +1669,11 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "CHEBI:15729", + "subject_id": "CHEBI:10545", + "object_id": "CHEBI:18154", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1664,16 +1681,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "CHEBI:132853", + "subject_id": "CHEBI:114786", + "object_id": "CHEBI:29256", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1681,20 +1698,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Drug", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "CHEBI:104872", + "subject_id": "CHV:0000010203", + "object_id": "CHEBI:16412", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -1703,15 +1720,15 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0079686", - "object_id": "CHEBI:15367", + "subject_id": "HGNC:10082", + "object_id": "CHEBI:33699", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -1720,11 +1737,11 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "CHEBI:15552", + "subject_id": "CHEBI:114786", + "object_id": "MESH:D004156", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1732,16 +1749,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Drug", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0496675", - "object_id": "CHEBI:135530", + "subject_id": "CHV:0000010203", + "object_id": "CHEBI:16412", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1754,28 +1771,28 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Protein", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:5783", - "object_id": "CHEBI:66682", + "subject_id": "CHEMBL.TARGET:CHEMBL1075313", + "object_id": "CHEMBL.COMPOUND:CHEMBL3137350", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "CHEBI:142437", + "subject_id": "UMLS:C0000936", + "object_id": "CHEBI:33853", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1788,11 +1805,11 @@ ] }, { - "subject_category": "biolink:GeneFamily", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Protein", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907606", - "object_id": "PUBCHEM.COMPOUND:121408882", + "subject_id": "CHEMBL.TARGET:CHEMBL1075319", + "object_id": "CHEMBL.COMPOUND:CHEMBL3707315", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1800,29 +1817,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:116443", - "object_id": "CHEBI:53289", + "subject_id": "NCBIGene:10381", + "object_id": "CHEBI:32296", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Drug", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCIT:C28506", - "object_id": "MESH:D010206", + "subject_id": "CHEMBL.TARGET:CHEMBL1907593", + "object_id": "CHEBI:55326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1830,16 +1851,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Drug", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "PUBCHEM.COMPOUND:21195079", + "subject_id": "UMLS:C0017654", + "object_id": "CHEBI:2417", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1847,20 +1868,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Drug", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002957", - "object_id": "PUBCHEM.COMPOUND:71306834", + "subject_id": "CHV:0000021208", + "object_id": "CHEBI:134126", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -1869,11 +1890,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Drug", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0016326", - "object_id": "PUBCHEM.COMPOUND:14781", + "subject_id": "MESH:D000077215", + "object_id": "CHEBI:133354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1886,11 +1907,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Drug", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10047593", - "object_id": "UMLS:C0242974", + "subject_id": "UBERON:0008826", + "object_id": "CHEBI:133354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1903,11 +1924,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL3826826", - "object_id": "UNII:033072U4MZ", + "subject_id": "UMLS:C0002085", + "object_id": "CHEBI:28966", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1915,16 +1936,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "UMLS:C0007165", - "object_id": "CHEBI:34674", + "object_id": "CHEBI:2417", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1938,10 +1959,10 @@ }, { "subject_category": "biolink:Disease", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MONDO:0000313", - "object_id": "UMLS:C0011947", + "subject_id": "MONDO:0000837", + "object_id": "CHEBI:190513", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1955,10 +1976,10 @@ }, { "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "UMLS:C0005839", - "object_id": "CHEBI:34674", + "object_id": "CHEBI:27899", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1971,15 +1992,15 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Device", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0150598", - "object_id": "RXCUI:795705", + "subject_id": "UMLS:C0011323", + "object_id": "CHEBI:30251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -1988,15 +2009,15 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Drug", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "PUBCHEM.COMPOUND:9433", + "subject_id": "UMLS:C0449238", + "object_id": "CHEBI:2417", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -2005,28 +2026,28 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Drug", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:116443", - "object_id": "PUBCHEM.COMPOUND:11029", + "subject_id": "UMLS:C0001811", + "object_id": "CHEBI:26710", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:100241", - "object_id": "PUBCHEM.COMPOUND:13743928", + "subject_id": "NCIT:C28506", + "object_id": "CHEBI:137694", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2039,11 +2060,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Cell", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "PUBCHEM.COMPOUND:10313163", + "subject_id": "CL:0000010", + "object_id": "CHEBI:81567", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2051,16 +2072,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Drug", + "subject_category": "biolink:Activity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB12768", - "object_id": "UMLS:C0003448", + "subject_id": "UMLS:C0015259", + "object_id": "CHEBI:6446", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2073,11 +2094,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Drug", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB10276", - "object_id": "MESH:C492535", + "subject_id": "UMLS:C0004793", + "object_id": "CHEBI:17833", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2085,16 +2106,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "CHEBI:34674", + "subject_id": "HP:0003651", + "object_id": "PUBCHEM.COMPOUND:167704086", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2102,16 +2123,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Food", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017654", - "object_id": "CHEBI:34674", + "subject_id": "UMLS:C0012171", + "object_id": "CHEBI:25681", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2119,16 +2140,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Drug", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "CHEBI:34674", + "subject_id": "MESH:D020077", + "object_id": "CHEBI:4462", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2136,16 +2157,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "PUBCHEM.COMPOUND:10313163", + "subject_id": "UMLS:C0184511", + "object_id": "CHEBI:4508", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2153,16 +2174,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1075126", - "object_id": "CHEMBL.COMPOUND:CHEMBL4297223", + "subject_id": "CHEMBL.TARGET:CHEMBL2366047", + "object_id": "CHEBI:7977", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2170,16 +2191,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "PUBCHEM.COMPOUND:11378442", + "subject_id": "UBERON:0001048", + "object_id": "CHEBI:4026", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2187,33 +2208,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:Procedure", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "PUBCHEM.COMPOUND:453626", + "subject_id": "UMLS:C0001884", + "object_id": "CHEBI:31453", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Behavior", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "HP:0000144", - "object_id": "PUBCHEM.COMPOUND:168266256", + "subject_id": "UMLS:C0002957", + "object_id": "CHEBI:5781", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2226,11 +2247,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", + "subject_category": "biolink:Activity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001166", - "object_id": "PUBCHEM.COMPOUND:453626", + "subject_id": "UMLS:C0237820", + "object_id": "CHEBI:133354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2243,11 +2264,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:Protein", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "GO:0005604", - "object_id": "PUBCHEM.COMPOUND:53356667", + "subject_id": "UMLS:C0002198", + "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2260,11 +2281,11 @@ ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:Procedure", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MONDO:0000490", - "object_id": "PUBCHEM.COMPOUND:168009821", + "subject_id": "UMLS:C0001884", + "object_id": "CHEBI:2417", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2277,11 +2298,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Publication", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10047593", - "object_id": "PUBCHEM.COMPOUND:57402144", + "subject_id": "UMLS:C0599740", + "object_id": "CHEBI:4462", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2294,15 +2315,15 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHV:0000042589", - "object_id": "CHEBI:16737", + "subject_id": "MESH:C045793", + "object_id": "CHEBI:31934", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "localization" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -2311,11 +2332,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Activity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1875", - "object_id": "UNII:J4VNV64ARB", + "subject_id": "UMLS:C0496675", + "object_id": "CHEBI:32151", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2323,20 +2344,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:100", - "object_id": "MESH:D004798", + "subject_id": "UMLS:C1167395", + "object_id": "CHEBI:17843", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -2345,45 +2366,45 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "CHEBI:22563", + "subject_id": "CHEBI:60285", + "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017654", - "object_id": "CHEBI:132952", + "subject_id": "UMLS:C0020969", + "object_id": "CHEBI:17843", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Food", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "CHEBI:17029", + "subject_id": "UMLS:C0012171", + "object_id": "CHEBI:30251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2396,11 +2417,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "HP:0000016", - "object_id": "UMLS:C0242402", + "subject_id": "CHEBI:60160", + "object_id": "CHEBI:5781", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2413,33 +2434,16 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1075308", - "object_id": "CHEMBL.COMPOUND:CHEMBL1201554", + "subject_id": "UMLS:C0449238", + "object_id": "CHEBI:102166", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:ChemicalEntity", - "predicate": "biolink:causes", - "subject_id": "NCIT:C77665", - "object_id": "CHEBI:23044", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -2447,11 +2451,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Procedure", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "HGNC:12529", - "object_id": "PUBCHEM.COMPOUND:168266256", + "subject_id": "UMLS:C0001884", + "object_id": "CHEBI:132853", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2459,16 +2463,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0150479", - "object_id": "CHEBI:16243", + "subject_id": "UMLS:C0005938", + "object_id": "CHEBI:104872", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2481,11 +2485,11 @@ ] }, { - "subject_category": "biolink:Behavior", + "subject_category": "biolink:GeneFamily", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009928", - "object_id": "CHEBI:16236", + "subject_id": "CHEMBL.TARGET:CHEMBL1907606", + "object_id": "PUBCHEM.COMPOUND:124122366", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2501,42 +2505,38 @@ "subject_category": "biolink:Gene", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1544", - "object_id": "CHEBI:10033", + "subject_id": "NCBIGene:100", + "object_id": "CHEBI:27834", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Gene", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597832", - "object_id": "CHEBI:15903", + "subject_id": "NCBIGene:116443", + "object_id": "CHEBI:145499", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Cell", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907598", - "object_id": "UNII:X85G7936GV", + "subject_id": "CL:0000010", + "object_id": "CHEBI:33699", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2544,16 +2544,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Drug", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0496675", - "object_id": "UMLS:C0003211", + "subject_id": "GO:0009008", + "object_id": "MESH:D008233", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2561,29 +2561,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10000", - "object_id": "CHEBI:67271", + "subject_id": "UMLS:C0002085", + "object_id": "CHEBI:16412", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "CHEBI:15377", + "subject_id": "HP:0000016", + "object_id": "UMLS:C0242402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2596,45 +2600,45 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Disease", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "HGNC:39002", - "object_id": "PUBCHEM.COMPOUND:3085415", + "subject_id": "DOID:0111252", + "object_id": "CHEBI:26519", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Behavior", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1075232", - "object_id": "PUBCHEM.COMPOUND:91809208", + "subject_id": "UMLS:C0002957", + "object_id": "MESH:D004602", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Device", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCIT:C28506", - "object_id": "PUBCHEM.COMPOUND:11560225", + "subject_id": "UMLS:C0002671", + "object_id": "MESH:D019255", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2647,11 +2651,11 @@ ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007742", - "object_id": "CHEBI:30185", + "subject_id": "CHV:0000018086", + "object_id": "CHEMBL.COMPOUND:CHEMBL2108747", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2659,16 +2663,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL3833461", - "object_id": "UNII:2NU6F9601K", + "subject_id": "UMLS:C0007165", + "object_id": "CHEBI:16684", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2681,11 +2685,11 @@ ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Disease", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907589", - "object_id": "CHEBI:17688", + "subject_id": "MONDO:0000837", + "object_id": "CHEBI:16684", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2693,16 +2697,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "CHEBI:15377", + "subject_id": "GO:0005604", + "object_id": "CHEBI:18085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2715,11 +2719,11 @@ ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0238711", - "object_id": "CHEBI:16236", + "subject_id": "UMLS:C0005839", + "object_id": "CHEBI:24261", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2732,15 +2736,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "CHEBI:18154", + "subject_id": "GO:0000012", + "object_id": "CHEBI:26523", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -2749,49 +2753,49 @@ ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Activity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "CHEBI:16247", + "subject_id": "UMLS:C0150598", + "object_id": "DRUGBANK:DB14222", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Cell", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "HGNC:12278", - "object_id": "MESH:C022466", + "subject_id": "CL:0000010", + "object_id": "CHEBI:15430", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Procedure", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "HGNC:10082", - "object_id": "CHEBI:33699", + "subject_id": "UMLS:C0001884", + "object_id": "CHEBI:16684", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -2800,15 +2804,15 @@ ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "DOID:0081144", - "object_id": "MESH:D057134", + "subject_id": "CHV:0000021208", + "object_id": "CHEBI:16038", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -2817,45 +2821,45 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHV:0000004522", - "object_id": "CHEBI:24261", + "subject_id": "MESH:D000077215", + "object_id": "CHEBI:26710", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Device", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000854", - "object_id": "CHEBI:32952", + "subject_id": "UMLS:C0016326", + "object_id": "CHEBI:32129", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { "subject_category": "biolink:Drug", - "object_category": "biolink:ChemicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "CHEBI:16247", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C0003308", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2869,14 +2873,14 @@ }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ChemicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:16027", - "object_id": "UNII:HW3H7D91F6", + "subject_id": "CHEBI:100", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -2885,11 +2889,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UBERON:0001236", - "object_id": "CHEBI:2719", + "subject_id": "HP:0000016", + "object_id": "UMLS:C0001641", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2897,67 +2901,67 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Pathway", + "subject_category": "biolink:Activity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0000077", - "object_id": "CHEBI:27732", + "subject_id": "UMLS:C0549255", + "object_id": "CHEBI:10093", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:NamedThing", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0221279", - "object_id": "CHEBI:15422", + "subject_id": "CHV:0000042589", + "object_id": "CHEBI:16737", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004112", - "object_id": "PUBCHEM.COMPOUND:137699677", + "subject_id": "NCBIGene:10381", + "object_id": "UNII:P188ANX8CK", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", "subject_id": "UMLS:C0017654", - "object_id": "PUBCHEM.COMPOUND:104840", + "object_id": "CHEBI:132952", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2970,11 +2974,11 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0006260", - "object_id": "PUBCHEM.COMPOUND:159842316", + "subject_id": "UMLS:C0150479", + "object_id": "CHEBI:16243", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2988,27 +2992,27 @@ }, { "subject_category": "biolink:Procedure", - "object_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", "subject_id": "UMLS:C0001884", - "object_id": "PUBCHEM.COMPOUND:72028", + "object_id": "CHEBI:16684", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Activity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "PUBCHEM.COMPOUND:133082075", + "subject_id": "UMLS:C0260581", + "object_id": "CHEBI:18154", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3021,11 +3025,11 @@ ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:Behavior", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002671", - "object_id": "MESH:D019255", + "subject_id": "UMLS:C0009928", + "object_id": "CHEBI:16684", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3033,20 +3037,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10008573", - "object_id": "MESH:C484670", + "subject_id": "UMLS:C0005938", + "object_id": "CHEBI:24621", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -3055,15 +3059,15 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:NamedThing", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "CHEBI:16038", + "subject_id": "CHV:0000042589", + "object_id": "CHEBI:16412", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -3072,11 +3076,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCIT:C19989", - "object_id": "MESH:D001463", + "subject_id": "UMLS:C0002085", + "object_id": "CHEBI:16247", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3089,11 +3093,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:100", - "object_id": "CHEBI:25029", + "subject_id": "CHEMBL.TARGET:CHEMBL3826826", + "object_id": "CHEMBL.COMPOUND:CHEMBL2108735", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3101,16 +3105,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Behavior", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "CHEBI:17002", + "subject_id": "UMLS:C0009928", + "object_id": "CHEBI:16236", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3123,28 +3127,28 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200470", - "object_id": "MESH:C022761", + "subject_id": "NCBIGene:1544", + "object_id": "UNII:P14877CDX2", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UBERON:0001048", - "object_id": "CHEBI:18154", + "subject_id": "UMLS:C0597832", + "object_id": "CHEBI:4167", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3157,28 +3161,41 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "CHEBI:18154", + "subject_id": "NCBIGene:1544", + "object_id": "CHEBI:10033", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "MESH:C061028", + "subject_id": "NCBIGene:10000", + "object_id": "CHEBI:67271", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + } + ] + }, + { + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0033213", + "object_id": "CHEBI:15729", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3191,11 +3208,11 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0026377", - "object_id": "MESH:D007106", + "subject_id": "UMLS:C0015919", + "object_id": "CHEBI:133011", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3203,20 +3220,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "EFO:0004351", - "object_id": "MESH:D062789", + "subject_id": "UMLS:C0007742", + "object_id": "CHEBI:27363", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -3225,11 +3242,28 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0000049", - "object_id": "CHEBI:15986", + "subject_id": "CHEMBL.TARGET:CHEMBL1907589", + "object_id": "CHEBI:17688", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0677040", + "object_id": "CHEBI:15377", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3242,11 +3276,28 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005839", - "object_id": "CHEBI:24261", + "subject_id": "CHEBI:25614", + "object_id": "CHEBI:142437", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0238711", + "object_id": "CHEBI:16236", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3259,11 +3310,28 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Behavior", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UBERON:0000044", - "object_id": "CHEBI:16412", + "subject_id": "UMLS:C0009928", + "object_id": "CHEBI:31228", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:MolecularMixture", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0677040", + "object_id": "CHEBI:61040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3276,11 +3344,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "CHEBI:16412", + "subject_id": "UMLS:C0079686", + "object_id": "CHEBI:15367", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3293,11 +3361,28 @@ ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0150598", - "object_id": "MESH:D004602", + "subject_id": "CHEBI:15724", + "object_id": "UNII:T9FVH03HMZ", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "CHV:0000000950", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3310,11 +3395,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Pathway", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0005604", - "object_id": "CHEBI:18085", + "subject_id": "GO:0000077", + "object_id": "CHEBI:25016", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3327,11 +3412,28 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Cell", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0221279", + "object_id": "CHEBI:15422", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "MESH:D010770", + "subject_id": "UMLS:C0449238", + "object_id": "CHEBI:10545", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3344,11 +3446,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D042461", - "object_id": "CHEMBL.COMPOUND:CHEMBL2108313", + "subject_id": "UBERON:0008826", + "object_id": "CHEBI:135590", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3356,16 +3458,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Food", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB10276", - "object_id": "MESH:D000906", + "subject_id": "UMLS:C0006494", + "object_id": "CHEBI:17002", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3373,16 +3475,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL3826826", - "object_id": "CHEMBL.COMPOUND:CHEMBL2108735", + "subject_id": "UBERON:0001048", + "object_id": "CHEBI:18154", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3390,33 +3492,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Drug", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "PUBCHEM.COMPOUND:168010173", + "subject_id": "UMLS:C0033213", + "object_id": "CHEBI:18154", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Drug", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001811", - "object_id": "PUBCHEM.COMPOUND:5234", + "subject_id": "DRUGBANK:DB10276", + "object_id": "MESH:D000906", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3429,11 +3531,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "CHEBI:16261", + "subject_id": "CHEBI:10545", + "object_id": "UMLS:C0309989", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3467,7 +3569,7 @@ "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", "subject_id": "UMLS:C0314621", - "object_id": "CHEBI:15903", + "object_id": "CHEBI:17561", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3480,11 +3582,11 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0039703", - "object_id": "CHEBI:15428", + "subject_id": "MESH:D008925", + "object_id": "CHEBI:18295", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3497,11 +3599,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Drug", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0598962", - "object_id": "UMLS:C0003289", + "subject_id": "GO:0039703", + "object_id": "CHEBI:15428", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3509,16 +3611,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "HP:0000752", - "object_id": "PUBCHEM.COMPOUND:125677", + "subject_id": "UMLS:C0598962", + "object_id": "CHEBI:51063", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3535,7 +3637,7 @@ "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", "subject_id": "NCBIGene:117159", - "object_id": "PUBCHEM.COMPOUND:5727", + "object_id": "UNII:86Q357L16B", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3564,12 +3666,46 @@ } ] }, + { + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "UBERON:0002481", + "object_id": "CHEBI:28262", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", "subject_id": "CHEBI:17002", - "object_id": "PUBCHEM.COMPOUND:71354164", + "object_id": "UNII:K4YTU42T8G", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:MolecularMixture", + "predicate": "biolink:causes", + "subject_id": "CHEBI:16336", + "object_id": "PUBCHEM.COMPOUND:91820602", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3599,11 +3735,11 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "CHEBI:16261", + "subject_id": "MESH:D059365", + "object_id": "MESH:D010770", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3616,11 +3752,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597832", - "object_id": "CHEBI:28017", + "subject_id": "UMLS:C0001873", + "object_id": "MESH:D017672", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3633,11 +3769,11 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Drug", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "CHEBI:28017", + "subject_id": "CHEMBL.TARGET:CHEMBL3833461", + "object_id": "UNII:2NU6F9601K", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3650,32 +3786,32 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Drug", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16991", - "object_id": "UNII:953A26OA1Y", + "subject_id": "UMLS:C0541989", + "object_id": "MESH:D007773", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Drug", + "subject_category": "biolink:Protein", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "UMLS:C0006280", + "subject_id": "UniProtKB:O91936", + "object_id": "CHEBI:133009", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -3684,11 +3820,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Gene", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "CHEBI:28017", + "subject_id": "HGNC:12529", + "object_id": "UMLS:C0002842", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3702,14 +3838,14 @@ }, { "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UniProtKB:O91936", - "object_id": "CHEBI:133009", + "subject_id": "CHEMBL.TARGET:CHEMBL1991", + "object_id": "UMLS:C4305726", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -3718,11 +3854,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "CHEBI:16412", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3730,33 +3866,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0260581", - "object_id": "CHEBI:18154", + "subject_id": "UMLS:C1167395", + "object_id": "CHEBI:16412", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Publication", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "CHEBI:49159", + "subject_id": "UMLS:C0599740", + "object_id": "CHEBI:15627", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3769,32 +3905,32 @@ ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GeneFamily", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002957", - "object_id": "MESH:D004602", + "subject_id": "CHEMBL.TARGET:CHEMBL2093863", + "object_id": "CHEBI:2659", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "CHEBI:32952", + "subject_id": "NCBIGene:117159", + "object_id": "CHEBI:32312", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "stability" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -3803,15 +3939,15 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GeneFamily", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "CHEBI:24621", + "subject_id": "CHEMBL.TARGET:CHEMBL2094123", + "object_id": "CHEBI:59730", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -3820,11 +3956,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D011387", - "object_id": "UMLS:C1550678", + "subject_id": "NCBIGene:545", + "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3837,19 +3973,19 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "CHEBI:15627", + "subject_id": "UMLS:C0033213", + "object_id": "CHEBI:31645", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -3857,7 +3993,7 @@ "subject_category": "biolink:GeneFamily", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907610", + "subject_id": "CHEMBL.TARGET:CHEMBL2094251", "object_id": "CHEBI:6933", "qualifiers": [ { @@ -3874,8 +4010,8 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:16027", - "object_id": "PUBCHEM.COMPOUND:121488177", + "subject_id": "CHEBI:15724", + "object_id": "UNII:7D96IR0PPM", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3902,10 +4038,10 @@ }, { "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2111348", - "object_id": "PUBCHEM.COMPOUND:11963622", + "subject_id": "CHEMBL.TARGET:CHEMBL1907589", + "object_id": "UNII:CP1A26546Z", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3918,11 +4054,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "HP:0003651", - "object_id": "PUBCHEM.COMPOUND:71306834", + "subject_id": "CHEBI:100147", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3930,16 +4066,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "PUBCHEM.COMPOUND:453626", + "subject_id": "CHEBI:10545", + "object_id": "UMLS:C0003451", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3952,15 +4088,15 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Protein", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "GO:0000049", - "object_id": "PUBCHEM.COMPOUND:159842316", + "subject_id": "CHEMBL.TARGET:CHEMBL1995", + "object_id": "UNII:CQY12ZJN6E", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -3969,11 +4105,11 @@ ] }, { - "subject_category": "biolink:GeneFamily", + "subject_category": "biolink:Gene", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2094111", - "object_id": "PUBCHEM.COMPOUND:71717894", + "subject_id": "HGNC:12529", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3981,20 +4117,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2520", - "object_id": "CHEBI:31947", + "subject_id": "CHEBI:132103", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "synthesis" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -4003,11 +4139,11 @@ ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "CHEBI:16236", + "subject_id": "UMLS:C0001884", + "object_id": "UMLS:C0006280", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4015,16 +4151,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0238711", - "object_id": "CHEBI:16236", + "subject_id": "UMLS:C0007165", + "object_id": "UMLS:C0001640", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4037,28 +4173,28 @@ ] }, { - "subject_category": "biolink:Cohort", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Disease", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0338666", - "object_id": "CHEBI:16236", + "subject_id": "MONDO:0000313", + "object_id": "UMLS:C0011947", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "GO:0000012", - "object_id": "CHEBI:26523", + "subject_id": "DOID:3125", + "object_id": "UMLS:C0242908", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4071,41 +4207,28 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C0003289", + "subject_id": "HP:0000016", + "object_id": "UMLS:C0003385", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", - "predicate": "biolink:causes", - "subject_id": "UniProtKB:P36544", - "object_id": "CHEBI:42944", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "MESH:C039351", + "subject_id": "UMLS:C0001117", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4113,20 +4236,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "MESH:D059365", - "object_id": "MESH:D010770", + "subject_id": "UMLS:C0005938", + "object_id": "UMLS:C0001645", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -4135,15 +4258,15 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001873", - "object_id": "MESH:D017672", + "subject_id": "NCBIGene:2520", + "object_id": "CHEBI:31947", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "synthesis" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -4152,11 +4275,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL4630577", - "object_id": "CHEMBL.COMPOUND:CHEMBL3989993", + "subject_id": "UMLS:C0017654", + "object_id": "CHV:0000044484", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4169,32 +4292,32 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "CHEBI:16646", + "subject_id": "CHEBI:5781", + "object_id": "CHEBI:66682", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "CHEBI:16412", + "subject_id": "UMLS:C0696628", + "object_id": "CHEBI:16236", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -4203,11 +4326,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "MESH:D000888", + "subject_id": "UMLS:C0238711", + "object_id": "CHEBI:16236", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4220,11 +4343,28 @@ ] }, { - "subject_category": "biolink:Behavior", + "subject_category": "biolink:Cohort", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009990", - "object_id": "CHEBI:16469", + "subject_id": "UMLS:C0338666", + "object_id": "CHEBI:16236", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "DRUGBANK:DB12768", + "object_id": "UMLS:C0003448", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4237,11 +4377,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "GO:0009008", - "object_id": "MESH:D008233", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4254,11 +4394,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "MONDO:0001196", - "object_id": "MESH:D011098", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C1254351", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4266,16 +4406,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB10276", - "object_id": "UMLS:C0369951", + "subject_id": "CHEBI:132106", + "object_id": "UMLS:C0003289", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4288,11 +4445,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0450138", - "object_id": "PUBCHEM.COMPOUND:157010069", + "subject_id": "UBERON:0000044", + "object_id": "UMLS:C0002932", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4305,16 +4462,101 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "NCBIGene:3716", - "object_id": "UNII:HPH1166CKX", + "subject_id": "GO:0000049", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity_or_abundance" }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Cell", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "CL:0000010", + "object_id": "UMLS:C0013227", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "UBERON:0000002", + "object_id": "UMLS:C0243192", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0001166", + "object_id": "UMLS:C0013227", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "GO:0005604", + "object_id": "UMLS:C0077803", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C0003289", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "decreased" @@ -4322,11 +4564,28 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "MESH:C465023", - "object_id": "MESH:D010957", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C1611640", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:MolecularMixture", + "predicate": "biolink:causes", + "subject_id": "CHEBI:25614", + "object_id": "CHEBI:4762", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4339,16 +4598,59 @@ ] }, { - "subject_category": "biolink:Publication", + "subject_category": "biolink:Protein", + "object_category": "biolink:MolecularMixture", + "predicate": "biolink:causes", + "subject_id": "UniProtKB:P36544", + "object_id": "CHEBI:6078", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + } + ] + }, + { + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularMixture", + "predicate": "biolink:causes", + "subject_id": "NCBIGene:1139", + "object_id": "CHEBI:6078", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + } + ] + }, + { + "subject_category": "biolink:Device", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "CHEBI:17087", + "subject_id": "UMLS:C0003072", + "object_id": "CHEBI:16646", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0020969", + "object_id": "CHEBI:16412", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -4356,11 +4658,28 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "HP:0003651", - "object_id": "CHEBI:26523", + "subject_id": "MESH:D000086942", + "object_id": "MESH:D000888", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Behavior", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0009990", + "object_id": "CHEBI:16469", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4373,11 +4692,11 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "CHEBI:24922", + "subject_id": "DRUGBANK:DB10276", + "object_id": "MESH:C492535", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4390,11 +4709,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Protein", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "MESH:C495669", + "subject_id": "HP:0003651", + "object_id": "CHEBI:26523", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4407,15 +4726,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Device", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "UMLS:C0015858", + "subject_id": "UMLS:C0450138", + "object_id": "PUBCHEM.COMPOUND:157010069", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -4424,11 +4743,28 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "MESH:D007371", + "subject_id": "CHEBI:66682", + "object_id": "CHEBI:7872", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:MolecularMixture", + "predicate": "biolink:causes", + "subject_id": "UMLS:C1373040", + "object_id": "CHEBI:17833", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4440,12 +4776,29 @@ } ] }, + { + "subject_category": "biolink:Cell", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "CL:0000010", + "object_id": "UMLS:C0002318", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Protein", "predicate": "biolink:causes", "subject_id": "CHEBI:10545", - "object_id": "UMLS:C0015858", + "object_id": "UMLS:C0010762", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4453,16 +4806,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB11003", - "object_id": "UMLS:C0051962", + "subject_id": "CHEBI:10545", + "object_id": "UMLS:C0015858", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4470,16 +4823,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "MESH:D008049", + "subject_id": "DRUGBANK:DB11003", + "object_id": "UMLS:C0051962", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4495,8 +4848,8 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:100241", - "object_id": "MESH:D014613", + "subject_id": "CHEBI:10106", + "object_id": "MESH:D000077215", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4529,8 +4882,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "MESH:D014121", + "subject_id": "UMLS:C0001060", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4559,12 +4912,29 @@ } ] }, + { + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ComplexMolecularMixture", + "predicate": "biolink:causes", + "subject_id": "CHEBI:10022", + "object_id": "MESH:D001688", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:16412", - "object_id": "MESH:D003439", + "subject_id": "CHEBI:15884", + "object_id": "MESH:D010936", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4580,7 +4950,7 @@ "subject_category": "biolink:Cell", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", + "subject_id": "CL:0000081", "object_id": "MESH:D019496", "qualifiers": [ { @@ -4597,8 +4967,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "MESH:D014612", + "subject_id": "UMLS:C0001060", + "object_id": "MESH:D015164", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4648,7 +5018,7 @@ "subject_category": "biolink:Drug", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", + "subject_id": "MESH:D006131", "object_id": "MESH:D014612", "qualifiers": [ { @@ -4682,8 +5052,8 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100653366", - "object_id": "MESH:D022401", + "subject_id": "UMLS:C0009221", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4733,8 +5103,8 @@ "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001811", - "object_id": "MESH:D005620", + "subject_id": "UMLS:C0020964", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4750,8 +5120,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:134820399", - "object_id": "MESH:D022282", + "subject_id": "CHEBI:133354", + "object_id": "MESH:D000077215", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4767,8 +5137,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "MESH:D007252", + "subject_id": "CHV:0000010203", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4802,7 +5172,7 @@ "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", "subject_id": "HP:0001824", - "object_id": "MESH:D005620", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4818,8 +5188,8 @@ "subject_category": "biolink:GenomicEntity", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C3539704", - "object_id": "MESH:D010578", + "subject_id": "UMLS:C0017346", + "object_id": "MESH:D001688", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4835,7 +5205,7 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2489", + "subject_id": "UMLS:C0004793", "object_id": "MESH:D014612", "qualifiers": [ { @@ -4882,23 +5252,6 @@ } ] }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ComplexMolecularMixture", - "predicate": "biolink:causes", - "subject_id": "CHEBI:100241", - "object_id": "MESH:D000077215", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, { "subject_category": "biolink:DiseaseOrPhenotypicFeature", "object_category": "biolink:ComplexMolecularMixture", @@ -4937,8 +5290,8 @@ "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0011313", - "object_id": "MESH:D014612", + "subject_id": "NCBITaxon:5052", + "object_id": "MESH:D010936", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4988,25 +5341,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:107756", - "object_id": "MESH:D005620", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:ComplexMolecularMixture", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "MESH:D014612", + "subject_id": "CHEBI:18070", + "object_id": "MESH:D010936", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5022,8 +5358,8 @@ "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHV:0000011375", - "object_id": "MESH:D003031", + "subject_id": "CHV:0000041586", + "object_id": "MESH:D014613", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5125,7 +5461,7 @@ "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", "subject_id": "UMLS:C0001038", - "object_id": "MESH:D014612", + "object_id": "MESH:D001688", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5141,8 +5477,8 @@ "subject_category": "biolink:Cell", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "MESH:D014613", + "subject_id": "CL:0000066", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5158,8 +5494,8 @@ "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UBERON:0000044", - "object_id": "MESH:D005620", + "subject_id": "UBERON:0000178", + "object_id": "MESH:D001428", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5210,7 +5546,7 @@ "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", "subject_id": "UMLS:C0020969", - "object_id": "MESH:D014612", + "object_id": "MESH:D010936", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5257,11 +5593,11 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "MESH:D000086663", + "subject_id": "GO:0006260", + "object_id": "DRUGBANK:DB15794", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5274,11 +5610,11 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "GO:0006260", - "object_id": "DRUGBANK:DB15794", + "subject_id": "UMLS:C0033213", + "object_id": "MESH:D000086663", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5329,7 +5665,7 @@ "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", "subject_id": "UMLS:C0006494", - "object_id": "CHEBI:35366", + "object_id": "CHEBI:26125", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5342,32 +5678,32 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:21195079", - "object_id": "CHEBI:44185", + "subject_id": "UMLS:C0031911", + "object_id": "CHEBI:4026", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Drug", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "PUBCHEM.COMPOUND:23443659", + "subject_id": "CHEBI:83353", + "object_id": "CHEMBL.TARGET:CHEMBL2366040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5376,11 +5712,11 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Drug", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "PUBCHEM.COMPOUND:10339178", + "subject_id": "UBERON:0002481", + "object_id": "CHEBI:31690", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5393,11 +5729,11 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:Drug", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "PUBCHEM.COMPOUND:9887054", + "subject_id": "CHEMBL.TARGET:CHEMBL1907593", + "object_id": "CHEMBL.COMPOUND:CHEMBL3707249", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5410,62 +5746,11 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Drug", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "CHEBI:26125", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Drug", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "PUBCHEM.COMPOUND:5284359", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:Drug", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0314621", - "object_id": "PUBCHEM.COMPOUND:4873", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Publication", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "CHEBI:28017", + "subject_id": "UMLS:C0599740", + "object_id": "CHEBI:137694", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5473,20 +5758,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Drug", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "CHEBI:16261", + "subject_id": "CHEMBL.TARGET:CHEMBL2364185", + "object_id": "UNII:9GJ8S4GU0M", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5496,44 +5781,44 @@ }, { "subject_category": "biolink:Gene", - "object_category": "biolink:Drug", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCBIGene:117159", - "object_id": "PUBCHEM.COMPOUND:24424", + "subject_id": "NCBIGene:1756", + "object_id": "UNII:8CQO07490I", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "expression" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004268", - "object_id": "PUBCHEM.COMPOUND:131634907", + "subject_id": "CHEMBL.TARGET:CHEMBL4296741", + "object_id": "UNII:ROV204583W", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:18296", - "object_id": "UNII:ODJ69JZG85", + "subject_id": "CHEMBL.TARGET:CHEMBL4495602", + "object_id": "UNII:2O4BE0K238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5546,28 +5831,28 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Drug", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:28017", - "object_id": "PUBCHEM.COMPOUND:8519", + "subject_id": "UMLS:C0015919", + "object_id": "CHEBI:147402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:18296", - "object_id": "UNII:7SI2UZG934", + "subject_id": "CHEBI:3815", + "object_id": "UNII:9X7O8V25IT", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5580,15 +5865,15 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1781", - "object_id": "PUBCHEM.COMPOUND:9941008", + "subject_id": "UMLS:C0015919", + "object_id": "MESH:D003031", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5597,15 +5882,15 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Device", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1756", - "object_id": "PUBCHEM.COMPOUND:131842141", + "subject_id": "UMLS:C0032616", + "object_id": "MESH:D010578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5614,15 +5899,15 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL4296741", - "object_id": "PUBCHEM.COMPOUND:156323004", + "subject_id": "CHEBI:61452", + "object_id": "MESH:D010578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5631,15 +5916,15 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Drug", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1756", - "object_id": "UNII:033072U4MZ", + "subject_id": "UMLS:C0015919", + "object_id": "MESH:D010578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5648,15 +5933,15 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL4296221", - "object_id": "UNII:50FKX8CB2Y", + "subject_id": "UMLS:C0012933", + "object_id": "MESH:D010578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5665,11 +5950,11 @@ ] }, { - "subject_category": "biolink:GeneFamily", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907610", - "object_id": "PUBCHEM.COMPOUND:11368", + "subject_id": "UBERON:0008826", + "object_id": "MESH:D000077215", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5677,54 +5962,54 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0541989", - "object_id": "MESH:D007773", + "subject_id": "DOID:11613", + "object_id": "MONDO:0000816", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "CHEBI:16412", + "subject_id": "CHEBI:100", + "object_id": "UMLS:C0596402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Protein", + "subject_category": "biolink:Drug", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "HGNC:10082", - "object_id": "UMLS:C0005456", + "subject_id": "CHV:0000010203", + "object_id": "MONDO:0005043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5733,15 +6018,15 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "GO:0008022", - "object_id": "UMLS:C0033684", + "subject_id": "CHEBI:10545", + "object_id": "UBERON:0000119", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5751,14 +6036,14 @@ }, { "subject_category": "biolink:Protein", - "object_category": "biolink:Protein", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "UMLS:C0626314", + "subject_id": "PR:000003980", + "object_id": "UBERON:0000479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5767,15 +6052,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:Gene", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEBI:100", - "object_id": "UMLS:C0083867", + "subject_id": "HGNC:12529", + "object_id": "UBERON:0000479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5784,45 +6069,45 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364165", - "object_id": "UNII:VRN8S9CW5V", + "subject_id": "CHEBI:100147", + "object_id": "UBERON:0000158", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEBI:10002", - "object_id": "MESH:D015850", + "subject_id": "DRUGBANK:DB11003", + "object_id": "UBERON:0000344", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Protein", + "subject_category": "biolink:Drug", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHV:0000004522", - "object_id": "UMLS:C0052441", + "subject_id": "CHV:0000010203", + "object_id": "UBERON:0000948", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5835,15 +6120,15 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Protein", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UNII:7V6HE3DM5A", - "object_id": "CHEBI:3815", + "subject_id": "NCIT:C158448", + "object_id": "UMLS:C3896693", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5852,15 +6137,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:75007581", - "object_id": "CHEBI:3815", + "subject_id": "CHEBI:16247", + "object_id": "CL:0000129", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5869,11 +6154,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Protein", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200380", - "object_id": "CHEMBL.TARGET:CHEMBL1872", + "subject_id": "UMLS:C0002085", + "object_id": "CL:0000047", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5881,20 +6166,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "PUBCHEM.COMPOUND:10340", + "subject_id": "ENSEMBL:ENSG00000232216", + "object_id": "CL:0000236", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5903,15 +6188,15 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "UMLS:C0039194", + "subject_id": "CHEBI:100", + "object_id": "CL:0000763", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5937,15 +6222,15 @@ ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Drug", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0004561", + "subject_id": "CHV:0000010203", + "object_id": "CL:0000084", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -5954,11 +6239,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Gene", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:100", - "object_id": "UMLS:C0887899", + "subject_id": "HGNC:39001", + "object_id": "CL:0000198", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5971,11 +6256,11 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000232216", - "object_id": "UMLS:C0004561", + "subject_id": "CHEBI:137694", + "object_id": "CL:0000084", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5991,8 +6276,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "UMLS:C0039194", + "subject_id": "UMLS:C0001060", + "object_id": "CL:0000066", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6005,28 +6290,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Cell", - "predicate": "biolink:causes", - "subject_id": "CHEBI:10037", - "object_id": "UMLS:C0227525", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Gene", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "HGNC:39001", - "object_id": "UMLS:C0026473", + "subject_id": "CHEBI:114786", + "object_id": "CL:0000232", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6039,11 +6307,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:16247", - "object_id": "UMLS:C0024432", + "subject_id": "CHEBI:10037", + "object_id": "CL:0000182", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6056,11 +6324,11 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:Device", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C0001280", + "subject_id": "UMLS:C0002671", + "object_id": "CL:0000232", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6073,15 +6341,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Food", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "UMLS:C0004561", + "subject_id": "UMLS:C0078479", + "object_id": "CL:0000115", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6090,11 +6358,11 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:34674", - "object_id": "UMLS:C0004561", + "subject_id": "DRUGBANK:DB12768", + "object_id": "CL:0000235", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6107,11 +6375,11 @@ ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "UMLS:C0014597", + "subject_id": "DRUGBANK:DB11003", + "object_id": "CL:0000084", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6124,11 +6392,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10207414", - "object_id": "UMLS:C0029418", + "subject_id": "UBERON:0008826", + "object_id": "CL:0000094", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6144,12 +6412,12 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "UMLS:C0003315", + "subject_id": "CHV:0000021208", + "object_id": "CL:0000047", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6158,49 +6426,41 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Cell", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB11003", - "object_id": "UMLS:C0004561", + "subject_id": "GO:0000012", + "object_id": "GO:1903518", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Cell", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11560225", - "object_id": "UMLS:C0005821", + "subject_id": "GO:0000012", + "object_id": "GO:1903517", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Cell", + "subject_category": "biolink:Protein", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "HP:0045047", - "object_id": "UMLS:C0004561", + "subject_id": "UMLS:C0000254", + "object_id": "MESH:D010861", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6209,11 +6469,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Cell", + "subject_category": "biolink:Gene", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "NCIT:C120860", - "object_id": "UMLS:C0879593", + "subject_id": "HGNC:12529", + "object_id": "MESH:D008862", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6226,11 +6486,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Cell", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002671", - "object_id": "UMLS:C0014792", + "subject_id": "CHEBI:10545", + "object_id": "MESH:D002736", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6243,11 +6503,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "CHEBI:10002", - "object_id": "UMLS:C0225957", + "subject_id": "CHV:0000021208", + "object_id": "MESH:D001369", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6260,11 +6520,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "HGNC:12529", - "object_id": "UBERON:0002435", + "subject_id": "CHEBI:100147", + "object_id": "MESH:D002736", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6277,11 +6537,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "MESH:C421864", - "object_id": "UBERON:0000178", + "subject_id": "RXCUI:1085956", + "object_id": "UMLS:C0225328", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6294,11 +6554,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "UMLS:C5211512", + "subject_id": "CHEBI:100", + "object_id": "UMLS:C0005972", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6312,10 +6572,10 @@ }, { "subject_category": "biolink:Drug", - "object_category": "biolink:AnatomicalEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UBERON:0000044", + "subject_id": "CHV:0000010203", + "object_id": "MESH:D014158", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6328,15 +6588,15 @@ ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "CHEBI:16646", + "subject_id": "HGNC:10082", + "object_id": "UMLS:C1516334", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6345,11 +6605,11 @@ ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "CHEBI:16646", + "subject_id": "CHEBI:10545", + "object_id": "MESH:D011995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6362,15 +6622,15 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "CHEBI:16412", + "subject_id": "NCIT:C158448", + "object_id": "UMLS:C0020964", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6379,11 +6639,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Disease", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEBI:100", - "object_id": "UMLS:C0596402", + "subject_id": "CHV:0000021208", + "object_id": "CHV:0000055769", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6396,11 +6656,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Disease", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "DOID:0081144", - "object_id": "MONDO:0005266", + "subject_id": "CHEBI:114786", + "object_id": "UMLS:C0018270", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6430,11 +6690,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Gene", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB10276", - "object_id": "MONDO:0007835", + "subject_id": "HGNC:10082", + "object_id": "UMLS:C0012860", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6450,8 +6710,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "MONDO:0002459", + "subject_id": "PR:000016417", + "object_id": "MONDO:0006515", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6464,32 +6724,32 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Disease", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "HGNC:10082", - "object_id": "UMLS:C0012860", + "subject_id": "CHEBI:10022", + "object_id": "UMLS:C0006660", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Disease", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "MONDO:0001226", + "subject_id": "MESH:D022761", + "object_id": "UMLS:C0087111", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6498,15 +6758,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:Activity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "UBERON:0000119", + "subject_id": "UMLS:C0001288", + "object_id": "UMLS:C0033970", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6515,15 +6775,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:100147", - "object_id": "UBERON:0000158", + "subject_id": "UMLS:C0871470", + "object_id": "CHEBI:50114", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6532,11 +6792,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UBERON:0000329", + "subject_id": "CHEBI:2930", + "object_id": "UMLS:C3846005", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6549,32 +6809,32 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "UBERON:0000062", + "subject_id": "UMLS:C0015919", + "object_id": "CHEBI:16247", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "UBERON:0000158", + "subject_id": "UMLS:C0015919", + "object_id": "CHEBI:28966", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6583,15 +6843,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0227365", + "subject_id": "UMLS:C0449238", + "object_id": "RXCUI:1535257", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6600,11 +6860,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "MESH:D000077215", - "object_id": "UMLS:C0233929", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6617,11 +6877,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "HP:0001541", + "subject_id": "CHV:0000021208", + "object_id": "MESH:D006213", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6629,20 +6889,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Device", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:100", - "object_id": "UMLS:C0427184", + "subject_id": "UMLS:C0020266", + "object_id": "UMLS:C0304604", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6651,45 +6911,45 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Device", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "HP:0001945", + "subject_id": "UMLS:C0027673", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:Activity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB11003", - "object_id": "UBERON:0000344", + "subject_id": "UMLS:C0496675", + "object_id": "UMLS:C0003211", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "HGNC:12529", - "object_id": "UBERON:0000479", + "subject_id": "UMLS:C0005839", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6702,11 +6962,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Activity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "CHV:0000041902", + "subject_id": "UMLS:C0237820", + "object_id": "RXCUI:219008", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6719,49 +6979,49 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "UMLS:C0007582", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0001637", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "HGNC:10082", - "object_id": "UMLS:C1516334", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "UMLS:C0011065", + "subject_id": "CHEBI:18085", + "object_id": "UNII:7XZ4062R17", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6770,11 +7030,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10022", - "object_id": "UMLS:C0006660", + "subject_id": "UMLS:C0015919", + "object_id": "CHEBI:16646", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6782,20 +7042,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:100", - "object_id": "UMLS:C0005972", + "subject_id": "CHEMBL.TARGET:CHEMBL2364181", + "object_id": "CHEMBL.COMPOUND:CHEMBL1201482", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6804,15 +7064,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Protein", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "UMLS:C0596290", + "subject_id": "CHEMBL.TARGET:CHEMBL2487", + "object_id": "CHEBI:1457", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "stability" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6821,15 +7081,15 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C0021826", + "subject_id": "NCBIGene:1191", + "object_id": "CHEMBL.COMPOUND:CHEMBL2108309", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "expression" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6838,15 +7098,15 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "UMLS:C0020964", + "subject_id": "CHEMBL.TARGET:CHEMBL4296221", + "object_id": "CHEMBL.COMPOUND:CHEMBL4594492", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6855,15 +7115,15 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Publication", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006138", - "object_id": "UMLS:C0221102", + "subject_id": "UMLS:C0599740", + "object_id": "CHEBI:15552", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6872,11 +7132,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Publication", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:132952", - "object_id": "UMLS:C0011431", + "subject_id": "UMLS:C0599740", + "object_id": "CHEBI:16412", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6889,15 +7149,15 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Gene", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10198055", - "object_id": "UMLS:C0007587", + "subject_id": "HGNC:10082", + "object_id": "UMLS:C0005456", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6906,15 +7166,15 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "HGNC:10082", - "object_id": "UMLS:C0220781", + "subject_id": "GO:0009008", + "object_id": "UMLS:C0006631", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6923,15 +7183,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Protein", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:100147", - "object_id": "UMLS:C0012222", + "subject_id": "NCIT:C158448", + "object_id": "UMLS:C0041538", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6940,11 +7200,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Procedure", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D022761", - "object_id": "UMLS:C0087111", + "subject_id": "CHEBI:100", + "object_id": "UMLS:C0010762", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6958,14 +7218,14 @@ }, { "subject_category": "biolink:Drug", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "HP:0000155", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3545347", + "object_id": "UMLS:C5445121", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -6974,45 +7234,45 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Protein", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "HGNC:12224", - "object_id": "NCIT:C3824", + "subject_id": "NCIT:C158448", + "object_id": "UMLS:C0040648", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:C421864", - "object_id": "NCIT:C55998", + "subject_id": "CHEBI:100", + "object_id": "UMLS:C0026456", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10313163", - "object_id": "HP:0001944", + "subject_id": "CHV:0000000950", + "object_id": "UMLS:C0005221", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7025,15 +7285,15 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0011324", - "object_id": "UBERON:0001831", + "subject_id": "UNII:7V6HE3DM5A", + "object_id": "CHEBI:3815", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7042,15 +7302,15 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Disease", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0221928", - "object_id": "MONDO:0002406", + "subject_id": "UNII:9X7O8V25IT", + "object_id": "CHEBI:3815", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7060,23 +7320,27 @@ }, { "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:5553", - "object_id": "CHEBI:193860", + "subject_id": "NCBIGene:133", + "object_id": "CHEMBL.COMPOUND:CHEMBL4650434", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "stability" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C1115729", - "object_id": "CHEBI:18421", + "subject_id": "CHEBI:114786", + "object_id": "UMLS:C0041242", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7084,16 +7348,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:SmallMolecule", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0012872", - "object_id": "CHEBI:16991", + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0677040", + "object_id": "CHEBI:16646", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7106,15 +7370,15 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Drug", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "MESH:D000067128", + "subject_id": "CHV:0000044864", + "object_id": "CL:0000232", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7123,11 +7387,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Food", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "HGNC:12529", - "object_id": "MESH:D008862", + "subject_id": "UMLS:C0012171", + "object_id": "CL:0000066", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7140,11 +7404,45 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "MESH:D002736", + "subject_id": "CHV:0000021208", + "object_id": "CL:0000010", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Cell", + "predicate": "biolink:causes", + "subject_id": "HP:0045047", + "object_id": "CL:0000084", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Cell", + "predicate": "biolink:causes", + "subject_id": "NCIT:C120860", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7158,10 +7456,10 @@ }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:CellularComponent", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:100147", - "object_id": "MESH:D002736", + "subject_id": "CHEBI:10002", + "object_id": "UMLS:C0225957", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7174,11 +7472,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Gene", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "MESH:D000067128", + "subject_id": "HGNC:12529", + "object_id": "UBERON:0002435", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7191,15 +7489,15 @@ ] }, { - "subject_category": "biolink:GeneFamily", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Protein", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907610", - "object_id": "PUBCHEM.COMPOUND:25137863", + "subject_id": "UMLS:C0000254", + "object_id": "UBERON:0001759", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7208,11 +7506,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Disease", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10008573", - "object_id": "UMLS:C1140999", + "subject_id": "CHEBI:10545", + "object_id": "UMLS:C5211512", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7225,15 +7523,15 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001288", - "object_id": "UMLS:C0033970", + "subject_id": "CHEBI:114786", + "object_id": "UMLS:C0501385", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7242,11 +7540,11 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:ChemicalMixture", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0871470", - "object_id": "CHEBI:50114", + "subject_id": "CHEBI:25614", + "object_id": "CHEBI:24922", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7254,16 +7552,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Protein", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "UMLS:C1335439", + "subject_id": "CHEBI:25614", + "object_id": "CHEBI:16261", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7276,11 +7574,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Protein", + "subject_category": "biolink:Drug", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "HGNC:10082", - "object_id": "UMLS:C0966511", + "subject_id": "CHV:0000010203", + "object_id": "HP:0001824", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7293,28 +7591,28 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "DOID:0081144", - "object_id": "UMLS:C0018284", + "subject_id": "CHEBI:10002", + "object_id": "UMLS:C0449820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UBERON:0000044", - "object_id": "MESH:D015850", + "subject_id": "CHEBI:100", + "object_id": "UMLS:C0427184", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7327,11 +7625,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Protein", + "subject_category": "biolink:Gene", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "HP:0000020", - "object_id": "UMLS:C0019018", + "subject_id": "HGNC:12224", + "object_id": "NCIT:C3824", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7344,11 +7642,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "NCIT:C77665", - "object_id": "UMLS:C0021665", + "subject_id": "CHEBI:132106", + "object_id": "UMLS:C1140999", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7361,11 +7659,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Protein", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001166", - "object_id": "UMLS:C0061928", + "subject_id": "DRUGBANK:DB10276", + "object_id": "MONDO:0007835", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7379,14 +7677,14 @@ }, { "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Protein", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200644", - "object_id": "PR:000003252", + "subject_id": "CHEBI:131391", + "object_id": "UBERON:0000955", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7396,44 +7694,44 @@ }, { "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Protein", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHV:0000045014", - "object_id": "UMLS:C0040690", + "subject_id": "CHV:0000021208", + "object_id": "UBERON:0000019", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Drug", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188776", - "object_id": "UMLS:C0379528", + "subject_id": "CHV:0000010203", + "object_id": "UBERON:0000178", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085555", - "object_id": "UMLS:C0061928", + "subject_id": "CHV:0000021208", + "object_id": "UBERON:0000044", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7446,11 +7744,11 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005373", - "object_id": "UMLS:C0009325", + "subject_id": "MESH:D000077215", + "object_id": "UMLS:C0233929", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7463,11 +7761,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005778", - "object_id": "UMLS:C0003410", + "subject_id": "CHEBI:132952", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7480,11 +7778,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "GO:0005604", - "object_id": "UMLS:C0009325", + "subject_id": "CHEBI:10545", + "object_id": "HP:0001945", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7497,45 +7795,45 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Drug", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0000049", - "object_id": "UMLS:C0013662", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C0302600", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Protein", + "subject_category": "biolink:Protein", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002957", - "object_id": "UMLS:C0026455", + "subject_id": "UMLS:C0000254", + "object_id": "UMLS:C0015214", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Protein", + "subject_category": "biolink:Food", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0000373", - "object_id": "UMLS:C0033684", + "subject_id": "UMLS:C0006138", + "object_id": "UMLS:C0221102", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7548,11 +7846,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "MESH:D007371", + "subject_id": "CHEBI:132952", + "object_id": "UMLS:C0011431", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7560,16 +7858,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100048905", - "object_id": "MESH:D007371", + "subject_id": "CHEBI:132106", + "object_id": "UMLS:C0017127", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7577,20 +7875,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Protein", + "subject_category": "biolink:Gene", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002671", - "object_id": "UMLS:C0242417", + "subject_id": "HGNC:10082", + "object_id": "UMLS:C0220781", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7599,11 +7897,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:453626", - "object_id": "CHEBI:16247", + "subject_id": "CHEBI:100147", + "object_id": "UMLS:C0012222", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7616,75 +7914,83 @@ ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "CHEBI:16247", + "subject_id": "CHEBI:131391", + "object_id": "UMLS:C0162703", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Drug", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "GO:0000012", - "object_id": "GO:1903518", + "subject_id": "CHV:0000010203", + "object_id": "HP:0001824", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Protein", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "GO:0000012", - "object_id": "GO:1903517", + "subject_id": "NCIT:C158448", + "object_id": "NCIT:C165206", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, { "subject_category": "biolink:Device", - "object_category": "biolink:Protein", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0011323", - "object_id": "UMLS:C0026682", + "subject_id": "UMLS:C0011324", + "object_id": "UBERON:0001831", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364185", - "object_id": "PUBCHEM.COMPOUND:44564107", + "subject_id": "UMLS:C0221928", + "object_id": "MONDO:0002406", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7693,15 +7999,28 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Gene", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL4495602", - "object_id": "PUBCHEM.COMPOUND:121494122", + "subject_id": "NCBIGene:5553", + "object_id": "CHEBI:193860", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "degradation" + } + ] + }, + { + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "UMLS:C1115729", + "object_id": "CHEBI:18421", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7710,15 +8029,15 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "PR:000004191", - "object_id": "PUBCHEM.COMPOUND:6477182", + "subject_id": "UMLS:C0012872", + "object_id": "CHEBI:16991", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7727,15 +8046,32 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:3815", - "object_id": "PUBCHEM.COMPOUND:75007581", + "subject_id": "GO:0009279", + "object_id": "CHEBI:71226", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Disease", + "predicate": "biolink:causes", + "subject_id": "CHV:0000021208", + "object_id": "MONDO:0000816", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7744,11 +8080,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:Device", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "MONDO:0006485", + "subject_id": "UMLS:C0003072", + "object_id": "UMLS:C0036679", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7761,11 +8097,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0041904", - "object_id": "UMLS:C0162735", + "subject_id": "MESH:D000086942", + "object_id": "MONDO:0006485", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7778,11 +8114,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100187749", - "object_id": "MONDO:0005249", + "subject_id": "UMLS:C0041904", + "object_id": "UMLS:C0162735", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7795,11 +8131,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "HP:0000011", - "object_id": "MONDO:0001953", + "subject_id": "UMLS:C0004793", + "object_id": "MONDO:0004992", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7813,10 +8149,10 @@ }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "HP:0000020", - "object_id": "HP:0002607", + "subject_id": "HP:0000011", + "object_id": "MONDO:0001953", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7846,15 +8182,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Disease", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "MONDO:0002363", + "subject_id": "MESH:C465023", + "object_id": "MESH:D010957", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -7883,8 +8219,8 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "UMLS:C0010423", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0007382", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7900,8 +8236,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "UMLS:C0003261", + "subject_id": "UMLS:C0000254", + "object_id": "UMLS:C0016315", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7917,8 +8253,8 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188864", - "object_id": "UMLS:C0020291", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0002074", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7968,7 +8304,7 @@ "subject_category": "biolink:Drug", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", + "subject_id": "CHV:0000010203", "object_id": "UMLS:C0003261", "qualifiers": [ { @@ -7985,8 +8321,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10313163", - "object_id": "UMLS:C0007382", + "subject_id": "CHEBI:114786", + "object_id": "UMLS:C0023693", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7999,11 +8335,28 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "PUBCHEM.COMPOUND:182599", + "subject_id": "CHEBI:114786", + "object_id": "UMLS:C0017968", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0005778", + "object_id": "UMLS:C0003410", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8016,11 +8369,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Drug", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MONDO:0000988", - "object_id": "PUBCHEM.COMPOUND:9794626", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C0001451", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8033,11 +8386,11 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "PUBCHEM.COMPOUND:123812", + "subject_id": "HGNC:10082", + "object_id": "UMLS:C0966511", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8050,11 +8403,11 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005839", - "object_id": "PUBCHEM.COMPOUND:175988", + "subject_id": "HP:0000020", + "object_id": "UMLS:C0019018", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8067,15 +8420,49 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "PUBCHEM.COMPOUND:15938", + "subject_id": "UMLS:C1167395", + "object_id": "UMLS:C0001060", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "GO:0005604", + "object_id": "UMLS:C0009325", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Disease", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "DOID:0111253", + "object_id": "UMLS:C0079284", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8085,31 +8472,31 @@ }, { "subject_category": "biolink:Behavior", - "object_category": "biolink:Drug", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009928", - "object_id": "UMLS:C0003921", + "subject_id": "UMLS:C0002957", + "object_id": "UMLS:C0026455", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1544", - "object_id": "PUBCHEM.COMPOUND:68579", + "subject_id": "UBERON:0000044", + "object_id": "UMLS:C0003595", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8118,15 +8505,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Activity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:C103123", - "object_id": "PUBCHEM.COMPOUND:68579", + "subject_id": "UMLS:C0085555", + "object_id": "UMLS:C0061928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8135,11 +8522,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "MESH:D007371", + "subject_id": "UBERON:0000004", + "object_id": "UMLS:C0001924", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8155,8 +8542,8 @@ "subject_category": "biolink:Cell", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "MESH:D007371", + "subject_id": "CL:0000010", + "object_id": "UMLS:C0027754", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8169,15 +8556,15 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Drug", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C1520698", - "object_id": "PUBCHEM.COMPOUND:71306834", + "subject_id": "UMLS:C0001166", + "object_id": "UMLS:C0061928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8186,11 +8573,11 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Drug", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "GO:0006401", - "object_id": "PUBCHEM.COMPOUND:71306834", + "subject_id": "CHEMBL.TARGET:CHEMBL1907589", + "object_id": "CHEMBL.COMPOUND:CHEMBL3707250", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8203,15 +8590,15 @@ ] }, { - "subject_category": "biolink:Pathway", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "GO:0000077", - "object_id": "CHEBI:9160", + "subject_id": "MESH:D000086942", + "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8220,11 +8607,28 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "PUBCHEM.COMPOUND:135499568", + "subject_id": "GO:0006401", + "object_id": "UNII:43K1W2T1M6", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Pathway", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "GO:0000077", + "object_id": "CHEBI:9160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8237,11 +8641,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0002481", - "object_id": "CHEBI:9168", + "subject_id": "UMLS:C0019868", + "object_id": "UMLS:C0908045", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8249,16 +8653,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907594", - "object_id": "CHEMBL.COMPOUND:CHEMBL3707249", + "subject_id": "UBERON:0002481", + "object_id": "CHEBI:9168", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8302,10 +8706,10 @@ }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C3846005", - "object_id": "PUBCHEM.COMPOUND:6104", + "subject_id": "CHEBI:16247", + "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8318,11 +8722,11 @@ ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907594", - "object_id": "PUBCHEM.COMPOUND:441310", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0001347", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8330,7 +8734,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -8351,12 +8755,46 @@ } ] }, + { + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0000254", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Device", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0008576", + "object_id": "UMLS:C0029419", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, { "subject_category": "biolink:GenomicEntity", "object_category": "biolink:Protein", "predicate": "biolink:causes", "subject_id": "UMLS:C0002085", - "object_id": "MESH:D015850", + "object_id": "UMLS:C0002248", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8368,6 +8806,57 @@ } ] }, + { + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0005373", + "object_id": "UMLS:C0009325", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "GO:0000049", + "object_id": "UMLS:C0013662", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "GO:0000373", + "object_id": "UMLS:C0033684", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:Protein", @@ -8386,11 +8875,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0016328", - "object_id": "PUBCHEM.COMPOUND:10207414", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0000254", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8398,16 +8887,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:MolecularMixture", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188695", - "object_id": "PUBCHEM.COMPOUND:168266256", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0005290", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8420,15 +8909,15 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Device", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "PUBCHEM.COMPOUND:130821", + "subject_id": "UMLS:C0002671", + "object_id": "UMLS:C0242417", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8440,8 +8929,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "UMLS:C0025260", + "subject_id": "UMLS:C0000107", + "object_id": "UMLS:C0871786", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8522,19 +9011,19 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:GeneFamily", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "UMLS:C0005482", + "subject_id": "CHEMBL.TARGET:CHEMBL2093863", + "object_id": "UNII:30LE65637T", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -8542,8 +9031,21 @@ "subject_category": "biolink:Gene", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2741", - "object_id": "PUBCHEM.COMPOUND:57402144", + "subject_id": "NCBIGene:29126", + "object_id": "CHEBI:4667", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" + } + ] + }, + { + "subject_category": "biolink:Procedure", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0001884", + "object_id": "UMLS:C0001645", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8551,33 +9053,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Event", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040537", - "object_id": "CHEBI:4470", + "subject_id": "UMLS:C0003808", + "object_id": "UMLS:C2927841", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2366047", - "object_id": "CHEMBL.COMPOUND:CHEMBL2107359", + "subject_id": "NCIT:C28506", + "object_id": "UMLS:C1172734", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8585,37 +9087,37 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Cell", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UniProtKB:P06434", - "object_id": "UNII:QX5LK7YCHV", + "subject_id": "CL:0000010", + "object_id": "UMLS:C1518041", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1615322", - "object_id": "CHEMBL.COMPOUND:CHEMBL4297246", + "subject_id": "NCBIGene:6530", + "object_id": "CHEBI:51063", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "expression" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8625,27 +9127,44 @@ }, { "subject_category": "biolink:Gene", - "object_category": "biolink:Drug", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2243", - "object_id": "RXCUI:1441688", + "subject_id": "NCBIGene:6530", + "object_id": "CHEBI:135925", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "expression" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" } ] }, { "subject_category": "biolink:Protein", - "object_category": "biolink:Drug", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "PR:000007581", - "object_id": "UNII:7V6HE3DM5A", + "subject_id": "UniProtKB:P36544", + "object_id": "CHEBI:42944", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" + } + ] + }, + { + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:MolecularMixture", + "predicate": "biolink:causes", + "subject_id": "UMLS:C1511997", + "object_id": "CHEBI:3385", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8654,15 +9173,15 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Drug", + "subject_category": "biolink:Event", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:3815", - "object_id": "UNII:7V6HE3DM5A", + "subject_id": "UMLS:C0040537", + "object_id": "CHEBI:17688", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8671,32 +9190,32 @@ ] }, { - "subject_category": "biolink:GeneFamily", - "object_category": "biolink:Drug", + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL3559684", - "object_id": "UNII:B6E7K36KT8", + "subject_id": "NCBIGene:7276", + "object_id": "UNII:0IEO0F56LV", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "expression" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Protein", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:6530", - "object_id": "CHEBI:132233", + "subject_id": "PR:000016801", + "object_id": "UNII:0IEO0F56LV", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8705,15 +9224,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C1511997", - "object_id": "PUBCHEM.COMPOUND:5831", + "subject_id": "UMLS:C0034917", + "object_id": "RXCUI:2639621", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -8722,19 +9241,19 @@ ] }, { - "subject_category": "biolink:Event", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040537", - "object_id": "CHEBI:17688", + "subject_id": "DRUGBANK:DB10276", + "object_id": "RXCUI:493191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -8790,11 +9309,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Food", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10313163", - "object_id": "UBERON:0000119", + "subject_id": "UMLS:C0006494", + "object_id": "UBERON:0001155", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8807,11 +9326,11 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UBERON:0001155", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0005482", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8844,8 +9363,8 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100329167", - "object_id": "UBERON:0002114", + "subject_id": "UMLS:C0004793", + "object_id": "UBERON:0000479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8878,8 +9397,8 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100271694", - "object_id": "UMLS:C0237529", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0233820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8892,36 +9411,19 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PhenotypicFeature", - "predicate": "biolink:causes", - "subject_id": "CHEBI:132952", - "object_id": "UMLS:C0034917", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "CHEBI:10002", - "object_id": "UMLS:C0449820", + "subject_id": "CHEBI:137694", + "object_id": "UMLS:C0011109", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -8929,8 +9431,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "UMLS:C0560175", + "subject_id": "UMLS:C0000107", + "object_id": "UMLS:C1272641", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8960,33 +9462,67 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "UBERON:0000019", + "subject_id": "CHEBI:131371", + "object_id": "NCIT:C52648", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:Event", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006685", - "object_id": "UBERON:0001236", + "subject_id": "UMLS:C0040537", + "object_id": "CHEBI:4470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Protein", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "UniProtKB:P06434", + "object_id": "UNII:QX5LK7YCHV", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "expression" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "CHEMBL.TARGET:CHEMBL1615322", + "object_id": "CHEMBL.COMPOUND:CHEMBL4297246", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" + }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -8995,14 +9531,27 @@ }, { "subject_category": "biolink:Gene", - "object_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1029", - "object_id": "UBERON:0001236", + "subject_id": "NCBIGene:2243", + "object_id": "DRUGBANK:DB11311", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" + } + ] + }, + { + "subject_category": "biolink:Protein", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "CHEMBL.TARGET:CHEMBL2364159", + "object_id": "CHEBI:3160", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -9011,11 +9560,28 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:33699", - "object_id": "UBERON:0002481", + "subject_id": "CHEBI:3815", + "object_id": "UNII:7V6HE3DM5A", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:GeneFamily", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "CHEMBL.TARGET:CHEMBL2111480", + "object_id": "CHEMBL.COMPOUND:CHEMBL2108557", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9028,15 +9594,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEBI:15603", - "object_id": "UBERON:0006907", + "subject_id": "UMLS:C0449238", + "object_id": "UBERON:0000019", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -9048,8 +9614,8 @@ "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "MESH:D007371", + "subject_id": "UMLS:C0026377", + "object_id": "UMLS:C0020960", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9082,8 +9648,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:C421864", - "object_id": "NCIT:C28506", + "subject_id": "NCIT:C158448", + "object_id": "UMLS:C0086982", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9133,8 +9699,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:28017", - "object_id": "UMLS:C1148564", + "subject_id": "CHV:0000031831", + "object_id": "UMLS:C1373120", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9150,7 +9716,7 @@ "subject_category": "biolink:Drug", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", + "subject_id": "CHV:0000010203", "object_id": "NCIT:C28506", "qualifiers": [ { @@ -9181,11 +9747,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10313163", - "object_id": "UMLS:C0013846", + "subject_id": "CHEBI:100", + "object_id": "UMLS:C0243102", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9198,11 +9764,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:100", - "object_id": "UMLS:C0243102", + "subject_id": "CHEBI:114786", + "object_id": "UMLS:C0023775", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9235,8 +9801,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:C421864", - "object_id": "UMLS:C0301641", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C0025246", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9269,8 +9835,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:104840", - "object_id": "UMLS:C0009528", + "subject_id": "CHEBI:114786", + "object_id": "UMLS:C1149836", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9321,7 +9887,7 @@ "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", "subject_id": "UMLS:C0002085", - "object_id": "CHV:0000005406", + "object_id": "CHV:0000000950", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9354,8 +9920,8 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188776", - "object_id": "UMLS:C0003618", + "subject_id": "UMLS:C0004793", + "object_id": "CHV:0000000950", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9372,7 +9938,7 @@ "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", "subject_id": "GO:0003677", - "object_id": "NCIT:C19077", + "object_id": "UMLS:C0007577", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9439,8 +10005,8 @@ "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEBI:23899", - "object_id": "UMLS:C1153198", + "subject_id": "CHEBI:16261", + "object_id": "UMLS:C0011065", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9538,11 +10104,11 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C0011065", + "subject_id": "CHEBI:132238", + "object_id": "UMLS:C0043240", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9555,11 +10121,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Drug", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D005620", - "object_id": "UMLS:C0001811", + "subject_id": "UMLS:C0001640", + "object_id": "UMLS:C1153198", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9589,11 +10155,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "HP:0010546", + "subject_id": "HP:0000020", + "object_id": "HP:0002607", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9606,19 +10172,19 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10008573", - "object_id": "NCIT:C165206", + "subject_id": "CHV:0000021208", + "object_id": "HP:0000718", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -9643,8 +10209,8 @@ "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHV:0000005405", - "object_id": "NCIT:C19077", + "subject_id": "CHV:0000000950", + "object_id": "UMLS:C0007586", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9678,7 +10244,7 @@ "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", "subject_id": "MESH:C465023", - "object_id": "MESH:D053583", + "object_id": "MESH:D015850", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9690,23 +10256,6 @@ } ] }, - { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "PUBCHEM.COMPOUND:168266382", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:AnatomicalEntity", @@ -9724,29 +10273,12 @@ } ] }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:AnatomicalEntity", - "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10008573", - "object_id": "UMLS:C1280541", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:116833", - "object_id": "UMLS:C0015350", + "subject_id": "UMLS:C0004793", + "object_id": "UBERON:0000178", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9776,11 +10308,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Drug", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0318759", - "object_id": "UMLS:C0003280", + "subject_id": "UMLS:C1115729", + "object_id": "UMLS:C0002716", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9793,11 +10325,11 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C1115729", - "object_id": "UMLS:C0002716", + "subject_id": "HP:0001902", + "object_id": "UMLS:C0005286", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9810,11 +10342,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Food", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "HP:0001902", - "object_id": "UMLS:C0005286", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0033684", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9831,7 +10363,7 @@ "object_category": "biolink:Protein", "predicate": "biolink:causes", "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0033684", + "object_id": "UMLS:C0007578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9839,16 +10371,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0007578", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0002520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9864,8 +10396,8 @@ "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB15864", - "object_id": "UMLS:C1136102", + "subject_id": "DRUGBANK:DB10276", + "object_id": "UMLS:C0729663", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9949,8 +10481,8 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0524637", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0003808", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9963,15 +10495,15 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Behavior", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C0004268", + "subject_id": "CHEBI:3160", + "object_id": "CHEMBL.TARGET:CHEMBL2364159", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -9980,28 +10512,28 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:18085", - "object_id": "UNII:7XZ4062R17", + "subject_id": "HP:0000752", + "object_id": "UMLS:C0000392", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188776", - "object_id": "NCIT:C42083", + "subject_id": "DRUGBANK:DB15794", + "object_id": "UMLS:C0243102", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10014,33 +10546,16 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Protein", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "HP:0000092", - "object_id": "UNII:D7RD81HE4W", + "subject_id": "UMLS:C0001811", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB15794", - "object_id": "UMLS:C0243102", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -10051,8 +10566,8 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188784", - "object_id": "UMLS:C0597295", + "subject_id": "UMLS:C0004793", + "object_id": "GO:0003677", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10085,8 +10600,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D007371", - "object_id": "UMLS:C0018270", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C1153198", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10098,6 +10613,23 @@ } ] }, + { + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:GeneFamily", + "predicate": "biolink:causes", + "subject_id": "CHEBI:10127", + "object_id": "CHEMBL.TARGET:CHEMBL2331043", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, { "subject_category": "biolink:GenomicEntity", "object_category": "biolink:MolecularActivity", @@ -10119,8 +10651,8 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0017715", + "subject_id": "CHV:0000021208", + "object_id": "GO:0003677", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10133,11 +10665,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188776", - "object_id": "UMLS:C1156201", + "subject_id": "CHV:0000021208", + "object_id": "NCIT:C28506", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10153,8 +10685,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:104871", - "object_id": "UMLS:C0521119", + "subject_id": "CHEBI:131371", + "object_id": "UMLS:C0175996", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10218,11 +10750,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Food", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHV:0000005405", - "object_id": "UMLS:C0037080", + "subject_id": "UMLS:C0012155", + "object_id": "HP:0004324", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10235,28 +10767,28 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "GO:0001510", - "object_id": "UMLS:C0013081", + "subject_id": "UBERON:0001048", + "object_id": "UMLS:C0029960", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "GO:0003677", - "object_id": "UMLS:C0013081", + "subject_id": "UMLS:C0178587", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10269,79 +10801,71 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Device", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599946", - "object_id": "UMLS:C0013081", + "subject_id": "UMLS:C0003072", + "object_id": "NCIT:C35041", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0080129", - "object_id": "UMLS:C0013081", + "subject_id": "DRUGBANK:DB10276", + "object_id": "UMLS:C1306577", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "GO:0003677", + "subject_id": "MESH:D042003", + "object_id": "UMLS:C3271005", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:C465023", - "object_id": "UMLS:C1150132", + "subject_id": "MESH:D000073399", + "object_id": "UMLS:C3547208", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { "subject_category": "biolink:Device", - "object_category": "biolink:MolecularActivity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035191", - "object_id": "UMLS:C0243102", + "subject_id": "UMLS:C0014631", + "object_id": "UMLS:C1304649", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10354,49 +10878,49 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Protein", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0023775", + "subject_id": "NCIT:C158448", + "object_id": "NCBIGene:103", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "HP:0001518", + "subject_id": "GO:0005604", + "object_id": "NCBIGene:22795", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0003677", - "object_id": "UMLS:C1160466", + "subject_id": "CHEBI:10545", + "object_id": "NCBIGene:140821", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -10405,15 +10929,15 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Cell", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0178587", - "object_id": "UMLS:C0543421", + "subject_id": "CL:0000010", + "object_id": "NCBIGene:1030", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -10425,8 +10949,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "NCBIGene:2944", + "subject_id": "NCIT:C158448", + "object_id": "NCBIGene:3439", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10434,20 +10958,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0005604", - "object_id": "NCBIGene:22795", + "subject_id": "GO:0009008", + "object_id": "NCBIGene:3398", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -10493,8 +11017,8 @@ "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHV:0000004522", - "object_id": "NCBIGene:2551", + "subject_id": "CHV:0000000950", + "object_id": "NCBIGene:10286", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10544,8 +11068,8 @@ "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "NCIT:C77665", - "object_id": "NCBIGene:23038", + "subject_id": "UBERON:0000004", + "object_id": "NCBIGene:102723407", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10557,74 +11081,6 @@ } ] }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "NCBIGene:1806", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Cell", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "NCBIGene:10490", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "MESH:C000726347", - "object_id": "NCBIGene:340061", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "GO:0009008", - "object_id": "NCBIGene:3398", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", @@ -10680,8 +11136,8 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "UMLS:C1332838", + "subject_id": "CHV:0000021208", + "object_id": "HGNC:5816", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10779,11 +11235,11 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "HGNC:1798", + "subject_id": "CHEBI:114786", + "object_id": "NCBIGene:4589", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10795,6 +11251,23 @@ } ] }, + { + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Gene", + "predicate": "biolink:causes", + "subject_id": "CHEBI:114786", + "object_id": "NCBIGene:11034", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:GenomicEntity", "object_category": "biolink:Gene", @@ -10865,44 +11338,44 @@ }, { "subject_category": "biolink:Drug", - "object_category": "biolink:Disease", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "MONDO:0005594", + "subject_id": "CHV:0000043683", + "object_id": "UMLS:C0043012", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "UMLS:C0036679", + "subject_id": "CHEBI:16684", + "object_id": "MONDO:0000837", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Drug", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "CHEBI:18154", - "object_id": "UMLS:C0457949", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C0376618", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10915,11 +11388,11 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "MONDO:0005578", + "subject_id": "CHEBI:134126", + "object_id": "MONDO:0002050", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10948,12 +11421,29 @@ } ] }, + { + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:PhenotypicFeature", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0004793", + "object_id": "HP:0006699", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:GenomicEntity", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", "subject_id": "UMLS:C0002085", - "object_id": "HP:0002172", + "object_id": "HP:0003493", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11037,8 +11527,8 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "NCBIGene:116833", - "object_id": "UMLS:C0225336", + "subject_id": "UMLS:C0004793", + "object_id": "CL:0000023", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11051,15 +11541,15 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Cell", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188776", - "object_id": "UMLS:C1515077", + "subject_id": "UMLS:C5202641", + "object_id": "UMLS:C0004268", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -11068,11 +11558,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Food", "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C5202641", - "object_id": "UMLS:C0004268", + "subject_id": "UMLS:C0012171", + "object_id": "UMLS:C0023185", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11102,11 +11592,11 @@ ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "UMLS:C0023185", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0004268", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11119,11 +11609,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Behavior", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11560225", - "object_id": "UMLS:C0011109", + "subject_id": "MESH:D000086942", + "object_id": "UBERON:0000158", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11136,11 +11626,24 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Pathway", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "UMLS:C0004268", + "subject_id": "GO:0000075", + "object_id": "GO:1901978", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:Device", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "UMLS:C1328924", + "object_id": "UMLS:C0004434", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11153,11 +11656,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UBERON:0000158", + "subject_id": "UMLS:C1157038", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11170,11 +11673,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Protein", + "subject_category": "biolink:Cell", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C1328924", - "object_id": "UMLS:C0004434", + "subject_id": "CL:0000066", + "object_id": "UMLS:C0879438", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11187,15 +11690,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:10033", - "object_id": "UMLS:C0696946", + "subject_id": "MESH:D020077", + "object_id": "CL:0000236", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -11207,8 +11710,8 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100329167", - "object_id": "MESH:D008870", + "subject_id": "UMLS:C0004793", + "object_id": "MESH:D000067128", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11343,8 +11846,8 @@ "subject_category": "biolink:Disease", "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MONDO:0001534", - "object_id": "UMLS:C0033086", + "subject_id": "MONDO:0000837", + "object_id": "UMLS:C0699612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11357,11 +11860,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Device", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10207414", - "object_id": "UMLS:C0115137", + "subject_id": "UMLS:C0017654", + "object_id": "UMLS:C0002520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11374,15 +11877,15 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "PUBCHEM.COMPOUND:124201532", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C0030956", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -11391,15 +11894,15 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:D000077215", - "object_id": "PUBCHEM.COMPOUND:24501", + "subject_id": "CHV:0000005405", + "object_id": "UMLS:C0037080", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -11408,28 +11911,28 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017654", - "object_id": "MESH:C495669", + "subject_id": "GO:0001510", + "object_id": "UMLS:C0013081", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Protein", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C0030956", + "subject_id": "GO:0003677", + "object_id": "UMLS:C0013081", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11442,11 +11945,11 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Activity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012155", - "object_id": "HP:0004324", + "subject_id": "UMLS:C0599946", + "object_id": "UMLS:C0013081", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11459,62 +11962,62 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UBERON:0001048", - "object_id": "UMLS:C0029960", + "subject_id": "UMLS:C0080129", + "object_id": "UMLS:C0013081", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Disease", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0350056", - "object_id": "UMLS:C0543419", + "subject_id": "UMLS:C0002085", + "object_id": "GO:0003677", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Disease", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB15864", - "object_id": "MONDO:0005594", + "subject_id": "MESH:C465023", + "object_id": "UMLS:C1150132", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Device", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "MESH:D003600", + "subject_id": "UMLS:C0035191", + "object_id": "UMLS:C0243102", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11527,37 +12030,45 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Food", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:D017578", - "object_id": "UMLS:C1155011", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0023775", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D017578", - "object_id": "UMLS:C1155010", + "subject_id": "UMLS:C0449238", + "object_id": "HP:0001518", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0014631", - "object_id": "UMLS:C1304649", + "subject_id": "GO:0003677", + "object_id": "UMLS:C1160466", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11587,11 +12098,11 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "NCBIGene:4956", - "object_id": "UMLS:C0079686", + "subject_id": "UMLS:C1511997", + "object_id": "UMLS:C0003601", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11604,11 +12115,11 @@ ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:Gene", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "MESH:D013482", + "subject_id": "NCBIGene:4956", + "object_id": "UMLS:C0079686", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11621,11 +12132,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Procedure", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C1511997", - "object_id": "UMLS:C0003601", + "subject_id": "UMLS:C0001884", + "object_id": "UMLS:C0020855", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11756,6 +12267,57 @@ } ] }, + { + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Cell", + "predicate": "biolink:causes", + "subject_id": "UMLS:C1515464", + "object_id": "UMLS:C0007600", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Cell", + "object_category": "biolink:Cell", + "predicate": "biolink:causes", + "subject_id": "CL:0000081", + "object_id": "UMLS:C0879438", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:PhysiologicalProcess", + "predicate": "biolink:causes", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0005823", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:GrossAnatomicalStructure", @@ -11791,10 +12353,10 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "MESH:C546842", + "subject_id": "CHEBI:31690", "object_id": "UBERON:0002481", "qualifiers": [ { @@ -11803,15 +12365,15 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033684", + "subject_id": "CHEBI:33699", "object_id": "UBERON:0002481", "qualifiers": [ { @@ -11820,16 +12382,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085268", - "object_id": "UBERON:0002481", + "subject_id": "CHEBI:15603", + "object_id": "UBERON:0006907", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11837,15 +12399,15 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "NCBIGene:5290", + "subject_id": "MESH:C546842", "object_id": "UBERON:0002481", "qualifiers": [ { @@ -11859,27 +12421,27 @@ ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:Protein", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0039194", + "subject_id": "UMLS:C0033684", "object_id": "UBERON:0002481", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEBI:9168", + "subject_id": "UMLS:C0085268", "object_id": "UBERON:0002481", "qualifiers": [ { @@ -11893,45 +12455,28 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Disease", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "MONDO:0000088", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364159", - "object_id": "CHEMBL.COMPOUND:CHEMBL4594539", + "subject_id": "NCBIGene:5290", + "object_id": "UBERON:0002481", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Food", + "subject_category": "biolink:Cell", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHV:0000005405", - "object_id": "UMLS:C0376596", + "subject_id": "CL:0000084", + "object_id": "UBERON:0002481", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11945,10 +12490,10 @@ }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Food", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEBI:10106", - "object_id": "UMLS:C0353942", + "subject_id": "CHEBI:9168", + "object_id": "UBERON:0002481", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11961,11 +12506,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C1373045", - "object_id": "UBERON:0003126", + "subject_id": "UMLS:C0005938", + "object_id": "MONDO:0000088", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11978,11 +12523,11 @@ ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C1137094", - "object_id": "UMLS:C0006147", + "subject_id": "CHEBI:10106", + "object_id": "UMLS:C0353942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11990,20 +12535,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Protein", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UBERON:0001236", - "object_id": "UMLS:C0006685", + "subject_id": "CHV:0000005405", + "object_id": "UMLS:C0376596", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12012,28 +12557,28 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004924", - "object_id": "PUBCHEM.COMPOUND:68245", + "subject_id": "UMLS:C1373045", + "object_id": "UBERON:0003126", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Behavior", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "PUBCHEM.COMPOUND:15666", + "subject_id": "UMLS:C1137094", + "object_id": "UMLS:C0006147", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12114,11 +12659,11 @@ ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "MESH:D003031", + "subject_id": "CHEBI:25614", + "object_id": "UMLS:C0009630", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12135,7 +12680,7 @@ "object_category": "biolink:Protein", "predicate": "biolink:causes", "subject_id": "UMLS:C0020969", - "object_id": "MESH:D007371", + "object_id": "UMLS:C0003440", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12148,15 +12693,15 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Protein", + "subject_category": "biolink:Device", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "UMLS:C0009630", + "subject_id": "UMLS:C0004924", + "object_id": "UMLS:C0587342", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12165,19 +12710,19 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004924", - "object_id": "UMLS:C0587342", + "subject_id": "CHEBI:16684", + "object_id": "UMLS:C0009928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -12199,11 +12744,11 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:23686432", - "object_id": "UMLS:C0235146", + "subject_id": "CHEBI:31228", + "object_id": "UMLS:C0009928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12216,11 +12761,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Drug", "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "MESH:D062789", - "object_id": "UMLS:C0543414", + "subject_id": "UMLS:C0003921", + "object_id": "UMLS:C0009928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12250,11 +12795,11 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Disease", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "PUBCHEM.COMPOUND:131634907", + "subject_id": "MONDO:0020724", + "object_id": "UMLS:C0145779", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12267,28 +12812,28 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "PUBCHEM.COMPOUND:131634907", + "subject_id": "UMLS:C0949469", + "object_id": "UMLS:C0105729", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Publication", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "PUBCHEM.COMPOUND:122164822", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C0002272", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12301,11 +12846,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:GeneFamily", + "subject_category": "biolink:Drug", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:10127", - "object_id": "CHEMBL.TARGET:CHEMBL2331043", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3545347", + "object_id": "NCBIGene:4142", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12313,16 +12858,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Drug", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009528", - "object_id": "UMLS:C0023823", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2368925", + "object_id": "NCBIGene:3359", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12330,20 +12875,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "UMLS:C0010762", + "subject_id": "UMLS:C0000854", + "object_id": "NCBIGene:26155", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12352,15 +12897,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:100", - "object_id": "UMLS:C0010762", + "subject_id": "UMLS:C0005839", + "object_id": "NCBIGene:10800", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12369,11 +12914,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "UMLS:C0010762", + "subject_id": "UMLS:C0002085", + "object_id": "NCBIGene:100124700", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12386,11 +12931,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Disease", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:10023", - "object_id": "UMLS:C0010762", + "subject_id": "MONDO:0020724", + "object_id": "NCBIGene:3725", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12398,20 +12943,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MONDO:0000490", - "object_id": "UMLS:C0012924", + "subject_id": "CHEBI:10033", + "object_id": "NCBIGene:1544", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "localization" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12420,15 +12965,15 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "HGNC:39005", - "object_id": "UMLS:C1099354", + "subject_id": "UMLS:C0002085", + "object_id": "MESH:D002875", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12437,11 +12982,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Activity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C1099354", + "subject_id": "UMLS:C0001288", + "object_id": "UMLS:C0150141", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12454,15 +12999,15 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "HP:0003651", - "object_id": "UMLS:C0023823", + "subject_id": "UBERON:0008826", + "object_id": "MONDO:0005002", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12471,28 +13016,28 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "UMLS:C0000702", + "subject_id": "NCIT:C28506", + "object_id": "UMLS:C0079291", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "HGNC:2708", - "object_id": "UMLS:C1101610", + "subject_id": "HP:0004324", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12505,11 +13050,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:C421864", - "object_id": "UMLS:C1099354", + "subject_id": "CHV:0000021208", + "object_id": "HP:0001824", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12522,28 +13067,28 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C1099354", + "subject_id": "CHEBI:60160", + "object_id": "UBERON:0000043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10220267", - "object_id": "UMLS:C1099354", + "subject_id": "MESH:D000086942", + "object_id": "CL:0000084", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12551,20 +13096,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "HP:0000718", - "object_id": "UMLS:C0012929", + "subject_id": "CHEBI:32955", + "object_id": "UMLS:C1515498", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12573,28 +13118,28 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "CHV:0000004522", - "object_id": "UMLS:C0242962", + "subject_id": "CHEBI:22689", + "object_id": "MESH:D000088502", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Food", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UBERON:0000044", - "object_id": "UMLS:C0006556", + "subject_id": "UMLS:C0078479", + "object_id": "UMLS:C0596901", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12607,11 +13152,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "UMLS:C0001060", + "subject_id": "HP:0000718", + "object_id": "UMLS:C1520381", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12624,11 +13169,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "GO:0003676", - "object_id": "UMLS:C1099354", + "subject_id": "DRUGBANK:DB12768", + "object_id": "UMLS:C1819995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12641,11 +13186,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UBERON:0000004", - "object_id": "UMLS:C1956352", + "subject_id": "MESH:D000071439", + "object_id": "MESH:D016615", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12658,11 +13203,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "UMLS:C0001060", + "subject_id": "UMLS:C0428696", + "object_id": "UMLS:C0938430", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12670,16 +13215,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "UMLS:C0010762", + "subject_id": "UMLS:C0016323", + "object_id": "UMLS:C0008071", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12692,15 +13237,15 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0687133", - "object_id": "UMLS:C0010762", + "subject_id": "GO:0000266", + "object_id": "GO:0005739", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12709,15 +13254,15 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "GO:0000724", - "object_id": "UMLS:C0028948", + "subject_id": "MESH:D008925", + "object_id": "UMLS:C0242565", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12726,28 +13271,28 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005839", - "object_id": "UMLS:C1099354", + "subject_id": "MESH:D020077", + "object_id": "UMLS:C0002520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Pathway", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "UMLS:C0012929", + "subject_id": "GO:0000077", + "object_id": "UMLS:C0008546", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12760,15 +13305,15 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Gene", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "UMLS:C0012476", + "subject_id": "HGNC:5756", + "object_id": "UMLS:C0534010", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12777,45 +13322,45 @@ ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Protein", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002957", - "object_id": "UMLS:C0035702", + "subject_id": "UMLS:C0001346", + "object_id": "UMLS:C0115137", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MESH:D000086663", - "object_id": "UMLS:C0010762", + "subject_id": "UMLS:C0001876", + "object_id": "UMLS:C0042838", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0012868", + "subject_id": "HP:0003651", + "object_id": "NCBIGene:100506897", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12828,11 +13373,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Food", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10915", - "object_id": "UMLS:C0242958", + "subject_id": "UMLS:C0003920", + "object_id": "NCBIGene:6523", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12845,11 +13390,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C1373040", - "object_id": "UMLS:C0010762", + "subject_id": "MESH:D059365", + "object_id": "NCBIGene:1278", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12857,37 +13402,37 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "UMLS:C0012929", + "subject_id": "UMLS:C0002957", + "object_id": "NCBIGene:23013", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "UMLS:C1101610", + "subject_id": "UMLS:C0001884", + "object_id": "NCBIGene:196", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -12896,11 +13441,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "NCBIGene:266790", - "object_id": "UMLS:C0242958", + "subject_id": "DRUGBANK:DB10276", + "object_id": "NCBIGene:55364", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12913,11 +13458,11 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Activity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "UMLS:C0010762", + "subject_id": "UMLS:C0015259", + "object_id": "NCBIGene:7076", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12925,16 +13470,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "UMLS:C0023823", + "subject_id": "MESH:D000086942", + "object_id": "UMLS:C0020960", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12942,50 +13487,50 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Disease", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "UMLS:C0010762", + "subject_id": "MONDO:0000248", + "object_id": "UMLS:C0011313", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Food", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100528023", - "object_id": "UMLS:C0073434", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0013764", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Gene", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "HP:0001945", - "object_id": "UMLS:C0001060", + "subject_id": "NCBIGene:10730", + "object_id": "UMLS:C0027793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12998,11 +13543,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:Publication", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "NCBIGene:100124700", + "subject_id": "UMLS:C0599740", + "object_id": "CHEBI:17087", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13015,15 +13560,15 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Gene", + "subject_category": "biolink:Activity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000854", - "object_id": "NCBIGene:26155", + "subject_id": "UMLS:C0015259", + "object_id": "CHEBI:50114", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13032,11 +13577,11 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005839", - "object_id": "NCBIGene:10800", + "subject_id": "NCBIGene:11", + "object_id": "MESH:D016824", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13049,11 +13594,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Gene", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MONDO:0020724", - "object_id": "NCBIGene:3725", + "subject_id": "UMLS:C0031911", + "object_id": "CHEBI:17401", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13061,16 +13606,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Gene", + "subject_category": "biolink:Gene", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "NCBIGene:1268", + "subject_id": "NCBIGene:2043", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13083,11 +13628,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Gene", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "NCBIGene:10908", + "subject_id": "HP:0030365", + "object_id": "UMLS:C0022400", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13100,15 +13645,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10033", - "object_id": "NCBIGene:1544", + "subject_id": "CHEBI:38757", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13117,11 +13662,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Gene", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200396", - "object_id": "NCBIGene:6329", + "subject_id": "CHEBI:125472", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13129,16 +13674,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Gene", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200644", - "object_id": "NCBIGene:462", + "subject_id": "CHEBI:26710", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13151,15 +13696,15 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Protein", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "MESH:D002875", + "subject_id": "UMLS:C0021665", + "object_id": "UMLS:C0015259", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13168,11 +13713,11 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Activity", + "subject_category": "biolink:Device", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001288", - "object_id": "UMLS:C0150141", + "subject_id": "UMLS:C0003072", + "object_id": "UMLS:C0035191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13185,28 +13730,28 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Disease", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10008573", - "object_id": "MONDO:0003019", + "subject_id": "CHV:0000055769", + "object_id": "UMLS:C0699612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0025248", + "subject_id": "CHEBI:133326", + "object_id": "UMLS:C0038888", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13214,16 +13759,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Protein", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11560225", - "object_id": "UMLS:C1153198", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C0071500", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13236,11 +13781,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MONDO:0000248", - "object_id": "UMLS:C0011313", + "subject_id": "UBERON:0000019", + "object_id": "UMLS:C0033086", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13253,28 +13798,28 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Device", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0013764", + "subject_id": "UMLS:C0003072", + "object_id": "UMLS:C0017120", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Protein", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "UMLS:C0031715", + "subject_id": "UMLS:C0000254", + "object_id": "MONDO:0002050", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13282,67 +13827,67 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "MONDO:0005002", + "subject_id": "DRUGBANK:DB15864", + "object_id": "MONDO:0006496", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Cell", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C1515464", - "object_id": "UMLS:C0007600", + "subject_id": "UMLS:C0001413", + "object_id": "MONDO:0002050", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Cell", + "subject_category": "biolink:Protein", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004561", - "object_id": "UMLS:C0879438", + "subject_id": "UMLS:C0002716", + "object_id": "UMLS:C0353942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:CellularComponent", + "object_category": "biolink:Food", "predicate": "biolink:causes", "subject_id": "HP:0000718", - "object_id": "UMLS:C1520381", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13355,15 +13900,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "CHEBI:32955", - "object_id": "UMLS:C1515498", + "subject_id": "UBERON:0000158", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13372,11 +13917,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10730", - "object_id": "UMLS:C0027793", + "subject_id": "CHEBI:16038", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13384,37 +13929,37 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:104840", - "object_id": "UMLS:C0232804", + "subject_id": "CHEBI:100147", + "object_id": "GO:0006260", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015259", - "object_id": "CHEBI:50114", + "subject_id": "CHEBI:15986", + "object_id": "GO:0006401", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13423,28 +13968,28 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031911", - "object_id": "CHEBI:18154", + "subject_id": "UMLS:C0002085", + "object_id": "GO:0006281", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:11", - "object_id": "MESH:D016824", + "subject_id": "HGNC:10084", + "object_id": "GO:0006338", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13457,15 +14002,15 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Activity", + "subject_category": "biolink:Protein", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2043", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0000254", + "object_id": "GO:0010467", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13474,15 +14019,15 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Activity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "HP:0030365", - "object_id": "UMLS:C0022400", + "subject_id": "MESH:D011995", + "object_id": "GO:0006281", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13491,15 +14036,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Activity", + "subject_category": "biolink:Drug", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEBI:38757", - "object_id": "UMLS:C0237820", + "subject_id": "RXCUI:198959", + "object_id": "GO:0034337", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13508,15 +14053,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Activity", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEBI:125472", - "object_id": "UMLS:C0237820", + "subject_id": "CHV:0000021208", + "object_id": "GO:0006260", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13525,15 +14070,15 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Activity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:91820602", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0004793", + "object_id": "GO:0006260", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13542,15 +14087,15 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Cell", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB12768", - "object_id": "UMLS:C0024432", + "subject_id": "CHEBI:17439", + "object_id": "GO:0030488", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13559,11 +14104,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Cell", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D020077", - "object_id": "UMLS:C0004561", + "subject_id": "UMLS:C0013081", + "object_id": "GO:0001510", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13576,15 +14121,15 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Device", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "UMLS:C0035191", + "subject_id": "DRUGBANK:DB15794", + "object_id": "GO:0006260", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13593,28 +14138,24 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Device", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D008049", - "object_id": "UMLS:C0032616", + "subject_id": "MESH:D011995", + "object_id": "GO:0045910", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Device", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHV:0000011375", - "object_id": "UMLS:C0242902", + "subject_id": "GO:0006260", + "object_id": "GO:0006334", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13627,15 +14168,15 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Device", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "UMLS:C0035191", + "subject_id": "UMLS:C0003261", + "object_id": "GO:0006260", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13644,15 +14185,15 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Device", + "subject_category": "biolink:Gene", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UBERON:0000019", - "object_id": "UMLS:C0033086", + "subject_id": "NCBIGene:1001", + "object_id": "GO:0043568", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13661,49 +14202,45 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "UMLS:C0017120", + "subject_id": "MESH:D000073399", + "object_id": "GO:1901537", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Disease", + "subject_category": "biolink:Cell", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "MONDO:0002050", + "subject_id": "CL:0000010", + "object_id": "NCBIGene:3497", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Food", + "subject_category": "biolink:Device", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "HP:0000718", - "object_id": "UMLS:C0012171", + "subject_id": "UMLS:C0003072", + "object_id": "NCBIGene:4589", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13712,11 +14249,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Food", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "NCIT:C77665", - "object_id": "UMLS:C0037732", + "subject_id": "UMLS:C0696628", + "object_id": "UBERON:0010163", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13729,11 +14266,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Food", + "subject_category": "biolink:Cell", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D007371", - "object_id": "UMLS:C0037732", + "subject_id": "UMLS:C0221279", + "object_id": "UMLS:C0604331", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13746,15 +14283,15 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Food", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D007371", - "object_id": "UMLS:C0078479", + "subject_id": "CHEBI:17843", + "object_id": "CHEMBL.COMPOUND:CHEMBL2108479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13763,11 +14300,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:100147", - "object_id": "GO:0006260", + "subject_id": "UBERON:0000062", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13780,15 +14317,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Disease", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "CHEBI:15986", - "object_id": "GO:0006401", + "subject_id": "UMLS:C0152152", + "object_id": "UMLS:C0015915", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13797,11 +14334,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "GO:0006281", + "subject_id": "UBERON:0008826", + "object_id": "UBERON:0000019", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13814,28 +14351,28 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "HGNC:10084", - "object_id": "GO:0006338", + "subject_id": "UBERON:0008826", + "object_id": "HP:0001945", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D007371", - "object_id": "GO:0006260", + "subject_id": "CHEBI:25614", + "object_id": "NCIT:C35979", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13848,11 +14385,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "NCIT:C19077", - "object_id": "GO:0006260", + "subject_id": "UBERON:0008826", + "object_id": "MESH:D005407", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13865,11 +14402,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "GO:0006308", + "subject_id": "MESH:D000086942", + "object_id": "UMLS:C0003261", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13882,49 +14419,49 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006556", - "object_id": "GO:0001171", + "subject_id": "CHEBI:17439", + "object_id": "UMLS:C0350056", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188830", - "object_id": "GO:0006260", + "subject_id": "CHEBI:10545", + "object_id": "UMLS:C2348951", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013081", - "object_id": "GO:0001510", + "subject_id": "UMLS:C0004793", + "object_id": "NCBIGene:10670", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13933,15 +14470,15 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Procedure", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB15794", - "object_id": "GO:0006260", + "subject_id": "UMLS:C0523584", + "object_id": "CHEBI:33375", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -13950,54 +14487,45 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:104840", - "object_id": "GO:0006312", + "subject_id": "DRUGBANK:DB11003", + "object_id": "UMLS:C0020964", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCIT:C20153", - "object_id": "GO:0060148", + "subject_id": "UMLS:C0449238", + "object_id": "GO:0010467", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "NCIT:C30023", - "object_id": "GO:0032057", - "qualifiers": [ + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Device", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0006260", - "object_id": "GO:0006334", + "subject_id": "UMLS:C0032616", + "object_id": "GO:0010467", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14010,11 +14538,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", + "subject_category": "biolink:Food", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "GO:0006260", + "subject_id": "UMLS:C0012171", + "object_id": "GO:0010467", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14027,15 +14555,15 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1001", - "object_id": "GO:0043568", + "subject_id": "UBERON:0008826", + "object_id": "GO:0010467", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -14044,11 +14572,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Protein", + "subject_category": "biolink:Protein", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:C465023", - "object_id": "MESH:D015850", + "subject_id": "UniProtKB:P68431", + "object_id": "GO:0010467", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14056,16 +14584,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB12768", - "object_id": "UMLS:C1819995", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0008813", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14078,11 +14606,11 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "GO:0000012", - "object_id": "UMLS:C0007586", + "subject_id": "CHEBI:140618", + "object_id": "UMLS:C0017191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14095,11 +14623,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Protein", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "MESH:D020077", - "object_id": "MESH:D005075", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14112,28 +14640,28 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0443611", - "object_id": "UMLS:C0042784", + "subject_id": "CHEBI:10033", + "object_id": "UMLS:C0489482", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "UBERON:0010163", + "subject_id": "HGNC:39025", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14146,28 +14674,28 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0221279", - "object_id": "UMLS:C0604331", + "subject_id": "CHEBI:10093", + "object_id": "UMLS:C0017191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "NCIT:C35041", + "subject_id": "CHEBI:10043", + "object_id": "UMLS:C1099354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14180,15 +14708,15 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "CHEBI:28017", - "object_id": "CHEMBL.COMPOUND:CHEMBL1201648", + "subject_id": "CHEBI:16038", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -14197,11 +14725,11 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Protein", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "PUBCHEM.COMPOUND:168266256", + "subject_id": "PR:000016417", + "object_id": "UMLS:C0006556", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14214,11 +14742,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "PUBCHEM.COMPOUND:131842327", + "subject_id": "NCIT:C28506", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14226,16 +14754,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Cell", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0812399", - "object_id": "PUBCHEM.COMPOUND:443495", + "subject_id": "CL:0000010", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14243,16 +14771,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Drug", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "PUBCHEM.COMPOUND:168266256", + "subject_id": "MESH:D006213", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14260,16 +14788,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0034917", - "object_id": "PUBCHEM.COMPOUND:15938", + "subject_id": "HGNC:39005", + "object_id": "UMLS:C1099354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14282,15 +14810,15 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UBERON:0000062", - "object_id": "UMLS:C0034917", + "subject_id": "GO:0006401", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -14299,11 +14827,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Procedure", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0152152", - "object_id": "UMLS:C0015915", + "subject_id": "UMLS:C0005823", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14316,15 +14844,15 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "UBERON:0000019", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0001413", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -14333,11 +14861,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB10276", - "object_id": "UMLS:C1306577", + "subject_id": "CHEBI:10022", + "object_id": "UMLS:C0023823", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14345,16 +14873,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "HP:0001945", + "subject_id": "CHEBI:134126", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14362,20 +14890,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "NCIT:C35979", + "subject_id": "HP:0003651", + "object_id": "UMLS:C0023823", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -14384,11 +14912,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "HP:0001945", + "subject_id": "CHEBI:10545", + "object_id": "UMLS:C0000702", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14401,62 +14929,62 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Protein", + "subject_category": "biolink:Gene", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:121493436", - "object_id": "PR:000016801", + "subject_id": "HGNC:2708", + "object_id": "UMLS:C1101610", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Protein", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "MESH:D005407", + "subject_id": "UMLS:C0000254", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0003261", + "subject_id": "UMLS:C0871470", + "object_id": "UMLS:C0023823", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Device", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C0032616", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0001413", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14464,33 +14992,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Device", + "subject_category": "biolink:Drug", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001876", - "object_id": "UMLS:C0042838", + "subject_id": "MESH:D006131", + "object_id": "UMLS:C1099354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Food", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "CHEBI:16038", - "object_id": "UMLS:C0597423", + "subject_id": "HP:0001824", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14503,11 +15031,11 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Activity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0021498", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0027793", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14515,16 +15043,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Activity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C0035028", + "subject_id": "CHEBI:134126", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14532,16 +15060,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Activity", + "subject_category": "biolink:Food", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0025513", - "object_id": "UMLS:C0425422", + "subject_id": "UMLS:C0017517", + "object_id": "UMLS:C0023823", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14549,20 +15077,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Activity", + "subject_category": "biolink:Disease", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0019868", - "object_id": "UMLS:C0035028", + "subject_id": "MONDO:0000490", + "object_id": "UMLS:C0012924", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -14571,15 +15099,15 @@ ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Activity", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035007", - "object_id": "UMLS:C0035953", + "subject_id": "UBERON:0000044", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -14588,11 +15116,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "UMLS:C0007577", + "subject_id": "CHV:0000000950", + "object_id": "UMLS:C0073432", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14605,11 +15133,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0020964", + "subject_id": "UMLS:C0005839", + "object_id": "UMLS:C1099354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14622,11 +15150,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "NCIT:C28506", - "object_id": "UMLS:C0079291", + "subject_id": "HP:0000718", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14639,28 +15167,28 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "HP:0004324", - "object_id": "UMLS:C0034917", + "subject_id": "UMLS:C0003261", + "object_id": "UMLS:C0006556", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "CHEBI:60160", - "object_id": "UBERON:0000043", + "subject_id": "UBERON:0000004", + "object_id": "UMLS:C1956352", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14674,14 +15202,14 @@ }, { "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Cell", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0007600", + "subject_id": "MESH:D000067128", + "object_id": "UMLS:C0012929", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -14690,28 +15218,28 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "CHEBI:22689", - "object_id": "MESH:D000088502", + "subject_id": "GO:0003676", + "object_id": "UMLS:C1099354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Cell", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "UMLS:C0596901", + "subject_id": "CL:0000010", + "object_id": "UMLS:C0006556", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14724,11 +15252,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D000071439", - "object_id": "MESH:D016615", + "subject_id": "UMLS:C0002957", + "object_id": "UMLS:C0035702", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14741,32 +15269,32 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Food", + "subject_category": "biolink:Activity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0428696", - "object_id": "UMLS:C0938430", + "subject_id": "UMLS:C0237820", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0016323", - "object_id": "UMLS:C0008071", + "subject_id": "UMLS:C0005938", + "object_id": "UMLS:C1101610", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -14775,32 +15303,32 @@ ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "CHEBI:28017", + "subject_id": "GO:0000724", + "object_id": "UMLS:C0028948", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "GO:0000266", - "object_id": "GO:0005739", + "subject_id": "UMLS:C0008813", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -14809,11 +15337,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Protein", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "MESH:D007371", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0012868", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14826,28 +15354,28 @@ ] }, { - "subject_category": "biolink:Pathway", - "object_category": "biolink:Protein", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "GO:0000077", - "object_id": "UMLS:C0008546", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0012931", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Device", + "subject_category": "biolink:Food", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "HGNC:5756", - "object_id": "UMLS:C0534010", + "subject_id": "UMLS:C0012171", + "object_id": "CHV:0000021208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14860,11 +15388,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Device", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "HGNC:39002", - "object_id": "UMLS:C0071500", + "subject_id": "HP:0045047", + "object_id": "UMLS:C0031715", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14872,67 +15400,59 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C1444783", + "subject_id": "MESH:D059365", + "object_id": "UMLS:C3157932", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597832", - "object_id": "HP:0004324", + "subject_id": "MESH:D059365", + "object_id": "UMLS:C3157931", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032042", - "object_id": "NCIT:C35041", + "subject_id": "UMLS:C0009393", + "object_id": "UMLS:C0033086", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "NCIT:C35041", + "subject_id": "UMLS:C0037392", + "object_id": "UBERON:0002398", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14945,84 +15465,16 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:PhenotypicFeature", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:100381270", - "object_id": "UMLS:C0543421", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Activity", - "object_category": "biolink:Protein", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0496675", - "object_id": "UNII:B72HH48FLU", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Protein", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0949469", - "object_id": "UMLS:C0105729", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Publication", - "object_category": "biolink:Protein", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "MESH:D008049", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C0035028", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:SmallMolecule", - "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:453626", - "object_id": "CHEBI:60285", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -15030,11 +15482,11 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Protein", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0523584", - "object_id": "CHEBI:33375", + "subject_id": "UMLS:C0001642", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15047,28 +15499,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB11003", - "object_id": "UMLS:C0020964", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "GO:0010467", + "subject_id": "MESH:D020077", + "object_id": "UMLS:C0015219", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15081,11 +15516,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032616", - "object_id": "GO:0010467", + "subject_id": "UBERON:0004590", + "object_id": "UMLS:C0021167", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15098,15 +15533,15 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "GO:0010467", + "subject_id": "CHV:0000021208", + "object_id": "HGNC:5756", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -15115,11 +15550,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Activity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "GO:0010467", + "subject_id": "UMLS:C0150598", + "object_id": "NCBIGene:1789", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15132,11 +15567,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UniProtKB:P68431", - "object_id": "GO:0010467", + "subject_id": "UMLS:C0012797", + "object_id": "NCBIGene:27", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15144,33 +15579,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Procedure", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0006556", - "object_id": "UMLS:C0040669", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:16038", - "object_id": "UMLS:C0040669", + "subject_id": "CHEBI:10033", + "object_id": "NCBIGene:79001", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15178,33 +15596,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Procedure", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "UMLS:C1176468", + "subject_id": "UMLS:C0004793", + "object_id": "NCBIGene:1026", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Procedure", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:10033", - "object_id": "UMLS:C0489482", + "subject_id": "DRUGBANK:DB10276", + "object_id": "NCBIGene:7099", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15217,11 +15635,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "HGNC:39025", - "object_id": "UMLS:C0040669", + "subject_id": "UMLS:C1511997", + "object_id": "CHEBI:24621", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15234,11 +15652,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Procedure", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:10093", - "object_id": "UMLS:C0017191", + "subject_id": "UMLS:C0238884", + "object_id": "CHEBI:30251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15251,11 +15669,11 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Protein", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0006401", - "object_id": "UMLS:C0033684", + "subject_id": "DRUGBANK:DB12768", + "object_id": "UMLS:C0086982", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15285,28 +15703,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "HP:0045047", - "object_id": "UMLS:C0031715", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D059365", - "object_id": "UMLS:C3157932", + "subject_id": "UMLS:C0003261", + "object_id": "UMLS:C1818753", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -15315,11 +15716,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D059365", - "object_id": "UMLS:C3157931", + "subject_id": "UMLS:C0003261", + "object_id": "UMLS:C1818752", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -15328,11 +15729,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Cell", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "UMLS:C0018183", + "subject_id": "UMLS:C0020969", + "object_id": "NCBIGene:100289419", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15345,28 +15746,28 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:Device", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009393", - "object_id": "UMLS:C0033086", + "subject_id": "UMLS:C0003072", + "object_id": "NCBIGene:3156", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0037392", - "object_id": "UBERON:0002398", + "subject_id": "GO:0000012", + "object_id": "UMLS:C0007586", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15379,11 +15780,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Disease", + "subject_category": "biolink:Cell", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UBERON:0004590", - "object_id": "UMLS:C0021167", + "subject_id": "UMLS:C0443611", + "object_id": "UMLS:C0042784", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15396,28 +15797,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Protein", - "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "MESH:D008049", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Protein", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHV:0000042589", - "object_id": "MESH:D015850", + "subject_id": "MESH:D000086942", + "object_id": "UMLS:C1444783", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15430,11 +15814,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188771", - "object_id": "NCBIGene:7003", + "subject_id": "UMLS:C0597832", + "object_id": "HP:0004324", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15442,16 +15826,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Gene", + "subject_category": "biolink:Procedure", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005974", - "object_id": "NCBIGene:796", + "subject_id": "UMLS:C0032042", + "object_id": "NCIT:C35041", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15464,45 +15848,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0001646", - "object_id": "NCBIGene:4803", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0002957", - "object_id": "NCBIGene:23013", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Activity", - "object_category": "biolink:Gene", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0150598", - "object_id": "NCBIGene:1789", + "subject_id": "UMLS:C0015919", + "object_id": "NCIT:C35041", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15515,28 +15865,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "CHEBI:10033", - "object_id": "NCBIGene:79001", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:Gene", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100049542", - "object_id": "UMLS:C1335144", + "subject_id": "NCBIGene:100381270", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15549,11 +15882,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Gene", + "subject_category": "biolink:Activity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB10276", - "object_id": "NCBIGene:7099", + "subject_id": "UMLS:C0549255", + "object_id": "UMLS:C0000254", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15566,11 +15899,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1511997", - "object_id": "CHEBI:24621", + "subject_id": "CHEBI:10072", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15625,130 +15958,11 @@ } ] }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:MolecularEntity", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1742988", - "object_id": "CHEMBL.TARGET:CHEMBL3833421", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "MESH:D000077215", - "object_id": "PUBCHEM.COMPOUND:15666", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:545", - "object_id": "PUBCHEM.COMPOUND:453626", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "CHEBI:60285", - "object_id": "PUBCHEM.COMPOUND:453626", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "PUBCHEM.COMPOUND:453626", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "CHEBI:16247", - "object_id": "PUBCHEM.COMPOUND:453626", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0002198", - "object_id": "PUBCHEM.COMPOUND:453626", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:16057918", + "subject_id": "CHEBI:18070", "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { @@ -15778,33 +15992,16 @@ } ] }, - { - "subject_category": "biolink:Cell", - "object_category": "biolink:Cell", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0005773", - "object_id": "UMLS:C0879438", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Cell", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", "subject_id": "UBERON:0008826", - "object_id": "UMLS:C0085236", + "object_id": "MESH:D014158", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -15813,28 +16010,11 @@ ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "UMLS:C0024432", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Food", - "predicate": "biolink:causes", - "subject_id": "CHEBI:16038", - "object_id": "UMLS:C0597423", + "subject_id": "UBERON:0008826", + "object_id": "CL:0000583", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15850,7 +16030,7 @@ "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16038", + "subject_id": "CHEBI:135590", "object_id": "UBERON:0008826", "qualifiers": [ { @@ -15910,19 +16090,6 @@ } ] }, - { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "UMLS:C1818752", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" - } - ] - }, { "subject_category": "biolink:Protein", "object_category": "biolink:Protein", @@ -15961,8 +16128,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C0038239", + "subject_id": "RXCUI:1085956", + "object_id": "UMLS:C0699612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15979,7 +16146,7 @@ "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", "subject_id": "CHEBI:25614", - "object_id": "UMLS:C0007577", + "object_id": "MESH:D014158", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15995,8 +16162,8 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "UMLS:C0017127", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0027793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16013,7 +16180,7 @@ "object_category": "biolink:Cell", "predicate": "biolink:causes", "subject_id": "UMLS:C0449238", - "object_id": "UMLS:C0009013", + "object_id": "CL:0000084", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16047,7 +16214,7 @@ "object_category": "biolink:Cell", "predicate": "biolink:causes", "subject_id": "CHEBI:25614", - "object_id": "UMLS:C0027950", + "object_id": "CL:0000084", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16060,58 +16227,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "UMLS:C1818753", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] - }, - { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:ChemicalEntity", - "predicate": "biolink:causes", - "subject_id": "CHV:0000042589", - "object_id": "CHEBI:16412", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB12768", - "object_id": "UMLS:C0086982", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Gene", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "MESH:D059365", - "object_id": "NCBIGene:1278", + "subject_id": "CHEBI:16113", + "object_id": "MESH:D000086942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16124,11 +16244,11 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Gene", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "NCBIGene:100289419", + "subject_id": "UMLS:C0003261", + "object_id": "MESH:D000086942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16141,11 +16261,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Gene", + "subject_category": "biolink:Protein", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "NCBIGene:3156", + "subject_id": "UMLS:C0020960", + "object_id": "MESH:D000086942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16159,70 +16279,10 @@ }, { "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "MESH:D018965", - "object_id": "UMLS:C3270822", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0006660", - "object_id": "UMLS:C2610824", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0013470", - "object_id": "PUBCHEM.COMPOUND:168266256", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Food", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0037732", - "object_id": "UMLS:C0032058", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Device", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UBERON:0000045", - "object_id": "UMLS:C0649526", + "subject_id": "MESH:D011995", + "object_id": "MESH:D000086942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16235,32 +16295,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ChemicalMixture", - "predicate": "biolink:causes", - "subject_id": "CHEBI:132844", - "object_id": "CHEBI:60160", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "CHEBI:16412", - "object_id": "CHEBI:25614", + "subject_id": "UMLS:C5202641", + "object_id": "MESH:D008928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16269,28 +16312,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:ChemicalMixture", - "predicate": "biolink:causes", - "subject_id": "CHEBI:16646", - "object_id": "CHEBI:60160", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:GeneFamily", "predicate": "biolink:causes", - "subject_id": "HGNC:12696", - "object_id": "CHEBI:25614", + "subject_id": "CHEBI:261649", + "object_id": "CHEMBL.TARGET:CHEMBL4523964", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16303,28 +16329,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:ChemicalMixture", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0007577", - "object_id": "CHEBI:25614", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:D008247", - "object_id": "CHEBI:60160", + "subject_id": "CHEBI:134126", + "object_id": "NCBIGene:2741", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16332,20 +16341,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0030012", - "object_id": "CHEBI:25614", + "subject_id": "UMLS:C0021498", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16354,15 +16363,15 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005520", - "object_id": "CHEBI:60027", + "subject_id": "UMLS:C0025513", + "object_id": "UMLS:C0425422", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16371,15 +16380,15 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Procedure", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:14228836", - "object_id": "CHEBI:25614", + "subject_id": "UMLS:C0032042", + "object_id": "UBERON:0001384", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16388,15 +16397,15 @@ ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:Protein", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "UMLS:C0019046", + "subject_id": "UBERON:0000045", + "object_id": "UMLS:C0649526", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16405,11 +16414,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013119", - "object_id": "UMLS:C0043240", + "subject_id": "UMLS:C0019868", + "object_id": "UMLS:C0035028", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16422,11 +16431,11 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Device", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0026687", - "object_id": "UMLS:C0033086", + "subject_id": "UMLS:C0035007", + "object_id": "UMLS:C0035953", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16434,16 +16443,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Device", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "UMLS:C0649526", + "subject_id": "MESH:D000086942", + "object_id": "MESH:D011995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16456,15 +16465,15 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D000086663", - "object_id": "UMLS:C0033213", + "subject_id": "CHEMBL.TARGET:CHEMBL2364181", + "object_id": "CHEBI:81916", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16473,15 +16482,15 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:23443659", - "object_id": "UMLS:C0033213", + "subject_id": "CHEBI:28017", + "object_id": "CHEBI:81916", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16490,15 +16499,15 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:Protein", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1704723", - "object_id": "UMLS:C0033213", + "subject_id": "UMLS:C0002520", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16507,49 +16516,41 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10125", - "object_id": "UMLS:C0205160", + "subject_id": "GO:0000014", + "object_id": "GO:1990600", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "UMLS:C0033213", + "subject_id": "GO:0000150", + "object_id": "GO:0140620", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0073432", - "object_id": "UMLS:C0205160", + "subject_id": "UMLS:C0677040", + "object_id": "UMLS:C0019046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16558,45 +16559,37 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "CHEBI:28017", - "object_id": "UMLS:C0205082", + "subject_id": "UMLS:C0006660", + "object_id": "UMLS:C2610825", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100288687", - "object_id": "UMLS:C0205160", + "subject_id": "UMLS:C0006660", + "object_id": "UMLS:C2610824", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:Food", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002520", - "object_id": "UMLS:C0205160", + "subject_id": "UMLS:C0037732", + "object_id": "UMLS:C0032058", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16609,15 +16602,15 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "MESH:D015850", - "object_id": "UMLS:C0205082", + "subject_id": "CHEBI:60160", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16626,15 +16619,15 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100736251", - "object_id": "UMLS:C0205082", + "subject_id": "CHEBI:132844", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16643,11 +16636,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D000086663", - "object_id": "UMLS:C0205082", + "subject_id": "CHEBI:16261", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16655,76 +16648,84 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:10033", - "object_id": "UMLS:C0205082", + "subject_id": "MESH:D014158", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:18154", - "object_id": "UMLS:C0033213", + "subject_id": "MESH:D008247", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "GO:0000288", - "object_id": "UMLS:C3269665", + "subject_id": "UMLS:C0030012", + "object_id": "CHEBI:25614", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "GO:0000288", - "object_id": "UMLS:C3269655", + "subject_id": "UMLS:C0005520", + "object_id": "CHEBI:60027", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:GeneFamily", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201454", - "object_id": "CHEMBL.TARGET:CHEMBL2094111", + "subject_id": "CHEBI:16646", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16737,11 +16738,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:16113", - "object_id": "MESH:D000086942", + "subject_id": "HGNC:12696", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16749,20 +16750,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "MESH:D000086942", + "subject_id": "CHEBI:26710", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16771,11 +16772,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Device", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0025248", - "object_id": "MESH:D000086942", + "subject_id": "UMLS:C0013119", + "object_id": "UMLS:C0043240", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16783,33 +16784,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "NCIT:C18016", - "object_id": "UMLS:C1520765", + "subject_id": "UMLS:C0026687", + "object_id": "UMLS:C0033086", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Cell", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C5202641", - "object_id": "MESH:D008928", + "subject_id": "CL:0000010", + "object_id": "UMLS:C0699612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16822,11 +16823,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:GeneFamily", + "subject_category": "biolink:Gene", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200357", - "object_id": "CHEMBL.TARGET:CHEMBL2354204", + "subject_id": "HGNC:39002", + "object_id": "UMLS:C0071500", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16839,11 +16840,11 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032042", - "object_id": "UBERON:0001384", + "subject_id": "MESH:D000086663", + "object_id": "UMLS:C0033213", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16856,15 +16857,15 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "HP:0003651", - "object_id": "NCBIGene:100506897", + "subject_id": "CHEBI:10545", + "object_id": "UMLS:C0033213", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16873,15 +16874,15 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Gene", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003920", - "object_id": "NCBIGene:6523", + "subject_id": "UMLS:C1704723", + "object_id": "UMLS:C0033213", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16890,11 +16891,11 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Gene", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "NCBIGene:196", + "subject_id": "CHEBI:10125", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16907,15 +16908,15 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Gene", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB10276", - "object_id": "NCBIGene:55364", + "subject_id": "UMLS:C0073432", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16924,11 +16925,11 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Gene", + "subject_category": "biolink:Drug", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015259", - "object_id": "NCBIGene:7076", + "subject_id": "UMLS:C0003209", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16936,20 +16937,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Gene", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364181", - "object_id": "PUBCHEM.COMPOUND:8519", + "subject_id": "NCBIGene:100288687", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16959,10 +16960,10 @@ }, { "subject_category": "biolink:Protein", - "object_category": "biolink:PhysicalEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D013482", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C0001060", + "object_id": "UMLS:C4748586", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16970,20 +16971,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Drug", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "PUBCHEM.COMPOUND:433294", + "subject_id": "RXCUI:1922754", + "object_id": "UMLS:C1299586", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -16992,54 +16993,62 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Protein", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "GO:0000014", - "object_id": "GO:1990600", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C0205160", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "GO:0000150", - "object_id": "GO:0140620", + "subject_id": "UMLS:C0080089", + "object_id": "UMLS:C0033213", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032616", - "object_id": "MESH:D010578", + "subject_id": "CHEBI:2417", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:61452", - "object_id": "MESH:D010578", + "subject_id": "MESH:D000086663", + "object_id": "UMLS:C0205082", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17052,11 +17061,11 @@ ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "MESH:D010578", + "subject_id": "CHEBI:10033", + "object_id": "UMLS:C0205082", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17069,11 +17078,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "MESH:D000077215", + "subject_id": "CHEBI:18154", + "object_id": "UMLS:C0033213", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17081,16 +17090,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Gene", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "NCBIGene:4589", + "subject_id": "UMLS:C0718215", + "object_id": "CHV:0000010203", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17098,16 +17107,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Gene", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0005219", - "object_id": "NCBIGene:6717", + "subject_id": "GO:0000288", + "object_id": "UMLS:C3269665", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -17116,11 +17125,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Gene", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0005219", - "object_id": "NCBIGene:1193", + "subject_id": "GO:0000288", + "object_id": "UMLS:C3269655", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -17129,32 +17138,32 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:GeneFamily", "predicate": "biolink:causes", - "subject_id": "CHEBI:16336", - "object_id": "PUBCHEM.COMPOUND:91820602", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201454", + "object_id": "CHEMBL.TARGET:CHEMBL2095203", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Publication", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "UMLS:C0001451", + "subject_id": "CHEBI:229213", + "object_id": "UMLS:C0665341", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -17163,11 +17172,11 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Publication", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0549255", - "object_id": "PUBCHEM.COMPOUND:105053", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C0001451", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17175,7 +17184,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -17200,8 +17209,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "MESH:D015850", - "object_id": "MESH:C465023", + "subject_id": "UMLS:C0002520", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17230,6 +17239,23 @@ } ] }, + { + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0001271", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Phenomenon", @@ -17251,12 +17277,12 @@ "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "GO:0001960", - "object_id": "GO:0019221", + "subject_id": "GO:0000747", + "object_id": "GO:0032005", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "upregulated" } ] }, @@ -17264,12 +17290,12 @@ "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "GO:0001961", + "subject_id": "GO:0001960", "object_id": "GO:0019221", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "downregulated" } ] }, @@ -17328,8 +17354,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:28017", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C0003280", + "object_id": "UMLS:C0037392", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17345,7 +17371,7 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:15377", + "subject_id": "CHEBI:133011", "object_id": "UMLS:C0015919", "qualifiers": [ { @@ -17481,8 +17507,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:28017", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C1330330", + "object_id": "UMLS:C0037392", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17495,11 +17521,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Activity", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:100241", - "object_id": "UMLS:C0549255", + "subject_id": "UMLS:C0042834", + "object_id": "MESH:D053260", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17512,15 +17538,15 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "MESH:D005075", - "object_id": "UMLS:C1160466", + "subject_id": "CHEBI:10072", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -17529,11 +17555,28 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "GO:0006260", - "object_id": "UMLS:C0003261", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0035191", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Publication", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C1301821", + "object_id": "CHEBI:35341", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17546,11 +17589,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Cell", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C1157038", - "object_id": "UMLS:C0879593", + "subject_id": "UMLS:C0043085", + "object_id": "UMLS:C0206217", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17563,11 +17606,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Cell", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UBERON:0000019", - "object_id": "UMLS:C0879438", + "subject_id": "CHV:0000055769", + "object_id": "UMLS:C1160466", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17580,45 +17623,45 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Disease", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "MONDO:0001576", + "subject_id": "GO:0006260", + "object_id": "UMLS:C0003261", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Disease", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "MONDO:0019182", + "subject_id": "UBERON:0000019", + "object_id": "UMLS:C0879438", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0205082", - "object_id": "PUBCHEM.COMPOUND:168266382", + "subject_id": "UMLS:C0449238", + "object_id": "MONDO:0001576", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17648,11 +17691,11 @@ ] }, { - "subject_category": "biolink:Behavior", + "subject_category": "biolink:Event", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009928", - "object_id": "UMLS:C0719201", + "subject_id": "UMLS:C0040537", + "object_id": "MESH:D062789", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17665,11 +17708,11 @@ ] }, { - "subject_category": "biolink:Event", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040537", - "object_id": "MESH:D062789", + "subject_id": "CHEBI:10033", + "object_id": "UMLS:C0696946", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17677,7 +17720,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -17698,12 +17741,29 @@ } ] }, + { + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:OrganismTaxon", + "predicate": "biolink:causes", + "subject_id": "CHEBI:132952", + "object_id": "UMLS:C0718215", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, { "subject_category": "biolink:ChemicalMixture", "object_category": "biolink:Protein", "predicate": "biolink:causes", "subject_id": "CHEBI:25614", - "object_id": "UMLS:C0033684", + "object_id": "UMLS:C0020960", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17719,8 +17779,8 @@ "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004391", - "object_id": "UMLS:C0040669", + "subject_id": "MESH:D014158", + "object_id": "UMLS:C1515979", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17736,8 +17796,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C0040669", + "subject_id": "UMLS:C0001645", + "object_id": "UMLS:C0001884", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17801,10 +17861,10 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11105", + "subject_id": "UMLS:C0004793", "object_id": "UMLS:C0008813", "qualifiers": [ { @@ -17818,10 +17878,10 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "NCBIGene:57760", + "subject_id": "CHEBI:133354", "object_id": "UMLS:C0040669", "qualifiers": [ { @@ -17852,15 +17912,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C1511997", - "object_id": "PUBCHEM.COMPOUND:133128", + "subject_id": "UMLS:C0004933", + "object_id": "UMLS:C0032942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -17869,33 +17929,16 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C1373040", - "object_id": "PUBCHEM.COMPOUND:168010178", + "subject_id": "CHEBI:16469", + "object_id": "UMLS:C0009990", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:ComplexMolecularMixture", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0042834", - "object_id": "MESH:D053260", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -17903,11 +17946,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Food", + "subject_category": "biolink:Activity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:26125", - "object_id": "UMLS:C0006494", + "subject_id": "UMLS:C0015259", + "object_id": "UMLS:C0452415", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17921,10 +17964,10 @@ }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Food", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:10072", - "object_id": "UMLS:C0597423", + "subject_id": "CHEBI:10044", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17936,29 +17979,12 @@ } ] }, - { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Drug", - "predicate": "biolink:causes", - "subject_id": "NCBITaxon:1301", - "object_id": "CHEBI:28017", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, { "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Device", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10207414", - "object_id": "UMLS:C0016328", + "subject_id": "CHEBI:141517", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17971,11 +17997,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:Food", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "UMLS:C0035191", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17988,11 +18014,11 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C1301821", - "object_id": "CHEBI:35341", + "subject_id": "UBERON:0000029", + "object_id": "NCBITaxon:11089", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18005,28 +18031,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "CHEBI:10110", - "object_id": "UMLS:C0812399", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Protein", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "UMLS:C0215825", + "subject_id": "MESH:D014612", + "object_id": "NCBITaxon:11089", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18034,7 +18043,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -18055,46 +18064,12 @@ } ] }, - { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Behavior", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0004933", - "object_id": "UMLS:C0032942", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Behavior", - "predicate": "biolink:causes", - "subject_id": "CHEBI:16469", - "object_id": "UMLS:C0009990", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Activity", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015259", - "object_id": "UMLS:C0452415", + "subject_id": "CHEBI:134742", + "object_id": "NCBITaxon:83332", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18102,16 +18077,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "CHEBI:10044", - "object_id": "UMLS:C0034917", + "subject_id": "HP:0001824", + "object_id": "UMLS:C0115137", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18119,33 +18094,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0043085", - "object_id": "UMLS:C0206217", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0543421", + "subject_id": "NCBITaxon:5052", + "object_id": "CHEBI:52492", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18158,11 +18116,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UBERON:0000029", - "object_id": "NCBITaxon:11089", + "subject_id": "UMLS:C1167395", + "object_id": "NCBIGene:10133", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18175,11 +18133,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:D014612", - "object_id": "NCBITaxon:11089", + "subject_id": "MESH:D008925", + "object_id": "NCBIGene:3497", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18192,11 +18150,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:134742", - "object_id": "NCBITaxon:83332", + "subject_id": "UMLS:C0001884", + "object_id": "UMLS:C0215825", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18209,50 +18167,16 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Protein", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "CHEBI:132952", + "subject_id": "UMLS:C0002520", "object_id": "UMLS:C0718215", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Device", - "predicate": "biolink:causes", - "subject_id": "HP:0001824", - "object_id": "UMLS:C0115137", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "NCBIGene:10133", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -18260,11 +18184,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Gene", + "subject_category": "biolink:Disease", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "NCBIGene:3497", + "subject_id": "MONDO:0000837", + "object_id": "UMLS:C0002520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18272,7 +18196,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -18280,8 +18204,8 @@ "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0001236", - "object_id": "MESH:C423320", + "subject_id": "UBERON:0002481", + "object_id": "CHEBI:33699", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18345,10 +18269,10 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006938", + "subject_id": "CHEBI:3645", "object_id": "NCBIGene:1565", "qualifiers": [ { @@ -18362,28 +18286,28 @@ ] }, { - "subject_category": "biolink:Publication", + "subject_category": "biolink:Protein", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "NCBIGene:10013", + "subject_id": "UMLS:C0006938", + "object_id": "NCBIGene:1565", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Publication", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "UMLS:C1257737", + "subject_id": "UMLS:C0599740", + "object_id": "NCBIGene:10013", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18396,11 +18320,11 @@ ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MONDO:0020724", - "object_id": "UMLS:C0145779", + "subject_id": "GO:0006401", + "object_id": "UMLS:C0033684", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18413,11 +18337,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:GeneFamily", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:16682734", - "object_id": "CHEMBL.TARGET:CHEMBL2094253", + "subject_id": "UMLS:C0812399", + "object_id": "UMLS:C0006938", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18429,29 +18353,12 @@ } ] }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:Activity", - "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "UMLS:C0599946", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:Drug", + "object_category": "biolink:Protein", "predicate": "biolink:causes", "subject_id": "UMLS:C0677040", - "object_id": "CHEBI:34674", + "object_id": "UMLS:C0012512", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18464,11 +18371,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Gene", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C1373035", - "object_id": "NCBIGene:7032", + "subject_id": "UBERON:0002481", + "object_id": "UMLS:C0033684", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18481,11 +18388,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:GeneFamily", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:10082", - "object_id": "CHEMBL.TARGET:CHEMBL2094111", + "subject_id": "UMLS:C0015919", + "object_id": "UMLS:C0002520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18499,27 +18406,10 @@ }, { "subject_category": "biolink:Drug", - "object_category": "biolink:MolecularEntity", - "predicate": "biolink:causes", - "subject_id": "UNII:3JB47N2Q2P", - "object_id": "CHEMBL.TARGET:CHEMBL1907599", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Disease", - "object_category": "biolink:Activity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0302295", - "object_id": "UMLS:C0150141", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C0035191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18532,45 +18422,37 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0879593", - "object_id": "HP:0011157", + "subject_id": "GO:0005219", + "object_id": "NCBIGene:6717", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:16243", - "object_id": "UMLS:C0150479", + "subject_id": "GO:0005219", + "object_id": "NCBIGene:1193", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Protein", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "UMLS:C0442751", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18586,7 +18468,7 @@ "subject_category": "biolink:Protein", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", + "subject_id": "UMLS:C0001271", "object_id": "UMLS:C0162326", "qualifiers": [ { @@ -18604,7 +18486,7 @@ "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", "subject_id": "UMLS:C0002085", - "object_id": "NCBIGene:470", + "object_id": "UMLS:C0004793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18634,11 +18516,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10022", - "object_id": "UMLS:C3178810", + "subject_id": "CHEBI:16247", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18654,8 +18536,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:28966", - "object_id": "NCBIGene:878", + "subject_id": "UMLS:C0003376", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18668,11 +18550,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "NCBIGene:140821", + "subject_id": "UMLS:C1335464", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18685,11 +18567,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1335464", - "object_id": "UMLS:C0162326", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0012872", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18702,11 +18584,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188830", - "object_id": "UMLS:C0677504", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0752046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18719,11 +18601,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006556", - "object_id": "UMLS:C0162326", + "subject_id": "CHEBI:10022", + "object_id": "UMLS:C3178810", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18739,8 +18621,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11560225", - "object_id": "NCBIGene:6012", + "subject_id": "CHEBI:17833", + "object_id": "UMLS:C0004793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18787,11 +18669,11 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "HGNC:12529", - "object_id": "UMLS:C0752046", + "subject_id": "CHEBI:10545", + "object_id": "UMLS:C0080089", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18804,11 +18686,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10022", - "object_id": "NCBIGene:7908", + "subject_id": "MESH:D020077", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18821,11 +18703,11 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Protein", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "NCBIGene:140821", + "subject_id": "UMLS:C0001239", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18838,11 +18720,11 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:Gene", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D007371", - "object_id": "NCBIGene:57762", + "subject_id": "HGNC:12529", + "object_id": "UMLS:C0752046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18855,11 +18737,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "NCBIGene:780904", + "subject_id": "CHEBI:10022", + "object_id": "UMLS:C5236345", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18872,11 +18754,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100329167", - "object_id": "NCBIGene:100505390", + "subject_id": "CHEBI:17439", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18889,10 +18771,10 @@ ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D000071439", + "subject_id": "CHV:0000021208", "object_id": "UMLS:C0162326", "qualifiers": [ { @@ -18906,11 +18788,11 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "NCBIGene:100271694", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18923,10 +18805,10 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010744", + "subject_id": "MESH:D010578", "object_id": "UMLS:C0162326", "qualifiers": [ { @@ -18940,11 +18822,11 @@ ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0879593", - "object_id": "UMLS:C0162326", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0012591", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18957,11 +18839,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Drug", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D020077", - "object_id": "UMLS:C0162326", + "subject_id": "UMLS:C0003015", + "object_id": "UMLS:C0752046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18974,11 +18856,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2107359", - "object_id": "CHEMBL.TARGET:CHEMBL2366047", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0080089", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18991,11 +18873,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D010578", - "object_id": "NCBIGene:4397", + "subject_id": "MESH:D000071439", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19008,11 +18890,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Cell", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0012591", + "subject_id": "UMLS:C0879593", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19025,11 +18907,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002074", - "object_id": "UMLS:C0004793", + "subject_id": "GO:0005604", + "object_id": "UMLS:C0162327", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19042,10 +18924,10 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000125", + "subject_id": "UMLS:C1167395", "object_id": "UMLS:C0162326", "qualifiers": [ { @@ -19059,11 +18941,11 @@ ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MONDO:0000448", - "object_id": "UMLS:C0162326", + "subject_id": "CHV:0000000950", + "object_id": "UMLS:C0004793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19076,10 +18958,10 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "GO:0003677", + "subject_id": "UMLS:C0002074", "object_id": "UMLS:C0004793", "qualifiers": [ { @@ -19093,11 +18975,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "GO:0005604", - "object_id": "NCBIGene:84565", + "subject_id": "GO:0000712", + "object_id": "UMLS:C1258072", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19110,11 +18992,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "HP:0000718", - "object_id": "NCBIGene:4963", + "subject_id": "GO:0003677", + "object_id": "UMLS:C0004793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19127,10 +19009,10 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Behavior", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHV:0000005405", + "subject_id": "UMLS:C0003646", "object_id": "UMLS:C0162326", "qualifiers": [ { @@ -19144,11 +19026,11 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Disease", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "GO:0000712", - "object_id": "UMLS:C1258072", + "subject_id": "DOID:0111252", + "object_id": "UMLS:C1521100", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19161,10 +19043,10 @@ ] }, { - "subject_category": "biolink:Behavior", + "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003646", + "subject_id": "UBERON:0000029", "object_id": "UMLS:C0162326", "qualifiers": [ { @@ -19181,8 +19063,8 @@ "subject_category": "biolink:Cell", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "UMLS:C0162326", + "subject_id": "CL:0000010", + "object_id": "UMLS:C1512886", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19195,11 +19077,11 @@ ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "NCBIGene:100528023", + "subject_id": "HP:0000752", + "object_id": "UMLS:C0600477", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19212,10 +19094,10 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009393", + "subject_id": "UBERON:0000125", "object_id": "UMLS:C0162326", "qualifiers": [ { @@ -19229,11 +19111,11 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Procedure", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "NCBIGene:5120", + "subject_id": "UMLS:C0008813", + "object_id": "UMLS:C0004793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19246,10 +19128,10 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000029", + "subject_id": "UMLS:C0009393", "object_id": "UMLS:C0162326", "qualifiers": [ { @@ -19263,10 +19145,10 @@ ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:Activity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0238815", + "subject_id": "UMLS:C0237820", "object_id": "UMLS:C0162326", "qualifiers": [ { @@ -19280,11 +19162,11 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C0080089", + "subject_id": "UMLS:C0455829", + "object_id": "UMLS:C0752046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19297,11 +19179,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:PopulationOfIndividualOrganisms", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "UMLS:C0033755", + "subject_id": "UMLS:C0238815", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19314,11 +19196,11 @@ ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0008813", - "object_id": "UMLS:C0004793", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C0080089", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19364,6 +19246,91 @@ } ] }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Gene", + "predicate": "biolink:causes", + "subject_id": "UMLS:C1373035", + "object_id": "NCBIGene:7032", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Disease", + "object_category": "biolink:Activity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0302295", + "object_id": "UMLS:C0150141", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Cell", + "object_category": "biolink:PhenotypicFeature", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0879593", + "object_id": "NCIT:C36289", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "CHEBI:16243", + "object_id": "UMLS:C0150479", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:PhenotypicFeature", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0696628", + "object_id": "UMLS:C0442751", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:Device", @@ -19416,11 +19383,11 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C0012171", + "subject_id": "CHEBI:25681", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19450,28 +19417,28 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", + "subject_id": "CHEBI:2361", "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:16213644", - "object_id": "UMLS:C0205161", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19501,11 +19468,11 @@ ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907589", - "object_id": "CHEMBL.COMPOUND:CHEMBL2104964", + "subject_id": "CHEBI:10110", + "object_id": "UMLS:C0812399", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19513,7 +19480,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -19534,23 +19501,6 @@ } ] }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:68579", - "object_id": "NCBIGene:1544", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:CellularComponent", "object_category": "biolink:Gene", @@ -19616,11 +19566,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Cell", + "subject_category": "biolink:Food", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0675244", - "object_id": "UMLS:C0225828", + "subject_id": "UMLS:C0012171", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19628,42 +19578,50 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Disease", + "subject_category": "biolink:Food", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C1326509", - "object_id": "MONDO:0002459", + "subject_id": "UMLS:C0012171", + "object_id": "UMLS:C0003402", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Disease", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C1155230", - "object_id": "UMLS:C1155247", + "subject_id": "UMLS:C1167395", + "object_id": "RXCUI:237976", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:47775", - "object_id": "UMLS:C0240321", + "subject_id": "GO:0000724", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19676,15 +19634,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:16236", - "object_id": "UMLS:C0238711", + "subject_id": "UMLS:C0675244", + "object_id": "CL:0000746", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -19693,19 +19651,19 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:129831", - "object_id": "UMLS:C0240321", + "subject_id": "CHEBI:25614", + "object_id": "UMLS:C1257737", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -19794,6 +19752,100 @@ } ] }, + { + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Disease", + "predicate": "biolink:causes", + "subject_id": "UMLS:C1160588", + "object_id": "MONDO:0000837", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Disease", + "predicate": "biolink:causes", + "subject_id": "UMLS:C1155230", + "object_id": "UMLS:C1155247", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" + } + ] + }, + { + "subject_category": "biolink:Cell", + "object_category": "biolink:Disease", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0879593", + "object_id": "MONDO:0006892", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PopulationOfIndividualOrganisms", + "predicate": "biolink:causes", + "subject_id": "CHEBI:47775", + "object_id": "UMLS:C0240321", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PopulationOfIndividualOrganisms", + "predicate": "biolink:causes", + "subject_id": "CHEBI:16236", + "object_id": "UMLS:C0238711", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Gene", + "object_category": "biolink:PopulationOfIndividualOrganisms", + "predicate": "biolink:causes", + "subject_id": "NCBIGene:129831", + "object_id": "UMLS:C0240321", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:Cell", "object_category": "biolink:PhysiologicalProcess", @@ -19815,8 +19867,8 @@ "subject_category": "biolink:DiseaseOrPhenotypicFeature", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "OMIM:MTHU067598", - "object_id": "NCBIGene:388389", + "subject_id": "UMLS:C0033213", + "object_id": "NCBIGene:100996939", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19866,8 +19918,8 @@ "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEBI:18154", - "object_id": "UMLS:C0260581", + "subject_id": "CHEBI:16684", + "object_id": "UMLS:C0549255", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19880,15 +19932,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "CHEBI:16412", - "object_id": "CHV:0000042589", + "subject_id": "CHEBI:144351", + "object_id": "UMLS:C1572543", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -19898,10 +19950,10 @@ }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0034917", - "object_id": "UMLS:C0543421", + "subject_id": "HP:0001518", + "object_id": "UMLS:C0078479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19909,7 +19961,24 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Gene", + "object_category": "biolink:Food", + "predicate": "biolink:causes", + "subject_id": "NCBIGene:1071", + "object_id": "UMLS:C0597423", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" } ] }, @@ -19948,11 +20017,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Drug", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "HP:0001518", - "object_id": "UMLS:C0078479", + "subject_id": "RXCUI:237976", + "object_id": "UMLS:C0353942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19960,15 +20029,15 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Food", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1071", + "subject_id": "UMLS:C0006494", "object_id": "UMLS:C0597423", "qualifiers": [ { @@ -19982,28 +20051,58 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Food", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010762", - "object_id": "UMLS:C0012171", + "subject_id": "CHEBI:16412", + "object_id": "CHV:0000042589", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Food", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0597423", + "subject_id": "NCBIGene:4856", + "object_id": "DRUGBANK:DB00030", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" + } + ] + }, + { + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0677040", + "object_id": "UMLS:C0243192", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:PhenotypicFeature", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0034917", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20011,7 +20110,24 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Procedure", + "object_category": "biolink:PhenotypicFeature", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0054889", + "object_id": "UMLS:C0518031", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" } ] }, @@ -20051,10 +20167,10 @@ }, { "subject_category": "biolink:Procedure", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0054889", - "object_id": "UMLS:C0518031", + "subject_id": "UMLS:C0040669", + "object_id": "UMLS:C0004391", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20066,6 +20182,40 @@ } ] }, + { + "subject_category": "biolink:Procedure", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0032042", + "object_id": "MESH:C082218", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Protein", + "object_category": "biolink:PhenotypicFeature", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0001924", + "object_id": "HP:0003651", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:Drug", "object_category": "biolink:Cohort", @@ -20135,11 +20285,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "MESH:D007371", - "object_id": "HP:0003651", + "subject_id": "CHEBI:17439", + "object_id": "UMLS:C0489482", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20147,7 +20297,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -20155,7 +20305,7 @@ "subject_category": "biolink:Cell", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0018183", + "subject_id": "CL:0000094", "object_id": "UBERON:0008826", "qualifiers": [ { @@ -20202,6 +20352,40 @@ } ] }, + { + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:PhenotypicFeature", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C3849996", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Food", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0008858", + "object_id": "UMLS:C0376596", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:Disease", "object_category": "biolink:Food", @@ -20220,15 +20404,15 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C3849996", + "subject_id": "UBERON:0000125", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -20287,23 +20471,6 @@ } ] }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Event", - "predicate": "biolink:causes", - "subject_id": "CHEBI:17688", - "object_id": "UMLS:C0040537", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:Behavior", @@ -20342,7 +20509,7 @@ "subject_category": "biolink:Drug", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "MESH:C542869", + "subject_id": "RXCUI:237976", "object_id": "UMLS:C0549255", "qualifiers": [ { @@ -20376,7 +20543,7 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:105053", + "subject_id": "CHEBI:2417", "object_id": "UMLS:C0549255", "qualifiers": [ { @@ -20393,7 +20560,7 @@ "subject_category": "biolink:Drug", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", + "subject_id": "RXCUI:219008", "object_id": "UMLS:C0237820", "qualifiers": [ { @@ -20427,8 +20594,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10313163", - "object_id": "UMLS:C0549255", + "subject_id": "CHEBI:133354", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20441,10 +20608,10 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100528023", + "subject_id": "CHV:0000021208", "object_id": "UMLS:C0237820", "qualifiers": [ { @@ -20458,10 +20625,10 @@ ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035191", + "subject_id": "UMLS:C0162326", "object_id": "UMLS:C0237820", "qualifiers": [ { @@ -20475,11 +20642,11 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Device", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040669", - "object_id": "UMLS:C0004391", + "subject_id": "UMLS:C0035191", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20492,15 +20659,15 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Event", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032042", - "object_id": "MESH:C082218", + "subject_id": "CHEBI:17688", + "object_id": "UMLS:C0040537", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -20509,28 +20676,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Protein", - "predicate": "biolink:causes", - "subject_id": "MONDO:0001075", - "object_id": "UMLS:C0920330", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:Protein", + "subject_category": "biolink:Drug", + "object_category": "biolink:Event", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "UMLS:C0012512", + "subject_id": "UMLS:C1874451", + "object_id": "UMLS:C0574035", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20542,23 +20692,6 @@ } ] }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Food", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:2489", - "object_id": "UMLS:C0597423", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, { "subject_category": "biolink:OrganismAttribute", "object_category": "biolink:Food", @@ -20648,8 +20781,8 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010762", - "object_id": "UMLS:C0032846", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0037570", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20657,16 +20790,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Drug", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0543421", - "object_id": "UMLS:C0006494", + "subject_id": "UMLS:C0003015", + "object_id": "UMLS:C0078479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20674,16 +20807,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11294", - "object_id": "UMLS:C1440480", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20696,11 +20829,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:53369", - "object_id": "UMLS:C0597423", + "subject_id": "UMLS:C0543421", + "object_id": "UMLS:C0006494", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20712,45 +20845,11 @@ } ] }, - { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Food", - "predicate": "biolink:causes", - "subject_id": "UBERON:0000125", - "object_id": "UMLS:C0012171", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Food", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0008858", - "object_id": "UMLS:C0376596", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:Cell", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0014597", + "subject_id": "CL:0000066", "object_id": "UMLS:C0012171", "qualifiers": [ { @@ -20764,10 +20863,10 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:156614059", + "subject_id": "UMLS:C0752046", "object_id": "UMLS:C0597423", "qualifiers": [ { @@ -20776,7 +20875,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -20814,23 +20913,6 @@ } ] }, - { - "subject_category": "biolink:Drug", - "object_category": "biolink:Event", - "predicate": "biolink:causes", - "subject_id": "UMLS:C1874451", - "object_id": "UMLS:C0574035", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:MolecularActivity", "object_category": "biolink:PhysiologicalProcess", @@ -20882,23 +20964,6 @@ } ] }, - { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Activity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0237820", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:Activity", @@ -21036,11 +21101,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Gene", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004561", - "object_id": "MESH:D020077", + "subject_id": "NCBIGene:2272", + "object_id": "CHV:0000042589", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21053,11 +21118,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Drug", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "MESH:D005075", - "object_id": "MESH:D020077", + "subject_id": "UMLS:C0002842", + "object_id": "CHV:0000042589", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21070,11 +21135,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UBERON:0000178", - "object_id": "UMLS:C0600465", + "subject_id": "CHEBI:16737", + "object_id": "CHV:0000042589", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21087,11 +21152,11 @@ ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:Drug", + "subject_category": "biolink:Protein", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0238815", - "object_id": "UMLS:C0626053", + "subject_id": "UMLS:C0017968", + "object_id": "CHV:0000042589", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21104,10 +21169,10 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2272", + "subject_id": "UMLS:C0012939", "object_id": "CHV:0000042589", "qualifiers": [ { @@ -21121,11 +21186,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Cell", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002842", - "object_id": "CHV:0000042589", + "subject_id": "CL:0000160", + "object_id": "UMLS:C0718215", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21138,11 +21203,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "CHEBI:16737", - "object_id": "CHV:0000042589", + "subject_id": "MESH:D014158", + "object_id": "UMLS:C0600465", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21155,11 +21220,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "MESH:D015850", - "object_id": "CHV:0000042589", + "subject_id": "UBERON:0000178", + "object_id": "UMLS:C0600465", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21172,11 +21237,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012939", - "object_id": "CHV:0000042589", + "subject_id": "UMLS:C0020969", + "object_id": "UMLS:C0003204", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21189,15 +21254,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0079925", - "object_id": "UMLS:C0678121", + "subject_id": "UMLS:C0238815", + "object_id": "UMLS:C0626053", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -21222,63 +21287,12 @@ } ] }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0002520", - "object_id": "UMLS:C1160534", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Drug", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "CHEBI:28017", - "object_id": "UMLS:C1160534", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:443495", - "object_id": "UMLS:C0812399", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, { "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "NCBIGene:117189", - "object_id": "UMLS:C0074530", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0071500", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21291,11 +21305,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Disease", "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "NCBIGene:470", - "object_id": "UMLS:C0699612", + "subject_id": "MONDO:0000837", + "object_id": "UMLS:C0115137", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21426,40 +21440,6 @@ } ] }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:OrganismTaxon", - "predicate": "biolink:causes", - "subject_id": "MESH:D007371", - "object_id": "MESH:D008925", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Drug", - "object_category": "biolink:OrganismTaxon", - "predicate": "biolink:causes", - "subject_id": "MESH:D000681", - "object_id": "UMLS:C0718215", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:OrganismTaxon", @@ -21566,8 +21546,8 @@ "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "HP:0032326", - "object_id": "UMLS:C1295823", + "subject_id": "UMLS:C0516981", + "object_id": "UMLS:C0718215", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21580,28 +21560,28 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Drug", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "MONDO:0000490", - "object_id": "UMLS:C0240035", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C0718215", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Protein", + "subject_category": "biolink:Protein", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0812399", - "object_id": "UMLS:C0006938", + "subject_id": "UMLS:C0002520", + "object_id": "UMLS:C1160534", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21614,11 +21594,11 @@ ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Drug", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "CHEBI:8027", + "subject_id": "UMLS:C0003015", + "object_id": "UMLS:C0812399", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21626,21 +21606,72 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015259", - "object_id": "UMLS:C0021665", + "subject_id": "CHEBI:2361", + "object_id": "UMLS:C0812399", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Disease", + "object_category": "biolink:Procedure", + "predicate": "biolink:causes", + "subject_id": "MONDO:0000490", + "object_id": "UMLS:C0240035", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "CHEMBL.TARGET:CHEMBL2095182", + "object_id": "CHEBI:177512", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "stability" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Protein", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "PR:000004191", + "object_id": "PUBCHEM.COMPOUND:6477182", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" + }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -21715,6 +21746,40 @@ } ] }, + { + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:ChemicalEntity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0677040", + "object_id": "CHEBI:8027", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Behavior", + "predicate": "biolink:causes", + "subject_id": "MESH:D000086942", + "object_id": "UMLS:C0870509", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:Cohort", "object_category": "biolink:Drug", @@ -21750,19 +21815,19 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Food", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0870509", + "subject_id": "UMLS:C0078479", + "object_id": "UMLS:C0872084", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -21783,6 +21848,23 @@ } ] }, + { + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0598962", + "object_id": "UMLS:C0003289", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, { "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:Behavior", @@ -21932,7 +22014,7 @@ "subject_category": "biolink:Cell", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007600", + "subject_id": "CL:0000084", "object_id": "MESH:D000086942", "qualifiers": [ { @@ -21966,8 +22048,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:453626", - "object_id": "MESH:D000086942", + "subject_id": "CHEBI:30251", + "object_id": "UMLS:C1520263", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21983,8 +22065,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "MESH:D015850", - "object_id": "UMLS:C1520988", + "subject_id": "UMLS:C0001271", + "object_id": "MESH:D011992", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -22082,15 +22164,15 @@ ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907589", - "object_id": "CHEMBL.COMPOUND:CHEMBL3707250", + "subject_id": "UMLS:C0021167", + "object_id": "UBERON:0004590", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -22099,11 +22181,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0021167", - "object_id": "UBERON:0004590", + "subject_id": "UMLS:C0015919", + "object_id": "MONDO:0005271", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -22149,40 +22231,6 @@ } ] }, - { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:Disease", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "MONDO:0005271", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:GeneFamily", - "object_category": "biolink:ChemicalEntity", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2094111", - "object_id": "CHEMBL.COMPOUND:CHEMBL1201454", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Publication", @@ -22252,15 +22300,15 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Protein", + "subject_category": "biolink:GeneFamily", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2217", - "object_id": "UNII:961YV2O515", + "subject_id": "CHEMBL.TARGET:CHEMBL2363062", + "object_id": "UNII:2ZT81PV5UM", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -22268,23 +22316,6 @@ } ] }, - { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:SmallMolecule", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2111464", - "object_id": "CHEBI:177512", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:Gene", "object_category": "biolink:SmallMolecule", @@ -22319,26 +22350,9 @@ } ] }, - { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Protein", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0019868", - "object_id": "UNII:D7RD81HE4W", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:GeneFamily", - "object_category": "biolink:ChemicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", "subject_id": "CHEMBL.TARGET:CHEMBL2095181", "object_id": "UNII:7GDW9S3GN3", @@ -22355,32 +22369,15 @@ }, { "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:Protein", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907598", - "object_id": "UNII:8202AY8I7H", + "subject_id": "CHEMBL.TARGET:CHEMBL3831282", + "object_id": "UNII:4S0HBYW6QE", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:Protein", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364181", - "object_id": "UNII:X8R2D92QP1", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" - }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -22388,58 +22385,32 @@ ] }, { - "subject_category": "biolink:GeneFamily", - "object_category": "biolink:Protein", + "subject_category": "biolink:Pathway", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364696", - "object_id": "UNII:UY9LQ8P6HW", + "subject_id": "GO:0000075", + "object_id": "GO:0044770", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:6616", - "object_id": "CHEMBL.COMPOUND:CHEMBL3707322", + "subject_id": "GO:0005634", + "object_id": "GO:0000280", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "degradation" - } - ] - }, - { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "GO:0000104", - "object_id": "GO:1904231", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] - }, - { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "GO:0000104", - "object_id": "GO:1904230", - "qualifiers": [ + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, @@ -22447,8 +22418,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "UMLS:C0178587", + "subject_id": "UMLS:C0001060", + "object_id": "UMLS:C0806909", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -22498,8 +22469,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C0175895", + "subject_id": "CHV:0000038439", + "object_id": "UMLS:C0178587", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -22512,71 +22483,49 @@ ] }, { - "subject_category": "biolink:Pathway", + "subject_category": "biolink:Protein", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0000075", - "object_id": "GO:1901977", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" - } - ] - }, - { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0162404", - "object_id": "UMLS:C4235467", + "subject_id": "UMLS:C0002520", + "object_id": "GO:0010252", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] - }, - { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0162404", - "object_id": "UMLS:C4235468", - "qualifiers": [ + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Pathway", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0000075", - "object_id": "GO:1901978", + "subject_id": "GO:0000104", + "object_id": "GO:1904230", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "GO:0005634", - "object_id": "GO:0000280", + "subject_id": "CHEBI:71226", + "object_id": "GO:0009279", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -22618,8 +22567,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "MESH:D015850", - "object_id": "SMPDB:SMP0063813", + "subject_id": "UMLS:C0001271", + "object_id": "SMPDB:SMP0000477", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -22635,7 +22584,7 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "CHEBI:27732", + "subject_id": "CHEBI:25016", "object_id": "GO:0000077", "qualifiers": [ { @@ -22675,15 +22624,28 @@ ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:Pathway", + "object_category": "biolink:Pathway", + "predicate": "biolink:causes", + "subject_id": "GO:0000165", + "object_id": "GO:0090080", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D055550", - "object_id": "GO:0031648", + "subject_id": "GO:0000104", + "object_id": "GO:1904231", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "upregulated" } ] }, @@ -22701,11 +22663,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UniProtKB:P0DMV8", - "object_id": "REACT:R-HSA-192746", + "subject_id": "GO:0000709", + "object_id": "UMLS:C2755867", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -22739,6 +22701,19 @@ } ] }, + { + "subject_category": "biolink:Protein", + "object_category": "biolink:MolecularActivity", + "predicate": "biolink:causes", + "subject_id": "UniProtKB:P0DMV8", + "object_id": "REACT:R-HSA-192746", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" + } + ] + }, { "subject_category": "biolink:Disease", "object_category": "biolink:BiologicalProcess", @@ -22757,10 +22732,10 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033684", + "subject_id": "MESH:C019760", "object_id": "GO:0006401", "qualifiers": [ { @@ -22791,10 +22766,10 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:C019760", + "subject_id": "CHV:0000021208", "object_id": "GO:0006401", "qualifiers": [ { @@ -22808,10 +22783,10 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:71306834", + "subject_id": "UNII:43K1W2T1M6", "object_id": "GO:0006401", "qualifiers": [ { @@ -22825,19 +22800,15 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:NamedThing", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:168009910", - "object_id": "GO:0006757", + "subject_id": "MESH:D055550", + "object_id": "GO:0031648", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, @@ -22845,21 +22816,21 @@ "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0000709", - "object_id": "UMLS:C2755867", + "subject_id": "GO:0000336", + "object_id": "UMLS:C1817270", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Disease", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0001514", - "object_id": "UMLS:C4235960", + "subject_id": "MONDO:0000837", + "object_id": "UMLS:C1160588", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -22868,19 +22839,28 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:134129842", - "object_id": "GO:0009279", + "subject_id": "UMLS:C0162404", + "object_id": "UMLS:C4235467", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:MolecularActivity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0162404", + "object_id": "UMLS:C4235468", + "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, @@ -22915,11 +22895,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Pathway", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0027540", - "object_id": "GO:0010940", + "subject_id": "GO:0086095", + "object_id": "GO:0015467", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -22927,19 +22907,6 @@ } ] }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:10019", - "object_id": "GO:0035162", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" - } - ] - }, { "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:BiologicalProcess", @@ -22968,10 +22935,10 @@ }, { "subject_category": "biolink:Gene", - "object_category": "biolink:Pathway", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:4208", - "object_id": "GO:0098989", + "subject_id": "NCBIGene:10019", + "object_id": "GO:0035162", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -22996,158 +22963,22 @@ "subject_category": "biolink:Gene", "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10019", - "object_id": "GO:0038163", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "CHEBI:15428", - "object_id": "GO:0039703", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Disease", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "MONDO:0002459", - "object_id": "UMLS:C1326508", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" - } - ] - }, - { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "NCBIGene:10216", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Pathway", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "GO:0000077", - "object_id": "NCBIGene:11073", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "NCBIGene:3497", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "UBERON:0001236", - "object_id": "NCBIGene:1029", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "HGNC:39025", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0012872", - "object_id": "NCBIGene:10524", + "subject_id": "NCBIGene:4208", + "object_id": "GO:0098989", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:Gene", + "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017654", - "object_id": "NCBIGene:472", + "subject_id": "NCBIGene:10019", + "object_id": "GO:0038163", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "decreased" @@ -23155,11 +22986,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Gene", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0443611", - "object_id": "NCBIGene:4240", + "subject_id": "CHEBI:15428", + "object_id": "GO:0039703", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23167,16 +22998,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Gene", + "subject_category": "biolink:Disease", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0035162", - "object_id": "NCBIGene:10019", + "subject_id": "MONDO:0000837", + "object_id": "UMLS:C1160587", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -23185,28 +23016,24 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "NCBIGene:1109", + "subject_id": "GO:0015467", + "object_id": "GO:0086095", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:ChemicalMixture", + "subject_category": "biolink:PhysicalEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "NCBIGene:19", + "subject_id": "UMLS:C0015919", + "object_id": "NCBIGene:10777", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23214,50 +23041,54 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Cell", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C1511997", - "object_id": "NCBIGene:10413", + "subject_id": "UMLS:C0443611", + "object_id": "NCBIGene:4240", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:ChemicalMixture", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0006486", - "object_id": "NCBIGene:9528", + "subject_id": "CHEBI:25614", + "object_id": "NCBIGene:19", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:ChemicalMixture", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:121493436", - "object_id": "NCBIGene:7276", + "subject_id": "CHEBI:25614", + "object_id": "HGNC:12696", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23266,11 +23097,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UNII:0A6JH35GMQ", - "object_id": "NCBIGene:6616", + "subject_id": "UMLS:C0005938", + "object_id": "NCBIGene:10216", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23278,20 +23109,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11029", - "object_id": "NCBIGene:116443", + "subject_id": "UBERON:0008826", + "object_id": "NCBIGene:1109", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23317,28 +23148,28 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:IndividualOrganism", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UNII:961YV2O515", - "object_id": "NCBIGene:2217", + "subject_id": "UMLS:C0677040", + "object_id": "NCBIGene:1026", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:IndividualOrganism", + "subject_category": "biolink:Gene", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "NCBIGene:1806", + "subject_id": "NCBIGene:1154", + "object_id": "UMLS:C0314621", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23354,25 +23185,21 @@ "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0006401", - "object_id": "NCBIGene:10045", + "subject_id": "GO:0035162", + "object_id": "NCBIGene:10019", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MONDO:0008000", - "object_id": "NCBIGene:114548", + "subject_id": "MESH:D000086942", + "object_id": "HGNC:39025", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23380,33 +23207,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Device", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "HGNC:12696", + "subject_id": "UMLS:C0450138", + "object_id": "NCBIGene:7040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Publication", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "NCBIGene:10653", + "subject_id": "UMLS:C0017654", + "object_id": "NCBIGene:472", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23414,16 +23241,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysicalEntity", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "NCBIGene:10777", + "subject_id": "MESH:D008925", + "object_id": "NCBIGene:3497", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23452,12 +23279,12 @@ "subject_category": "biolink:Pathway", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0019722", - "object_id": "NCBIGene:2769", + "subject_id": "GO:0000077", + "object_id": "NCBIGene:11073", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23466,15 +23293,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:132233", - "object_id": "NCBIGene:6530", + "subject_id": "UMLS:C1511997", + "object_id": "NCBIGene:10413", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23483,41 +23310,24 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL3707322", - "object_id": "NCBIGene:6616", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:64317", - "object_id": "NCBIGene:6647", + "subject_id": "GO:0006486", + "object_id": "NCBIGene:9528", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:IndividualOrganism", + "subject_category": "biolink:Disease", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "NCBIGene:1026", + "subject_id": "MONDO:0000837", + "object_id": "NCBIGene:796", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23525,16 +23335,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1154", - "object_id": "UMLS:C0314621", + "subject_id": "CHEBI:3160", + "object_id": "NCBIGene:6616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23542,16 +23352,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0450138", - "object_id": "NCBIGene:7040", + "subject_id": "UMLS:C0012872", + "object_id": "NCBIGene:10524", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23564,11 +23374,11 @@ ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:Publication", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0058928", - "object_id": "NCBIGene:9308", + "subject_id": "UMLS:C0599740", + "object_id": "NCBIGene:10653", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23581,15 +23391,15 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C1115729", - "object_id": "NCBIGene:2357", + "subject_id": "CHEBI:135925", + "object_id": "NCBIGene:6530", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "expression" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23598,15 +23408,15 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005456", - "object_id": "UMLS:C0314621", + "subject_id": "CHEBI:51063", + "object_id": "NCBIGene:6530", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "expression" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23615,28 +23425,28 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:15365", - "object_id": "NCBIGene:4609", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3707322", + "object_id": "NCBIGene:6616", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHV:0000042589", - "object_id": "NCBIGene:2272", + "subject_id": "CHEBI:31453", + "object_id": "NCBIGene:6647", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "stability" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23645,24 +23455,28 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Pathway", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:10125", - "object_id": "NCBIGene:2554", + "subject_id": "GO:0019722", + "object_id": "NCBIGene:2769", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UBERON:0002481", - "object_id": "NCBIGene:5290", + "subject_id": "GO:0006401", + "object_id": "NCBIGene:10045", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23670,20 +23484,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:Procedure", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:24424", - "object_id": "NCBIGene:117159", + "subject_id": "UMLS:C0058928", + "object_id": "NCBIGene:9308", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23692,28 +23506,32 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Protein", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "REACT:R-HSA-9825751", - "object_id": "NCBIGene:23411", + "subject_id": "UMLS:C0005456", + "object_id": "UMLS:C0314621", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:50114", - "object_id": "UMLS:C0314614", + "subject_id": "UMLS:C1115729", + "object_id": "NCBIGene:2357", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23722,50 +23540,58 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL3545206", - "object_id": "NCBIGene:5027", + "subject_id": "CHEBI:145499", + "object_id": "NCBIGene:116443", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:IndividualOrganism", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:193860", - "object_id": "NCBIGene:5553", + "subject_id": "UMLS:C0677040", + "object_id": "NCBIGene:1806", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:NamedThing", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:64312", - "object_id": "NCBIGene:116443", + "subject_id": "CHV:0000042589", + "object_id": "NCBIGene:2272", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2108287", - "object_id": "NCBIGene:5578", + "subject_id": "UNII:0IEO0F56LV", + "object_id": "NCBIGene:7276", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23778,15 +23604,15 @@ ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017191", - "object_id": "NCBIGene:56477", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2108287", + "object_id": "NCBIGene:5578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "expression" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23798,16 +23624,12 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:176399", - "object_id": "NCBIGene:255738", + "subject_id": "CHEBI:10125", + "object_id": "NCBIGene:2554", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "activity" } ] }, @@ -23829,15 +23651,15 @@ ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0238686", - "object_id": "NCBIGene:2532", + "subject_id": "CHEMBL.COMPOUND:CHEMBL4650434", + "object_id": "NCBIGene:133", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "stability" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23846,32 +23668,36 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL4650434", - "object_id": "NCBIGene:133", + "subject_id": "UBERON:0002481", + "object_id": "NCBIGene:5290", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Pathway", + "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0038163", - "object_id": "NCBIGene:10019", + "subject_id": "UBERON:0006907", + "object_id": "NCBIGene:27", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -23879,25 +23705,25 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:31947", - "object_id": "NCBIGene:2520", + "subject_id": "UNII:86Q357L16B", + "object_id": "NCBIGene:117159", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "synthesis" + "qualifier_value": "stability" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Publication", + "subject_category": "biolink:PopulationOfIndividualOrganisms", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C1301821", - "object_id": "NCBIGene:2168", + "subject_id": "UMLS:C0238686", + "object_id": "NCBIGene:2532", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -23910,32 +23736,32 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "RXCUI:1441688", - "object_id": "NCBIGene:2243", + "subject_id": "CHEBI:50114", + "object_id": "UMLS:C0314614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:21850", - "object_id": "NCBIGene:5139", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3545221", + "object_id": "NCBIGene:729230", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "activity" } ] }, @@ -23943,46 +23769,38 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:25567", - "object_id": "NCBIGene:3043", + "subject_id": "CHEBI:193860", + "object_id": "NCBIGene:5553", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "molecular_modification" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:453626", - "object_id": "NCBIGene:545", + "subject_id": "CHEBI:64312", + "object_id": "NCBIGene:116443", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Disease", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C4552608", - "object_id": "MONDO:0005044", + "subject_id": "CHEBI:176399", + "object_id": "NCBIGene:255738", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "expression" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -23991,28 +23809,24 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "HGNC:12529", - "object_id": "UMLS:C0806909", + "subject_id": "CHEBI:4667", + "object_id": "NCBIGene:29126", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:132952", - "object_id": "UMLS:C0017654", + "subject_id": "UMLS:C0017191", + "object_id": "NCBIGene:56477", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24025,33 +23839,25 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:100241", - "object_id": "UMLS:C0449238", + "subject_id": "CHEBI:6078", + "object_id": "NCBIGene:1139", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Pathway", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C0449238", + "subject_id": "GO:0038163", + "object_id": "NCBIGene:10019", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "decreased" @@ -24059,32 +23865,32 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Protein", + "subject_category": "biolink:Publication", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C0030956", + "subject_id": "UMLS:C1301821", + "object_id": "NCBIGene:2168", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "MESH:D013482", + "subject_id": "CHEBI:31947", + "object_id": "NCBIGene:2520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "synthesis" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -24093,15 +23899,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "UMLS:C0806909", + "subject_id": "CHEBI:25567", + "object_id": "NCBIGene:3043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "molecular_modification" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -24110,15 +23916,15 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188830", - "object_id": "UMLS:C0080129", + "subject_id": "UMLS:C0003618", + "object_id": "UMLS:C0039795", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -24127,10 +23933,10 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10313163", + "subject_id": "HGNC:12529", "object_id": "UMLS:C0806909", "qualifiers": [ { @@ -24161,15 +23967,28 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003618", - "object_id": "UMLS:C0039795", + "subject_id": "DRUGBANK:DB00030", + "object_id": "NCBIGene:4856", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" + } + ] + }, + { + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Gene", + "predicate": "biolink:causes", + "subject_id": "CHEBI:31453", + "object_id": "UMLS:C0314621", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -24178,11 +23997,11 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Procedure", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D055432", - "object_id": "UMLS:C0023690", + "subject_id": "CHEBI:132952", + "object_id": "UMLS:C0017654", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24190,16 +24009,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Procedure", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005612", - "object_id": "UMLS:C0087111", + "subject_id": "CHEBI:100246", + "object_id": "UMLS:C0017654", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24207,16 +24026,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Device", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:23405", - "object_id": "UMLS:C1552216", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0178587", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24229,45 +24048,45 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Drug", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16247", - "object_id": "UMLS:C0426688", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:100241", - "object_id": "UMLS:C0026687", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C0030956", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100381270", - "object_id": "UMLS:C0543421", + "subject_id": "UMLS:C0015919", + "object_id": "UMLS:C0002520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24275,15 +24094,15 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Gene", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", + "subject_id": "NCBIGene:100381270", "object_id": "UMLS:C0543421", "qualifiers": [ { @@ -24297,11 +24116,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:16247", - "object_id": "UMLS:C0034917", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24314,10 +24133,10 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010762", + "subject_id": "CHEBI:16247", "object_id": "UMLS:C0034917", "qualifiers": [ { @@ -24331,11 +24150,11 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:26125", - "object_id": "UMLS:C0543421", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24374,45 +24193,45 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Disease", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "MONDO:0005468", + "subject_id": "UMLS:C0086908", + "object_id": "UMLS:C0162806", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0718215", - "object_id": "HP:0100678", + "subject_id": "CHEBI:133354", + "object_id": "UMLS:C1510470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:D009154", - "object_id": "HP:0045047", + "subject_id": "CHEBI:135590", + "object_id": "UMLS:C0026687", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24425,11 +24244,28 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017952", - "object_id": "UMLS:C0034917", + "subject_id": "CHEBI:10033", + "object_id": "UMLS:C0871470", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Procedure", + "predicate": "biolink:causes", + "subject_id": "NCIT:C49019", + "object_id": "UMLS:C0023690", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24442,11 +24278,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "UMLS:C0034917", + "subject_id": "UMLS:C0005612", + "object_id": "UMLS:C0087111", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24459,11 +24295,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Gene", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010423", - "object_id": "HP:0045047", + "subject_id": "NCBIGene:23405", + "object_id": "UMLS:C1552216", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24476,11 +24312,28 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Disease", + "predicate": "biolink:causes", + "subject_id": "UMLS:C4552608", + "object_id": "MONDO:0005044", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0205082", - "object_id": "HP:0045047", + "subject_id": "UMLS:C0005938", + "object_id": "HP:0000938", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24493,11 +24346,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2489", - "object_id": "UMLS:C0543421", + "subject_id": "UBERON:0008826", + "object_id": "MONDO:0005468", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24510,11 +24363,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Disease", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1555", - "object_id": "UMLS:C0687133", + "subject_id": "UMLS:C0017952", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24527,15 +24380,15 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Disease", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11560225", - "object_id": "MONDO:0020724", + "subject_id": "CHV:0000055769", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -24544,11 +24397,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Disease", + "subject_category": "biolink:Cell", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:26523", - "object_id": "MONDO:0020724", + "subject_id": "CL:0000084", + "object_id": "HP:0045047", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24561,15 +24414,15 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Disease", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010798", - "object_id": "UMLS:C0687133", + "subject_id": "UMLS:C0010423", + "object_id": "HP:0045047", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -24578,15 +24431,15 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Disease", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031715", - "object_id": "MONDO:0020724", + "subject_id": "UMLS:C0205082", + "object_id": "HP:0045047", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -24595,11 +24448,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Disease", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "NCBIGene:114548", - "object_id": "MONDO:0008000", + "subject_id": "UMLS:C0718215", + "object_id": "HP:0100678", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24612,11 +24465,11 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "HGNC:39022", - "object_id": "UMLS:C1515672", + "subject_id": "CHEBI:24870", + "object_id": "UMLS:C1373120", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24629,11 +24482,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Gene", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10033", - "object_id": "UMLS:C1373124", + "subject_id": "HGNC:39022", + "object_id": "UMLS:C1515672", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24646,11 +24499,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:24870", - "object_id": "UMLS:C1373120", + "subject_id": "CHEBI:10033", + "object_id": "UMLS:C1373124", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24700,7 +24553,7 @@ "subject_category": "biolink:Protein", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:D015850", + "subject_id": "UMLS:C0003438", "object_id": "UMLS:C1373124", "qualifiers": [ { @@ -24751,8 +24604,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:168009821", - "object_id": "UMLS:C1515672", + "subject_id": "CHEBI:17833", + "object_id": "UMLS:C1373040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24765,28 +24618,28 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Cell", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010762", - "object_id": "UMLS:C1373040", + "subject_id": "CL:0000023", + "object_id": "UMLS:C1373111", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:28017", - "object_id": "UMLS:C0597832", + "subject_id": "UMLS:C0025513", + "object_id": "UMLS:C0279023", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24794,7 +24647,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -24816,19 +24669,53 @@ ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004561", - "object_id": "UMLS:C1515672", + "subject_id": "UMLS:C0012929", + "object_id": "UMLS:C1373111", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Drug", + "object_category": "biolink:MolecularActivity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0003280", + "object_id": "UMLS:C1373140", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0949469", + "object_id": "UMLS:C1443643", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" } ] }, @@ -24849,11 +24736,28 @@ } ] }, + { + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:MolecularActivity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0752046", + "object_id": "UMLS:C1515672", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, { "subject_category": "biolink:Cell", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0225828", + "subject_id": "CL:0000746", "object_id": "UMLS:C0675244", "qualifiers": [ { @@ -24867,11 +24771,28 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0025513", - "object_id": "UMLS:C0279023", + "subject_id": "UMLS:C0009928", + "object_id": "UMLS:C0003921", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Activity", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0237820", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24884,11 +24805,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0752046", - "object_id": "UMLS:C1515672", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0001637", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24896,16 +24817,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0871470", - "object_id": "UMLS:C0023823", + "subject_id": "UMLS:C0015919", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -24913,20 +24834,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0008813", + "subject_id": "UMLS:C0449238", "object_id": "UMLS:C0023823", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -24985,6 +24906,23 @@ } ] }, + { + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Polypeptide", + "predicate": "biolink:causes", + "subject_id": "MESH:D010578", + "object_id": "UMLS:C0012933", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ChemicalEntity", @@ -25036,23 +24974,6 @@ } ] }, - { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "PUBCHEM.COMPOUND:14228836", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:PopulationOfIndividualOrganisms", @@ -25071,11 +24992,11 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "UMLS:C0205160", - "object_id": "PUBCHEM.COMPOUND:168266306", + "subject_id": "CHEBI:30251", + "object_id": "UMLS:C0238884", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25087,40 +25008,6 @@ } ] }, - { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "PUBCHEM.COMPOUND:6096946", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "NCBITaxon:5052", - "object_id": "PUBCHEM.COMPOUND:76957227", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, { "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:ChemicalEntity", @@ -25138,23 +25025,6 @@ } ] }, - { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:causes", - "subject_id": "GO:0009279", - "object_id": "PUBCHEM.COMPOUND:134129842", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, { "subject_category": "biolink:Gene", "object_category": "biolink:Procedure", @@ -25173,10 +25043,10 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:24261", + "subject_id": "CHEBI:135864", "object_id": "MESH:C510163", "qualifiers": [ { @@ -25190,10 +25060,10 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "RXCUI:1596453", + "subject_id": "CHEBI:24261", "object_id": "MESH:C510163", "qualifiers": [ { @@ -25207,10 +25077,10 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Drug", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:23663977", + "subject_id": "RXCUI:1596453", "object_id": "MESH:C510163", "qualifiers": [ { @@ -25292,15 +25162,15 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Gene", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "UMLS:C0030012", + "subject_id": "NCBIGene:1555", + "object_id": "UMLS:C0687133", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -25309,15 +25179,15 @@ ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0238711", - "object_id": "UMLS:C0242402", + "subject_id": "CHEBI:137694", + "object_id": "MONDO:0020724", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -25326,15 +25196,15 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "CHEBI:60027", - "object_id": "MESH:D021982", + "subject_id": "CHEBI:26523", + "object_id": "MONDO:0020724", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -25343,15 +25213,15 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Protein", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599946", - "object_id": "UMLS:C0001272", + "subject_id": "UMLS:C0010762", + "object_id": "UMLS:C0687133", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -25360,11 +25230,11 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "GO:0006757", - "object_id": "PUBCHEM.COMPOUND:168009910", + "subject_id": "UMLS:C0031715", + "object_id": "MONDO:0020724", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25377,11 +25247,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Gene", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017127", - "object_id": "UMLS:C0001060", + "subject_id": "NCBIGene:114548", + "object_id": "MONDO:0008000", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25394,11 +25264,11 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0001413", + "subject_id": "GO:0006308", + "object_id": "UMLS:C0019054", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25411,15 +25281,15 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Disease", + "subject_category": "biolink:Drug", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "GO:0006308", - "object_id": "UMLS:C0019054", + "subject_id": "UMLS:C1443643", + "object_id": "UMLS:C0019868", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -25428,15 +25298,32 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004793", - "object_id": "UMLS:C0012872", + "subject_id": "UMLS:C0908045", + "object_id": "UMLS:C0019868", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:Activity", + "object_category": "biolink:Phenomenon", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0035028", + "object_id": "UMLS:C0019868", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -25462,10 +25349,10 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "CHEBI:15552", + "subject_id": "CHEBI:17087", "object_id": "UMLS:C0599740", "qualifiers": [ { @@ -25496,10 +25383,10 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Drug", "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "CHEBI:17087", + "subject_id": "UMLS:C0003286", "object_id": "UMLS:C0599740", "qualifiers": [ { @@ -25513,10 +25400,10 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003286", + "subject_id": "CHEBI:15552", "object_id": "UMLS:C0599740", "qualifiers": [ { @@ -25530,10 +25417,10 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "MESH:D008049", + "subject_id": "CHEBI:4462", "object_id": "UMLS:C0599740", "qualifiers": [ { @@ -25542,7 +25429,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -25564,10 +25451,10 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Protein", "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10013", + "subject_id": "UMLS:C0002272", "object_id": "UMLS:C0599740", "qualifiers": [ { @@ -25581,10 +25468,10 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Gene", "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "CHEBI:15627", + "subject_id": "NCBIGene:10013", "object_id": "UMLS:C0599740", "qualifiers": [ { @@ -25598,10 +25485,10 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11560225", + "subject_id": "CHEBI:15627", "object_id": "UMLS:C0599740", "qualifiers": [ { @@ -25615,10 +25502,10 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:9887054", + "subject_id": "CHEBI:137694", "object_id": "UMLS:C0599740", "qualifiers": [ { @@ -25700,45 +25587,45 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Publication", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010762", - "object_id": "UMLS:C0599740", + "subject_id": "CHEBI:24261", + "object_id": "UMLS:C0079686", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Publication", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "NCBIGene:57762", - "object_id": "UMLS:C0599740", + "subject_id": "CHEBI:15367", + "object_id": "UMLS:C0079686", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Activity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C3827014", + "subject_id": "UMLS:C0599946", + "object_id": "UMLS:C0001272", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25785,28 +25672,28 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Publication", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0079925", + "subject_id": "UMLS:C1301821", + "object_id": "UMLS:C0002763", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Food", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0043076", - "object_id": "UMLS:C0600680", + "subject_id": "UMLS:C0597423", + "object_id": "UMLS:C0003072", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25820,10 +25707,10 @@ }, { "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Polypeptide", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "UMLS:C0001060", + "subject_id": "UMLS:C0718215", + "object_id": "UMLS:C1709375", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25836,11 +25723,11 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Event", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "UMLS:C0012924", + "subject_id": "UMLS:C0040537", + "object_id": "MESH:D000936", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25853,28 +25740,28 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "UMLS:C1101610", + "subject_id": "UMLS:C0031911", + "object_id": "UMLS:C0003448", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C1515508", - "object_id": "UMLS:C0600680", + "subject_id": "CHEBI:52492", + "object_id": "NCBITaxon:5052", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25887,11 +25774,28 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Device", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "CHEBI:24261", - "object_id": "UMLS:C0079686", + "subject_id": "UMLS:C0115137", + "object_id": "MONDO:0000837", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:NucleicAcidEntity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0012872", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25904,10 +25808,27 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Device", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0806909", + "object_id": "UMLS:C0037111", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:15367", + "subject_id": "CHEBI:4462", "object_id": "UMLS:C0079686", "qualifiers": [ { @@ -25921,15 +25842,15 @@ ] }, { - "subject_category": "biolink:IndividualOrganism", + "subject_category": "biolink:PopulationOfIndividualOrganisms", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "MESH:D000110", + "subject_id": "UMLS:C0238711", + "object_id": "UMLS:C0242402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -25938,28 +25859,28 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C4748586", - "object_id": "UMLS:C0001060", + "subject_id": "CHEBI:60027", + "object_id": "MESH:D021982", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "MONDO:0002050", - "object_id": "UMLS:C0001060", + "subject_id": "UMLS:C1099354", + "object_id": "MESH:D008925", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25972,11 +25893,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D015164", - "object_id": "UMLS:C0001060", + "subject_id": "UMLS:C0185624", + "object_id": "UMLS:C0026649", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -25989,11 +25910,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Procedure", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C1160534", - "object_id": "UMLS:C0001413", + "subject_id": "UMLS:C0032042", + "object_id": "UMLS:C0027880", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26006,15 +25927,15 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:Drug", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1301821", - "object_id": "UMLS:C0002763", + "subject_id": "UMLS:C3541329", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26023,11 +25944,11 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Device", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597423", - "object_id": "UMLS:C0003072", + "subject_id": "UMLS:C1517336", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26035,20 +25956,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Protein", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0718215", - "object_id": "UMLS:C1709375", + "subject_id": "UMLS:C0009630", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26057,15 +25978,15 @@ ] }, { - "subject_category": "biolink:Event", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040537", - "object_id": "MESH:D000936", + "subject_id": "NCBIGene:19", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26074,11 +25995,11 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Drug", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031911", - "object_id": "UMLS:C0003448", + "subject_id": "UMLS:C0079160", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26091,11 +26012,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:76957227", - "object_id": "NCBITaxon:5052", + "subject_id": "UMLS:C0232407", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26108,11 +26029,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Protein", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0162326", - "object_id": "MESH:D020077", + "subject_id": "UMLS:C0016006", + "object_id": "CHEBI:61452", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26125,28 +26046,28 @@ ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "UMLS:C0006556", + "subject_id": "CHEBI:142437", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012931", - "object_id": "UMLS:C1511997", + "subject_id": "HP:0001945", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26159,11 +26080,11 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Disease", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "CHV:0000042589", - "object_id": "UMLS:C0012939", + "subject_id": "MONDO:0002459", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26176,15 +26097,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Disease", + "subject_category": "biolink:Cell", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010762", - "object_id": "UMLS:C0687133", + "subject_id": "CL:0000084", + "object_id": "CHEBI:25614", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26193,11 +26114,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Protein", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:453626", - "object_id": "UMLS:C0002198", + "subject_id": "CHEBI:25614", + "object_id": "UMLS:C0030012", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26210,15 +26131,15 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Drug", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012872", - "object_id": "UMLS:C0080065", + "subject_id": "UMLS:C0013227", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26227,11 +26148,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Drug", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020964", - "object_id": "UMLS:C0919262", + "subject_id": "UMLS:C0013227", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26239,16 +26160,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0079925", + "subject_id": "CHEBI:5781", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26256,37 +26177,37 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Polypeptide", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "UMLS:C0079925", + "subject_id": "UMLS:C1304649", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1443643", - "object_id": "UMLS:C0019868", + "subject_id": "UBERON:0000043", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26295,11 +26216,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Device", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0908045", - "object_id": "UMLS:C0019868", + "subject_id": "UMLS:C0699612", + "object_id": "CHEBI:61452", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26313,14 +26234,14 @@ }, { "subject_category": "biolink:Activity", - "object_category": "biolink:Phenomenon", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035028", - "object_id": "UMLS:C0019868", + "subject_id": "UMLS:C0599946", + "object_id": "CHEBI:61452", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26329,11 +26250,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Device", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UNII:D7RD81HE4W", - "object_id": "UMLS:C0019868", + "subject_id": "UMLS:C0032616", + "object_id": "CHEBI:61452", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26341,16 +26262,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1099354", - "object_id": "MESH:D008925", + "subject_id": "MESH:D010578", + "object_id": "CHEBI:61452", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26363,11 +26284,11 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0185624", - "object_id": "UMLS:C0026649", + "subject_id": "CHEBI:61452", + "object_id": "UMLS:C0032616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26375,46 +26296,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Disease", - "predicate": "biolink:causes", - "subject_id": "GO:0010940", - "object_id": "UMLS:C0027540", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] - }, - { - "subject_category": "biolink:Procedure", - "object_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032042", - "object_id": "UMLS:C0027880", + "subject_id": "GO:0010467", + "object_id": "UMLS:C0032616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C3541329", - "object_id": "CHEBI:25614", + "subject_id": "MESH:D000077215", + "object_id": "UMLS:C0032616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26427,11 +26335,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C1517336", - "object_id": "CHEBI:25614", + "subject_id": "MESH:D010578", + "object_id": "UMLS:C0032616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26439,20 +26347,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Device", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009630", - "object_id": "CHEBI:25614", + "subject_id": "UMLS:C0115137", + "object_id": "UMLS:C0032942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26461,11 +26369,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "NCBIGene:19", - "object_id": "CHEBI:25614", + "subject_id": "UMLS:C0011065", + "object_id": "UMLS:C0033081", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26478,11 +26386,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0079160", - "object_id": "CHEBI:25614", + "subject_id": "CHEBI:133354", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26490,16 +26398,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Protein", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0232407", - "object_id": "CHEBI:60160", + "subject_id": "UMLS:C0001271", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26507,16 +26415,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D008049", - "object_id": "CHEBI:60160", + "subject_id": "CHEBI:10432", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26524,16 +26432,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:142437", - "object_id": "CHEBI:25614", + "subject_id": "MESH:D000077215", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26541,20 +26449,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "HP:0001945", - "object_id": "CHEBI:60160", + "subject_id": "UMLS:C0005615", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26563,15 +26471,15 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Drug", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MONDO:0002459", - "object_id": "CHEBI:25614", + "subject_id": "UMLS:C0001637", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26580,28 +26488,28 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0016030", - "object_id": "CHEBI:61452", + "subject_id": "HP:0001945", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "CHEBI:25614", + "subject_id": "UMLS:C0449238", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26609,16 +26517,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D011095", - "object_id": "CHEBI:25614", + "subject_id": "CHEBI:16247", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26631,11 +26539,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Protein", + "subject_category": "biolink:Gene", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0002481", - "object_id": "UMLS:C0033684", + "subject_id": "NCBIGene:1109", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26648,62 +26556,62 @@ ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "PUBCHEM.COMPOUND:7886", + "subject_id": "UMLS:C1705143", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Protein", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1304649", - "object_id": "CHEBI:60160", + "subject_id": "UMLS:C0001924", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Drug", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000043", - "object_id": "CHEBI:60160", + "subject_id": "UMLS:C0003402", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0699612", - "object_id": "CHEBI:61452", + "subject_id": "UMLS:C0004048", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26711,33 +26619,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599946", - "object_id": "CHEBI:61452", + "subject_id": "MESH:D000088502", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032616", - "object_id": "CHEBI:61452", + "subject_id": "CHEBI:26710", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26751,10 +26659,10 @@ }, { "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:ChemicalMixture", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D010578", - "object_id": "CHEBI:61452", + "subject_id": "MESH:D000077215", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26767,11 +26675,11 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Drug", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "MESH:D011095", + "subject_id": "UMLS:C0026687", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26784,11 +26692,11 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Device", + "subject_category": "biolink:Device", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61452", - "object_id": "UMLS:C0032616", + "subject_id": "UMLS:C0035191", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26801,32 +26709,32 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Device", + "subject_category": "biolink:Disease", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "GO:0010467", - "object_id": "UMLS:C0032616", + "subject_id": "MONDO:0005468", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Device", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D000077215", - "object_id": "UMLS:C0032616", + "subject_id": "MESH:D014158", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26835,28 +26743,28 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Device", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D010578", - "object_id": "UMLS:C0032616", + "subject_id": "UMLS:C0005482", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Behavior", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0115137", - "object_id": "UMLS:C0032942", + "subject_id": "UBERON:0000019", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26869,15 +26777,15 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Publication", + "subject_category": "biolink:Disease", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0011065", - "object_id": "UMLS:C0033081", + "subject_id": "MONDO:0004995", + "object_id": "UMLS:C0022650", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26886,11 +26794,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16412", - "object_id": "UMLS:C1167395", + "subject_id": "NCIT:C49019", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26903,11 +26811,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Behavior", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10022", - "object_id": "MESH:D011387", + "subject_id": "UMLS:C0004268", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26921,10 +26829,10 @@ }, { "subject_category": "biolink:Activity", - "object_category": "biolink:Device", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0035191", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26937,15 +26845,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2108479", - "object_id": "PUBCHEM.COMPOUND:159842316", + "subject_id": "UMLS:C0205161", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -26954,11 +26862,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1328924", - "object_id": "UMLS:C0035736", + "subject_id": "UMLS:C0026687", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -26971,28 +26879,28 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0806909", - "object_id": "UMLS:C0037111", + "subject_id": "GO:0010467", + "object_id": "UBERON:0008826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Activity", + "subject_category": "biolink:Activity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0037680", + "object_id": "UMLS:C0233929", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27005,11 +26913,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Cell", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10432", - "object_id": "UBERON:0008826", + "subject_id": "CL:0000235", + "object_id": "UMLS:C0369078", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27022,10 +26930,10 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D008049", + "subject_id": "UMLS:C0079925", "object_id": "UBERON:0008826", "qualifiers": [ { @@ -27034,20 +26942,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Activity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0237820", + "object_id": "UMLS:C0035191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27056,11 +26964,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:124201532", - "object_id": "UBERON:0008826", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27073,15 +26981,15 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0037680", - "object_id": "UMLS:C0233929", + "subject_id": "CHV:0000042589", + "object_id": "UMLS:C0017968", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27090,15 +26998,15 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005615", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0012872", + "object_id": "UMLS:C0080065", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27107,15 +27015,15 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0024432", - "object_id": "UMLS:C0369078", + "subject_id": "UMLS:C0080129", + "object_id": "UMLS:C1335464", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27124,11 +27032,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "MESH:D000077215", - "object_id": "UBERON:0008826", + "subject_id": "NCBIGene:27", + "object_id": "UBERON:0006907", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27141,11 +27049,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "HP:0001945", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0027100", + "object_id": "UBERON:0006907", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27153,16 +27061,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Food", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0078479", + "object_id": "UBERON:0006908", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27170,16 +27078,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "CHEBI:16247", - "object_id": "UBERON:0008826", + "subject_id": "CHEBI:16684", + "object_id": "UMLS:C0001884", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27192,11 +27100,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1109", - "object_id": "UBERON:0008826", + "subject_id": "CHEBI:72544", + "object_id": "UMLS:C0282515", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27204,16 +27112,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C1705143", - "object_id": "UBERON:0008826", + "subject_id": "UBERON:0006907", + "object_id": "UMLS:C0027100", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27221,33 +27129,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D008049", - "object_id": "UBERON:0008826", + "subject_id": "CHEBI:135923", + "object_id": "PR:000008015", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "stability" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "CHEBI:34674", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0162326", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27260,11 +27168,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004048", - "object_id": "UBERON:0008826", + "subject_id": "CHEBI:4462", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27272,16 +27180,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D000088502", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0696628", + "object_id": "UMLS:C0061928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27289,16 +27197,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:122164822", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0013216", + "object_id": "UMLS:C0302295", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27306,67 +27214,59 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "MESH:D000077215", - "object_id": "UBERON:0008826", + "subject_id": "MESH:D021982", + "object_id": "UMLS:C1621278", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0026687", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C1516324", + "object_id": "MESH:D021982", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Publication", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035191", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C1301821", + "object_id": "UMLS:C0166415", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { "subject_category": "biolink:Disease", - "object_category": "biolink:AnatomicalEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MONDO:0005468", - "object_id": "UBERON:0008826", + "subject_id": "MONDO:0020724", + "object_id": "CHEBI:137694", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27374,16 +27274,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:84565", - "object_id": "UBERON:0008826", + "subject_id": "CHEBI:25614", + "object_id": "UMLS:C1517336", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27391,16 +27291,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Food", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007577", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C1572543", + "object_id": "NCIT:C49019", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27413,15 +27313,15 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005482", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0023690", + "object_id": "NCIT:C49019", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27430,11 +27330,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UBERON:0000019", - "object_id": "UBERON:0008826", + "subject_id": "UBERON:0008826", + "object_id": "NCIT:C49019", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27447,15 +27347,41 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "MONDO:0004995", - "object_id": "UMLS:C0022650", + "subject_id": "GO:0007204", + "object_id": "OBA:0006038", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:NamedThing", + "predicate": "biolink:causes", + "subject_id": "GO:0007042", + "object_id": "OBA:0000091", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" + } + ] + }, + { + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0318759", + "object_id": "UMLS:C0003280", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27464,15 +27390,15 @@ ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D055432", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C1705280", + "object_id": "UBERON:0014374", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27481,32 +27407,32 @@ ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004268", - "object_id": "UBERON:0008826", + "subject_id": "NCIT:C35041", + "object_id": "UMLS:C0032042", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0002085", + "object_id": "MESH:D059365", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27515,11 +27441,11 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0205161", - "object_id": "UBERON:0008826", + "subject_id": "CHEBI:24621", + "object_id": "UMLS:C1511997", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27532,11 +27458,11 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0026687", - "object_id": "UBERON:0008826", + "subject_id": "NCBIGene:10413", + "object_id": "UMLS:C1511997", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27549,28 +27475,28 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "GO:0010467", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0037392", + "object_id": "UMLS:C1330330", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Activity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0079925", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0026606", + "object_id": "UMLS:C0279023", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27578,16 +27504,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Publication", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:907", - "object_id": "UBERON:0008826", + "subject_id": "UMLS:C0033081", + "object_id": "UMLS:C0011065", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27600,28 +27526,28 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "CHEBI:28017", - "object_id": "NCBITaxon:1301", + "subject_id": "CHEBI:134044", + "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysicalEntity", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "MESH:D013482", + "subject_id": "GO:0006346", + "object_id": "UniProtKB:Q9BXT5", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27634,32 +27560,32 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:OrganismAttribute", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:134044", - "object_id": "UMLS:C0020969", + "subject_id": "CHEMBL.TARGET:CHEMBL2095182", + "object_id": "NCIT:C116748", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "MESH:D015164", + "subject_id": "NCBIGene:1544", + "object_id": "UMLS:C1831768", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27668,15 +27594,15 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Cell", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0026606", - "object_id": "UMLS:C0279023", + "subject_id": "CL:0000010", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27685,28 +27611,28 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0080129", - "object_id": "UMLS:C1335464", + "subject_id": "UMLS:C1515464", + "object_id": "UMLS:C1520749", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Disease", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013216", - "object_id": "UMLS:C0302295", + "subject_id": "UMLS:C1515464", + "object_id": "UMLS:C1521630", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27719,15 +27645,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:26523", - "object_id": "UMLS:C0489482", + "subject_id": "CHEMBL.TARGET:CHEMBL4630576", + "object_id": "CHEMBL.COMPOUND:CHEMBL2103797", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27737,10 +27663,10 @@ }, { "subject_category": "biolink:Protein", - "object_category": "biolink:Procedure", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "MESH:D013482", - "object_id": "UMLS:C0521974", + "subject_id": "UMLS:C0015498", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27753,32 +27679,32 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Procedure", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "NCIT:C35041", - "object_id": "UMLS:C0032042", + "subject_id": "UMLS:C0020964", + "object_id": "UMLS:C0879438", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Disease", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "MESH:D059365", + "subject_id": "MONDO:0004992", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27787,15 +27713,15 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Cell", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "NCBIGene:4096", - "object_id": "MESH:D059365", + "subject_id": "CL:0000066", + "object_id": "UMLS:C1520405", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27804,11 +27730,11 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "UBERON:0006908", + "subject_id": "UMLS:C0162326", + "object_id": "UMLS:C1335464", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27821,11 +27747,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "CHEBI:72544", - "object_id": "UMLS:C0282515", + "subject_id": "UMLS:C0600680", + "object_id": "UMLS:C1515508", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27833,20 +27759,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:135923", - "object_id": "PR:000008015", + "subject_id": "UMLS:C1510470", + "object_id": "UMLS:C0279023", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27855,15 +27781,15 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1572543", - "object_id": "MESH:D055432", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C0279023", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27872,15 +27798,15 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0023690", - "object_id": "MESH:D055432", + "subject_id": "MESH:C103123", + "object_id": "UMLS:C2348756", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -27889,11 +27815,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Gene", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "MESH:D055432", + "subject_id": "NCBIGene:10524", + "object_id": "UMLS:C0012872", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27906,37 +27832,45 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "GO:0007204", - "object_id": "OBA:0006038", + "subject_id": "CHEBI:26523", + "object_id": "UMLS:C0012872", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "GO:0007042", - "object_id": "OBA:0000091", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0350056", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:Protein", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "UMLS:C0061928", + "subject_id": "UMLS:C1134718", + "object_id": "UMLS:C0302600", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27944,42 +27878,50 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:D021982", - "object_id": "UMLS:C1621278", + "subject_id": "UMLS:C0015919", + "object_id": "UMLS:C0243102", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Food", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1516324", - "object_id": "MESH:D021982", + "subject_id": "UMLS:C0597423", + "object_id": "UMLS:C0752046", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "UMLS:C1099354", + "subject_id": "UMLS:C0034917", + "object_id": "UMLS:C0752046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -27987,50 +27929,50 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:Protein", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1301821", - "object_id": "UMLS:C0166415", + "subject_id": "UMLS:C0543421", + "object_id": "UMLS:C0752046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0489482", - "object_id": "UMLS:C1144709", + "subject_id": "UMLS:C0020969", + "object_id": "UMLS:C0162327", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MONDO:0020724", - "object_id": "PUBCHEM.COMPOUND:11560225", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0752046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28043,11 +27985,11 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "PUBCHEM.COMPOUND:11560225", + "subject_id": "UMLS:C1515672", + "object_id": "UMLS:C0752046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28060,11 +28002,11 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:25614", - "object_id": "UMLS:C1517336", + "subject_id": "NCIT:C36289", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28072,16 +28014,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C1705280", - "object_id": "UBERON:0014374", + "subject_id": "MONDO:0006892", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28089,50 +28031,50 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:24621", - "object_id": "UMLS:C1511997", + "subject_id": "UMLS:C0023823", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10413", - "object_id": "UMLS:C1511997", + "subject_id": "UMLS:C1704842", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033081", - "object_id": "UMLS:C0011065", + "subject_id": "UMLS:C0162326", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28140,16 +28082,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Protein", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0006346", - "object_id": "UniProtKB:Q9BXT5", + "subject_id": "UMLS:C0009221", + "object_id": "UMLS:C0003319", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28162,11 +28104,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Cell", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "MESH:D015850", - "object_id": "UMLS:C0879438", + "subject_id": "CHEBI:60160", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28179,15 +28121,15 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Cell", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020964", - "object_id": "UMLS:C0879438", + "subject_id": "UMLS:C0015919", + "object_id": "UMLS:C1511518", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -28196,32 +28138,32 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Cell", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "MONDO:0004992", - "object_id": "UMLS:C0879593", + "subject_id": "UMLS:C1373149", + "object_id": "UMLS:C0877248", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1544", - "object_id": "UMLS:C1831768", + "subject_id": "UMLS:C1520625", + "object_id": "UMLS:C1519692", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -28230,11 +28172,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005821", - "object_id": "UMLS:C0543421", + "subject_id": "UMLS:C1519692", + "object_id": "UMLS:C1520625", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28247,28 +28189,28 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "UMLS:C1515464", - "object_id": "UMLS:C1520749", + "subject_id": "UMLS:C1155876", + "object_id": "SMPDB:SMP0000477", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Drug", + "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005773", - "object_id": "UMLS:C1520768", + "subject_id": "UMLS:C0013227", + "object_id": "SMPDB:SMP0063813", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28281,11 +28223,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0600680", - "object_id": "UMLS:C1515508", + "subject_id": "CHEBI:33375", + "object_id": "UMLS:C0523584", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28293,20 +28235,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0162326", - "object_id": "UMLS:C1335464", + "subject_id": "UNII:0IEO0F56LV", + "object_id": "PR:000016801", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -28315,15 +28257,15 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Gene", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C1515464", - "object_id": "UMLS:C1521630", + "subject_id": "NCBIGene:1544", + "object_id": "UMLS:C2684108", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -28332,15 +28274,15 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Protein", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:71306834", - "object_id": "UMLS:C1520698", + "subject_id": "CHEMBL.TARGET:CHEMBL2179", + "object_id": "PUBCHEM.COMPOUND:70697642", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "stability" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -28349,45 +28291,45 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL4296221", - "object_id": "CHEMBL.COMPOUND:CHEMBL4594492", + "subject_id": "UMLS:C0054889", + "object_id": "UMLS:C1331418", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "abundance" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Disease", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL4630576", - "object_id": "CHEMBL.COMPOUND:CHEMBL2103797", + "subject_id": "MONDO:0005271", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "abundance" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C1510470", - "object_id": "UMLS:C0279023", + "subject_id": "UMLS:C0302600", + "object_id": "UMLS:C1134718", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28395,20 +28337,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C0279023", + "subject_id": "MESH:D008928", + "object_id": "UMLS:C5202641", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -28417,11 +28359,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Behavior", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:6104", - "object_id": "UMLS:C3846005", + "subject_id": "UMLS:C0004268", + "object_id": "UMLS:C5202641", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28434,11 +28376,11 @@ ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "UMLS:C0243102", + "subject_id": "UMLS:C0032942", + "object_id": "UMLS:C0115137", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28451,11 +28393,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10524", - "object_id": "UMLS:C0012872", + "subject_id": "NCIT:C49019", + "object_id": "UMLS:C1572543", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28468,11 +28410,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Event", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:26523", - "object_id": "UMLS:C0012872", + "subject_id": "UMLS:C0574035", + "object_id": "UMLS:C1874451", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28485,15 +28427,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Drug", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:C103123", - "object_id": "UMLS:C2348756", + "subject_id": "RXCUI:196476", + "object_id": "UMLS:C0426731", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -28502,28 +28444,28 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Device", + "subject_category": "biolink:Gene", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "MONDO:0005594", - "object_id": "UMLS:C0535454", + "subject_id": "HGNC:5756", + "object_id": "UMLS:C0007165", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:Drug", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "UMLS:C0350056", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28531,16 +28473,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C1134718", - "object_id": "UMLS:C0302600", + "subject_id": "CHEBI:135590", + "object_id": "UMLS:C1507013", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28553,11 +28495,11 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597423", - "object_id": "NCBIGene:53369", + "subject_id": "CHEBI:100246", + "object_id": "UMLS:C0026687", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28565,20 +28507,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0034917", - "object_id": "UMLS:C0752046", + "subject_id": "UMLS:C0001347", + "object_id": "UMLS:C0007165", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -28587,28 +28529,28 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "HP:0045047", - "object_id": "NCBIGene:619511", + "subject_id": "CHEBI:17833", + "object_id": "UMLS:C0040210", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "UMLS:C0162327", + "subject_id": "MESH:D053260", + "object_id": "UMLS:C0042834", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28621,11 +28563,11 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "UMLS:C0752046", + "subject_id": "CHEBI:2417", + "object_id": "UMLS:C0007165", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28633,16 +28575,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C1515672", - "object_id": "UMLS:C0752046", + "subject_id": "UMLS:C0162326", + "object_id": "UMLS:C0534010", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28655,11 +28597,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Disease", + "subject_category": "biolink:Drug", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C1373149", - "object_id": "UMLS:C0877248", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28667,16 +28609,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Behavior", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C1519692", - "object_id": "UMLS:C1520625", + "subject_id": "UMLS:C0037322", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28689,11 +28631,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Cell", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "HP:0011157", - "object_id": "UMLS:C0879593", + "subject_id": "UMLS:C0752046", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28701,50 +28643,50 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Cell", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0023823", - "object_id": "UMLS:C0879593", + "subject_id": "UMLS:C1167395", + "object_id": "UMLS:C0012934", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Cell", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C1704842", - "object_id": "UMLS:C0879593", + "subject_id": "UMLS:C0020969", + "object_id": "UMLS:C0012924", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Cell", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0162326", - "object_id": "UMLS:C0879593", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0079925", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28757,11 +28699,11 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Device", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C1520625", - "object_id": "UMLS:C1519692", + "subject_id": "UMLS:C1328924", + "object_id": "UMLS:C0035736", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28774,11 +28716,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Pathway", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C1155876", - "object_id": "SMPDB:SMP0000477", + "subject_id": "UMLS:C0871470", + "object_id": "UMLS:C0037570", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28791,32 +28733,32 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Pathway", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013227", - "object_id": "SMPDB:SMP0063813", + "subject_id": "UMLS:C0017127", + "object_id": "UMLS:C0078479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "NCBIGene:8066", + "subject_id": "GO:0010467", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -28825,11 +28767,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Device", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "CHEBI:33375", - "object_id": "UMLS:C0523584", + "subject_id": "UMLS:C0033086", + "object_id": "UMLS:C0026687", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28837,37 +28779,37 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Drug", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1544", - "object_id": "UMLS:C2684108", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0026687", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2278", - "object_id": "PUBCHEM.COMPOUND:70697642", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0026687", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -28876,28 +28818,28 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Behavior", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0054889", - "object_id": "UMLS:C1331418", + "subject_id": "UMLS:C0011313", + "object_id": "UMLS:C0318761", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:Activity", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "MONDO:0005271", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C0599946", + "object_id": "UMLS:C0011313", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28910,11 +28852,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001060", - "object_id": "UMLS:C4748586", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0012868", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28922,33 +28864,33 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0302600", - "object_id": "UMLS:C1134718", + "subject_id": "CHEBI:16991", + "object_id": "UMLS:C0012872", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Device", + "subject_category": "biolink:Protein", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032942", - "object_id": "UMLS:C0115137", + "subject_id": "UMLS:C0080065", + "object_id": "UMLS:C0012872", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28961,28 +28903,28 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D008928", - "object_id": "UMLS:C5202641", + "subject_id": "UMLS:C1373111", + "object_id": "UMLS:C0012929", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004268", - "object_id": "UMLS:C5202641", + "subject_id": "UMLS:C0012931", + "object_id": "UMLS:C1511997", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -28996,10 +28938,10 @@ }, { "subject_category": "biolink:NamedThing", - "object_category": "biolink:Food", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D055432", - "object_id": "UMLS:C1572543", + "subject_id": "CHV:0000042589", + "object_id": "UMLS:C0012939", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29012,11 +28954,11 @@ ] }, { - "subject_category": "biolink:Event", - "object_category": "biolink:Drug", + "subject_category": "biolink:Publication", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0574035", - "object_id": "UMLS:C1874451", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C0004391", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29029,28 +28971,37 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0025246", + "subject_id": "UMLS:C0015745", + "object_id": "UMLS:C3895854", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Behavior", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0015745", + "object_id": "UMLS:C3895852", + "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "UMLS:C0017654", + "subject_id": "UMLS:C0087111", + "object_id": "UMLS:C0005612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29058,50 +29009,50 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10044", - "object_id": "UMLS:C0449238", + "subject_id": "MONDO:0000088", + "object_id": "UMLS:C0005938", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:104840", - "object_id": "UMLS:C0017654", + "subject_id": "HP:0000938", + "object_id": "UMLS:C0005938", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:D000077215", - "object_id": "UMLS:C0428696", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C0007165", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29114,28 +29065,28 @@ ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "UMLS:C0018270", + "subject_id": "UMLS:C0015919", + "object_id": "UMLS:C0079291", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Activity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "UMLS:C0018270", + "subject_id": "UMLS:C0237820", + "object_id": "UMLS:C0079925", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29148,11 +29099,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Device", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0011313", - "object_id": "UMLS:C0318761", + "subject_id": "UMLS:C0043076", + "object_id": "UMLS:C0600680", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29165,28 +29116,28 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599946", - "object_id": "UMLS:C0011313", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0079925", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Food", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "GO:0010467", - "object_id": "UMLS:C0012171", + "subject_id": "MESH:D016192", + "object_id": "UMLS:C0080129", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29199,28 +29150,28 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Protein", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031911", - "object_id": "UMLS:C0002520", + "subject_id": "MESH:D017729", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Drug", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "CHV:0000042589", - "object_id": "UMLS:C0002842", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0009393", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29233,11 +29184,11 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "UMLS:C0004391", + "subject_id": "NCIT:C28506", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29250,37 +29201,45 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015745", - "object_id": "UMLS:C3895854", + "subject_id": "UMLS:C1160534", + "object_id": "UMLS:C0001413", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Disease", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015745", - "object_id": "UMLS:C3895852", + "subject_id": "MONDO:0002050", + "object_id": "UMLS:C0001413", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Protein", "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:123812", - "object_id": "UMLS:C0001884", + "subject_id": "UMLS:C0015506", + "object_id": "UMLS:C0489482", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29347,8 +29306,8 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:140821", - "object_id": "UMLS:C1705549", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29364,8 +29323,8 @@ "subject_category": "biolink:Protein", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "UMLS:C1706005", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C1705751", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29432,8 +29391,8 @@ "subject_category": "biolink:Cell", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "UMLS:C4049611", + "subject_id": "CL:0000023", + "object_id": "UMLS:C1704842", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29449,8 +29408,8 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010762", - "object_id": "UMLS:C1881502", + "subject_id": "UMLS:C0012868", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29517,8 +29476,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11321986", - "object_id": "UMLS:C3890397", + "subject_id": "CHEBI:137694", + "object_id": "UMLS:C0678941", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29534,8 +29493,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", - "object_id": "UMLS:C1708154", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C1706005", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29599,11 +29558,11 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C495669", - "object_id": "UMLS:C3538782", + "subject_id": "UMLS:C0009221", + "object_id": "UMLS:C0678941", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29616,11 +29575,11 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:8081", - "object_id": "UMLS:C0017346", + "subject_id": "CHEBI:10022", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29633,11 +29592,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Protein", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10022", - "object_id": "UMLS:C0002085", + "subject_id": "PR:000001849", + "object_id": "UMLS:C1706240", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29704,8 +29663,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:131842327", - "object_id": "UMLS:C0002085", + "subject_id": "CHEBI:132767", + "object_id": "UMLS:C3890206", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29721,8 +29680,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:28017", - "object_id": "UMLS:C0002085", + "subject_id": "CHV:0000010203", + "object_id": "UMLS:C3715113", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29738,8 +29697,8 @@ "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "CHV:0000005405", - "object_id": "UMLS:C3540820", + "subject_id": "CHV:0000000950", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29925,8 +29884,8 @@ "subject_category": "biolink:Cell", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004112", - "object_id": "UMLS:C3813609", + "subject_id": "CL:0000025", + "object_id": "UMLS:C3890018", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29973,11 +29932,11 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:OrganismAttribute", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0087111", - "object_id": "UMLS:C0005612", + "subject_id": "UMLS:C0031911", + "object_id": "UMLS:C0002520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -29985,67 +29944,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Disease", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "MONDO:0000088", - "object_id": "UMLS:C0005938", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "HGNC:5756", - "object_id": "UMLS:C0007165", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Drug", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "CHEBI:26125", - "object_id": "UMLS:C0871470", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C1101610", - "object_id": "UMLS:C0005938", + "subject_id": "CHV:0000042589", + "object_id": "UMLS:C0002842", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30058,11 +29966,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MESH:D013482", - "object_id": "UMLS:C0871470", + "subject_id": "UMLS:C0007165", + "object_id": "UMLS:C0074339", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30075,11 +29983,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:123812", - "object_id": "UMLS:C0040210", + "subject_id": "UMLS:C0677040", + "object_id": "UMLS:C0006556", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30112,58 +30020,7 @@ "subject_category": "biolink:Protein", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:D008049", - "object_id": "UMLS:C0455829", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "CHEBI:100246", - "object_id": "UMLS:C0026687", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "CHEBI:18154", - "object_id": "UMLS:C0026687", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Drug", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", + "subject_id": "UMLS:C0002520", "object_id": "UMLS:C0871470", "qualifiers": [ { @@ -30176,40 +30033,6 @@ } ] }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:123812", - "object_id": "UMLS:C0040210", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0543421", - "object_id": "UMLS:C0007165", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:Device", "object_category": "biolink:ClinicalAttribute", @@ -30227,29 +30050,12 @@ } ] }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:2489", - "object_id": "UMLS:C0871470", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:MolecularActivity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "NCIT:C28506", - "object_id": "NCBIGene:100188784", + "subject_id": "UMLS:C0003319", + "object_id": "UMLS:C0009221", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30278,80 +30084,12 @@ } ] }, - { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:InformationContentEntity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0009393", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Procedure", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0040669", - "object_id": "UMLS:C0041904", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "MESH:D053260", - "object_id": "UMLS:C0042834", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:NucleicAcidEntity", - "predicate": "biolink:causes", - "subject_id": "CHEBI:16991", - "object_id": "UMLS:C0012872", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0080065", - "object_id": "UMLS:C0012872", + "subject_id": "MESH:D000077215", + "object_id": "UMLS:C0428696", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30444,7 +30182,7 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:15666", + "subject_id": "CHEBI:28966", "object_id": "UMLS:C0015919", "qualifiers": [ { @@ -30495,7 +30233,7 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:6096946", + "subject_id": "CHEBI:147402", "object_id": "UMLS:C0015919", "qualifiers": [ { @@ -30512,7 +30250,7 @@ "subject_category": "biolink:Protein", "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D013482", + "subject_id": "UMLS:C0002520", "object_id": "UMLS:C0015919", "qualifiers": [ { @@ -30580,7 +30318,7 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:8066", + "subject_id": "UMLS:C1511518", "object_id": "UMLS:C0015919", "qualifiers": [ { @@ -30611,11 +30349,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C1373045", - "object_id": "UMLS:C0017191", + "subject_id": "MESH:D014612", + "object_id": "UMLS:C0020964", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30623,16 +30361,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Food", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:56477", - "object_id": "UMLS:C0017191", + "subject_id": "UMLS:C0078479", + "object_id": "UMLS:C0018270", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30640,37 +30378,37 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0699612", - "object_id": "UMLS:C0017346", + "subject_id": "UMLS:C0003204", + "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:15938", - "object_id": "UMLS:C0034917", + "subject_id": "CHEBI:16412", + "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -30679,28 +30417,28 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Protein", + "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0238876", - "object_id": "UMLS:C0034917", + "subject_id": "UMLS:C0000392", + "object_id": "UMLS:C0517355", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Gene", + "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0037322", - "object_id": "UMLS:C0034917", + "subject_id": "NCBIGene:100289419", + "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30713,15 +30451,15 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2489", - "object_id": "UMLS:C0543421", + "subject_id": "UMLS:C0012924", + "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -30730,10 +30468,10 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:5284359", + "subject_id": "MESH:D010936", "object_id": "UMLS:C0020969", "qualifiers": [ { @@ -30747,10 +30485,10 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "CHEBI:16412", + "subject_id": "UMLS:C0162327", "object_id": "UMLS:C0020969", "qualifiers": [ { @@ -30764,10 +30502,10 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:D007371", + "subject_id": "MESH:D020077", "object_id": "UMLS:C0020969", "qualifiers": [ { @@ -30781,10 +30519,10 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100289419", + "subject_id": "CHEBI:17843", "object_id": "UMLS:C0020969", "qualifiers": [ { @@ -30798,10 +30536,10 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Food", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012924", + "subject_id": "UMLS:C0012171", "object_id": "UMLS:C0020969", "qualifiers": [ { @@ -30815,32 +30553,41 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:D014612", + "subject_id": "UMLS:C1155270", "object_id": "UMLS:C0020969", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0162327", + "subject_id": "UMLS:C1155269", "object_id": "UMLS:C0020969", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" + } + ] + }, + { + "subject_category": "biolink:Activity", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0015259", + "object_id": "UMLS:C0021665", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -30849,88 +30596,96 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:OrganismAttribute", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "MESH:D020077", - "object_id": "UMLS:C0020969", + "subject_id": "UMLS:C1373045", + "object_id": "UMLS:C0017191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:OrganismAttribute", + "subject_category": "biolink:Gene", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "UMLS:C0020969", + "subject_id": "NCBIGene:56477", + "object_id": "UMLS:C0017191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:OrganismAttribute", + "subject_category": "biolink:Device", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:135499568", - "object_id": "UMLS:C0020969", + "subject_id": "UMLS:C0699612", + "object_id": "UMLS:C0017346", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:OrganismAttribute", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1155270", - "object_id": "UMLS:C0020969", + "subject_id": "DRUGBANK:DB12768", + "object_id": "UMLS:C3811714", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:OrganismAttribute", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1155269", - "object_id": "UMLS:C0020969", + "subject_id": "CHEBI:133354", + "object_id": "UMLS:C0449238", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Protein", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:10545", - "object_id": "UMLS:C0449238", + "subject_id": "UMLS:C0002191", + "object_id": "UMLS:C0205254", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30938,7 +30693,7 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -30946,13 +30701,30 @@ "subject_category": "biolink:Gene", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10010", + "subject_id": "NCBIGene:10044", "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:PhysiologicalProcess", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0696628", + "object_id": "UMLS:C0018270", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -30960,11 +30732,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033086", - "object_id": "UMLS:C0026687", + "subject_id": "MESH:D000086942", + "object_id": "UMLS:C0025246", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30972,16 +30744,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Protein", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "UMLS:C0026687", + "subject_id": "UMLS:C0001643", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -30989,20 +30761,20 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Gene", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "UMLS:C0026687", + "subject_id": "NCBIGene:10010", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -31082,7 +30854,7 @@ "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "CHEBI:18154", + "subject_id": "CHEBI:17401", "object_id": "UMLS:C0031911", "qualifiers": [ { @@ -31112,6 +30884,23 @@ } ] }, + { + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:OrganismAttribute", + "predicate": "biolink:causes", + "subject_id": "CHEBI:2911", + "object_id": "UMLS:C0517355", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, { "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:Procedure", @@ -31181,11 +30970,11 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Food", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0871470", - "object_id": "UMLS:C0037570", + "subject_id": "UMLS:C1331418", + "object_id": "UMLS:C0054889", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -31197,23 +30986,6 @@ } ] }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Food", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0017127", - "object_id": "UMLS:C0078479", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, { "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:InformationContentEntity", @@ -31283,11 +31055,11 @@ ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Procedure", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1331418", - "object_id": "UMLS:C0054889", + "subject_id": "UMLS:C0040669", + "object_id": "UMLS:C0041904", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -31300,11 +31072,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0002481", - "object_id": "UMLS:C0085268", + "subject_id": "UMLS:C0696628", + "object_id": "UMLS:C0105185", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -31316,11 +31088,28 @@ } ] }, + { + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:Polypeptide", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C3827014", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:Cell", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0024432", + "subject_id": "CL:0000115", "object_id": "UMLS:C0078479", "qualifiers": [ { @@ -31388,7 +31177,7 @@ "subject_category": "biolink:Disease", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "MONDO:0019182", + "subject_id": "UMLS:C0872084", "object_id": "UMLS:C0078479", "qualifiers": [ { @@ -31418,91 +31207,6 @@ } ] }, - { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:PhenotypicFeature", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "UMLS:C0079291", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:InformationContentEntity", - "predicate": "biolink:causes", - "subject_id": "MESH:D016192", - "object_id": "UMLS:C0080129", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:InformationContentEntity", - "predicate": "biolink:causes", - "subject_id": "MESH:D017729", - "object_id": "UMLS:C0449238", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:InformationContentEntity", - "predicate": "biolink:causes", - "subject_id": "NCIT:C28506", - "object_id": "UMLS:C0449238", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Device", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "UMLS:C0074339", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:Procedure", "object_category": "biolink:InformationContentEntity", @@ -31521,11 +31225,11 @@ ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "UMLS:C0105185", + "subject_id": "UBERON:0002481", + "object_id": "UMLS:C0085268", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -31555,10 +31259,10 @@ ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "MONDO:0001627", + "subject_id": "UBERON:0000044", "object_id": "UMLS:C0449238", "qualifiers": [ { @@ -31584,23 +31288,6 @@ } ] }, - { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:InformationContentEntity", - "predicate": "biolink:causes", - "subject_id": "UBERON:0000044", - "object_id": "UMLS:C0449238", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:Activity", "object_category": "biolink:Device", @@ -31619,11 +31306,11 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Activity", + "subject_category": "biolink:Activity", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0185624", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0237820", + "object_id": "UMLS:C0185624", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -31636,11 +31323,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Activity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0182473", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0014653", + "object_id": "UMLS:C0851312", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -31653,32 +31340,32 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Activity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0205082", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Activity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0079925", - "object_id": "UMLS:C0237820", + "subject_id": "HP:0045047", + "object_id": "UMLS:C0205082", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -31687,10 +31374,10 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:NamedThing", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10339178", + "subject_id": "UMLS:C0185624", "object_id": "UMLS:C0237820", "qualifiers": [ { @@ -31704,10 +31391,10 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Device", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:433294", + "subject_id": "UMLS:C0182473", "object_id": "UMLS:C0237820", "qualifiers": [ { @@ -31721,10 +31408,10 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", + "subject_id": "MESH:D000086942", "object_id": "UMLS:C0237820", "qualifiers": [ { @@ -31738,11 +31425,11 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0185624", + "subject_id": "UMLS:C0079925", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -31755,15 +31442,15 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0014653", - "object_id": "UMLS:C0851312", + "subject_id": "UBERON:0008826", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -31772,50 +31459,16 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:DiseaseOrPhenotypicFeature", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "UMLS:C0205082", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:Drug", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:168266382", - "object_id": "UMLS:C0205082", + "subject_id": "UMLS:C0003402", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:DiseaseOrPhenotypicFeature", - "predicate": "biolink:causes", - "subject_id": "HP:0045047", - "object_id": "UMLS:C0205082", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -31823,19 +31476,19 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Disease", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D005620", - "object_id": "UMLS:C0806909", + "subject_id": "MONDO:0001627", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -31891,11 +31544,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Disease", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0034917", - "object_id": "UMLS:C0238876", + "subject_id": "MESH:D014612", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -31911,7 +31564,7 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:15903", + "subject_id": "CHEBI:17561", "object_id": "UMLS:C0314621", "qualifiers": [ { @@ -31926,14 +31579,14 @@ }, { "subject_category": "biolink:Drug", - "object_category": "biolink:Gene", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:4873", - "object_id": "UMLS:C0314621", + "subject_id": "UMLS:C0003280", + "object_id": "UMLS:C0318759", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -31976,15 +31629,15 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Procedure", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0441650", - "object_id": "UMLS:C0556030", + "subject_id": "UMLS:C0162326", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -32010,11 +31663,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "MESH:D007371", - "object_id": "UMLS:C0449238", + "subject_id": "UMLS:C0441650", + "object_id": "UMLS:C0556030", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32027,10 +31680,10 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:100241", + "subject_id": "CHEBI:10545", "object_id": "UMLS:C0449238", "qualifiers": [ { @@ -32060,6 +31713,23 @@ } ] }, + { + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:InformationContentEntity", + "predicate": "biolink:causes", + "subject_id": "CHEBI:102166", + "object_id": "UMLS:C0449238", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, { "subject_category": "biolink:GenomicEntity", "object_category": "biolink:InformationContentEntity", @@ -32081,7 +31751,7 @@ "subject_category": "biolink:Drug", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:16261", + "subject_id": "RXCUI:1535257", "object_id": "UMLS:C0449238", "qualifiers": [ { @@ -32095,10 +31765,10 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0752046", + "subject_id": "CHEBI:2417", "object_id": "UMLS:C0449238", "qualifiers": [ { @@ -32112,10 +31782,10 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:131634907", + "subject_id": "UMLS:C0752046", "object_id": "UMLS:C0449238", "qualifiers": [ { @@ -32149,7 +31819,7 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010762", + "subject_id": "UMLS:C0023823", "object_id": "UMLS:C0449238", "qualifiers": [ { @@ -32319,7 +31989,7 @@ "subject_category": "biolink:Cell", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009013", + "subject_id": "CL:0000084", "object_id": "UMLS:C0449238", "qualifiers": [ { @@ -32387,7 +32057,7 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:140821", + "subject_id": "UMLS:C0080089", "object_id": "UMLS:C0449238", "qualifiers": [ { @@ -32418,11 +32088,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Procedure", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C1144709", - "object_id": "UMLS:C0489482", + "subject_id": "UMLS:C1515508", + "object_id": "UMLS:C0600680", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32434,23 +32104,6 @@ } ] }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Protein", - "predicate": "biolink:causes", - "subject_id": "MESH:C510163", - "object_id": "UMLS:C0600128", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:Food", "object_category": "biolink:PhenotypicFeature", @@ -32469,19 +32122,19 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", + "subject_id": "UMLS:C0752046", "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, @@ -32521,14 +32174,14 @@ }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:C110027", - "object_id": "UMLS:C0696628", + "subject_id": "MESH:C510163", + "object_id": "UMLS:C0600128", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -32537,11 +32190,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0061928", - "object_id": "UMLS:C0696628", + "subject_id": "UMLS:C0452415", + "object_id": "UMLS:C0700219", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32555,10 +32208,10 @@ }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "UMLS:C0105185", - "object_id": "UMLS:C0696628", + "subject_id": "CHEBI:8027", + "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32566,16 +32219,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "MONDO:0004992", - "object_id": "UMLS:C0696628", + "subject_id": "CHEBI:16646", + "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32588,15 +32241,15 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:Gene", + "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "UMLS:C0442751", - "object_id": "UMLS:C0696628", + "subject_id": "NCBIGene:1026", + "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -32605,11 +32258,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:Gene", + "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "UMLS:C0018270", - "object_id": "UMLS:C0696628", + "subject_id": "NCBIGene:1806", + "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32622,15 +32275,15 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:Protein", + "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "UBERON:0010163", - "object_id": "UMLS:C0696628", + "subject_id": "UMLS:C0019046", + "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -32639,15 +32292,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:Protein", + "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "CHEBI:16236", - "object_id": "UMLS:C0696628", + "subject_id": "UMLS:C0012512", + "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -32656,15 +32309,15 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Drug", + "subject_category": "biolink:Drug", + "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "UMLS:C1115729", - "object_id": "UMLS:C0699251", + "subject_id": "UMLS:C0243192", + "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -32673,32 +32326,32 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "UMLS:C0449238", - "object_id": "UMLS:C0678941", + "subject_id": "CHEBI:15377", + "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "UMLS:C0019046", + "subject_id": "CHEBI:61040", "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -32707,10 +32360,10 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "CHEBI:16646", + "subject_id": "UMLS:C0006556", "object_id": "UMLS:C0677040", "qualifiers": [ { @@ -32724,10 +32377,10 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1026", + "subject_id": "UMLS:C0002085", "object_id": "UMLS:C0677040", "qualifiers": [ { @@ -32741,28 +32394,28 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:IndividualOrganism", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1806", - "object_id": "UMLS:C0677040", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0678941", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:IndividualOrganism", + "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "MESH:D000110", - "object_id": "UMLS:C0677040", + "subject_id": "MESH:C110027", + "object_id": "UMLS:C0696628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32776,10 +32429,44 @@ }, { "subject_category": "biolink:Protein", - "object_category": "biolink:IndividualOrganism", + "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012512", - "object_id": "UMLS:C0677040", + "subject_id": "UMLS:C0061928", + "object_id": "UMLS:C0696628", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PopulationOfIndividualOrganisms", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0105185", + "object_id": "UMLS:C0696628", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Disease", + "object_category": "biolink:PopulationOfIndividualOrganisms", + "predicate": "biolink:causes", + "subject_id": "MONDO:0004992", + "object_id": "UMLS:C0696628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32792,11 +32479,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:IndividualOrganism", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "CHEBI:34674", - "object_id": "UMLS:C0677040", + "subject_id": "UMLS:C0442751", + "object_id": "UMLS:C0696628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32809,11 +32496,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:IndividualOrganism", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "CHEBI:15377", - "object_id": "UMLS:C0677040", + "subject_id": "UMLS:C0018270", + "object_id": "UMLS:C0696628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32826,11 +32513,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:IndividualOrganism", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:7886", - "object_id": "UMLS:C0677040", + "subject_id": "UBERON:0010163", + "object_id": "UMLS:C0696628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32844,10 +32531,10 @@ }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:IndividualOrganism", + "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "CHEBI:8027", - "object_id": "UMLS:C0677040", + "subject_id": "CHEBI:16236", + "object_id": "UMLS:C0696628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32860,15 +32547,15 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:IndividualOrganism", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006556", - "object_id": "UMLS:C0677040", + "subject_id": "UMLS:C1115729", + "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -32877,11 +32564,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:IndividualOrganism", + "subject_category": "biolink:Procedure", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0677040", + "subject_id": "UMLS:C0004910", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32894,15 +32581,15 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Food", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0452415", - "object_id": "UMLS:C0700219", + "subject_id": "UMLS:C0037570", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -32911,16 +32598,101 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Food", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0233929", - "object_id": "UMLS:C0849355", + "subject_id": "UMLS:C0078479", + "object_id": "UMLS:C0871470", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:ClinicalAttribute", + "predicate": "biolink:causes", + "subject_id": "MESH:D014612", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Procedure", + "object_category": "biolink:ClinicalAttribute", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0032042", + "object_id": "UMLS:C0871470", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:ClinicalAttribute", + "predicate": "biolink:causes", + "subject_id": "CHV:0000021208", + "object_id": "UMLS:C1507013", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" + } + ] + }, + { + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ClinicalAttribute", + "predicate": "biolink:causes", + "subject_id": "CHEBI:37532", + "object_id": "UMLS:C1115729", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:ClinicalAttribute", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0871470", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "increased" @@ -32962,11 +32734,11 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004910", - "object_id": "UMLS:C0871470", + "subject_id": "UMLS:C0233929", + "object_id": "UMLS:C0849355", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -32979,28 +32751,11 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0037570", - "object_id": "UMLS:C0871470", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Food", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "UMLS:C0871470", + "subject_id": "MESH:D008925", + "object_id": "UMLS:C1099354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -33013,28 +32768,28 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Cell", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:D014612", - "object_id": "UMLS:C0871470", + "subject_id": "UMLS:C0027950", + "object_id": "UMLS:C1115729", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:Gene", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032042", - "object_id": "UMLS:C0871470", + "subject_id": "NCBIGene:2357", + "object_id": "UMLS:C1115729", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -33042,16 +32797,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Protein", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0023823", - "object_id": "UMLS:C0871470", + "subject_id": "UMLS:C0002716", + "object_id": "UMLS:C1115729", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -33059,15 +32814,15 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Drug", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "CHEBI:37532", + "subject_id": "UMLS:C0699251", "object_id": "UMLS:C1115729", "qualifiers": [ { @@ -33081,28 +32836,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0871470", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:ChemicalEntity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0019868", - "object_id": "UMLS:C0908045", + "subject_id": "CHEBI:18421", + "object_id": "UMLS:C1115729", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -33115,11 +32853,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Publication", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0027950", - "object_id": "UMLS:C1115729", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C1140999", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -33132,15 +32870,15 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Pathway", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2357", - "object_id": "UMLS:C1115729", + "subject_id": "SMPDB:SMP0000477", + "object_id": "UMLS:C1155876", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -33149,78 +32887,62 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002716", - "object_id": "UMLS:C1115729", + "subject_id": "UMLS:C0020969", + "object_id": "UMLS:C1155269", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0699251", - "object_id": "UMLS:C1115729", + "subject_id": "UMLS:C0020969", + "object_id": "UMLS:C1155270", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "CHEBI:18421", - "object_id": "UMLS:C1115729", + "subject_id": "UMLS:C1160638", + "object_id": "UMLS:C1655048", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:Disease", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "UMLS:C1140999", + "subject_id": "UMLS:C1160638", + "object_id": "UMLS:C1655748", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "MESH:D007371", + "subject_id": "CHEBI:16412", "object_id": "UMLS:C1167395", "qualifiers": [ { @@ -33254,7 +32976,7 @@ "subject_category": "biolink:Drug", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:168010173", + "subject_id": "RXCUI:237976", "object_id": "UMLS:C1167395", "qualifiers": [ { @@ -33271,7 +32993,7 @@ "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033755", + "subject_id": "UMLS:C0162326", "object_id": "UMLS:C1167395", "qualifiers": [ { @@ -33285,7 +33007,7 @@ ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Protein", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", "subject_id": "UMLS:C0001060", @@ -33302,10 +33024,10 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:131634907", + "subject_id": "CHEBI:133011", "object_id": "UMLS:C1167395", "qualifiers": [ { @@ -33319,10 +33041,10 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB12768", + "subject_id": "UMLS:C0012934", "object_id": "UMLS:C1167395", "qualifiers": [ { @@ -33336,37 +33058,11 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "UMLS:C1155269", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" - } - ] - }, - { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "UMLS:C1155270", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] - }, - { - "subject_category": "biolink:Pathway", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "SMPDB:SMP0000477", - "object_id": "UMLS:C1155876", + "subject_id": "CHEBI:17843", + "object_id": "UMLS:C1167395", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -33379,28 +33075,19 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C1160638", - "object_id": "UMLS:C1655048", + "subject_id": "DRUGBANK:DB12768", + "object_id": "UMLS:C1167395", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] - }, - { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "UMLS:C1160638", - "object_id": "UMLS:C1655748", - "qualifiers": [ + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, @@ -33451,19 +33138,6 @@ } ] }, - { - "subject_category": "biolink:Disease", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "MONDO:0002459", - "object_id": "UMLS:C1326509", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] - }, { "subject_category": "biolink:Disease", "object_category": "biolink:Disease", @@ -33524,23 +33198,6 @@ } ] }, - { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:InformationContentEntity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0279023", - "object_id": "UMLS:C1510470", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:Protein", "object_category": "biolink:Polypeptide", @@ -33562,7 +33219,7 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:133128", + "subject_id": "CHEBI:3385", "object_id": "UMLS:C1511997", "qualifiers": [ { @@ -33593,15 +33250,15 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:5831", - "object_id": "UMLS:C1511997", + "subject_id": "UMLS:C0279023", + "object_id": "UMLS:C1510470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -33733,32 +33390,6 @@ } ] }, - { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "UMLS:C2753278", - "object_id": "UMLS:C2753280", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] - }, - { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "UMLS:C2753278", - "object_id": "UMLS:C2753281", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" - } - ] - }, { "subject_category": "biolink:Phenomenon", "object_category": "biolink:InformationContentEntity", @@ -33786,28 +33417,28 @@ ] }, { - "subject_category": "biolink:Pathway", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "GO:0032933", - "object_id": "UMLS:C3157947", + "subject_id": "UMLS:C2753278", + "object_id": "UMLS:C2753280", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:Pathway", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "GO:0000077", - "object_id": "UMLS:C3157104", + "subject_id": "UMLS:C2753278", + "object_id": "UMLS:C2753281", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "downregulated" } ] }, @@ -33837,6 +33468,19 @@ } ] }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Disease", + "predicate": "biolink:causes", + "subject_id": "UMLS:C3156018", + "object_id": "UMLS:C3158581", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, { "subject_category": "biolink:Pathway", "object_category": "biolink:PhysiologicalProcess", @@ -33851,11 +33495,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Disease", + "subject_category": "biolink:Pathway", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C3156018", - "object_id": "UMLS:C3158581", + "subject_id": "GO:0000077", + "object_id": "UMLS:C3157104", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -33864,19 +33508,15 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Pathway", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB12768", - "object_id": "UMLS:C3811714", + "subject_id": "GO:0032933", + "object_id": "UMLS:C3157947", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, @@ -33898,15 +33538,15 @@ ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Disease", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C2262951", - "object_id": "UMLS:C3822357", + "subject_id": "UMLS:C3893499", + "object_id": "UMLS:C4328062", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "upregulated" } ] }, @@ -33915,20 +33555,20 @@ "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", "subject_id": "UMLS:C2262951", - "object_id": "UMLS:C3822358", + "object_id": "UMLS:C3822357", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Disease", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C3893499", - "object_id": "UMLS:C4328062", + "subject_id": "UMLS:C2262951", + "object_id": "UMLS:C3822358", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -34057,6 +33697,36 @@ } ] }, + { + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:NucleicAcidEntity", + "predicate": "biolink:causes", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2108280", + "object_id": "CHEMBL.TARGET:CHEMBL4622827", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" + }, + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "increased" + } + ] + }, + { + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "CHEBI:6078", + "object_id": "UniProtKB:P36544", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + } + ] + }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Protein", @@ -34071,15 +33741,19 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "GO:0005219", - "object_id": "UniProtKB:P0DP23", + "subject_id": "PUBCHEM.COMPOUND:70697642", + "object_id": "CHEMBL.TARGET:CHEMBL2179", "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "stability" + }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "increased" } ] }, @@ -34087,29 +33761,25 @@ "subject_category": "biolink:MolecularActivity", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "REACT:R-HSA-5649873", - "object_id": "UniProtKB:Q86W56", + "subject_id": "GO:0005219", + "object_id": "UniProtKB:P0DP23", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL460785", - "object_id": "PR:000007752", + "subject_id": "REACT:R-HSA-5649873", + "object_id": "UniProtKB:Q86W56", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" - }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, @@ -34117,12 +33787,12 @@ "subject_category": "biolink:NamedThing", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "OBO:INO_0000074", + "subject_id": "OBO:INO_0000072", "object_id": "OBO:INO_0000173", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "upregulated" } ] }, @@ -34130,12 +33800,12 @@ "subject_category": "biolink:NamedThing", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "OBO:INO_0000072", + "subject_id": "OBO:INO_0000074", "object_id": "OBO:INO_0000173", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "downregulated" } ] }, @@ -34160,12 +33830,12 @@ "subject_category": "biolink:MolecularEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364181", - "object_id": "CHEMBL.COMPOUND:CHEMBL1201482", + "subject_id": "CHEMBL.TARGET:CHEMBL2095182", + "object_id": "CHEMBL.COMPOUND:CHEMBL2108628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "stability" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -34177,29 +33847,25 @@ "subject_category": "biolink:Gene", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1191", - "object_id": "CHEMBL.COMPOUND:CHEMBL2108309", + "subject_id": "NCBIGene:729230", + "object_id": "CHEMBL.COMPOUND:CHEMBL3545221", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:GeneFamily", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:159842316", - "object_id": "CHEMBL.COMPOUND:CHEMBL2108479", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2108557", + "object_id": "CHEMBL.TARGET:CHEMBL2111480", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -34208,15 +33874,15 @@ ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:GeneFamily", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2111464", - "object_id": "CHEMBL.COMPOUND:CHEMBL2108628", + "subject_id": "CHEBI:10082", + "object_id": "CHEMBL.TARGET:CHEMBL2095203", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -34225,28 +33891,15 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:GeneFamily", "predicate": "biolink:causes", - "subject_id": "NCBIGene:5027", - "object_id": "CHEMBL.COMPOUND:CHEMBL3545206", + "subject_id": "CHEBI:31453", + "object_id": "CHEMBL.TARGET:CHEMBL2095166", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:133", - "object_id": "CHEMBL.COMPOUND:CHEMBL4650434", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -34255,11 +33908,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:GeneFamily", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1788132", - "object_id": "CHEMBL.TARGET:CHEMBL2093864", + "subject_id": "CHEBI:10102", + "object_id": "CHEMBL.TARGET:CHEMBL2111392", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34272,11 +33925,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:GeneFamily", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2108557", - "object_id": "CHEMBL.TARGET:CHEMBL2111480", + "subject_id": "CHEBI:100246", + "object_id": "CHEMBL.TARGET:CHEMBL2363076", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34284,16 +33937,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:GeneFamily", + "subject_category": "biolink:Drug", + "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "UNII:8202AY8I7H", - "object_id": "CHEMBL.TARGET:CHEMBL3832947", + "subject_id": "UNII:4S0HBYW6QE", + "object_id": "CHEMBL.TARGET:CHEMBL3831282", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34301,16 +33954,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:GeneFamily", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "UNII:B6E7K36KT8", - "object_id": "CHEMBL.TARGET:CHEMBL3559684", + "subject_id": "CHEBI:5938", + "object_id": "CHEMBL.TARGET:CHEMBL2364170", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34323,32 +33976,32 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "UNII:X8R2D92QP1", - "object_id": "CHEMBL.TARGET:CHEMBL2364181", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1742988", + "object_id": "CHEMBL.TARGET:CHEMBL3833421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201482", - "object_id": "CHEMBL.TARGET:CHEMBL2364181", + "subject_id": "CHEBI:3229", + "object_id": "CHEMBL.TARGET:CHEMBL1907607", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", @@ -34357,27 +34010,27 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:193860", - "object_id": "CHEMBL.TARGET:CHEMBL2364181", + "subject_id": "CHEBI:2619", + "object_id": "CHEMBL.TARGET:CHEMBL2094124", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:8519", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201482", "object_id": "CHEMBL.TARGET:CHEMBL2364181", "qualifiers": [ { @@ -34391,11 +34044,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2108280", - "object_id": "CHEMBL.TARGET:CHEMBL4622827", + "subject_id": "CHEBI:193860", + "object_id": "CHEMBL.TARGET:CHEMBL2364181", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34408,11 +34061,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:121493436", - "object_id": "CHEMBL.TARGET:CHEMBL4296221", + "subject_id": "CHEBI:81916", + "object_id": "CHEMBL.TARGET:CHEMBL2364181", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34425,19 +34078,19 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UNII:50FKX8CB2Y", + "subject_id": "UNII:0IEO0F56LV", "object_id": "CHEMBL.TARGET:CHEMBL4296221", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "abundance" + "qualifier_value": "degradation" }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, @@ -34479,7 +34132,7 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:121494122", + "subject_id": "UNII:2O4BE0K238", "object_id": "CHEMBL.TARGET:CHEMBL4495602", "qualifiers": [ { @@ -34492,23 +34145,6 @@ } ] }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:NucleicAcidEntity", - "predicate": "biolink:causes", - "subject_id": "MESH:D059365", - "object_id": "NCBIGene:4096", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:NucleicAcidEntity", @@ -34526,114 +34162,12 @@ } ] }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:MolecularEntity", - "predicate": "biolink:causes", - "subject_id": "CHEBI:10102", - "object_id": "CHEMBL.TARGET:CHEMBL2111392", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:MolecularEntity", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201557", - "object_id": "CHEMBL.TARGET:CHEMBL2364170", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:MolecularEntity", - "predicate": "biolink:causes", - "subject_id": "CHEBI:100241", - "object_id": "CHEMBL.TARGET:CHEMBL2363033", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:MolecularEntity", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200703", - "object_id": "CHEMBL.TARGET:CHEMBL2093872", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:MolecularEntity", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200498", - "object_id": "CHEMBL.TARGET:CHEMBL2363033", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularEntity", - "predicate": "biolink:causes", - "subject_id": "UNII:8202AY8I7H", - "object_id": "CHEMBL.TARGET:CHEMBL1907598", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", "subject_id": "CHEBI:177512", - "object_id": "CHEMBL.TARGET:CHEMBL2111464", + "object_id": "CHEMBL.TARGET:CHEMBL2095182", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34650,7 +34184,7 @@ "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", "subject_id": "CHEMBL.COMPOUND:CHEMBL2108628", - "object_id": "CHEMBL.TARGET:CHEMBL2111464", + "object_id": "CHEMBL.TARGET:CHEMBL2095182", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34666,59 +34200,8 @@ "subject_category": "biolink:Drug", "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11963622", - "object_id": "CHEMBL.TARGET:CHEMBL2111348", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Cell", - "object_category": "biolink:NucleicAcidEntity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "NCBIGene:84565", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:NucleicAcidEntity", - "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "NCBIGene:907", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:NucleicAcidEntity", - "predicate": "biolink:causes", - "subject_id": "UBERON:0008826", - "object_id": "NCBIGene:84565", + "subject_id": "NCIT:C116748", + "object_id": "CHEMBL.TARGET:CHEMBL2095182", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34731,11 +34214,11 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:GeneFamily", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599740", - "object_id": "NCBIGene:57762", + "subject_id": "UNII:7GDW9S3GN3", + "object_id": "CHEMBL.TARGET:CHEMBL2095181", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34743,16 +34226,16 @@ }, { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "increased" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:GeneFamily", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597423", - "object_id": "NCBIGene:2489", + "subject_id": "UNII:2ZT81PV5UM", + "object_id": "CHEMBL.TARGET:CHEMBL2363062", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -34766,14 +34249,14 @@ }, { "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:SmallMolecule", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "GO:0015280", - "object_id": "REACT:R-ALL-2672379", + "subject_id": "GO:0000150", + "object_id": "REACT:R-HSA-913509", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "upregulated" } ] }, @@ -34792,14 +34275,14 @@ }, { "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:BiologicalEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "GO:0000150", - "object_id": "REACT:R-HSA-913509", + "subject_id": "GO:0015280", + "object_id": "REACT:R-ALL-2672379", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "downregulated" } ] }, @@ -34815,19 +34298,6 @@ "qualifier_value": "upregulated" } ] - }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:23411", - "object_id": "REACT:R-HSA-9825751", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" - } - ] } ] } \ No newline at end of file diff --git a/code/ARAX/KnowledgeSources/general_concepts.json b/code/ARAX/KnowledgeSources/general_concepts.json index 4e30b2e89..4ffb12aed 100644 --- a/code/ARAX/KnowledgeSources/general_concepts.json +++ b/code/ARAX/KnowledgeSources/general_concepts.json @@ -347,7 +347,6 @@ "umls:c0003209", "umls:c4045974", "umls:c0005522" - ], "synonyms": [ "used in nicotine dependence", @@ -459,6 +458,7 @@ "antidiarrheals in atc", "poisoning", "proteins", + "plasma proteins", "mineral supplements in atc", "virology", "antifungals for topical use in atc", @@ -684,7 +684,6 @@ "secondary", "uterotonics", "radiotherapy", - "pharmacolog.*", "medicament", "Anesthetics", "vaccines", @@ -708,6 +707,8 @@ "Introns", "antioxidant", "Oils" - + ], + "patterns": [ + "pharmacolog.*" ] } diff --git a/code/ARAX/NodeSynonymizer/node_synonymizer.py b/code/ARAX/NodeSynonymizer/node_synonymizer.py index 8abf890be..6f5feacd3 100644 --- a/code/ARAX/NodeSynonymizer/node_synonymizer.py +++ b/code/ARAX/NodeSynonymizer/node_synonymizer.py @@ -7,7 +7,8 @@ import string import sys import time -from collections import defaultdict +import math +from collections import defaultdict, Counter from typing import Optional, Union, List, Set, Dict, Tuple import pandas as pd @@ -286,6 +287,7 @@ def get_curie_names(self, curies: Union[str, Set[str], List[str]], debug: bool = return results_dict def get_normalizer_results(self, entities: Optional[Union[str, Set[str], List[str]]], + max_synonyms: int = 1000000, debug: bool = False) -> dict: start = time.time() @@ -296,6 +298,15 @@ def get_normalizer_results(self, entities: Optional[Union[str, Set[str], List[st entities = entities_dict.get("terms") output_format = entities_dict.get("format") + # Allow the caller to encode the max_synonyms in the input dict (used by web UI) + max_synonyms_raw = entities_dict.get("max_synonyms") + try: + max_synonyms_int = int(max_synonyms_raw) + if max_synonyms_int > 0: + max_synonyms = max_synonyms_int + except: + pass + # Convert any input curies to Set format entities_set = self._convert_to_set_format(entities) @@ -307,6 +318,26 @@ def get_normalizer_results(self, entities: Optional[Union[str, Set[str], List[st equivalent_curies_dict_names = self.get_equivalent_nodes(names=unrecognized_entities, include_unrecognized_entities=False) equivalent_curies_dict.update(equivalent_curies_dict_names) + # Truncate synonyms to max number allowed per node + # First record counts for full list of equivalent curies before trimming + equiv_curie_counts_untrimmed = {input_entity: len(equivalent_curies) if equivalent_curies else 0 + for input_entity, equivalent_curies in equivalent_curies_dict.items()} + all_node_ids_untrimmed = set().union(*equivalent_curies_dict.values()) + sql_query_template = f""" + SELECT N.id, N.category + FROM nodes as N + WHERE N.id in ('{self.placeholder_lookup_values_str}')""" + matching_rows = self._run_sql_query_in_batches(sql_query_template, all_node_ids_untrimmed) + categories_map_untrimmed = {row[0]: f"biolink:{row[1]}" for row in matching_rows} + category_counts_untrimmed = dict() + equivalent_curies_dict_trimmed = dict() + for input_entity, equivalent_curies in equivalent_curies_dict.items(): + category_counts_untrimmed[input_entity] = dict(Counter([categories_map_untrimmed[equiv_curie] + for equiv_curie in equivalent_curies])) + equivalent_curies_trimmed = equivalent_curies[:max_synonyms] if equivalent_curies else None + equivalent_curies_dict_trimmed[input_entity] = equivalent_curies_trimmed + equivalent_curies_dict = equivalent_curies_dict_trimmed + # Then get info for all of those equivalent nodes # Note: We don't need to query by capitalized curies because these are all curies that exist in the synonymizer all_node_ids = set().union(*equivalent_curies_dict.values()) @@ -340,13 +371,13 @@ def get_normalizer_results(self, entities: Optional[Union[str, Set[str], List[st "SRI_normalizer_name": cluster_rep["name_sri"], "SRI_normalizer_category": cluster_rep["category_sri"], "SRI_normalizer_curie": cluster_id if cluster_rep["category_sri"] else None}, - "categories": defaultdict(int), + "total_synonyms": equiv_curie_counts_untrimmed[input_entity], + "categories": category_counts_untrimmed[input_entity], "nodes": [nodes_dict[equivalent_curie] for equivalent_curie in equivalent_curies]} - # Do some post-processing (tally up category counts and remove no-longer-needed 'cluster_id' property) + # Do some post-processing (remove no-longer-needed 'cluster_id' property) for normalizer_info in results_dict.values(): for equivalent_node in normalizer_info["nodes"]: - normalizer_info["categories"][equivalent_node["category"]] += 1 if "cluster_id" in equivalent_node: del equivalent_node["cluster_id"] if "cluster_preferred_name" in equivalent_node: @@ -368,11 +399,26 @@ def get_normalizer_results(self, entities: Optional[Union[str, Set[str], List[st for dict_key in keys_to_delete: del normalizer_info[dict_key] # Otherwise add in cluster graphs + elif output_format == "slim": + pass else: for normalizer_info in results_dict.values(): if normalizer_info: normalizer_info["knowledge_graph"] = self._get_cluster_graph(normalizer_info) + # Attempt to squash NaNs, which are not legal in JSON. Turn them into nulls + if ( normalizer_info is not None and 'knowledge_graph' in normalizer_info and + normalizer_info["knowledge_graph"] is not None and 'edges' in normalizer_info["knowledge_graph"] and + isinstance(normalizer_info["knowledge_graph"]['edges'],dict) ): + for edge_name, edge_data in normalizer_info["knowledge_graph"]['edges'].items(): + if 'attributes' in edge_data and isinstance(edge_data['attributes'], list): + for attribute in edge_data['attributes']: + try: + if 'value' in attribute and math.isnan(attribute['value']): + attribute['value'] = None + except: + pass + if debug: print(f"Took {round(time.time() - start, 5)} seconds") return results_dict @@ -495,7 +541,13 @@ def _get_cluster_graph(self, normalizer_info: dict) -> dict: intra_cluster_edge_ids_str = "[]" if cluster_row[0] == "nan" else cluster_row[0] intra_cluster_edge_ids = ast.literal_eval(intra_cluster_edge_ids_str) # Lists are stored as strings in sqlite - edges_query = f"SELECT * FROM edges WHERE id IN ('{self._convert_to_str_format(intra_cluster_edge_ids)}')" + # Get rid of any orphan edges (may be present if max_synonyms is specified in get_normalizer_results()) + subj_obj_query = f"SELECT id, subject, object FROM edges WHERE id IN ('{self._convert_to_str_format(intra_cluster_edge_ids)}')" + subj_obj_rows = self._execute_sql_query(subj_obj_query) + intra_cluster_edge_ids_trimmed = {edge_id for edge_id, subject_id, object_id in subj_obj_rows + if subject_id in kg.nodes and object_id in kg.nodes} + + edges_query = f"SELECT * FROM edges WHERE id IN ('{self._convert_to_str_format(intra_cluster_edge_ids_trimmed)}')" edge_rows = self._execute_sql_query(edges_query) edges_df = self._load_records_into_dataframe(edge_rows, "edges") edge_dicts = edges_df.to_dict(orient="records") diff --git a/code/ARAX/ResponseCache/reinitialize_database.py b/code/ARAX/ResponseCache/reinitialize_database.py index 9e0b41b0d..e27b48859 100644 --- a/code/ARAX/ResponseCache/reinitialize_database.py +++ b/code/ARAX/ResponseCache/reinitialize_database.py @@ -1,5 +1,5 @@ #!/bin/env python3 -# Reinitialize the Message/Feedback MySQL database +# Reinitialize the ResponseCache MySQL database import os import sys @@ -13,11 +13,11 @@ sys.exit(0) if sys.argv[1] != 'yes': - print("If you really want to delete and re-create the feedback/Message database, use:") + print("If you really want to delete and re-create the ResponseCache database, use:") print(" python reinitialize_database.py yes") sys.exit(0) -#### Create an RTX Feedback management object +#### Create an RTX ResponseCache management object response_cache = ResponseCache() #### Purge and re-create the database diff --git a/code/ARAX/ResponseCache/response_cache.py b/code/ARAX/ResponseCache/response_cache.py index 33f4a9c16..4a48709f2 100644 --- a/code/ARAX/ResponseCache/response_cache.py +++ b/code/ARAX/ResponseCache/response_cache.py @@ -1,5 +1,5 @@ #!/usr/bin/python3 -# Database definition and RTXFeedback class +# Database definition and ResponseCache class import sys def eprint(*args, **kwargs): print(*args, file=sys.stderr, **kwargs) diff --git a/code/ARAX/Testing/test4_results_inference.py b/code/ARAX/Testing/test4_results_inference.py index df4e34bf0..2c943d56e 100644 --- a/code/ARAX/Testing/test4_results_inference.py +++ b/code/ARAX/Testing/test4_results_inference.py @@ -19,10 +19,10 @@ def main(): response = Response() #### Read message #2 from the database. This should be the acetaminophen proteins query result message - sys.path.append(os.path.dirname(os.path.abspath(__file__))+"/../../UI/Feedback") - from RTXFeedback import RTXFeedback - araxdb = RTXFeedback() - message_dict = araxdb.getMessage(2) + sys.path.append(os.path.dirname(os.path.abspath(__file__)) + "/../ResponseCache") + from response_cache import ResponseCache + response_cache = ResponseCache() + message_dict = response_cache.get_response(314204) #### The stored message comes back as a dict. Transform it to objects messenger = ARAXMessenger() diff --git a/code/ARAX/test/test_ARAX_connect.py b/code/ARAX/test/test_ARAX_connect.py index f4d437e34..8b58750d0 100644 --- a/code/ARAX/test/test_ARAX_connect.py +++ b/code/ARAX/test/test_ARAX_connect.py @@ -83,8 +83,12 @@ def _virtual_tester(message: Message, edge_predicate: str, relation: str, attrib def test_connect_ulcerative_colitis_to_adalimumab(): query = {"operations": {"actions": [ "create_message", - "add_qnode(ids=MONDO:0005101, key=n00)", - "add_qnode(ids=UNII:FYS6T7F842, key=n01)", + "add_qnode(ids=MONDO:0005101, key=n_src)", + "add_qnode(ids=UNII:FYS6T7F842, key=n_dst)", + "add_qnode(categories=biolink:NamedThing, key=n_cns)", + "add_qedge(key=e_src_dst,subject=n_src,object=n_dst,predicates=biolink:related_to)", + "add_qedge(key=e_src_cns,subject=n_src,object=n_cns,predicates=biolink:related_to)", + "add_qedge(key=e_cns_dst,subject=n_cns,object=n_dst,predicates=biolink:related_to)", "connect(action=connect_nodes, max_path_length=3)", "return(message=true, store=false)" ]}} @@ -93,11 +97,16 @@ def test_connect_ulcerative_colitis_to_adalimumab(): assert len(message.query_graph.edges) == 3 assert len(message.results) > 0 + def test_connect_resveratrol_glyoxalase(): query = {"operations": {"actions": [ "create_message", - "add_qnode(ids=PUBCHEM.COMPOUND:445154, key=n00)", - "add_qnode(ids=NCBIGene:2739, key=n01)", + "add_qnode(ids=PUBCHEM.COMPOUND:445154, key=n_src)", + "add_qnode(ids=NCBIGene:2739, key=n_dst)", + "add_qnode(categories=biolink:NamedThing, key=n_cns)", + "add_qedge(key=e_src_dst,subject=n_src,object=n_dst,predicates=biolink:related_to)", + "add_qedge(key=e_src_cns,subject=n_src,object=n_cns,predicates=biolink:related_to)", + "add_qedge(key=e_cns_dst,subject=n_cns,object=n_dst,predicates=biolink:related_to)", "connect(action=connect_nodes, max_path_length=4)", "return(message=true, store=false)" ]}} @@ -106,13 +115,15 @@ def test_connect_resveratrol_glyoxalase(): assert len(message.query_graph.edges) == 3 assert len(message.results) > 0 - -@pytest.mark.slow def test_connect_pde5i_alzheimer(): query = {"operations": {"actions": [ "create_message", - "add_qnode(ids=MONDO:0004975, key=n00)", - "add_qnode(ids=UMLS:C1318700, key=n01)", + "add_qnode(ids=MONDO:0004975, key=n_src)", + "add_qnode(ids=UMLS:C1318700, key=n_dst)", + "add_qnode(categories=biolink:NamedThing, key=n_cns)", + "add_qedge(key=e_src_dst,subject=n_src,object=n_dst,predicates=biolink:related_to)", + "add_qedge(key=e_src_cns,subject=n_src,object=n_cns,predicates=biolink:related_to)", + "add_qedge(key=e_cns_dst,subject=n_cns,object=n_dst,predicates=biolink:related_to)", "connect(action=connect_nodes, max_path_length=4)", "return(message=true, store=false)" ]}} @@ -121,11 +132,16 @@ def test_connect_pde5i_alzheimer(): assert len(message.query_graph.edges) == 3 assert len(message.results) > 0 + def test_glucose_diabetes(): query = {"operations": {"actions": [ "create_message", - "add_qnode(name=CHEBI:37626, key=n0)", - "add_qnode(name=MONDO:0005015, key=n1)", + "add_qnode(name=CHEBI:37626, key=n_src)", + "add_qnode(name=MONDO:0005015, key=n_dst)", + "add_qnode(categories=biolink:NamedThing, key=n_cns)", + "add_qedge(key=e_src_dst,subject=n_src,object=n_dst,predicates=biolink:related_to)", + "add_qedge(key=e_src_cns,subject=n_src,object=n_cns,predicates=biolink:related_to)", + "add_qedge(key=e_cns_dst,subject=n_cns,object=n_dst,predicates=biolink:related_to)", "connect(action=connect_nodes, max_path_length=3)", "return(message=true, store=false)" ]}} @@ -134,6 +150,62 @@ def test_glucose_diabetes(): assert len(message.query_graph.edges) == 3 assert len(message.results) > 0 +def test_query_by_query_graph_2(): + query = { + "message": { + "query_graph": { + "nodes": { + "n0": { + "ids": [ + "CHEBI:37626" + ] + }, + "un": { + "categories": [ + "biolink:NamedThing" + ] + }, + "n2": { + "ids": [ + "MONDO:0005015" + ] + } + }, + "edges": { + "e0": { + "subject": "n0", + "object": "un", + "predicates": [ + "biolink:related_to" + ], + "knowledge_type": "inferred" + }, + "e1": { + "subject": "un", + "object": "n2", + "predicates": [ + "biolink:related_to" + ], + "knowledge_type": "inferred" + }, + "e2": { + "subject": "n0", + "object": "n2", + "predicates": [ + "biolink:related_to" + ], + "knowledge_type": "inferred" + } + } + } + } + } + araxq = ARAXQuery() + araxq.query(query) + response = araxq.response + assert response.status == 'OK' + assert len(response.envelope.message.query_graph.edges) == 3 + assert len(response.envelope.message.results) > 0 if __name__ == "__main__": pytest.main(['-v']) diff --git a/code/ARAX/test/test_ARAX_expand.py b/code/ARAX/test/test_ARAX_expand.py index 17acba75a..4d314b92a 100644 --- a/code/ARAX/test/test_ARAX_expand.py +++ b/code/ARAX/test/test_ARAX_expand.py @@ -4,7 +4,6 @@ Run all expand tests: pytest -v test_ARAX_expand.py Run a single test: pytest -v test_ARAX_expand.py -k test_branched_query """ - import sys import os from typing import List, Dict, Optional @@ -131,6 +130,15 @@ def _check_attribute(attribute: Attribute): assert isinstance(attribute.description, str) or attribute.description is None +def get_primary_knowledge_source(edge: Edge) -> str: + return next(source.resource_id for source in edge.sources if source.resource_role == "primary_knowledge_source") + +def get_support_graphs_attribute(edge: Edge) -> any: + sg_attrs = [attribute for attribute in edge.attributes if attribute.attribute_type_id == "biolink:support_graphs"] + assert len(sg_attrs) <= 1 + return sg_attrs[0] if sg_attrs else None + + @pytest.mark.slow def test_720_multiple_qg_ids_in_different_results(): actions_list = [ @@ -1504,7 +1512,7 @@ def test_klat_attributes(): if attribute.attribute_type_id in {"biolink:knowledge_level", "biolink:agent_type"}) -def test_treats_patch_issue_2328(): +def test_treats_patch_issue_2328_a(): query = { "nodes": { "disease": { @@ -1531,19 +1539,25 @@ def test_treats_patch_issue_2328(): } } } - nodes_by_qg_id, edges_by_qg_id = _run_query_and_do_standard_testing(json_query=query) + nodes_by_qg_id, edges_by_qg_id, message = _run_query_and_do_standard_testing(json_query=query, return_message=True) assert edges_by_qg_id["t_edge"] - kg2_edges_treats = [edge for edge in edges_by_qg_id["t_edge"].values() - if any(source.resource_id == "infores:rtx-kg2" for source in edge.sources)] - print(f"Answer includes {len(kg2_edges_treats)} edges from KG2") - assert kg2_edges_treats - print(kg2_edges_treats) - for edge in kg2_edges_treats: - assert edge.predicate == "biolink:treats" - assert edge.attributes - assert not any(source.resource_id == "infores:semmeddb" for source in edge.sources) - - # Verify that the predicate editing doesn't happen outside of inferred mode + # Make sure the KG2 edges, which are higher-level treats edges, are in the KG (used as support edges) + creative_expand_treats_edges = [edge for edge_key, edge in message.knowledge_graph.edges.items() + if edge_key.startswith("creative_expand")] + support_edge_keys = set() + for edge in creative_expand_treats_edges: + aux_graph_keys = get_support_graphs_attribute(edge).value + assert aux_graph_keys + for aux_graph_key in aux_graph_keys: + aux_graph = message.auxiliary_graphs[aux_graph_key] + support_edge_keys.update(set(aux_graph.edges)) + support_edges = [message.knowledge_graph.edges[edge_key] for edge_key in support_edge_keys] + + assert any(source.resource_id == "infores:rtx-kg2" for edge in support_edges for source in edge.sources) + assert not any(source.resource_id == "infores:semmeddb" for edge in support_edges for source in edge.sources) + +def test_treats_patch_issue_2328_b(): + # Verify that the edge editing doesn't happen outside of inferred mode query = { "nodes": { "disease": { @@ -1579,5 +1593,52 @@ def test_treats_patch_issue_2328(): assert any(edge for edge in kg2_edges_treats_or if edge.predicate == "biolink:applied_to_treat") +@pytest.mark.external +def test_creative_treats_predicate_alteration_2412(): + query = { + "nodes": { + "n00": { + "ids": ["MONDO:0018958"] + }, + "n01": { + "categories": ["biolink:SmallMolecule"] + } + }, + "edges": { + "e00": { + "subject": "n01", + "object": "n00", + "predicates": ["biolink:treats"], + "knowledge_type": "inferred" + } + } + } + nodes_by_qg_id, edges_by_qg_id, message = _run_query_and_do_standard_testing(json_query=query, return_message=True) + + # Make sure we appear to have creative expand treats edges + assert edges_by_qg_id and edges_by_qg_id.get("e00") + assert any(edge_key for edge_key in edges_by_qg_id["e00"] if edge_key.startswith("creative_expand")) + primary_sources_e00 = {get_primary_knowledge_source(edge) for edge in edges_by_qg_id["e00"].values()} + print(f"primary_knowledge_sources are: {primary_sources_e00}") + assert "infores:arax" in primary_sources_e00 + + # Make sure 'support' edges, like from ROBOKOP, are present in the KG + primary_sources_all = {get_primary_knowledge_source(edge) for edges_dict in edges_by_qg_id.values() + for edge in edges_dict.values()} + assert "infores:automat-robokop" in primary_sources_all + + # Make sure that creative expand treats edges have support graphs that actually exist + for edge_key, edge in edges_by_qg_id["e00"].items(): + if get_primary_knowledge_source(edge) == "infores:arax": + support_graph_attr = get_support_graphs_attribute(edge) + assert support_graph_attr + aux_graph_keys = eu.convert_to_set(support_graph_attr.value) + assert aux_graph_keys.issubset(message.auxiliary_graphs) + for aux_graph_key in aux_graph_keys: + aux_graph = message.auxiliary_graphs[aux_graph_key] + assert set(aux_graph.edges).issubset(message.knowledge_graph.edges) + + + if __name__ == "__main__": pytest.main(['-v', 'test_ARAX_expand.py']) diff --git a/code/ARAX/test/test_ARAX_infer.py b/code/ARAX/test/test_ARAX_infer.py index a6d2c11af..cd6717f5d 100644 --- a/code/ARAX/test/test_ARAX_infer.py +++ b/code/ARAX/test/test_ARAX_infer.py @@ -289,7 +289,7 @@ def test_xcrg_infer_bomeol(): edge_key = creative_mode_edges[0] edge_result = message.knowledge_graph.edges[edge_key] assert edge_result.predicate in ['biolink:regulates', 'biolink:affects'] - + @pytest.mark.slow def test_xcrg_with_qg1(): query = { @@ -356,7 +356,7 @@ def test_xcrg_with_qg2(): "r_edge": { "object": "gene", "subject": "chemical", - "predicates": ['biolink:regulates', 'biolink:affects'], + "predicates": ['biolink:affects'], "knowledge_type": "inferred", "qualifier_constraints": [ { @@ -388,39 +388,52 @@ def test_xcrg_with_qg2(): edge_result = message.knowledge_graph.edges[edge_key] assert edge_result.predicate == 'biolink:regulates' - @pytest.mark.slow def test_xcrg_with_only_qg(): query = { - "message": {"query_graph": { - "nodes": { - "gene": { - "ids": ["UniProtKB:P48736"] - }, - "chemical": { - "categories": ['biolink:ChemicalEntity', 'biolink:ChemicalMixture','biolink:SmallMolecule'] - } - }, + "message": {"query_graph": { "edges": { - "r_edge": { - "object": "gene", - "subject": "chemical", - "predicates": ["biolink:regulates", "biolink:affects"], - "knowledge_type": "inferred", - "qualifier_constraints": [ + "t_edge": { + "knowledge_type": "inferred", + "object": "ON", + "predicates": [ + "biolink:affects" + ], + "qualifier_constraints": [ + { + "qualifier_set": [ { - "qualifier_set": [ - { - "qualifier_type_id": "biolink:object_direction_qualifier", - "qualifier_value": "decreased" - } - ] + "qualifier_type_id": "biolink:object_aspect_qualifier", + "qualifier_value": "activity_or_abundance" + }, + { + "qualifier_type_id": "biolink:object_direction_qualifier", + "qualifier_value": "decreased" } ] + } + ], + "subject": "SN" + } + }, + "nodes": { + "ON": { + "categories": [ + "biolink:Gene", + "biolink:Protein" + ], + "ids": [ + "NCBIGene:3043" + ] + }, + "SN": { + "categories": [ + "biolink:ChemicalEntity" + ] } } - } - } + } + } } [response, message] = _do_arax_query(query) # return response, message @@ -431,7 +444,7 @@ def test_xcrg_with_only_qg(): if len(creative_mode_edges) != 0: edge_key = creative_mode_edges[0] edge_result = message.knowledge_graph.edges[edge_key] - assert edge_result.predicate == 'biolink:regulates' + assert edge_result.predicate == 'biolink:affects' @pytest.mark.slow def test_xcrg_infer_dsl(): diff --git a/code/ARAX/test/test_ARAX_json_queries.py b/code/ARAX/test/test_ARAX_json_queries.py index cd20955cf..fa0a72dae 100644 --- a/code/ARAX/test/test_ARAX_json_queries.py +++ b/code/ARAX/test/test_ARAX_json_queries.py @@ -180,7 +180,7 @@ def test_workflow1(): } nodes_by_qg_id, edges_by_qg_id, response = _run_query_and_do_standard_testing(json_query=query) essences = [x.to_dict()['essence'].upper() for x in response.envelope.message.results] - assert 'CYCLOOXYGENASE' in essences + assert 'VANILLOID RECEPTOR' in essences @pytest.mark.slow def test_workflow2(): diff --git a/code/ARAX/test/test_ARAX_resultify.py b/code/ARAX/test/test_ARAX_resultify.py index 33b411291..6cbc3f08d 100644 --- a/code/ARAX/test/test_ARAX_resultify.py +++ b/code/ARAX/test/test_ARAX_resultify.py @@ -30,7 +30,7 @@ DIABETES_CURIE = "MONDO:0005015" TYPE_1_DIABETES_CURIE = "MONDO:0005147" -INSULIN_CURIE = "PUBCHEM.COMPOUND:16137271" +INSULIN_CURIE = "UNII:4FT78T86XV" HEART_DISEASE_CURIE = "MONDO:0005267" @@ -1478,6 +1478,7 @@ def test_node_binding_query_id_one_hop_single_input_curie(): assert any(edge.predicate == "biolink:subclass_of" for edge in message.knowledge_graph.edges.values()) insulin_results = [result for result in message.results if any([node_binding.id == INSULIN_CURIE for node_binding in result.node_bindings["n01"]])] + assert len(insulin_results) == 1 diff --git a/code/ARAX/test/test_ARAX_synonymizer.py b/code/ARAX/test/test_ARAX_synonymizer.py index 945a87a48..3f8500e98 100644 --- a/code/ARAX/test/test_ARAX_synonymizer.py +++ b/code/ARAX/test/test_ARAX_synonymizer.py @@ -417,5 +417,26 @@ def test_cluster_graphs(): assert node["attributes"] +def test_truncate_cluster(): + synonymizer = NodeSynonymizer() + results = synonymizer.get_normalizer_results([ACETAMINOPHEN_CURIE, PARKINSONS_CURIE], max_synonyms=2) + + print(json.dumps(results[ACETAMINOPHEN_CURIE]["nodes"], indent=2)) + assert len(results[ACETAMINOPHEN_CURIE]["nodes"]) == 2 + assert len(results[ACETAMINOPHEN_CURIE]["knowledge_graph"]["nodes"]) == 2 + assert len(results[ACETAMINOPHEN_CURIE]["knowledge_graph"]["edges"]) < 20 + assert results[ACETAMINOPHEN_CURIE]["total_synonyms"] > 2 + assert results[ACETAMINOPHEN_CURIE]["categories"]["biolink:Drug"] > 2 + assert "biolink:Disease" not in results[ACETAMINOPHEN_CURIE]["categories"] + + print(json.dumps(results[PARKINSONS_CURIE]["nodes"], indent=2)) + assert len(results[PARKINSONS_CURIE]["nodes"]) == 2 + assert len(results[PARKINSONS_CURIE]["knowledge_graph"]["nodes"]) == 2 + assert len(results[PARKINSONS_CURIE]["knowledge_graph"]["edges"]) < 20 + assert results[PARKINSONS_CURIE]["total_synonyms"] > 2 + assert results[PARKINSONS_CURIE]["categories"]["biolink:Disease"] > 2 + assert "biolink:Drug" not in results[PARKINSONS_CURIE]["categories"] + + if __name__ == "__main__": pytest.main(['-v', 'test_ARAX_synonymizer.py']) diff --git a/code/RTXConfiguration.py b/code/RTXConfiguration.py index 673a1b852..1580ef8f8 100644 --- a/code/RTXConfiguration.py +++ b/code/RTXConfiguration.py @@ -46,27 +46,7 @@ def _private_init(self): # Determine current ARAX and TRAPI versions # YAML is super slow to ready, so refresh a JSON if necessary or read the JSON, which is much faster openapi_yaml_path = f"{file_dir}/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml" - openapi_json_path = f"{file_dir}/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.json" - if not os.path.exists(openapi_json_path) or os.path.getmtime(openapi_yaml_path) > os.path.getmtime(openapi_json_path): - if DEBUG: - t1 = timeit.default_timer() - print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. OpenAPI JSON file is missing or stale") - with open(openapi_yaml_path) as api_file: - openapi_configuration = yaml.safe_load(api_file) - if DEBUG: - t1 = timeit.default_timer() - print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. Read OpenAPI YAML file") - with open(openapi_json_path, 'w') as api_file: - json.dump(openapi_configuration, api_file, default=str) - if DEBUG: - t1 = timeit.default_timer() - print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. Created OpenAPI JSON file") - else: - with open(openapi_json_path) as api_file: - openapi_configuration = json.load(api_file) - if DEBUG: - t1 = timeit.default_timer() - print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. Read OpenAPI JSON file") + openapi_configuration = self.load_openapi_json(openapi_yaml_path, t0) self.arax_version = openapi_configuration["info"]["version"] self.trapi_version = openapi_configuration["info"]["x-trapi"]["version"] @@ -107,10 +87,14 @@ def _private_init(self): # Determine our maturity maturity_override_value = self._read_override_file(f"{file_dir}/maturity_override.txt") + if DEBUG: + print(f"maturity_override_value={maturity_override_value} from {file_dir}/maturity_override.txt") if maturity_override_value: self.maturity = maturity_override_value else: # Otherwise we'll dynamically determine our maturity based on instance/domain name and/or branch + if DEBUG: + print(f"Auto-detecting maturity: self.domain={self.domain}, self.instance_name={self.instance_name}") if self.domain in ["arax.ci.transltr.io", "kg2.ci.transltr.io"]: self.maturity = "staging" elif self.domain in ["arax.test.transltr.io", "kg2.test.transltr.io"] or self.current_branch_name == "itrb-test": @@ -119,14 +103,14 @@ def _private_init(self): self.maturity = "production" elif self.domain == "arax.ncats.io": if self.instance_name in ["ARAX", "kg2"] or self.current_branch_name == "production": - self.maturity = "production" + self.maturity = "staging" else: self.maturity = "development" else: self.maturity = "development" if DEBUG: t1 = timeit.default_timer() - print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. Determined maturity") + print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. Determined maturity={self.maturity}") # Determine if this is an ITRB instance or our CICD instance self.is_itrb_instance = "transltr.io" in self.domain # Hacky, but works @@ -208,26 +192,17 @@ def _private_init(self): self.mysql_feedback_username = self.config_secrets["mysql_feedback"]["username"] self.mysql_feedback_password = self.config_secrets["mysql_feedback"]["password"] - # Set up correct Plover URL (since it's not registered in SmartAPI) - plover_url_override_value = self._read_override_file(f"{file_dir}/plover_url_override.txt") - if plover_url_override_value: - self.plover_url = plover_url_override_value - elif self.maturity in {"production", "prod"}: - self.plover_url = self.config_dbs["plover"]["prod"] - elif self.maturity in {"testing", "test"}: - self.plover_url = self.config_dbs["plover"]["test"] - else: # Includes staging, development - self.plover_url = self.config_dbs["plover"]["dev"] - if DEBUG: - t1 = timeit.default_timer() - print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. Read override file {file_dir}/plover_url_override.txt") - - # Set KG2 url if an override was provided - kg2_url_override_value = self._read_override_file(f"{file_dir}/kg2_url_override.txt") - if kg2_url_override_value: - self.rtx_kg2_url = kg2_url_override_value + # Find the correct KG2/Plover URL (defaults to our SmartAPI yaml, but can override in config_dbs.json) + plover_url_override = self.config_dbs.get("plover_url_override") + if plover_url_override: + self.plover_url = plover_url_override.strip("/") else: - self.rtx_kg2_url = None + # Default to what we list in our SmartAPI registration + # YAML is super slow to ready, so refresh a JSON if necessary or read the JSON, which is much faster + openapi_kg2_yaml_path = f"{file_dir}/UI/OpenAPI/specifications/export/KG2/1.5.0/openapi.yaml" + kg2_openapi_config = self.load_openapi_json(openapi_kg2_yaml_path, t0) + servers_map = {server["x-maturity"]: server for server in kg2_openapi_config["servers"]} + self.plover_url = servers_map[self.maturity]["url"] # Default to KG2c neo4j self.neo4j_kg2 = "KG2c" @@ -264,6 +239,33 @@ def get_neo4j_info(self, kg2_type: str) -> dict: 'username': config_secrets["neo4j"][kg2_type]["username"], 'password': config_secrets["neo4j"][kg2_type]["password"]} + @staticmethod + def load_openapi_json(yaml_path: str, t0: any) -> dict: + # YAML is super slow to ready, so refresh a JSON if necessary or read the JSON, which is much faster + json_path = yaml_path.replace(".yaml", ".json") + if not os.path.exists(json_path) or os.path.getmtime(yaml_path) > os.path.getmtime(json_path): + if DEBUG: + t1 = timeit.default_timer() + print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. OpenAPI JSON file is missing or stale") + with open(yaml_path) as api_file: + openapi_configuration = yaml.safe_load(api_file) + if DEBUG: + t1 = timeit.default_timer() + print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. Read OpenAPI YAML file") + with open(json_path, 'w') as api_file: + json.dump(openapi_configuration, api_file, default=str) + if DEBUG: + t1 = timeit.default_timer() + print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. Created OpenAPI JSON file") + else: + with open(json_path) as api_file: + openapi_configuration = json.load(api_file) + if DEBUG: + t1 = timeit.default_timer() + print(f"Elapsed time: {(t1-t0)*1000:.2f} ms. Read OpenAPI JSON file") + return openapi_configuration + + def main(): t0 = timeit.default_timer() @@ -273,7 +275,6 @@ def main(): kg2_info = rtxConfig.get_neo4j_info("KG2c") pprint.pprint(kg2_info) print("plover url: %s" % rtxConfig.plover_url) - print("rtx-kg2 url: %s" % rtxConfig.rtx_kg2_url) print("mysql feedback host: %s" % rtxConfig.mysql_feedback_host) print("mysql feedback port: %s" % rtxConfig.mysql_feedback_port) print("mysql feedback username: %s" % rtxConfig.mysql_feedback_username) diff --git a/code/UI/Feedback/Notes.txt b/code/UI/Feedback/Notes.txt deleted file mode 100644 index e618aeef9..000000000 --- a/code/UI/Feedback/Notes.txt +++ /dev/null @@ -1,39 +0,0 @@ - -Notes trying to SQLAlchemy working for the feedback system - -Useful web sites: -https://www.sqlalchemy.org/library.html#recipes -https://www.pythoncentral.io/introductory-tutorial-python-sqlalchemy/ - -Installation: -- Run ConEmu as Administrator -pip3 install sqlalchemy -pip3 install --upgrade pip - -cd C:\Users\deutsch\Subversion\RTX\trunk\code\UI\Feedback -python Test1.py - -#### This was supposed to help make a cute little ER diagram, but failed to install -#### Possibly needs a reboot after installing the C++ libraries, which I hadn't done yet -pip3 install eralchemy - - - -TO do: -- Update the YAML API for: - - Fetch a single response: - http://rtx.ncats.io/api/rtx/v1/response/26 - - Fetch a single result: - http://rtx.ncats.io/api/rtx/v1/response/26/result/333 - - Fetch the feedback for a particular response (all results) - GET http://rtx.ncats.io/api/rtx/v1/feedback/response/26 - - Fetch the feedback for a particular result - GET http://rtx.ncats.io/api/rtx/v1/feedback/response/26/result/333 - - Store the feedback for a particlar result - POST http://rtx.ncats.io/api/rtx/v1/feedback - including response=26 result=333 diff --git a/code/UI/Feedback/RTXFeedback.py b/code/UI/Feedback/RTXFeedback.py deleted file mode 100644 index c6f9dcdd0..000000000 --- a/code/UI/Feedback/RTXFeedback.py +++ /dev/null @@ -1,803 +0,0 @@ -#!/usr/bin/python3 -# Database definition and RTXFeedback class -import sys -def eprint(*args, **kwargs): print(*args, file=sys.stderr, **kwargs) - -import os -import sys -import re -import json -import ast -from datetime import datetime -import pickle -import hashlib -import collections -import requests -import json -from flask import Flask,redirect - -from sqlalchemy import Column, ForeignKey, Integer, Float, String, DateTime, Text, PickleType, LargeBinary -from sqlalchemy.ext.declarative import declarative_base -from sqlalchemy.orm import relationship -from sqlalchemy import create_engine -from sqlalchemy.orm import sessionmaker -from sqlalchemy import desc -from sqlalchemy import inspect - -sys.path.append(os.path.dirname(os.path.abspath(__file__))+"/../../") -from RTXConfiguration import RTXConfiguration - -sys.path.append(os.path.dirname(os.path.abspath(__file__))+"/../OpenAPI/python-flask-server/") -from swagger_server.models.result_feedback import ResultFeedback -from swagger_server.models.feedback import Feedback -from swagger_server.models.message import Message as TxMessage -from swagger_server.models.previous_message_processing_plan import PreviousMessageProcessingPlan - -#import Enricher -sys.path.append(os.path.dirname(os.path.abspath(__file__))+"/../../ARAX/ARAXQuery") -from actions_parser import ActionsParser -from ARAX_filter import ARAXFilter - -Base = declarative_base() - -#### Define the database tables as classes -class Message(Base): - __tablename__ = 'message09' - message_id = Column(Integer, primary_key=True) - message_datetime = Column(DateTime, nullable=False) - restated_question = Column(String(255), nullable=False) - query_type = Column(String(50), nullable=False) - terms = Column(String(1024), nullable=False) - tool_version = Column(String(50), nullable=False) - result_code = Column(String(50), nullable=False) - message = Column(Text, nullable=False) - n_results = Column(Integer, nullable=False) - # PickleType uses BLOB on MySQL, which is only 65k. Could not seem to work around it. Resort to LargeBinary with explicit length and my own pickling. - #message_object = Column(PickleType, nullable=False) - message_object = Column(LargeBinary(length=100500500), nullable=False) - -class Result(Base): - __tablename__ = 'result09' - result_id = Column(Integer, primary_key=True) - message_id = Column(Integer, ForeignKey('message09.message_id')) # for backward compat, this is retained as the *first* message_id - confidence = Column(Float, nullable=False) - n_nodes = Column(Integer, nullable=False) - n_edges = Column(Integer, nullable=False) - result_text = Column(Text, nullable=False) - result_object = Column(LargeBinary(length=16777200), nullable=False) - result_hash = Column(String(255), nullable=False) - message = relationship(Message) - -class Message_result(Base): - __tablename__ = 'message_result09' - message_result_id = Column(Integer, primary_key=True) - result_id = Column(Integer, ForeignKey('result09.result_id')) - message_id = Column(Integer, ForeignKey('message09.message_id')) - -class Commenter(Base): - __tablename__ = 'commenter09' - commenter_id = Column(Integer, primary_key=True) - full_name = Column(String(255), nullable=False) - email_address = Column(String(255), nullable=False) - password = Column(String(255), nullable=False) - -class Rating(Base): - __tablename__ = 'rating09' - rating_id = Column(Integer, primary_key=True) - score = Column(Integer, nullable=False) - tag = Column(String(50), nullable=False) - name = Column(String(255), nullable=False) - description = Column(String(255), nullable=False) - -class Expertise_level(Base): - __tablename__ = 'expertise_level09' - expertise_level_id = Column(Integer, primary_key=True) - score = Column(Integer, nullable=False) - tag = Column(String(50), nullable=False) - name = Column(String(255), nullable=False) - description = Column(String(255), nullable=False) - -class Result_rating(Base): - __tablename__ = 'result_rating09' - result_rating_id = Column(Integer, primary_key=True) - result_id = Column(Integer, ForeignKey('result09.result_id')) - commenter_id = Column(Integer, ForeignKey('commenter09.commenter_id')) - expertise_level_id = Column(Integer, ForeignKey('expertise_level09.expertise_level_id')) - rating_id = Column(Integer, ForeignKey('rating09.rating_id')) - comment_datetime = Column(DateTime, nullable=False) - comment = Column(Text, nullable=True) - result = relationship(Result) - commenter = relationship(Commenter) - expertise_level = relationship(Expertise_level) - rating = relationship(Rating) - - -#### The main RTXFeedback class -class RTXFeedback: - - #### Constructor - def __init__(self): - self.databaseName = "RTXFeedback" - self.connect() - - #### Destructor - def __del__(self): - self.disconnect() - - - #### Define attribute session - @property - def session(self) -> str: - return self._session - - @session.setter - def session(self, session: str): - self._session = session - - - #### Define attribute engine - @property - def engine(self) -> str: - return self._engine - - @engine.setter - def engine(self, engine: str): - self._engine = engine - - - #### Define attribute databaseName - @property - def databaseName(self) -> str: - return self._databaseName - - @databaseName.setter - def databaseName(self, databaseName: str): - self._databaseName = databaseName - - - #### Delete and create the RTXFeedback SQLite database. Careful! - def createDatabase(self): - print("Creating database") - #if os.path.exists(self.databaseName): - # os.remove(self.databaseName) - #engine = create_engine("sqlite:///"+self.databaseName) - rtxConfig = RTXConfiguration() - engine = create_engine("mysql+pymysql://" + rtxConfig.mysql_feedback_username + ":" + rtxConfig.mysql_feedback_password + "@" + rtxConfig.mysql_feedback_host + "/" + self.databaseName) - Base.metadata.drop_all(engine) - Base.metadata.create_all(engine) - self.connect() - - #### Create and store a database connection - def connect(self): - #engine = create_engine("sqlite:///"+self.databaseName) - rtxConfig = RTXConfiguration() - engine = create_engine("mysql+pymysql://" + rtxConfig.mysql_feedback_username + ":" + rtxConfig.mysql_feedback_password + "@" + rtxConfig.mysql_feedback_host + "/" + self.databaseName) - DBSession = sessionmaker(bind=engine) - session = DBSession() - self.session = session - self.engine = engine - - #### Create and store a database connection - def disconnect(self): - session = self.session - engine = self.engine - session.close() - try: - engine.dispose() - except: - pass - - - #### Pre-populate the database with reference data - def prepopulateDatabase(self): - session = self.session - rating = Rating(score=100,tag='Excellent',name='Excellent result',description='This result provides a correct and complete answer to the asked question.') - session.add(rating) - rating = Rating(score=90,tag='Very good',name='Very good result',description='This result provides a correct but slightly incomplete answer to the asked question.') - session.add(rating) - rating = Rating(score=80,tag='Intriguing',name='Intriguing result',description='This result may or may not be correct but provides a very intriguing thought process that bears further scrutiny.') - session.add(rating) - rating = Rating(score=50,tag='Good',name='Good result',description='This result provides a mostly correct but substantially incomplete answer to the asked question.') - session.add(rating) - rating = Rating(score=30,tag='Okay',name='Okay result',description='This result is not incorrect but is a vast oversimplification compared with a complete answer.') - session.add(rating) - rating = Rating(score=20,tag='Poor',name='Poor result',description='This result is some merit but includes thought paths that are incorrect.') - session.add(rating) - rating = Rating(score=10,tag='Irrelevant',name='Irrelevant result',description='This result does not address the question that was asked.') - session.add(rating) - rating = Rating(score=0,tag='Wrong',name='Wrong result',description='This result makes assertions that are wrong.') - session.add(rating) - session.commit() - - expertise_level = Expertise_level(score=100,tag='High',name='High expertise',description='Reviewer has a high degree of expertise related to this question and result. He or she writes papers on this question or treats patients with conditions related to this question.') - session.add(expertise_level) - expertise_level = Expertise_level(score=70,tag='Medium',name='Medium expertise',description='Reviewer has a medium degree of expertise related to this question and result. He or she is engaged in research or treats patients in a related field.') - session.add(expertise_level) - expertise_level = Expertise_level(score=50,tag='Some',name='Some expertise',description='Reviewer has some familiarity related with this question and result, but not enough to be authoritative.') - session.add(expertise_level) - expertise_level = Expertise_level(score=30,tag='Low',name='Low expertise',description='Reviewer has low familiarity with this question and result, but has basic understanding of biology and disease.') - session.add(expertise_level) - expertise_level = Expertise_level(score=10,tag='None',name='No expertise',description='Reviewer might best keep his thoughts on this to himself, but cannot prevent himself from amusing his colleagues with irrelevant nonsense. Coder.') - session.add(expertise_level) - session.commit() - - commenter = Commenter(full_name='Test User',email_address='testuser@systemsbioloy.org',password='None') - session.add(commenter) - session.commit() - - - #### Store a new Message into the database - def addNewMessage(self,message,query): - session = self.session - - #### Update the n_results information - n_results = 0 - if message.results is not None: - n_results = len(message.results) - if message.code_description is None: - plural = "s" - if n_results == 1: plural = "" - message.code_description = "Query returned %i result%s" % (n_results,plural) - - #### Add result metadata - if message.results is not None: - for result in message.results: - if result.reasoner_id is None: - result.reasoner_id = "ARAX" - - #### Update the message with current information - rtxConfig = RTXConfiguration() - if message.tool_version is None: - message.tool_version = rtxConfig.version - if message.schema_version is None: - message.schema_version = "0.9.3" - if message.reasoner_id is None: - message.reasoner_id = "ARAX" - message.n_results = n_results - message.type = "translator_reasoner_message" - message.context = "https://raw.githubusercontent.com/biolink/biolink-model/master/context.jsonld" - message.datetime = datetime.now().strftime("%Y-%m-%d %H:%M:%S") - - if message.restated_question is None: - message.restated_question = "" - if message.original_question is None: - message.original_question = "" - - termsString = "{}" - query_type_id = 0 - if query is not None and "query_type_id" in query: - query_type_id = query["query_type_id"] - if query_type_id == 0 and query is not None and "message" in query and "query_type_id" in query["message"]: - query_type_id = query["message"]["query_type_id"] - - if query is not None and "message" in query: - if "terms" in query["message"]: - termsString = stringifyDict(query["message"]["terms"]) - elif "query_graph" in query["message"]: - termsString = stringifyDict(query["message"]["query_graph"]) - - storedMessage = Message(message_datetime=datetime.now(),restated_question=message.restated_question,query_type=query_type_id, - terms=termsString,tool_version=rtxConfig.version,result_code=message.message_code,message=message.code_description,n_results=n_results,message_object=b'') - session.add(storedMessage) - session.flush() - session.commit() - message.id = "https://arax.ncats.io/api/rtx/v1/message/"+str(storedMessage.message_id) - - #### Instead of storing the message in the MySQL database as a message_object (the old way) - #### Instead now store it as a JSON file on the filesystem - message_dir = os.path.dirname(os.path.abspath(__file__)) + '/../../../data/responses' - if not os.path.exists(message_dir): - try: - os.mkdir(message_dir) - except: - eprint(f"ERROR: Unable to create dir {message_dir}") - - if os.path.exists(message_dir): - message_filename = f"{storedMessage.message_id}.json" - message_path = f"{message_dir}/{message_filename}" - try: - with open(message_path, 'w') as outfile: - json.dump(message.to_dict(), outfile, sort_keys=True) - except: - eprint(f"ERROR: Unable to write message to file {message_path}") - - #### This has been mostly castrated but it still puts ids in there, and may be resurrected someday - self.addNewResults(storedMessage.message_id,message) - - #### After updating all the ids, store an updated object - #### No longer needed because we're writing to a file after the INSERT - #storedMessage.message_object=pickle.dumps(ast.literal_eval(repr(message))) - #session.commit() - - return storedMessage.message_id - - - #### We used to store all the result as separate entities in the database, mostly to allow feedback on each one. - #### But this was not used and was slow, so this is being purged from the codebase on 2020-09-22. Can always bring - #### it back if desired. But set everything to a plain integer count for now. Not correct, but - #### not used anyway. - def addNewResults(self,message_id,message): - if message.results is None: - return - - id_counter = 1 - for result in message.results: - - if result.result_type is None: - result.result_type = "individual query answer" - if result.confidence is None: - result.confidence = 0 - try: - result.confidence = float(result.confidence) - except: - eprint(f"WARNING: Confidence value '{result.confidence}' cannot be converted to float") - result.confidence = -999.0 - - result.id = f"https://arax.ncats.io/api/rtx/v1/result/{id_counter}" - id_counter += 1 - - - #### Get a previously stored message for this query from the database - def getCachedMessage(self,query): - if "bypass_cache" in query and query["bypass_cache"] == "true": - return - session = self.session - rtxConfig = RTXConfiguration() - tool_version = rtxConfig.version - termsString = stringifyDict(query["message"]["terms"]) - - #### Look for previous messages we could use - storedMessage = session.query(Message).filter(Message.query_type==query["message"]["query_type_id"]).filter(Message.tool_version==tool_version).filter(Message.terms==termsString).order_by(desc(Message.message_datetime)).first() - if ( storedMessage is not None ): - return pickle.loads(storedMessage.message_object) - return - - - #### Get the list of ratings - def getRatings(self): - session = self.session - message = { "ratings": [] } - count = 0 - for rating in session.query(Rating).all(): - message["ratings"].append(object_as_dict(rating)) - count += 1 - message["n_ratings"] = count - return(message) - - - #### Get the list of expertise levels - def getExpertiseLevels(self): - session = self.session - message = { "expertise_levels": [] } - count = 0 - for level in session.query(Expertise_level).all(): - message["expertise_levels"].append(object_as_dict(level)) - count += 1 - message["n_expertise_levels"] = count - return(message) - - - #### Fetch a cached message - def getMessage(self, message_id): - session = self.session - - if message_id is None: - return( { "status": 400, "title": "message_id missing", "detail": "Required attribute message_id is missing from URL", "type": "about:blank" }, 400) - - #### Find the message - storedMessage = session.query(Message).filter(Message.message_id==message_id).first() - if storedMessage is not None: - if len(storedMessage.message_object) < 5: - message_dir = os.path.dirname(os.path.abspath(__file__)) + '/../../../data/responses' - message_filename = f"{storedMessage.message_id}.json" - message_path = f"{message_dir}/{message_filename}" - try: - with open(message_path) as infile: - return json.load(infile) - except: - eprint(f"ERROR: Unable to read message from file '{message_path}'") - - else: - return pickle.loads(storedMessage.message_object) - else: - return( { "status": 404, "title": "Message not found", "detail": "There is no message corresponding to message_id="+str(message_id), "type": "about:blank" }, 404) - - - #### Get a previously stored message for this query from the database - def processExternalPreviousMessageProcessingPlan(self,inputEnvelope): - debug = 1 - if debug: eprint("DEBUG: Entering processExternalPreviousMessageProcessingPlan") - messages = [] - finalMessage = None - finalMessage_id = None - query = None - - #### Pull out the main processing plan envelope - envelope = PreviousMessageProcessingPlan.from_dict(inputEnvelope["previous_message_processing_plan"]) - - #### If there are URIs provided, try to load them - if envelope.previous_message_uris is not None: - if debug: eprint("DEBUG: Got previous_message_uris") - for uri in envelope.previous_message_uris: - if debug: eprint("DEBUG: messageURI="+uri) - matchResult = re.match( r'http[s]://arax.ncats.io/.*api/rtx/.+/message/(\d+)',uri,re.M|re.I ) - if matchResult: - message_id = matchResult.group(1) - if debug: eprint("DEBUG: Found local ARAX identifier corresponding to message_id "+message_id) - if debug: eprint("DEBUG: Loading message_id "+message_id) - message = self.getMessage(message_id) - #eprint(type(message)) - if not isinstance(message,tuple): - if debug: eprint("DEBUG: Original question was: "+message["original_question"]) - messages.append(message) - finalMessage_id = message_id - query = { "query_type_id": message["query_type_id"], "restated_question": message["restated_question"], "terms": message["terms"] } - else: - eprint("ERROR: Unable to load message_id "+message_id) - return( { "status": 404, "title": "Message not found", "detail": "There is no local message corresponding to message_id="+str(message_id), "type": "about:blank" }, 404) - - #### If there are one or more previous_messages embedded in the POST, process them - if envelope.previous_messages is not None: - if debug: eprint("DEBUG: Got previous_messages") - for uploadedMessage in envelope.previous_messages: - if debug: eprint("DEBUG: uploadedMessage is a "+str(uploadedMessage.__class__)) - if str(uploadedMessage.__class__) == "": - if uploadedMessage.results: - message = ast.literal_eval(repr(uploadedMessage)) - messages.append(message) - - if message["terms"] is None: - message["terms"] = { "dummyTerm": "giraffe" } - if message["query_type_id"] is None: - message["query_type_id"] = "UnknownQ" - if message["restated_question"] is None: - message["restated_question"] = "What is life?" - if message["original_question"] is None: - message["original_question"] = "what is life" - - query = { "query_type_id": message["query_type_id"], "restated_question": message["restated_question"], "original_question": message["original_question"], "terms": message["terms"] } - else: - eprint("Uploaded message does not contain a results. May be the wrong format") - return( { "status": 404, "title": "Bad uploaded Message", "detail": "There is no results in the uploaded Message object=", "type": "about:blank" }, 404) - else: - eprint("Uploaded message is not of type Message. It is of type"+str(uploadedMessage.__class__)) - return( { "status": 404, "title": "Bad uploaded Message", "detail": "Uploaded message is not of type Message. It is of type"+str(uploadedMessage.__class__), "type": "about:blank" }, 404) - - #### Take different actions based on the number of messages we now have in hand - n_messages = len(messages) - if n_messages == 0: - return( { "status": 499, "title": "No Messages", "detail": "Did not get any useful Message objects", "type": "about:blank" }, 499) - elif n_messages == 1: - finalMessage = messages[0] - else: - finalMessage = TxMessage.from_dict(messages[0]) - counter = 1 - while counter < n_messages: - messageToMerge = TxMessage.from_dict(messages[counter]) - if messageToMerge.reasoner_id is None: - messageToMerge.reasoner_id = "Unknown" - if messageToMerge.reasoner_id != "ARAX": - messageToMerge = self.fix_message(query,messageToMerge,messageToMerge.reasoner_id) - - finalMessage = self.merge_message(finalMessage,messageToMerge) - counter += 1 - finalMessage = ast.literal_eval(repr(finalMessage)) - #return( { "status": 498, "title": "Multiple Messages", "detail": "I have multiple messages. Merging code awaits!", "type": "about:blank" }, 498) - - #### Examine the options that were provided and act accordingly - optionsDict = {} - if envelope.options: - if debug: eprint("DEBUG: Got options") - for option in envelope.options: - if debug: eprint("DEBUG: option="+option) - optionsDict[option] = 1 - - #### If there are processing_actions, then fulfill those - processing_actions = [] - if envelope.processing_actions: - if debug: eprint("DEBUG: Found processing_actions") - actions_parser = ActionsParser() - result = actions_parser.parse(envelope.processing_actions) - if result.error_code != 'OK': - eprint(result) - raise() - - #### Message suffers from a dual life as a dict and an object. above we seem to treat it as a dict. Fix that. FIXME - #### Below we start treating it as and object. This should be the way forward. - #### This is not a good place to do this, but may need to convert here - from ARAX_messenger import ARAXMessenger - finalMessage = ARAXMessenger().from_dict(finalMessage) - - #### Process each action in order - action_stats = { } - actions = result.data['actions'] - for action in actions: - if debug: eprint(f"DEBUG: Considering action '{action['command']}' with parameters {action['parameters']}") - #### If we encounter a return, then this is the end of the line - if action['command'] == 'return': - action_stats['return_action'] = action - break - if action['command'] == 'filter': - filter = ARAXFilter() - result = filter.apply(finalMessage,action['parameters']) - if result.error_code != 'OK': - response = result - break - else: - if debug: eprint(f"DEBUG: Action '{action['command']}' is not known") - - #### At the end, process the explicit return() action, or implicitly perform one - return_action = { 'command': 'return', 'parameters': { 'message': 'false', 'store': 'false' } } - if action is not None and action['command'] == 'return': - return_action = action - #### If an explicit one left out some parameters, set the defaults - if 'store' not in return_action['parameters']: - return_action['parameters']['store'] == 'false' - if 'message' not in return_action['parameters']: - return_action['parameters']['message'] == 'false' - - #if "AnnotateDrugs" in optionsDict: - # if debug: eprint("DEBUG: Annotating drugs") - # annotate_std_results(finalMessage) - - if return_action['parameters']['store'] == 'true': - if debug: eprint("DEBUG: Storing resulting Message") - finalMessage_id = self.addNewMessage(TxMessage.from_dict(finalMessage),query) - - #### If requesting a full redirect to the resulting message display. This doesn't really work I don't think - #if "RedirectToMessage" in optionsDict: - # #redirect("https://arax.ncats.io/api/rtx/v1/message/"+str(finalMessage_id), code=302) - # #return( { "status": 302, "redirect": "https://arax.ncats.io/api/rtx/v1/message/"+str(finalMessage_id) }, 302) - # return( "Location: https://arax.ncats.io/api/rtx/v1/message/"+str(finalMessage_id), 302) - - #### If asking for the full message back - if return_action['parameters']['message'] == 'true': - return(finalMessage) - - #### Else just the id is returned - else: - #return( { "status": 200, "message_id": str(finalMessage_id), "n_results": finalMessage['n_results'], "url": "https://arax.ncats.io/api/rtx/v1/message/"+str(finalMessage_id) }, 200) - return( { "status": 200, "message_id": str(finalMessage_id), "n_results": finalMessage.n_results, "url": "https://arax.ncats.io/api/rtx/v1/message/"+str(finalMessage_id) }, 200) - - - ########################################################################################################################## - def fix_message(self,query,message,reasoner_id): - - if reasoner_id == "ARAX": - base_url = "https://arax.ncats.io/api/rtx/v1" - elif reasoner_id == "Robokop": - base_url = "http://robokop.renci.org:6011/api" - elif reasoner_id == "Indigo": - base_url = "https://indigo.ncats.io/reasoner/api/v0" - else: - base_url = "https://unknown.url.org/" - eprint("ERROR: Unrecognized reasoner_id '"+reasoner_id+"'") - - if message.context is None: - message.context = "https://raw.githubusercontent.com/biolink/biolink-model/master/context.jsonld" - if message.id is None or message.id == "": - message.id = base_url + "/message/1234" - message.original_question = query["original_question"] - message.restated_question = query["restated_question"] - message.reasoner_id = reasoner_id - if message.message_code is None or message.message_code == "": - message.message_code = "OK" - if message.n_results is None: - if message.results is not None: - message.n_results = len(message.results) - else: - message.n_results = 0 - if message.code_description is None or message.code_description == "": - message.code_description = str(message.n_results) + " results returned" - - if message.results is not None: - result_id = 2345 - for result in message.results: - if result.id is None or result.id == "": - result.id = base_url + "/result/" + str(result_id) - result_id += 1 - if result.reasoner_id is None or result.reasoner_id == "": - result.reasoner_id = reasoner_id - if result.confidence is None: - result.confidence = 0 - - return(message) - - - def merge_message(self,final_message,message_to_merge): - for result in message_to_merge.results: - final_message.results.append(result) - final_message.n_results = len(final_message.results) - final_message.code_description = str(final_message.n_results) + " merged reults" - return(final_message) - - - - -############################################ General functions ############################################### -#### Turn a row into a dict -def object_as_dict(obj): - return {c.key: getattr(obj, c.key) - for c in inspect(obj).mapper.column_attrs} - -#### convert a dict into a string in guaranteed repeatable order i.e. sorted -def stringifyDict(inputDict): - outString = "{" - for key,value in sorted(inputDict.items(), key=lambda t: t[0]): - if outString != "{": - outString += "," - outString += "'"+str(key)+"':'"+str(value)+"'" - outString += "}" - return(outString) - - - -# This is from Kevin Xin from team orange. -# It performs MOD1 and MOD2 (annotation and scoring modules) of workflow 1 -# input std API message format -# output std API message format - -def annotate_drug(drug_id, id_type): - """ - Provide annotation for drug - """ - if id_type == 'chembl': - query_template = 'http://mychem.info/v1/query?q=drugcentral.xrefs.chembl_id:{{drug_id}}&fields=drugcentral' - elif id_type == 'chebi': - query_template = 'http://mychem.info/v1/query?q=drugcentral.xrefs.chebi:"{{drug_id}}"&fields=drugcentral' - query_url = query_template.replace('{{drug_id}}', drug_id) - results = {'annotate': {'common_side_effects': None, 'approval': None, 'indication': None, 'EPC': None}} - api_message = requests.get(query_url).json() - - # get drug approval information from mychem - approval = DictQuery(api_message).get("hits/drugcentral/approval") - if approval: - results['annotate']['approval'] = 'Yes' - # get drug approved indication information - indication = DictQuery(api_message).get("hits/drugcentral/drug_use/indication") - if len(indication) > 0 and indication[0] and not isinstance(indication[0], list): - results['annotate']['indication'] = [_doc['snomed_full_name'] for _doc in indication if - 'snomed_full_name' in _doc] - elif len(indication) > 0 and indication[0]: - results['annotate']['indication'] = [_doc['snomed_full_name'] for _doc in indication[0] if - 'snomed_full_name' in _doc] - # get drug established pharm class information - epc = DictQuery(api_message).get("hits/drugcentral/pharmacology_class/fda_epc") - if len(epc) > 0 and epc[0] and not isinstance(epc[0], list): - results['annotate']['EPC'] = [_doc['description'] for _doc in epc if 'description' in _doc] - elif len(epc) > 0 and epc[0]: - results['annotate']['EPC'] = [_doc['description'] for _doc in epc[0] if 'description' in _doc] - # get drug common side effects - side_effects = DictQuery(api_message).get("hits/drugcentral/fda_adverse_event") - if len(side_effects) > 0 and side_effects[0]: - if isinstance(side_effects[0], list): - # only keep side effects with likelihood higher than the threshold - results['annotate']['common_side_effects'] = [_doc['meddra_term'] for _doc in side_effects[0] if - _doc['llr'] > _doc['llr_threshold']] - if len(results['annotate']['common_side_effects']) > 10: - results['annotate']['common_side_effects'] = results['annotate']['common_side_effects'][:10] - elif isinstance(side_effects[0], dict) and 'meddra_term' in side_effects[0]: - results['annotate']['common_side_effects'] = side_effects[0]['meddra_term'] - - #### EWD: Now transform this into the schema! - results = unlist(results) - node_attributes = [] - for key,value in results["annotate"].items(): - if isinstance(value,list): - counter = 0 - for item in value: - node_attributes.append( { "name": key, "value": item } ) - counter += 1 - if counter > 11: break - else: - node_attributes.append( { "name": key, "value": value } ) - return node_attributes - - #return unlist(results) - - -""" -Helper functions -""" -def unlist(d): - """ - If the list contain only one element, unlist it - """ - for key, val in d.items(): - if isinstance(val, list): - if len(val) == 1: - d[key] = val[0] - elif isinstance(val, dict): - unlist(val) - return d - -class DictQuery(dict): - """ - Helper function to fetch value from a python dictionary - """ - def get(self, path, default = None): - keys = path.split("/") - val = None - - for key in keys: - if val: - if isinstance(val, list): - val = [ v.get(key, default) if v else None for v in val] - else: - val = val.get(key, default) - else: - val = dict.get(self, key, default) - - if not val: - break; - - return val - - -def annotate_std_results(input_json_doc): - """ - Annotate results from reasoner's standard output - """ - for _doc in input_json_doc['results']: - if 'result_graph' in _doc and _doc['result_graph'] is not None: - eprint("Found result_graph and it is") - eprint(_doc['result_graph']) - for _node in _doc['result_graph']['nodes']: - if _node['id'].startswith('CHEMBL'): - _drug = _node['id'].split(':')[-1] - _node['node_attributes'] = annotate_drug(_drug, 'chembl') - elif _node['id'].startswith("CHEBI:"): - _node['node_attributes'] = annotate_drug(_node['id'], 'chebi') - if 'knowledge_graph' in input_json_doc: - for _node in input_json_doc['knowledge_graph']['nodes']: - if _node['id'].startswith('CHEMBL'): - _drug = _node['id'].split(':')[-1] - _node['node_attributes'] = annotate_drug(_drug, 'chembl') - elif _node['id'].startswith("CHEBI:"): - _node['node_attributes'] = annotate_drug(_node['id'], 'chebi') - return input_json_doc - - - - - - -#### If this class is run from the command line, perform a short little test to see if it is working correctly -def main(): - - #### Create a new RTXFeedback object - rtxFeedback = RTXFeedback() - envelope = PreviousMessageProcessingPlan() - #envelope.options = [ "Store", "RedirectToMessage" ] - envelope.options = [ "AnnotateDrugs", "Store", "ReturnMessageId" ] - #envelope.options = [ "ReturnMessage" ] - #envelope.options = [ "AnnotateDrugs", "ReturnMessage" ] - envelope.message_ur_is = [ "https://arax.ncats.io/api/rtx/v1/message/300" ] - - #result = rtxFeedback.processExternalPreviousMessageProcessingPlan(envelope) - #print(result) - - - - #### Careful, don't destroy an important database!!! - ##rtxFeedback.createDatabase() - ##rtxFeedback.prepopulateDatabase() - #sys.exit() - - #### Connect to the database - session = rtxFeedback.session - - #### Query and print some rows from the reference tables - print("Querying database") - for rating in session.query(Rating).all(): - print(rating) - print("rating_id="+str(rating.rating_id)+" name="+rating.name+"\n") - - for expertise_level in session.query(Expertise_level).all(): - print(expertise_level) - print("expertise_level_id="+str(expertise_level.expertise_level_id)+" name="+expertise_level.name+"\n") - - print(rtxFeedback.getRatings()) - - -if __name__ == "__main__": main() diff --git a/code/UI/Feedback/RTXFeedback_Test1.py b/code/UI/Feedback/RTXFeedback_Test1.py deleted file mode 100644 index be672d3de..000000000 --- a/code/UI/Feedback/RTXFeedback_Test1.py +++ /dev/null @@ -1,64 +0,0 @@ -#!/usr/bin/python3 -# Some example test code for the RTX feedback system - -import os -import sys -import json -import ast - -from RTXFeedback import RTXFeedback -import requests -sys.path.append(os.path.dirname(os.path.abspath(__file__))+"/../OpenAPI/python-flask-server") -from swagger_server.models.response import Response - -url = "http://arax.ncats.io/api/rtx/v1/query" - -query = { - "known_query_type_id": "Q3", - "original_question": "what proteins does acetaminophen target", - "restated_question": "Which proteins are the target of acetaminophen?", - "terms": { - "chemical_substance": "CHEMBL112", - "rel_type": "directly_interacts_with", - "target_label": "protein" - } - } - -query = { - "known_query_type_id": "Q0", - "original_question": "what is malaria", - "restated_question": "What is malaria", - "terms": { - "term": "malaria" - } -} - - -#### Create an RTX Feedback management object -rtxFeedback = RTXFeedback() - -#### Purge and re-create the database if desired -#rtxFeedback.createDatabase() -#rtxFeedback.prepopulateDatabase() - -#### Connect to the database -rtxFeedback.connect() - -#### Fetch a cached response based on this query if there is one -cachedResponse = rtxFeedback.getCachedResponse(query) -#cachedResponse = None - -#### If there was one, then return it -if ( cachedResponse is not None ): - apiResponse = Response().from_dict(cachedResponse) - -#### Otherwise, send the query to the web service (which creates an entry in the cache) -else: - httpResponse = requests.post(url,json=query) - assert(httpResponse.status_code == 200) - apiResponse = Response.from_dict(httpResponse.json()) - rtxFeedback.addNewResponse(apiResponse,query) - -#### Print out the result as JSON -dumpString = json.dumps(ast.literal_eval(repr(apiResponse)),sort_keys=True,indent=2) -print(dumpString[0:1000]+"\n...") diff --git a/code/UI/Feedback/reinitiatizeDatabase.py b/code/UI/Feedback/reinitiatizeDatabase.py deleted file mode 100644 index 54aefe23c..000000000 --- a/code/UI/Feedback/reinitiatizeDatabase.py +++ /dev/null @@ -1,29 +0,0 @@ -#!/bin/env python3 -# Reinitialize the Message/Feedback MySQL database - -import os -import sys -import json -import ast - -from RTXFeedback import RTXFeedback - -if len(sys.argv) < 2: - print("Run reinitializeDatabase.pl with the parameter 'yes' if you really want to delete and re-create the feedback/Message database") - sys.exit(0) - -if sys.argv[1] != 'yes': - print("If you really want to delete and re-create the feedback/Message database, use:") - print(" python reinitializeDatabase.py yes") - sys.exit(0) - -#### Create an RTX Feedback management object -rtxFeedback = RTXFeedback() - -#### Purge and re-create the database -rtxFeedback.createDatabase() -rtxFeedback.prepopulateDatabase() - -#### Connect to the database -rtxFeedback.connect() - diff --git a/code/UI/Feedback/sqlalchemy_ericTest1.py b/code/UI/Feedback/sqlalchemy_ericTest1.py deleted file mode 100644 index 29e514209..000000000 --- a/code/UI/Feedback/sqlalchemy_ericTest1.py +++ /dev/null @@ -1,54 +0,0 @@ -#!/usr/bin/python3 -# Trivial sample program fiddling with SQLAlchemy - -import os -import sys -from sqlalchemy import Column, ForeignKey, Integer, String -from sqlalchemy.ext.declarative import declarative_base -from sqlalchemy.orm import relationship -from sqlalchemy import create_engine -from sqlalchemy.orm import sessionmaker - -Base = declarative_base() - -class Person(Base): - __tablename__ = 'person' - # Here we define columns for the table person - # Notice that each column is also a normal Python instance attribute. - id = Column(Integer, primary_key=True) - name = Column(String(250), nullable=False) - -class Address(Base): - __tablename__ = 'address' - # Here we define columns for the table address. - # Notice that each column is also a normal Python instance attribute. - id = Column(Integer, primary_key=True) - street_name = Column(String(250)) - street_number = Column(String(250)) - post_code = Column(String(250), nullable=False) - person_id = Column(Integer, ForeignKey('person.id')) - person = relationship(Person) - - -def main(): - print("Creating database") - engine = create_engine('sqlite:///sqlalchemy_example.db') - Base.metadata.create_all(engine) - - print("Writing to database") - DBSession = sessionmaker(bind=engine) - session = DBSession() - new_person = Person(name='Eric') - session.add(new_person) - session.commit() - new_address = Address(post_code='98008', person=new_person) - session.add(new_address) - session.commit() - - print("Querying database") - for person in session.query(Person).all(): - print(person) - print("id="+str(person.id)+" name="+person.name+"\n") - - -if __name__ == "__main__": main() diff --git a/code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml b/code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml index 7723578be..65ef52d13 100644 --- a/code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml +++ b/code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml @@ -9,7 +9,7 @@ info: url: http://www.apache.org/licenses/LICENSE-2.0.html termsOfService: https://github.com/RTXteam/RTX/blob/master/LICENSE title: RTX KG2 - TRAPI 1.5.0 - version: 2.10.0 + version: 2.10.1 x-translator: component: KP team: diff --git a/code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml b/code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml index d9adc70bd..60afa13f9 100644 --- a/code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml +++ b/code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml @@ -9,7 +9,7 @@ info: url: http://www.apache.org/licenses/LICENSE-2.0.html termsOfService: https://github.com/RTXteam/RTX/blob/master/LICENSE title: ARAX Translator Reasoner - TRAPI 1.5.0 - version: 1.5.3 + version: 1.5.4 x-translator: component: ARA team: diff --git a/code/UI/OpenAPI/specifications/export/ARAX/1.5.0/openapi.yaml b/code/UI/OpenAPI/specifications/export/ARAX/1.5.0/openapi.yaml index 5d7f57b49..e5411707f 100644 --- a/code/UI/OpenAPI/specifications/export/ARAX/1.5.0/openapi.yaml +++ b/code/UI/OpenAPI/specifications/export/ARAX/1.5.0/openapi.yaml @@ -15,7 +15,7 @@ info: team: - Expander Agent infores: infores:arax - biolink-version: 4.2.0 + biolink-version: 4.2.1 externalDocs: description: The values for component and team are restricted according to this external JSON schema. See schema and examples at url diff --git a/code/UI/OpenAPI/specifications/export/KG2/1.5.0/openapi.yaml b/code/UI/OpenAPI/specifications/export/KG2/1.5.0/openapi.yaml index 854ab4d29..f65129444 100644 --- a/code/UI/OpenAPI/specifications/export/KG2/1.5.0/openapi.yaml +++ b/code/UI/OpenAPI/specifications/export/KG2/1.5.0/openapi.yaml @@ -9,13 +9,13 @@ info: url: http://www.apache.org/licenses/LICENSE-2.0.html termsOfService: https://github.com/RTXteam/RTX/blob/master/LICENSE title: RTX KG2 - TRAPI 1.5.0 - version: 2.10.0 + version: 2.10.1 x-translator: component: KP team: - Expander Agent infores: infores:rtx-kg2 - biolink-version: 4.2.0 + biolink-version: 4.2.1 externalDocs: description: The values for component and team are restricted according to this external JSON schema. See schema and examples at url @@ -42,10 +42,10 @@ externalDocs: url: https://github.com/NCATSTranslator/ReasonerAPI servers: - description: RTX-KG2 TRAPI 1.5 endpoint - production - url: https://kg2.transltr.io/api/rtxkg2/v1.4 + url: https://kg2cploverdb.transltr.io x-maturity: production - description: RTX-KG2 TRAPI 1.5 endpoint - testing - url: https://kg2.test.transltr.io/api/rtxkg2/v1.4 + url: https://kg2cploverdb.test.transltr.io x-maturity: testing - description: RTX-KG2 TRAPI 1.5 endpoint - staging url: https://kg2cploverdb.ci.transltr.io diff --git a/code/UI/interactive/araxi.js b/code/UI/interactive/araxi.js index 75d1bff36..c9a9b51e4 100644 --- a/code/UI/interactive/araxi.js +++ b/code/UI/interactive/araxi.js @@ -1,5 +1,5 @@ // WARNING: -// This file was auto-generated by /mnt/data/orangeboard/devLM/RTX/code/UI/interactive/./dsl2json.py on: 2024-09-11 06:23:47 +// This file was auto-generated by /mnt/data/orangeboard/devLM/RTX/code/UI/interactive/./dsl2json.py on: 2024-11-01 01:58:59 // var araxi_commands = { "add_qedge()": { @@ -208,7 +208,7 @@ var araxi_commands = { "description": "Whether to omit supporting data on nodes/edges in the results (e.g., publications, description, etc.)." } }, - "description": "This command will expand (aka, answer/fill) your query graph in an edge-by-edge fashion, intelligently selecting which KPs to use for each edge. It selects KPs from the SmartAPI Registry based on the meta information provided by their TRAPI APIs, whether they have an endpoint running a matching TRAPI version, and whether they have an endpoint with matching maturity. For each QEdge, it queries the selected KPs concurrently; it will timeout for a particular KP if it decides it's taking too long to respond (this KP timeout can be controlled by the user). You may also optionally specify a particular KP to use via the 'kp' parameter (described below).\n\nCurrent candidate KPs include (for TRAPI 1.5, maturity 'development'): \ninfores:answer-coalesce, infores:automat-binding-db, infores:automat-cam-kp, infores:automat-ctd, infores:automat-drug-central, infores:automat-genome-alliance, infores:automat-gtex, infores:automat-gtopdb, infores:automat-gwas-catalog, infores:automat-hetionet, infores:automat-hgnc, infores:automat-hmdb, infores:automat-human-goa, infores:automat-icees-kg, infores:automat-intact, infores:automat-monarchinitiative, infores:automat-panther, infores:automat-pharos, infores:automat-reactome, infores:automat-robokop, infores:automat-string-db, infores:automat-ubergraph, infores:automat-viral-proteome, infores:cohd, infores:connections-hypothesis, infores:gelinea, infores:genetics-data-provider, infores:knowledge-collaboratory, infores:molepro, infores:multiomics-clinicaltrials, infores:multiomics-drugapprovals, infores:multiomics-microbiome, infores:multiomics-multiomics, infores:openpredict, infores:rtx-kg2, infores:service-provider-trapi, infores:spoke. \n\n(Note that this list of KPs may change unexpectedly based on the SmartAPI registry.)" + "description": "This command will expand (aka, answer/fill) your query graph in an edge-by-edge fashion, intelligently selecting which KPs to use for each edge. It selects KPs from the SmartAPI Registry based on the meta information provided by their TRAPI APIs, whether they have an endpoint running a matching TRAPI version, and whether they have an endpoint with matching maturity. For each QEdge, it queries the selected KPs concurrently; it will timeout for a particular KP if it decides it's taking too long to respond (this KP timeout can be controlled by the user). You may also optionally specify a particular KP to use via the 'kp' parameter (described below).\n\nCurrent candidate KPs include (for TRAPI 1.5, maturity 'development'): \ninfores:answer-coalesce, infores:automat-binding-db, infores:automat-cam-kp, infores:automat-ctd, infores:automat-drug-central, infores:automat-ehr-clinical-connections-kp, infores:automat-ehr-may-treat-kp, infores:automat-genome-alliance, infores:automat-gtex, infores:automat-gtopdb, infores:automat-gwas-catalog, infores:automat-hetionet, infores:automat-hgnc, infores:automat-hmdb, infores:automat-human-goa, infores:automat-icees-kg, infores:automat-intact, infores:automat-monarchinitiative, infores:automat-panther, infores:automat-pharos, infores:automat-reactome, infores:automat-robokop, infores:automat-string-db, infores:automat-ubergraph, infores:automat-viral-proteome, infores:cohd, infores:connections-hypothesis, infores:gelinea, infores:genetics-data-provider, infores:knowledge-collaboratory, infores:molepro, infores:multiomics-clinicaltrials, infores:multiomics-drugapprovals, infores:multiomics-microbiome, infores:multiomics-multiomics, infores:openpredict, infores:rtx-kg2, infores:service-provider-trapi, infores:spoke. \n\n(Note that this list of KPs may change unexpectedly based on the SmartAPI registry.)" }, "overlay(action=add_node_pmids)": { "parameters": { @@ -1360,32 +1360,10 @@ var araxi_commands = { "min": 1, "max": 5, "type": "integer", - "description": "The maximum edges to connect two nodes with. If not provided defaults to 2." - }, - "qnode_keys": { - "is_required": true, - "examples": [ - [ - "n01", - "n02" - ], - [] - ], - "type": "list", - "description": "List with just two qnode keys to connect. example: [n1, n2]" - }, - "node_category_constraint": { - "is_required": false, - "examples": [ - "biolink:Disease", - "biolink:Gene", - "biolink:ChemicalEntity" - ], - "type": "string", - "description": "This constraint will display paths that only pass through the user-specified category." + "description": "The maximum edges to connect two nodes with. If not provided defaults to 4." } }, - "description": "\nconnect_nodes adds paths between two nodes specified in the query.\n " + "description": "connect_nodes adds paths between two nodes specified in the query." }, "infer(action=chemical_gene_regulation_graph_expansion)": { "parameters": { @@ -1435,7 +1413,7 @@ var araxi_commands = { "qedge_id_3" ], "type": "string", - "description": "The id of the qedge you wish to perform the drug treatment/chemical regulation inference expansion." + "description": "The id of the qedge you wish to perform the chemical-gene regulation inference expansion." }, "threshold": { "is_required": false, @@ -1506,7 +1484,17 @@ var araxi_commands = { }, "infer(action=drug_treatment_graph_expansion)": { "parameters": { - "node_curie": { + "drug_curie": { + "is_required": true, + "examples": [ + "CHEMBL.COMPOUND:CHEMBL55643", + "CHEBI:8378", + "RXNORM:1011" + ], + "type": "string", + "description": "The CURIE for a drug node used to predict what potential diseases it may treat." + }, + "disease_curie": { "is_required": true, "examples": [ "DOID:9352", @@ -1514,7 +1502,7 @@ var araxi_commands = { "HP:0001945" ], "type": "string", - "description": "The curie for the node you wish to predict drugs which will treat." + "description": "The CURIE for a disease node used to predict what potential drugs can potentially treat it." }, "qedge_id": { "is_required": false, @@ -1524,7 +1512,7 @@ var araxi_commands = { "qedge_id_3" ], "type": "string", - "description": "The id of the qedge you wish to perform the drug treatment/chemical regulation inference expansion." + "description": "The id of the qedge you wish to perform the drug-disease treatment inference expansion." }, "n_drugs": { "is_required": false, @@ -1535,7 +1523,18 @@ var araxi_commands = { ], "default": 50, "type": "integer", - "description": "The number of drug nodes to return. If not provided defaults to 50. Considering the response speed, the maximum number of drugs returned is only allowed to be 50." + "description": "Given an interested disease CURIE, the number of drug nodes to return. If not provided defaults to 50. Considering the response speed, the maximum number of drugs returned is only allowed to be 50." + }, + "n_diseases": { + "is_required": false, + "examples": [ + 5, + 15, + 25 + ], + "default": 50, + "type": "integer", + "description": "Given an interested drug CURIE, The number of disease nodes to return. If not provided defaults to 50. Considering the response speed, the maximum number of diseases returned is only allowed to be 50." }, "n_paths": { "is_required": false, diff --git a/code/UI/interactive/index.html b/code/UI/interactive/index.html index 33dbb1f9a..b92b41ef7 100644 --- a/code/UI/interactive/index.html +++ b/code/UI/interactive/index.html @@ -4,7 +4,7 @@ ARAX User Interface - + @@ -465,6 +465,14 @@

Synonym Lookup:

╳ +
+ +
@@ -520,61 +528,102 @@

Synonym Lookup:

API Settings
-
-

REMOTE API TIMEOUT DURING ARAX EXPANSION (leave blank for default):

- - seconds - -

-

DEFAULT PRUNING THRESHOLD DURING ARAX EXPANSION:

- - nodes - -

-

BASE API URL (ARAX):

- - -
-

ARAX QUERY URL:

- - -

-

ARS API (post query):

- - -

-

EXTERNAL API (post query):

- - -
- - - - - - - - - - - - - - -

+
+ +

REMOTE API TIMEOUT DURING ARAX EXPANSION (leave blank for default):

+ + seconds + + + + + + +

DEFAULT PRUNING THRESHOLD DURING ARAX EXPANSION:

+ + nodes + + + + + + +

BASE API URL (ARAX):

+ + + + + + + +

ARAX QUERY URL:

+ + + + + + + +

ARS API (post query):

+ + + + + + + +

EXTERNAL API (post query):

+ + + + + + + + + + + + + + + + + + + + + +
Session Settings
-
-

MAXIMUM NUMBER OF RESULTS TO DISPLAY (very large values may crash UI):

- - -

-

SUBMITTER (enter a generic name to help track queries):

- - -

+
+ +

MAXIMUM NUMBER OF RESULTS TO DISPLAY (very large values may crash UI):

+ + results + + + + + +

MAXIMUM NUMBER OF SYNONYMS TO DISPLAY (values above 1000 may slow down UI):

+ + nodes + + + + + + +

SUBMITTER (enter a generic name to help track queries):

+ + + + +