CVD-COVID-UK, led by Professor Angela Wood, Associate Director of the British Heart Foundation (BHF) Data Science Centre, is one of the National Flagship Projects approved by the NIHR-BHF Cardiovascular Partnership.
It aims to understand the relationship between COVID-19 and cardiovascular diseases such as heart attack, heart failure, stroke, and blood clots in the lungs through analyses of de-identified, pseudonymised, linked, nationally collated healthcare datasets across the four nations of the UK.
CVD-COVID-UK is a collaboration of over 400 members across more than 50 institutions including data custodians, data scientists with methodological and analytical expertise and clinicians, all of whom have signed up to an agreed set of principles with an inclusive, open and transparent ethos.
Approved researchers access data within secure trusted research environments (TREs)/secure data environments (SDEs) provided by NHS England in England, the National Data Safe Haven in Scotland, the SAIL Databank in Wales and the Honest Broker Service in Northern Ireland.
Linkable datasets include those from primary and secondary care, COVID lab tests and vaccinations, deaths, critical care, prescribing/dispensing, cardiovascular, stroke and vascular surgical audits, maternity services and mental health.
Expansion to COVID-IMPACT
Building on the success of CVD-COVID-UK, the BHF Data Science Centre gained ethical and regulatory approval to broaden the scope of the programme to all COVID-related research (in NHS Englands’s SDE for England only). This is known as COVID-IMPACT and it helps to support research projects from the wider community.
If you are interested in becoming a member of CVD-COVID-UK / COVID-IMPACT Consortium, please email [email protected]
All analysis plans, protocols, code, code lists and reports arising from the consortium's work will be made publicly available via this GitHub organisation, the CVD-COVID-UK / COVID-IMPACT webpage, the Health Data Research Innovation Gateway (see below) and through open-access publications.
- Trends in pediatric hospital admissions caused or contributed by SARS-CoV-2 infection in England (2024)
- The impact of COVID-19 vaccination on patients with congenital heart disease in England: a case-control study (2024)
- COVID-19 diagnosis, vaccination during pregnancy, and adverse pregnancy outcomes of 865,654 women in England and Wales: a population-based cohort study (2024)
- COVID-19 vaccination and birth outcomes of 186,990 women vaccinated before pregnancy: an England-wide cohort study (2024)
- Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 million adults in England (2024)
- Vaccinations, cardiovascular drugs, hospitalisation and mortality in COVID-19 and Long COVID (2024)
- Risk of cardiovascular events following COVID-19 in people with and without pre-existing chronic respiratory disease (2024)
- A nationwide, population-based study on specialized care for acute heart failure throughout the COVID-19 pandemic (2024)
- Ethnicity data resource in population-wide health records: completeness, coverage and granularity of diversity (2024)
- Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales (2024)
- Understanding covid-19 outcomes among people with intellectual disabilities in England (2023)
- Sars-Cov-2 Infection in People with Type 1 Diabetes and Hospital Admission: An Analysis of Risk Factors for England (2023)
- Antipsychotic drug prescribing and mortality in people with dementia before and during the COVID-19 pandemic: a retrospective cohort study in Wales, UK (2023)
- Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England (2023)
- The impact of the COVID-19 pandemic on cardiovascular disease prevention and management (2023)
- Harmonising electronic health records for reproducible research: challenges, solutions and recommendations from a UK-wide COVID-19 research collaboration (2023)
- Better End of Life 2022. Mind the gaps: understanding and improving out-of-hours care for people with advanced illness and their informal carers. Research report. (2022)
- Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries (2022)
- Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19 – a data-driven retrospective cohort study (2022)
- Association of COVID-19 with major arterial and venous thrombotic diseases: a population-wide cohort study of 48 million adults in England and Wales (2022)
- A retrospective cohort study measured predicting and validating the impact of the COVID-19 pandemic in individuals with chronic kidney disease (2022)
- COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records (2022)
- Evaluation of antithrombotic use and COVID-19 outcomes in a nationwide atrial fibrillation cohort (2022)
- Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: A population-based cohort study of 46 million adults in England (2022)
- Linking electronic health records for research on a nationwide cohort including over 54 million people in England (2021)
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