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wtd2_params.txt
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wtd2_params.txt
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cai0_ca_ion = 0.001
cao0_ca_ion = 5
cali0_cal_ion = 0.001
calo0_cal_ion = 5
#celsius = 34
global_ra = 100 # not really sure what this is
RA = 100 # ohm-cm - constant for whole cell
CM = 1 # uF-cm2 - constant for whole cell
G_PAS = 1.15e-5 # S/cm2
E_PAS = -70 # mV
G_NAF = 1.5 # soma only
G_NAFD = 0.0195 # all dends
G_NAP = 4e-5 # soma only
G_NAPD = 1.3802e-7 # all dends, according to Wolf et al. paper
#G_NAPD = 1.3802e-6 # all dends -- CHANGED in Wolf modelDB entry
G_KIR = 0.00014 # S/cm2
G_KAS = 0.0104 # soma & prox dends; s/cm2
G_KASD = 0.00095142 # mid & distal dends; S/cm2
G_KAF = 0.0225 # soma & prox dends; S/cm2
G_KAFD = 0.020584 # mid & dist dends; S/cm2
G_BKKCA = 0.001 #
G_SKKCA = 0.145
G_KDR = 0.00604
G_KDR_AIS = 0.00604
G_NAF_AIS = 1.5 # different values allowed in axon initial segment
G_KAS_AIS = 0.0104
G_KAF_AIS = 0.0225
G_NAP_AIS = 4e-5
CAINF = 1e-5 # mM, steady state intracell ca conc.
TAUR = 43 # ms, time const of ca diffusion - Jackson 2003
CA_DRIVE = 10000
CA_PUMP = 0.02
caNMDA = 0.1
P_CAL = 6.7e-6 # cm/s
P_CALD = 6.7e-6 # cm/s
P_CAL13 = 4.25e-7 #1.7e-6 # cm/s
P_CAL13D = 4.25e-7 #1.7e-6 # cm/s
P_CAN = 0.000019383 # cm/s
P_CAQ = 6.0e-6 # cm/s
P_CAR = 0.0000380846 # cm/s
P_CAT = 0.0000005982 # cm/s 4e-7
EK = -94
ENA = 50
HSHIFT_NAP = -10
MSHIFT_NAP = -10
MSHIFT_KAS = 2
HSHIFT_KAS = 22.5
MSHIFT_KAF = 0
HSHIFT_KAF = 0
HTAUSHIFT_KAS = -90
M1HALF_BK = -10
M2HALF_BK = -65
M3HALF_BK = -44
CELSIUS_SK_SKKCA = 22
NET_N = 1e10
G_AMPA = 8.5e-4 #350e-6 #8.81e-4
G_NMDA = 12.2e-5 # 9.2e-5
G_GABA = 0.0021 #4300e-6 #0.0027
AMPA_WT = 1
NMDA_WT = 1
GABA_WT = 1
NOISE = 1
NGLU = 84
NGABA = 84
NSYN = NGABA + NGLU
# factors for adding the Hay axon
CM_MYELINFAC = 0.02 # Hay myelin had cm=0.02, cm=1 in AIS/soma
AXON_MSHIFT = 10
AXON_HSHIFT = 5
AXON_MSLOPEFAC = 1.29 # Hay NaT m_slope was 9/mV in axon, 7/mV in soma
SOMA_MVHALF_NAF = -23.9
SOMA_MSLOPE_NAF = -11.8
SOMA_MSHIFT_NAF = 0
SOMA_HVHALF_NAF = -62.9
SOMA_HSLOPE_NAF = 10.7
SOMA_HSHIFT_NAF = 0
G_PAS = 0.0000565446
E_PAS = -76.9443641966
CM = 0.900001
G_KIR = 0.0136006786
QKIR = 0.200000
SHKIR = 101.340908321
SLPKIR = 11.8894574774
V0 = -80
v_init=-80
P_CAQ = 0 # cm/s - turn this off, Evans excluded it.
# note, we will include NaP in this optimization due to the axon inclusion.