diff --git a/Modules/Filtering/ImageGrid/test/CMakeLists.txt b/Modules/Filtering/ImageGrid/test/CMakeLists.txt
index 541f8cc28a34..b9b57eb36e76 100644
--- a/Modules/Filtering/ImageGrid/test/CMakeLists.txt
+++ b/Modules/Filtering/ImageGrid/test/CMakeLists.txt
@@ -665,6 +665,7 @@ itk_add_test(
 
 set(ITKImageGridGTests
     itkChangeInformationImageFilterGTest.cxx
+    itkComposeImageFilterGTest.cxx
     itkResampleImageFilterGTest.cxx
     itkSliceImageFilterTest.cxx
     itkTileImageFilterGTest.cxx
diff --git a/Modules/Filtering/ImageGrid/test/itkComposeImageFilterGTest.cxx b/Modules/Filtering/ImageGrid/test/itkComposeImageFilterGTest.cxx
new file mode 100644
index 000000000000..19223eb68c82
--- /dev/null
+++ b/Modules/Filtering/ImageGrid/test/itkComposeImageFilterGTest.cxx
@@ -0,0 +1,104 @@
+/*=========================================================================
+ *
+ *  Copyright NumFOCUS
+ *
+ *  Licensed under the Apache License, Version 2.0 (the "License");
+ *  you may not use this file except in compliance with the License.
+ *  You may obtain a copy of the License at
+ *
+ *         https://www.apache.org/licenses/LICENSE-2.0.txt
+ *
+ *  Unless required by applicable law or agreed to in writing, software
+ *  distributed under the License is distributed on an "AS IS" BASIS,
+ *  WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ *  See the License for the specific language governing permissions and
+ *  limitations under the License.
+ *
+ *=========================================================================*/
+
+// The header file to be tested:
+#include "itkComposeImageFilter.h"
+#include "itkVectorIndexSelectionCastImageFilter.h"
+#include "itkMinimumMaximumImageCalculator.h"
+#include "itkExtractImageFilter.h"
+#include "itkPasteImageFilter.h"
+
+
+#include "itkImage.h"
+
+// Google Test header file:
+#include <gtest/gtest.h>
+
+// Standard C++ header files:
+#include <limits>
+#include <random>
+
+
+TEST(ComposeImageFilter, simpleitk_2220)
+{
+  // Test case for SimpleITK issue #2220
+  // Reported data corruption with 4G compose on Windows system
+
+
+  const unsigned int size = 400;
+  const unsigned int nchannels = 100;
+  using ImageType = itk::Image<unsigned char, 3>;
+  using VectorImageType = itk::VectorImage<unsigned char, 3>;
+  std::vector<ImageType::Pointer> images;
+
+  for (unsigned int i = 0; i < nchannels; ++i)
+  {
+    auto                  image = ImageType::New();
+    ImageType::RegionType region;
+    ImageType::SizeType   imageSize = { { size, size, size } };
+    region.SetSize(imageSize);
+    image->SetRegions(region);
+    image->Allocate();
+    image->FillBuffer(i % 250);
+
+    images.push_back(image);
+  }
+
+  using ComposeFilterType = itk::ComposeImageFilter<ImageType>;
+  ComposeFilterType::Pointer composeFilter = ComposeFilterType::New();
+  for (unsigned int i = 0; i < nchannels; ++i)
+  {
+    composeFilter->SetInput(i, images[i]);
+  }
+
+  composeFilter->Update();
+  VectorImageType::Pointer img = composeFilter->GetOutput();
+  std::cout << "Compose filter executed." << std::endl;
+
+  for (unsigned int i = 0; i < nchannels; ++i)
+  {
+    itk::IndexValueType                  z = i;
+    std::map<unsigned int, unsigned int> values;
+
+    for (itk::IndexValueType y = 0; y < size; ++y)
+    {
+      for (itk::IndexValueType x = 0; x < size; ++x)
+      {
+        itk::Index<3> idx = { { x, y, z } };
+
+        auto pixel = img->GetPixel(idx);
+        if (pixel[i] != i % 250)
+        {
+          ++values[pixel[i]];
+        }
+      }
+    }
+
+    EXPECT_TRUE(values.empty()) << "channel " << i << " has incorrect values;" << std::endl;
+
+    if (!values.empty())
+    {
+      std::cout << "values: ";
+      for (auto v : values)
+      {
+        std::cout << v.first << "(" << v.second << "), ";
+      }
+      std::cout << std::endl;
+    }
+  }
+}