diff --git a/release_notes.md b/release_notes.md
index 8224fe7ddc..2aea6ea9aa 100644
--- a/release_notes.md
+++ b/release_notes.md
@@ -10,3 +10,4 @@
   - [Added net9 prelaunch app.](https://github.com/Azure/azure-functions-dotnet-worker/pull/2898)
 - Update the `DefaultHttpProxyService` to better handle client disconnect scenarios (#10688)
   - Replaced `InvalidOperationException` with `HttpForwardingException` when there is a ForwarderError
+- Updated `WebJobs.Script` to target .NET 8 (instead of .NET Standard 2.1)
diff --git a/src/WebJobs.Script/Binding/Http/RawScriptResult.cs b/src/WebJobs.Script/Binding/Http/RawScriptResult.cs
index 3f7e3e5b84..f72474bd85 100644
--- a/src/WebJobs.Script/Binding/Http/RawScriptResult.cs
+++ b/src/WebJobs.Script/Binding/Http/RawScriptResult.cs
@@ -62,7 +62,7 @@ public async Task ExecuteResultAsync(ActionContext context)
                         }
                         else
                         {
-                            response.Headers.Add(header.Key, header.Value.ToString() ?? string.Empty);
+                            response.Headers.Append(header.Key, header.Value.ToString() ?? string.Empty);
                         }
                     }
                 }
diff --git a/src/WebJobs.Script/Binding/Http/ScriptObjectResult.cs b/src/WebJobs.Script/Binding/Http/ScriptObjectResult.cs
index bef5fd3251..d2e8cfe1ec 100644
--- a/src/WebJobs.Script/Binding/Http/ScriptObjectResult.cs
+++ b/src/WebJobs.Script/Binding/Http/ScriptObjectResult.cs
@@ -39,7 +39,7 @@ internal void AddResponseHeaders(HttpContext context)
                     }
                     else
                     {
-                        response.Headers.Add(header.Key, header.Value.ToString() ?? string.Empty);
+                        response.Headers.Append(header.Key, header.Value.ToString() ?? string.Empty);
                     }
                 }
             }
diff --git a/src/WebJobs.Script/Description/Compilation/CompilationServiceException.cs b/src/WebJobs.Script/Description/Compilation/CompilationServiceException.cs
index 4999fc6486..e99a0fb69d 100644
--- a/src/WebJobs.Script/Description/Compilation/CompilationServiceException.cs
+++ b/src/WebJobs.Script/Description/Compilation/CompilationServiceException.cs
@@ -11,7 +11,6 @@
 
 namespace Microsoft.Azure.WebJobs.Script.Description
 {
-    [Serializable]
     public sealed class CompilationServiceException : Exception
     {
         public CompilationServiceException()
@@ -25,9 +24,5 @@ public CompilationServiceException(string message) : base(message)
         public CompilationServiceException(string message, Exception innerException) : base(message, innerException)
         {
         }
-
-        private CompilationServiceException(SerializationInfo info, StreamingContext context) : base(info, context)
-        {
-        }
     }
 }
diff --git a/src/WebJobs.Script/Extensions/AssemblyExtensions.cs b/src/WebJobs.Script/Extensions/AssemblyExtensions.cs
index 37d8c75321..17a5f58847 100644
--- a/src/WebJobs.Script/Extensions/AssemblyExtensions.cs
+++ b/src/WebJobs.Script/Extensions/AssemblyExtensions.cs
@@ -25,7 +25,9 @@ public static string GetCodeBase(this Assembly assembly)
                 return codeBase;
             }
 
+#pragma warning disable SYSLIB0012 // Type or member is obsolete
             return assembly.CodeBase;
+#pragma warning restore SYSLIB0012 // Type or member is obsolete
         }
     }
 }
diff --git a/src/WebJobs.Script/ExternalStartupException.cs b/src/WebJobs.Script/ExternalStartupException.cs
index e38d99df62..614f76995a 100644
--- a/src/WebJobs.Script/ExternalStartupException.cs
+++ b/src/WebJobs.Script/ExternalStartupException.cs
@@ -9,7 +9,6 @@ namespace Microsoft.Azure.WebJobs.Script
     /// An exception that indicates an issue calling into an external Startup class. This will
     /// prevent the host from starting.
     /// </summary>
-    [Serializable]
     public class ExternalStartupException : Exception
     {
         public ExternalStartupException() { }
@@ -17,9 +16,5 @@ public ExternalStartupException() { }
         public ExternalStartupException(string message) : base(message) { }
 
         public ExternalStartupException(string message, Exception inner) : base(message, inner) { }
-
-        protected ExternalStartupException(
-          System.Runtime.Serialization.SerializationInfo info,
-          System.Runtime.Serialization.StreamingContext context) : base(info, context) { }
     }
 }
diff --git a/src/WebJobs.Script/FunctionConfigurationException.cs b/src/WebJobs.Script/FunctionConfigurationException.cs
index 19163937c9..3f22add71d 100644
--- a/src/WebJobs.Script/FunctionConfigurationException.cs
+++ b/src/WebJobs.Script/FunctionConfigurationException.cs
@@ -9,7 +9,6 @@ namespace Microsoft.Azure.WebJobs.Script
     /// An exception that indicates an issue with a function. These exceptions will be caught and
     /// logged, but not cause a host to restart.
     /// </summary>
-    [Serializable]
     public class FunctionConfigurationException : Exception
     {
         public FunctionConfigurationException() { }
@@ -17,9 +16,5 @@ public FunctionConfigurationException() { }
         public FunctionConfigurationException(string message) : base(message) { }
 
         public FunctionConfigurationException(string message, Exception inner) : base(message, inner) { }
-
-        protected FunctionConfigurationException(
-          System.Runtime.Serialization.SerializationInfo info,
-          System.Runtime.Serialization.StreamingContext context) : base(info, context) { }
     }
 }
diff --git a/src/WebJobs.Script/Host/ProxyFunctionProvider.cs b/src/WebJobs.Script/Host/ProxyFunctionProvider.cs
index aaedcd5643..01cdc36720 100644
--- a/src/WebJobs.Script/Host/ProxyFunctionProvider.cs
+++ b/src/WebJobs.Script/Host/ProxyFunctionProvider.cs
@@ -100,7 +100,7 @@ private ImmutableArray<FunctionMetadata> LoadFunctionMetadata()
             var functionErrors = new Dictionary<string, ICollection<string>>();
             Collection<ProxyFunctionMetadata> proxies = ReadProxyMetadata(_scriptOptions.Value.RootScriptPath, _logger, functionErrors);
 
-            ImmutableArray<FunctionMetadata> metadata;
+            ImmutableArray<FunctionMetadata> metadata = ImmutableArray<FunctionMetadata>.Empty;
             if (proxies != null && proxies.Any())
             {
                 metadata = proxies.ToImmutableArray<FunctionMetadata>();
diff --git a/src/WebJobs.Script/HostConfigurationException.cs b/src/WebJobs.Script/HostConfigurationException.cs
index a637c098b2..9be4d39121 100644
--- a/src/WebJobs.Script/HostConfigurationException.cs
+++ b/src/WebJobs.Script/HostConfigurationException.cs
@@ -9,7 +9,6 @@ namespace Microsoft.Azure.WebJobs.Script
     /// An exception that indicates an issue configuring a ScriptHost. This will
     /// prevent the host from starting.
     /// </summary>
-    [Serializable]
     public class HostConfigurationException : Exception
     {
         public HostConfigurationException() { }
@@ -17,9 +16,5 @@ public HostConfigurationException() { }
         public HostConfigurationException(string message) : base(message) { }
 
         public HostConfigurationException(string message, Exception inner) : base(message, inner) { }
-
-        protected HostConfigurationException(
-          System.Runtime.Serialization.SerializationInfo info,
-          System.Runtime.Serialization.StreamingContext context) : base(info, context) { }
     }
 }
diff --git a/src/WebJobs.Script/HostDisposedException.cs b/src/WebJobs.Script/HostDisposedException.cs
index 4ccfc005db..637007224d 100644
--- a/src/WebJobs.Script/HostDisposedException.cs
+++ b/src/WebJobs.Script/HostDisposedException.cs
@@ -11,7 +11,6 @@ namespace Microsoft.Azure.WebJobs.Script
     /// <summary>
     /// An exception that indicates that a service was used on a disposed host.
     /// </summary>
-    [Serializable]
     public class HostDisposedException : ObjectDisposedException
     {
         // For this exception, we want a full stack trace to pinpoint the method
@@ -24,17 +23,6 @@ public HostDisposedException(string disposedObjectName, Exception inner)
             _stackTraceString = GetStackTraceString();
         }
 
-        protected HostDisposedException(SerializationInfo info, StreamingContext context)
-            : base(info, context)
-        {
-            if (info == null)
-            {
-                throw new ArgumentNullException(nameof(info));
-            }
-
-            _stackTraceString = info.GetString("FullStackTraceString");
-        }
-
         public override string StackTrace => _stackTraceString;
 
         public string GetStackTraceString()
@@ -42,13 +30,6 @@ public string GetStackTraceString()
             return new StackTrace(true).ToString();
         }
 
-        public override void GetObjectData(SerializationInfo info, StreamingContext context)
-        {
-            base.GetObjectData(info, context);
-
-            info.AddValue("FullStackTraceString", _stackTraceString);
-        }
-
         private static string GetDefaultMessage(string disposedObjectName)
         {
             string message = $"The host is disposed and cannot be used. Disposed object: '{disposedObjectName}'";
diff --git a/src/WebJobs.Script/HostInitializationException.cs b/src/WebJobs.Script/HostInitializationException.cs
index 7297633b28..d4e870198a 100644
--- a/src/WebJobs.Script/HostInitializationException.cs
+++ b/src/WebJobs.Script/HostInitializationException.cs
@@ -8,7 +8,6 @@ namespace Microsoft.Azure.WebJobs.Script
     /// <summary>
     /// An exception that indicates an issue initializing a ScriptHost.
     /// </summary>
-    [Serializable]
     public class HostInitializationException : Exception
     {
         public HostInitializationException() { }
@@ -16,9 +15,5 @@ public HostInitializationException() { }
         public HostInitializationException(string message) : base(message) { }
 
         public HostInitializationException(string message, Exception inner) : base(message, inner) { }
-
-        protected HostInitializationException(
-          System.Runtime.Serialization.SerializationInfo info,
-          System.Runtime.Serialization.StreamingContext context) : base(info, context) { }
     }
 }
diff --git a/src/WebJobs.Script/InvalidHostServicesException.cs b/src/WebJobs.Script/InvalidHostServicesException.cs
index 6d41d63a4f..1ad26cc771 100644
--- a/src/WebJobs.Script/InvalidHostServicesException.cs
+++ b/src/WebJobs.Script/InvalidHostServicesException.cs
@@ -10,7 +10,6 @@ namespace Microsoft.Azure.WebJobs.Script
     /// An exception that indicates an issue with the registerd services for a ScriptHost. This will
     /// prevent the host from starting.
     /// </summary>
-    [Serializable]
     public class InvalidHostServicesException : Exception
     {
         public InvalidHostServicesException() { }
@@ -18,8 +17,5 @@ public InvalidHostServicesException() { }
         public InvalidHostServicesException(string message) : base(message) { }
 
         public InvalidHostServicesException(string message, Exception inner) : base(message, inner) { }
-
-        protected InvalidHostServicesException(SerializationInfo info, StreamingContext context)
-            : base(info, context) { }
     }
 }
diff --git a/src/WebJobs.Script/WebJobs.Script.csproj b/src/WebJobs.Script/WebJobs.Script.csproj
index 79038f1e08..8d85fef7d6 100644
--- a/src/WebJobs.Script/WebJobs.Script.csproj
+++ b/src/WebJobs.Script/WebJobs.Script.csproj
@@ -1,6 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
-    <TargetFramework>netstandard2.1</TargetFramework>
+    <TargetFramework>net8.0</TargetFramework>
     <PackageId>Microsoft.Azure.WebJobs.Script</PackageId>
     <AssemblyName>Microsoft.Azure.WebJobs.Script</AssemblyName>
     <RootNamespace>Microsoft.Azure.WebJobs.Script</RootNamespace>
diff --git a/src/WebJobs.Script/Workers/Rpc/Configuration/RpcWorkerConfigFactory.cs b/src/WebJobs.Script/Workers/Rpc/Configuration/RpcWorkerConfigFactory.cs
index dbfc1e8be8..5632c44b8c 100644
--- a/src/WebJobs.Script/Workers/Rpc/Configuration/RpcWorkerConfigFactory.cs
+++ b/src/WebJobs.Script/Workers/Rpc/Configuration/RpcWorkerConfigFactory.cs
@@ -64,7 +64,9 @@ public IList<RpcWorkerConfig> GetConfigs()
 
         internal static string GetDefaultWorkersDirectory(Func<string, bool> directoryExists)
         {
+#pragma warning disable SYSLIB0012 // Type or member is obsolete
             string assemblyLocalPath = Path.GetDirectoryName(new Uri(typeof(RpcWorkerConfigFactory).Assembly.CodeBase).LocalPath);
+#pragma warning restore SYSLIB0012 // Type or member is obsolete
             string workersDirPath = Path.Combine(assemblyLocalPath, RpcWorkerConstants.DefaultWorkersDirectoryName);
             if (!directoryExists(workersDirPath))
             {
diff --git a/src/WebJobs.Script/Workers/SharedMemoryDataTransfer/MemoryMappedFileAccessorWindows.cs b/src/WebJobs.Script/Workers/SharedMemoryDataTransfer/MemoryMappedFileAccessorWindows.cs
index 0bbf567e00..091a869635 100644
--- a/src/WebJobs.Script/Workers/SharedMemoryDataTransfer/MemoryMappedFileAccessorWindows.cs
+++ b/src/WebJobs.Script/Workers/SharedMemoryDataTransfer/MemoryMappedFileAccessorWindows.cs
@@ -60,6 +60,11 @@ public override bool TryCreate(string mapName, long size, out MemoryMappedFile m
 
         public override bool TryOpen(string mapName, out MemoryMappedFile mmf)
         {
+            if (!OperatingSystem.IsWindows())
+            {
+                throw new PlatformNotSupportedException($"{nameof(TryOpen)} is not supported on the current platform.");
+            }
+
             mmf = null;
 
             try
diff --git a/test/WebJobs.Script.Tests.Integration/WebHostEndToEnd/HostDisposedExceptionTests.cs b/test/WebJobs.Script.Tests.Integration/WebHostEndToEnd/HostDisposedExceptionTests.cs
index c8be6f188f..9b9eed3f8f 100644
--- a/test/WebJobs.Script.Tests.Integration/WebHostEndToEnd/HostDisposedExceptionTests.cs
+++ b/test/WebJobs.Script.Tests.Integration/WebHostEndToEnd/HostDisposedExceptionTests.cs
@@ -75,27 +75,6 @@ public async Task DisposedScriptLoggerFactory_UsesFullStackTrace()
         //    Assert.Contains("CustomListener.RunAsync", ex.StackTrace);
         //}
 
-        [Fact]
-        public void Serialization()
-        {
-            HostDisposedException originalEx = new HostDisposedException("someObject", new ObjectDisposedException("someObject"));
-            HostDisposedException deserializedEx;
-
-#pragma warning disable SYSLIB0011 // Type or member is obsolete
-            BinaryFormatter bf = new BinaryFormatter();
-#pragma warning restore SYSLIB0011 // Type or member is obsolete
-            using (MemoryStream ms = new MemoryStream())
-            {
-#pragma warning disable SYSLIB0011 // Type or member is obsolete
-                bf.Serialize(ms, originalEx);
-                ms.Seek(0, 0);
-                deserializedEx = (HostDisposedException)bf.Deserialize(ms);
-#pragma warning restore SYSLIB0011 // Type or member is obsolete
-            }
-
-            Assert.Equal(originalEx.ToString(), deserializedEx.ToString());
-        }
-
         private class TestScriptLoggerFactory : ScriptLoggerFactory
         {
             public static bool ShouldWait { get; set; } = false;